糖心原创

Contact

• workRoom B209 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8231822
• claire.seedhouse@nottingham.ac.uk

Biography

Dr Claire Seedhouse is an Associate Professor within the Division of Cancer and Stem Cells, in the School of Medicine, at the 糖心原创

Claire studied for a BSc (Hons) at Bath University which included two industrial placements (1995). She did her PhD at the Paterson Institute for Cancer Research, Manchester where she developed an interest in DNA damage and repair (1999). After completing several post-doctoral research positions and a fellowship at the 糖心原创 she was appointed as the Skillington Haematology Lecturer in 2009. She has published more than 40 papers (h index 24) and receives external, and local, peer-reviewed funding for her research.

Teaching Summary

School of Medicine Director of Postgraduate Education and Student Experience

Course Director MSc and PGCert Oncology

Lecturer - MSc Oncology, BMed Sciences, BSc/MSci Cancer Sciences

Research Summary

Claire's research focuses on mechanisms of drug action and resistance in haematological malignancies, including acute myeloid leukaemia (AML), multiple myeloma and lymphoma.

Current research projects include:

- Targeting Bcl2 family members in AML and myeloma

- NPM as a therapeutic target in AML

- Targeting dormant cells in leukaemia

- Response of AML and myeloma cells to novel therapeutic drugs

Research is funded by peer-reviewed grants from national and local charities and industrial support. The group is comprised of laboratory scientists and has strong links with clinicians and clinical scientists and has a solid publication track record in high-quality peer-reviewed journals with a number of highly cited (>100 citations) papers.

Selected Publications

• BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. SCIENTIFIC REPORTS. 10(1),
• BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. British journal of haematology.
• GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
• ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. BMC CANCER. 20(1),

• View all publications

• JAMES, JENNA R., CURD, JOHNATHAN, ASHWORTH, JENNIFER C., ABUHANTASH, MAYS, GRUNDY, MARTIN, SEEDHOUSE, CLAIRE H., ARKILL, KENTON P., WRIGHT, AMANDA J., MERRY, CATHERINE L. R. and THOMPSON, ALEXANDER, 2023. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24(4),
• JENKINS, HARRY H., LOPEZ, ANA A. TELLECHEA, TARANTINI, FRANCESCO SAVERIO, TOMLIN, HANNAH, SCALES, DANIELLE, LEE, I-NING, WU, SIYU, HYDE, RALPH, LIS-SLIMAK, KATARZYNA, BYARUHANGA, TIMOTHY, THOMPSON, JAMIE L., PIJUAN-GALITO, SARA, DOOLAN, LARA, KANEKO, KAZUYO, GWYNNE, PENNY, REFFIN, CAROLINE, PARK, EMILY, DEY, JAYASREE, HILL, JACK, ARENDT-TRANHOLM, ASTA, STROUD, AMY, PETRIE, MOIRA, DENNING, CHRIS, BENEST, ANDREW, V and SEEDHOUSE, CLAIRE, 2022. Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva SCIENTIFIC REPORTS. 12(1),
• NICHOLSON, RACHAEL, MENEZES, ANA CATARINA, AZEVEDO, ALEKSANDRA, LECKENBY, ADAM, DAVIES, SARA, SEEDHOUSE, CLAIRE, GILKES, AMANDA, KNAPPER, STEVE, TONKS, ALEX and DARLEY, RICHARD L., 2022. Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux FRONTIERS IN ONCOLOGY. 12,
• TARANTINI, FRANCESCO SAVERIO, WU, SIYU, JENKINS, HARRY, LOPEZ, ANA TELLECHEA, TOMLIN, HANNAH, HYDE, RALPH, LIS-SLIMAK, KATARZYNA, THOMPSON, JAMIE LOUISE, PIJUAN-GALITO, SARA, SCALES, DANIELLE, KANEKO, KAZUYO, DEY, JAYASREE, PARK, EMILY, HILL, JACK, LEE, I-NING, DOOLAN, LARA, ARENDT-TRANHOLM, ASTA, DENNING, CHRIS, SEEDHOUSE, CLAIRE and BENEST, ANDREW, V, 2022. Direct RT-qPCR Assay for the Detection of SARS-CoV-2 in Saliva Samples METHODS AND PROTOCOLS. 5(2),
• THOMPSON, JAMIE L., VELASCO, ANGELA DOWNIE RUIZ, CARDALL, ALICE, TARBOX, REBECCA, RICHARDSON, JAINEETA, CLARKE, GEMMA, LISTER, MICHELLE, HOWSON-WELLS, HANNAH C., FLEMING, VICKI M., KHAKH, MANJINDER, SLOAN, TIM, DUCKWORTH, NICHOLA, WALSH, SARAH, DENNING, CHRIS, MCCLURE, C. PATRICK, BENEST, ANDREW V. and SEEDHOUSE, CLAIRE H., 2021. JOURNAL OF MEDICAL MICROBIOLOGY. 70(3),
• ALMASMOUM, HIBAH ALI, AIRHIHEN, BLESSING, SEEDHOUSE, CLAIRE and WINKLER, GERLOF SEBASTIAAN, 2021. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma LEUKEMIA & LYMPHOMA. 62(2), 281-290
• GRUNDY, MARTIN, AL-KAISI, FIRAS, CULL, JOANNA, WILLIAMS, CATHY, SMITH, DEAN and SEEDHOUSE, CLAIRE H, 2021. A same-day assay predicts apoptotic response to combined BCL-2 and MCL-1 BH3-mimetic targeting in multiple myeloma cells. EJHaem. 2(1), 40-47
• ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. BMC CANCER. 20(1),
• BAILEY, G. D., DOOLAN, L., BASKAR, A., SMITH, L. C. and SEEDHOUSE, C. H., 2020. SCIENTIFIC REPORTS. 10(1),
• BAILEY, GRAHAM D, QUTOB, HAITHAM M H, AKHTAR, ASMA, RUSSELL, NIGEL H and SEEDHOUSE, CLAIRE H, 2019. British journal of haematology.
• ALMARS, AMANY, CHONDROU, PANAGIOTA S., ONYIDO, EMENIKE K., ALMOZYAN, SHEEMA, SEEDHOUSE, CLAIRE, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S., 2019. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 20(11),
• GRUNDY M, SEEDHOUSE C, JONES T, ELMI L, HALL M, GRAHAM A, RUSSELL N and PALLIS M, 2018. PloS one. 13(1), e0190682
• AL-ASADI MG, BRINDLE G, CASTELLANOS M, MAY ST, MILLS KI, RUSSELL NH, SