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Contact

• workRoom 210 South Laboratory
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6053
• fax0115 951 6099
• kevin.sinclair@nottingham.ac.uk

Biography

Ongoing research is addressing the hypothesis that maternal nutritional effects in developing oocytes and embryos, and procedures used in assisted reproduction, can program fetal development and adult health via heritable epigenetic changes to DNA methylation at specific gene loci in the oocyte and pre-implantation embryo. First to discover that developmental anomalies following mammalian embryo culture were due to errors in genomic imprinting (Nature Genetics, 27: 153-154). Similar phenomena have since been reported in human IVF pregnancies. Work supported by the National Institutes of Health (USA) demonstrated that reductions in folate and vitamin B₁₂ in the diets of intending mothers (rat and sheep) lead to epigenetic modifications to DNA methylation and adult offspring with increased body fat and blood pressure, altered immune function and insulin resistance (showcased to the NICHD Advisory Council in Washington DC in January 2007; PNAS, 104: 19351-19356).

Provided the first detailed report of cardio-metabolic and musculo-skeletal health in aged cloned (by somatic-cell nuclear transfer (SCNT)) offspring (Nature Communications 7: 12359; Scientific Reports 7: 15685) and, most recently, provided details of concordant DNA methylation in embryonic and somatic-cell lineages (PLOS Genetics. 13: e1007060). Ongoing work is determining if the nature extent of (a) mtDNA heteroplasmy and (b) DNA methylation in different cell types can explain observed differences in metabolic and musculoskeletal health within and between cloned animals

Additional EU-FP7 - sponsored studies in sheep and mice assessed the effects of exposure to real-life levels of environmental chemicals on development of the fetal hypothalamic-pituitary-gonadal axis. Studies in sheep were initially based on animals grazing sewage-sludge treated pastures at various intervals during pregnancy (Scientific Reports. 6: 22279). From these studies specific groups of chemicals (e.g. phthalates and PCBs) were identified as being particularly harmful and have since been studied in separate studies. Exposure to these chemicals has a profound effect on testis development, with more subtle effects observed in the fetal ovary. Molecular studies are assessing global changes in gene and protein expression associated with such effects.

Current BBSRC funded studies are investigating the genetics of one-carbon metabolism in sheep in relation to productivity, fertility and health. Also, seeking to generate generate cytogenetically 'normal' and developmentally competent bovine and porcine sexed-embryos that have undergone genomic evaluations in order to promote the production of livestock that are genetically superior for a number of health and production-related traits.

Research Summary

Ongoing research is addressing the hypothesis that maternal nutritional effects in developing oocytes and embryos, and procedures used in assisted reproduction, can program fetal development and… read more

Selected Publications

• YOUNG, L.E., FERNANDES, K., MCEVOY, T.G., BUTTERWITH, S.C., GUTIERREZ, C.G., CAROLAN, C., BROADBENT, P.J., ROBINSON, J.J., WILMUT, I. and SINCLAIR, K.D., 2001. Nature Genetics. 27(2), 153-154
• SINCLAIR, KEVIN D, ALLEGRUCCI, CINZIA, SINGH, RAVINDER, GARDNER, DAVID S, SEBASTIAN, SONIA, BISPHAM, JAYSON, THURSTON, ALEXANDRA, HUNTLEY, JOHN F, REES, WILLIAM D, MALONEY, CHRISTOPHER A and LEA, RICHARD, 2007. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proceedings of the National Academy of Sciences of the United States of America. 104(49), 19351-6
• ARMSTRONG, D.G., MCEVOY, T.G., BAXTER, G., ROBINSON, J.J., HOGG, C.O., WOAD, K.J., WEBB, R. and SINCLAIR, K.D., 2001. Biology of Reproduction. 64(6), 1624-1632
• ADAMIAK, S.J., POWELL, K., ROOKE, J.A., WEBB, R. and SINCLAIR, K.D., 2006. Reproduction. 131(2), 247-58

• View all publications

Current Research

Ongoing research is addressing the hypothesis that maternal nutritional effects in developing oocytes and embryos, and procedures used in assisted reproduction, can program fetal development and adult health via heritable epigenetic changes to DNA methylation at specific gene loci in the oocyte and pre-implantation embryo. First to discover that developmental anomalies following mammalian embryo culture were due to errors in genomic imprinting (Nature Genetics, 27: 153-154). Similar phenomena have since been reported in human IVF pregnancies. Work supported by the National Institutes of Health (USA) demonstrated that reductions in folate and vitamin B₁₂ in the diets of intending mothers (rat and sheep) lead to epigenetic modifications to DNA methylation and adult offspring with increased body fat and blood pressure, altered immune function and insulin resistance (showcased to the NICHD Advisory Council in Washington DC in January 2007; PNAS, 104: 19351-19356).

Provided the first detailed report of cardio-metabolic and musculo-skeletal health in aged cloned (by somatic-cell nuclear transfer (SCNT)) offspring (Nature Communications 7: 12359; Scientific Reports 7: 15685) and, most recently, provided details of concordant DNA methylation in embryonic and somatic-cell lineages (PLOS Genetics. 13: e1007060). Ongoing work is determining if the nature extent of (a) mtDNA heteroplasmy and (b) DNA methylation in different cell types can explain observed differences in metabolic and musculoskeletal health within and between cloned animals

Additional EU-FP7 - sponsored studies in sheep and mice assessed the effects of exposure to real-life levels of environmental chemicals on development of the fetal hypothalamic-pituitary-gonadal axis. Studies in sheep were initially based on animals grazing sewage-sludge treated pastures at various intervals during pregnancy (Scientific Reports. 6: 22279). From these studies specific groups of chemicals (e.g. phthalates and PCBs) were identified as being particularly harmful and have since been studied in separate studies. Exposure to these chemicals has a profound effect on testis development, with more subtle effects observed in the fetal ovary. Molecular studies are assessing global changes in gene and protein expression associated with such effects.

Current BBSRC funded studies are investigating the genetics of one-carbon metabolism in sheep in relation to productivity, fertility and health. Also, seeking to generate generate cytogenetically 'normal' and developmentally competent bovine and porcine sexed-embryos that have undergone genomic evaluations in order to promote the production of livestock that are genetically superior for a number of health and production-related traits.

• ZEEBAREE BK, KWONG WY, MANN GE, GUTIERREZ CG and SINCLAIR KD, 2018. Theriogenology. 105, 107-114
• KEVIN D SINCLAIR, 2018. Proceedings of the National Academy of Sciences of the United States of America.
• WATKINS AJ, DIAS I, TSURO H, ALLEN D, EMES RD, MORETON J, WILSON R, INGRAM RJM and SINCLAIR KD, 2018. Proceedings of the National Academy of Sciences of the United States of America. (In Press.)
• CLARE CE, BRASSINGTON AH, KWONG WY and SINCLAIR KD, 2018. Annual review of animal biosciences. (In Press.)
• WEERATHILAKE WADV, BRASSINGTON AH, WILLIAMS SJ, KWONG WY, SINCLAIR LA and SINCLAIR KD, 2018. Animal : an international journal of animal bioscience. 1-10 (In Press.)
• HUNTRISS J, BALEN AH, SINCLAIR KD, BRISON DR, PICTON HM and , 2018. BJOG : an international journal of obstetrics and gynaecology. 125(13), e43-e54
• CHOI M, GENEREUX DP, GOODSON J, AL-AZZAWI H, ALLAIN SQ, SIMON N, PALASEK S, WARE CB, CAVANAUGH C, MILLER DG, JOHNSON WC, SINCLAIR KD, ST脰GER R and LAIRD CD, 2017. PLoS genetics. 13(11), e1007060
• CORR SA, GARDNER DS, LANGLEY-HOBBS S, NESS MG, KITCHENER AC and SINCLAIR KD, 2017. Scientific reports. 7(1), 15685
• SINCLAIR, KEVIN, RUTHERFORD, KENNETH, WALLACE, JACQUELINE, BRAMELD, JOHN, ST脰GER, REINHARD, ALBERIO, RAMIRO, SWEETMAN, DYLAN, GARDNER, DAVID, PERRY, VIV, ADAM, CLARE and OTHERS, 2016. Reproduction, Fertility and Development.
• SINCLAIR KD, CORR SA, GUTIERREZ CG, FISHER PA, LEE JH, RATHBONE AJ, CHOI I, CAMPBELL KH and GARDNER DS, 2016. Nature communications. 7, 12359
• SINCLAIR, KD, RUTHERFORD, KMD, WALLACE, JM, BRAMELD, JM and ET AL., 2016. Reproduction, fertility, and development. 28(10), 1443-1478
• FOWLER PA, DRAKE AJ, O'SHAUGHNESSY PJ, BHATTACHARYA S, RAAB A, SINCLAIR KD, FELDMANN J and MEHARG AA, 2016. Environmental health perspectives. 124(6), A99
• GREGSON E, WEBB R, SHELDRICK EL, CAMPBELL BK, MANN GE, LIDDELL S and SINCLAIR KD, 2016. Reproduction (Cambridge, England). 151(6), 563-75
• LEA RG, AMEZAGA MR, LOUP B, MANDON-P脡PIN B, STEFANSDOTTIR A, FILIS P, KYLE C, ZHANG Z, ALLEN C, PURDIE L, JOUNEAU L, COTINOT C, RHIND SM, SINCLAIR KD and FOWLER PA, 2016. Scientific reports. 6, 22279
• XU J and SINCLAIR KD, 2015. Reproduction, fertility, and development. 27(4), 667-76
• DRAKE AJ, O'SHAUGHNESSY PJ, BHATTACHARYA S, MONTEIRO A, KERRIGAN D, GOETZ S, RAAB A, RHIND SM, SINCLAIR KD, MEHARG AA, FELDMANN J and FOWLER PA, 2015. BMC medicine. 13, 18
• DUNFORD, LOUISE J., SINCLAIR, KEVIN D., KWONG, WING Y., STURROCK, CRAIG, CLIFFORD, BETHAN L., GILES, TOM C. and GARDNER, DAVID S., 2014. Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development: Faseb Journal Faseb Journal. 28(11), 4880-4892
• SCHAEDLICH K, SCHMIDT JS, KWONG WY, SINCLAIR KD, KURZ R, JAHNKE HG and FISCHER B, 2014. Journal of applied toxicology : JAT. 35(7), 861-9
• DUNFORD LJ, SINCLAIR KD, KWONG WY, STURROCK C, CLIFFORD BL, GILES TC and GARDNER DS, 2014. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(11), 4880-92
• ALBERIO R and SINCLAIR KD, 2014. Reproduction (Cambridge, England). 147(5), E3
• WATKINS AJ and SINCLAIR KD, 2014. American journal of physiology. Heart and circulatory physiology. 306(10), H1444-52
• SINCLAIR KD, GARNSWORTHY PC, MANN GE and SINCLAIR LA, 2013. Animal : an international journal of animal bioscience. 8(2), 262-74
• SINCLAIR KD and WATKINS AJ, 2013. Reproduction, fertility, and development. 26(1), 99-114
• STEEGERS-THEUNISSEN RP, TWIGT J, PESTINGER V and SINCLAIR KD, 2013. Human reproduction update. 19(6), 640-55
• JOSEPH, C., HUNTER, M.G., SINCLAIR, K.D. and ROBINSON, R.S., 2012. Reproduction. 144(3), 361-372
• BELLINGHAM M, FIANDANESE N, BYERS A, COTINOT C, EVANS NP, POCAR P, AMEZAGA MR, LEA RG, SINCLAIR KD, RHIND SM and FOWLER PA, 2012. Reproduction in domestic animals = zuchthygiene. 47 Suppl 4, 15-22
• PRING SR, OWEN M, KING JR, SINCLAIR KD, WEBB R, FLINT APF and GARNSWORTHY PC, 2012. Journal of theoretical biology. 313, 115-26
• MALONEY CA, HAY SM, REID MD, DUNCAN G, NICOL F, SINCLAIR KD and REES WD, 2012. Genes & nutrition. (In Press.)
• MALONEY, CHRISTOPHER A, HAY, SUSAN M, YOUNG, LORAINE E, SINCLAIR, KEVIN D and REES, WILLIAM D, 2011. The Journal of nutrition. 141(1), 95-100
• FOWLER PA, BELLINGHAM M, SINCLAIR KD, EVANS NP, POCAR P, FISCHER B, SCHAEDLICH K, SCHMIDT J, AMEZAGA MR, BHATTACHARYA S, RHIND SM and O'SHAUGHNESSY PJ, 2011. Molecular And Cellular Endocrinology. (In Press.)
• TWIGT, J.M., HAMMICHE, F., SINCLAIR, K.D., BECKERS, N.G., VISSER, J.A., LINDEMANS, J., DE JONG, F.H., LAVEN, J.S.E. and STEEGERS-THEUNISSEN, R.P., 2011. JCEM: The Journal of Clinical Endocrinology and Metabolism. 96(2), E322-329
• HUGHES, J., KWONG, W.Y., LI, D., SALTER, A.M., LEA, R.G. and SINCLAIR, K.D., 2011. Reproduction: The Journal of the Society for Reproduction and Fertility. 141(1), 105-118
• MALONEY, CA, HAY, SM, YOUNG, LE, SINCLAIR, KD and REES, WD, 2011. Journal Of Nutrition. 141(1), 95-100
• WONNACOTT, K.E., KWONG, W.Y., HUGHES, J., SALTER, A.M., LEA, R.G., GARNSWORTHY, P.C. and SINCLAIR, K.D., 2010. Reproduction. 139(1), 57-69
• RHIND SM, EVANS NP, BELLINGHAM M, SHARPE RM, COTINOT C, MANDON-PEPIN B, LOUP B, SINCLAIR KD, LEA RG, POCAR P, FISCHER B, VAN DER ZALM E, HART K, SCHMIDT J, AMEZAGA MR and FOWLER PA, 2010. Animal : An International Journal Of Animal Bioscience. 4(7), 1227-1239
• KWONG, W.Y., ADAMIAK, S.J., GWYNN, A., SINGH, R. and SINCLAIR, K.D., 2010. Reproduction: The Journal of the Society for Reproduction and Fertility. 139(4), 705-15
• SINCLAIR KD, KARAMITRI A and GARDNER DS, 2010. Dietary Regulation Of Developmental Programming In Ruminants: Epigenetic Modifications In The Germline. Society Of Reproduction And Fertility Supplement. 67, 59-72
• GARDNER, D S, OZANNE, S E and SINCLAIR, K D, 2009. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364(1534), 3419-27
• GARNSWORTHY, P.C., FOULADI-NASHTA, A.A., MANN, G.E., SINCLAIR, K.D. and WEBB, R., 2009. Reproduction. 137(4), 759-768
• GRACE KS and SINCLAIR KD, 2009. Seminars In Reproductive Medicine. 27(5), 409-16
• FOULADI-NASHTA AA, WONNACOTT KE, GUTIERREZ CG, GONG JG, SINCLAIR KD, GARNSWORTHY PC and WEBB R, 2009. Reproduction (Cambridge, England). 138(5), 771-81
• ROOKE JA, AINSLIE A, WATT RG, ALINK FM, MCEVOY TG, SINCLAIR KD, GARNSWORTHY PC and WEBB R, 2009. Reproduction, Fertility, And Development. 21(3), 419-27
• KANAKKAPARAMBIL, R., SINGH, R., LI, D., WEBB, R. and SINCLAIR, K.D., 2009. Biology of Reproduction. 80(4), 743-752
• WONNACOTT KE, KWONG WY, HUGHES J, SALTER AM, LEA RG, GARNSWORTHY PC and SINCLAIR KD, 2009. Reproduction (Cambridge, England). 139(1), 57-69
• GARNSWORTHY PC, FOULADI-NASHTA AA, MANN GE, SINCLAIR KD and WEBB R, 2009. Reproduction (Cambridge, England). 137(4), 759-68
• THURSTON, A., TAYLOR, J., GARDNER, J., SINCLAIR, K.D. and YOUNG, L.E., 2008. Reproduction. 135(1), 29-40
• GARDNER, D.S., LEA R.G. and SINCLAIR, K.S., 2008. Animal. 2, 1128-1134
• SINCLAIR, KEVIN D, 2008. Seminars in reproductive medicine. 26(2), 153-61
• GARDNER, D.S., LEA R.G. and SINCLAIR, K.S., 2008. Animal. 2, 1128-1134
• GARNSWORTHY, P.C., LOCK, A., MANN, G.E., SINCLAIR, K.D. and WEBB, R, 2008. Journal of Dairy Science. 91(10), 3814-3823
• GARNSWORTHY, P.C., LOCK, A., MANN, G.E., SINCLAIR, K.D. and WEBB, R, 2008. Journal of Dairy Science. 91(10), 3824-3833
• ROOKE, JA, AINSLIE, A, WATT, RG, ALINK, FM, MCEVOY, TG, SINCLAIR, KD, GARNSWORTHY, PC and WEBB, R, 2008. Animal. 2(9), 1361-1370
• GARNSWORTHY PC, GONG JG, ARMSTRONG DG, NEWBOLD JR, MARSDEN M, RICHARDS SE, MANN GE, SINCLAIR KD and WEBB R, 2008. Journal Of Dairy Science. 91(11), 4190-7
• SINCLAIR, K.D., LUNN, L.A., KWONG, W.Y., WONNACOTT, K., LINFORTH, R.S.T. and CRAIGON, J., 2008. Reproductive Biomedicine Online. 16(6), 859-868
• GARNSWORTHY, P.C., SINCLAIR, K.D. and WEBB, R., 2008. Animal. 2(8), 1144-1152
• SINCLAIR KD, LUNN LA, KWONG WY, WONNACOTT K, LINFORTH RST and CRAIGON J, 2008. Amino acid and fatty acid composition of follicular fluid as predictors of in-vitro embryo development. Reproductive biomedicine online. 16(6), 859-68
• GARNSWORTHY PC, LOCK A, MANN GE, SINCLAIR KD and WEBB R, 2008. Journal of dairy science. 91(10), 3824-33
• GARNSWORTHY PC, LOCK A, MANN GE, SINCLAIR KD and WEBB R, 2008. Journal of dairy science. 91(10), 3814-23
• ROOKE JA, AINSLIE A, WATT RG, ALINK FM, MCEVOY TG, SINCLAIR KD, GARNSWORTHY PC and WEBB R, 2008. Animal : an international journal of animal bioscience. 2(9), 1361-70
• GARNSWORTHY PC, SINCLAIR KD and WEBB R, 2008. Animal : an international journal of animal bioscience. 2(8), 1144-52
• GARDNER DS, LEA RG and SINCLAIR KD, 2008. Animal : an international journal of animal bioscience. 2(8), 1128-34
• SINCLAIR, KEVIN D, ALLEGRUCCI, CINZIA, SINGH, RAVINDER, GARDNER, DAVID S, SEBASTIAN, SONIA, BISPHAM, JAYSON, THURSTON, ALEXANDRA, HUNTLEY, JOHN F, REES, WILLIAM D, MALONEY, CHRISTOPHER A and LEA, RICHARD, 2007. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proceedings of the National Academy of Sciences of the United States of America. 104(49), 19351-6
• ROOKE, JA, MCEVOY, TG, ASHWORTH,CJ, ROBINSON,JJ, WILMUT,I, YOUNG,LE and SINCLAIR,KD, 2007. Theriogenology. 67(3), 639-647
• SINCLAIR,K.D, LEA,R.G, REES,W.D and YOUNG,L.E, 2007. The developmental origins of health and disease; current theories and epigenetic mechanisms Society for Reproduction and Fertility Supplement. 64, 425-443
• SINCLAIR, KEVIN D and SINGH, RAVINDER, 2007. Theriogenology. 67(1), 43-53
• SINGH, R and SINCLAIR, K D, 2007. Theriogenology. 68 Suppl 1, S56-62
• SINCLAIR, K D, LEA, R G, REES, W D and YOUNG, L E, 2007. The developmental origins of health and disease: current theories and epigenetic mechanisms. Society of Reproduction and Fertility supplement. 64, 425-43
• SINGH, R, FOULADI-NASHTA, A A, LI, D, HALLIDAY, N, BARRETT, D A and SINCLAIR, K D, 2006. Journal of cellular biochemistry. 99(1), 146-55
• POWELL, K, ROOKE, J A, MCEVOY, T G, ASHWORTH, C J, ROBINSON, J J, WILMUT, I, YOUNG, L E and SINCLAIR, K D, 2006. Theriogenology. 66(8), 1901-12
• ADAMIAK, S.J., POWELL, K., ROOKE, J.A., WEBB, R. and SINCLAIR, K.D., 2006. Reproduction. 131(2), 247-58
• STEELE, W, ALLEGRUCCI, C, SINGH, R, LUCAS, E, PRIDDLE, H, DENNING, C, SINCLAIR, K and YOUNG, L, 2005. Reproductive Biomedicine online. 10(6), 755-66
• ALLEGRUCCI, C., DENNING, C.N., BURRIDGE, P., STEELE, W., SINCLAIR, K.D. and YOUNG, L.E., 2005. Reproductive Toxicology. 20(3), 353-367
• ADAMIAK, S.J., MACKIE, K., WATT, R.G., WEBB, R. and SINCLAIR, K.D., 2005. Biology of Reproduction. 73(5), 918-926
• ALLEGRUCCI C, DENNING CN, BURRIDGE P, STEELE W, SINCLAIR KD and YOUNG LE, 2005. Reproductive toxicology (Elmsford, N.Y.). 20(3), 353-67
• YOUNG,L.E., REES,W.D. and SINCLAIR,K.D, 2004. Programming in the pre-implantation embryo. In: Fetal nutrition and Adult Disease: Programming of chronic disease through fetal exposure to undernutrition CAB International, Oxford.
• QUINTANS, G., VINOLES, C. and SINCLAIR, K. D., 2004. Animal Reproduction Science. VOL 80(NUMBER 1-2), 5-14
• ROOKE, J A, EWEN, M, MACKIE, K, STAINES, M E, MCEVOY, T G and SINCLAIR, K D, 2004. Animal Reproduction Science. 84(1-2), 53-71
• QUINTANS, G, VI脩OLES, C and SINCLAIR, K D, 2004. Follicular growth and ovulation in postpartum beef cows following calf removal and GnRH treatment. Animal Reproduction Science. 80(1-2), 5-14
• MANN, G.E., GREEN, M.P., SINCLAIR, K.D., DEMMERS, K.J., FRAY, M.D., GUTIERREZ, C.G., GARNSWORTHY, P.C. and WEBB, R., 2003. Animal Reproduction Science. VOL 79(NUMBER 1-2), 71-79
• SINCLAIR, K.D., GARNSWORTHY, P.C. and WEBB, R., 2003. Recent advances in reproductive technologies : implications for livestock production and animal nutrition. In: GARNSWORTHY, P.C. and WISEMAN, J., eds., Recent Advances in Animal Nutrition - 2003 Nottingham University Press. 89-113
• MCEVOY, T. G., ASHWORTH, C. J., ROOKE, J. A. and SINCLAIR, K. D., 2003. Consequences of manipulating gametes and embryos of ruminant species Reproduction. Supplement. ISSU 61, 167-182
• SINCLAIR, K. D., ROOKE, J. A. and MCEVOY, T. G., 2003. Regulation of nutrient uptake and metabolism in pre-elongation ruminant embryos Reproduction. Supplement. ISSU 61, 371-385
• SINCLAIR KD, ROOKE JA and MCEVOY TG, 2003. Regulation of nutrient uptake and metabolism in pre-elongation ruminant embryos. Reproduction (Cambridge, England) Supplement. 61, 371-85
• MCEVOY TG, ASHWORTH CJ, ROOKE JA and SINCLAIR KD, 2003. Consequences of manipulating gametes and embryos of ruminant species. Reproduction (Cambridge, England) Supplement. 61, 167-82
• MANN GE, GREEN MP, SINCLAIR KD, DEMMERS KJ, FRAY MD, GUTIERREZ CG, GARNSWORTHY PC and WEBB R, 2003. Animal reproduction science. 79(1-2), 71-9
• PUSHPAKUMARA, P.G.A., ROBINSON, R.S., DEMMERS, K.J., MANN, G.E., SINCLAIR, K.D., WEBB, R. and WATHES, D.C., 2002. Reproduction. VOL 123(PART 6), 859-868
• DAWUDA, P. M., SCAIFE, J. R., HUTCHINSON, J. S. and SINCLAIR, K. D., 2002. Animal Reproduction Science. VOL 74(NUMBER 1-2), 11-26
• SINCLAIR, K. D., MOLLE, G., REVILLA, R., ROCHE, J. F., QUINTANS, G., MARONGIU, L., SANZ, A., MACKEY, D. R. and DISKIN, M. G., 2002. Ovulation of the first dominant follicle arising after day 21 post partum in suckling beef cows Animal Science. VOL 75(PART 1), 115-126
• DAWUDA PM, SCAIFE JR, HUTCHINSON JS and SINCLAIR KD, 2002. Animal reproduction science. 74(1-2), 11-26
• PUSHPAKUMARA PG, ROBINSON RS, DEMMERS KJ, MANN GE, SINCLAIR KD, WEBB R and WATHES DC, 2002. Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy. Reproduction (Cambridge, England). 123(6), 859-68
• ARMSTRONG, D.G., MCEVOY, T.G., BAXTER, G., ROBINSON, J.J., HOGG, C.O., WOAD, K.J., WEBB, R. and SINCLAIR, K.D., 2001. Biology of Reproduction. 64(6), 1624-1632
• YOUNG, L.E., FERNANDES, K., MCEVOY, T.G., BUTTERWITH, S.C., GUTIERREZ, C.G., CAROLAN, C., BROADBENT, P.J., ROBINSON, J.J., WILMUT, I. and SINCLAIR, K.D., 2001. Nature Genetics. 27(2), 153-154
• ARMSTRONG, D G, MCEVOY, T G, BAXTER, G, ROBINSON, J J, HOGG, C O, WOAD, K J, WEBB, R and SINCLAIR, K D, 2001. Biology of Reproduction. 64(6), 1624-32
• MALTIN, C A, DELDAY, M I, SINCLAIR, K D, STEVEN, J and SNEDDON, A A, 2001. Reproduction. 122(3), 359-74
• MCEVOY, T., ROBINSON, J. J., ASHWORTH, C. J., ROOKE, J. A. and SINCLAIR, K. D., 2001. Theriogenology. VOL 55(NO 1), 113-130
• SINCLAIR, K. D., LOBLEY, G. E., HORGAN, G. W., KYLE, D. J., PORTER, A. D., MATTHEWS, K. R., WARKUP, C. C. and MALTIN, C. A., 2001. Factors influencing beef eating quality. 1. Effects of nutritional regimen and genotype on organoleptic properties and instrumental texture Animal Science. VOL 72(PART 2), 269-278
• MCEVOY, T G, ROBINSON, J J and SINCLAIR, K D, 2001. Reproduction. 122(4), 507-18
• MALTIN,C.A., LOBLEY,G.E., GRANT,G.M., MILLER,L.A., KYLE,D.G., HORGAN,G.W., MATTHEWS,K.R. and SINCLAIR,K.D., 2001. Factors influencing beef eating quality. II. Effect of nutritional regimen and genotype on muscle fibre characteristics Animal Science. 72, 279
• SINCLAIR KD, YOUNG LE, WILMUT I and MCEVOY TG, 2001. In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men. Human reproduction (Oxford, England). 15 Suppl 5, 68-86
• MCEVOY TG, ROBINSON JJ, ASHWORTH CJ, ROOKE JA and SINCLAIR KD, 2001. Theriogenology. 55(1), 113-29
• YOUNG LE, FERNANDES K, MCEVOY TG, BUTTERWITH SC, GUTIERREZ CG, CAROLAN C, BROADBENT PJ, ROBINSON JJ, WILMUT I and SINCLAIR KD, 2001. Nature genetics. 27(2), 153-4
• SINCLAIR, K.D., KURAN, M., GEBBIE, F.E., WEBB, R. and MCEVOY, T.G., 2000. Nitrogen metabolism and fertility in cattle: II. Development of oocytes recovered from heifers offered diets differing in their rate of nitrogen release in the rumen Journal of Animal Science. VOL 78(PART 10), 2670-2680
• MCEVOY, T. G., SINCLAIR, K. D., YOUNG, L. E., WILMUT, I. and ROBINSON, J. J., 2000. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART Human Fertility. VOL 3(PART 4), 238-246
• SINCLAIR, K. D., YOUNG, L. E., WILMUT, I. and MCEVOY, T. G., 2000. In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men Human Reproduction. VOL 15(SUPP/5), 68-86
• MCEVOY,, SINCLAIR,, YOUNG,, WILMUT, and ROBINSON,, 2000. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART. Human Fertility. 3(4), 238-246
• SINCLAIR, K D, SINCLAIR, L A and ROBINSON, J J, 2000. Nitrogen metabolism and fertility in cattle: I. Adaptive changes in intake and metabolism to diets differing in their rate of energy and nitrogen release in the rumen. Journal of Animal Science. 78(10), 2659-69
• SINCLAIR KD, KURAN M, GEBBIE FE, WEBB R and MCEVOY TG, 2000. Nitrogen metabolism and fertility in cattle: II. Development of oocytes recovered from heifers offered diets differing in their rate of nitrogen release in the rumen. Journal of animal science. 78(10), 2670-80
• LOBLEY GE, SINCLAIR KD, GRANT CM, MILLER L, MANTLE D, CALDER AG, WARKUP CC and MALTIN CA, 2000. The effects of breed and level of nutrition on whole-body and muscle protein metabolism in pure-bred Aberdeen angus and Charolais beef steers. The British journal of nutrition. 84(3), 275-84
• MCEVOY TG, SINCLAIR KD, BROADBENT PJ, GOODHAND KL and ROBINSON JJ, 1999. Reproduction, fertility, and development. 10(6), 459-64
• SINCLAIR KD, MCEVOY TG, MAXFIELD EK, MALTIN CA, YOUNG LE, WILMUT I, BROADBENT PJ and ROBINSON JJ, 1999. Aberrant fetal growth and development after in vitro culture of sheep zygotes. Journal of reproduction and fertility. 116(1), 177-86
• ARMSTRONG, D.G., BAXTER, G., HOGG, C.O. and WOAD, K.J., 1998. The effect of different energy and protein diets on the expression of mRNA encoding components of the ovarian IGF-system in cattle Journal of Reproduction and Fertility. Abstract Series. ISSUE 22, 13
• SINCLAIR, K D, DUNNE, L D, MAXFIELD, E K, MALTIN, C A, YOUNG, L E, WILMUT, I, ROBINSON, J J and BROADBENT, P J, 1998. Reproduction, Fertility and Development. 10(3), 263-9
• YOUNG LE, SINCLAIR KD and WILMUT I, 1998. Reviews of reproduction. 3(3), 155-63
• MAXFIELD EK, SINCLAIR KD, DUNNE LD, BROADBENT PJ, ROBINSON JJ, STEWART E, KYLE DG and MALTIN CA, 1998. Biology of reproduction. 59(2), 321-5
• MAXFIELD EK, SINCLAIR KD, BROADBENT PJ, MCEVOY TG, ROBINSON JJ and MALTIN CA, 1998. Short-term culture of ovine embryos modifies fetal myogenesis. The American journal of physiology. 274(6 Pt 1), E1121-3
• ARMSTRONG, D.G., BAXTER, G., GUTIERREZ, C.G., WOAD, K.J., SINCLAIR, K.D., ROBINSON, J.J., MCEVOY, T.G. and WEBB, R., 1997. Ovarian IGF-II mRNA expression in cattle fed different energy and protein diets Journal of Reproduction and Fertility. Abstract Series. 19, 51
• MCEVOY, T.G., SINCLAIR, K.D., STAINES, M.E., ROBINSON, J.J., ARMSTRONG, D. and WEBB, R., 1997. In vitro blastocyst production in relation to energy and protein intake prior to oocyte collection Journal of Reproduction and Fertility. Abstract Series. 19, 51
• SINCLAIR KD and BROADBENT PJ, 1996. The Veterinary record. 139(17), 409-12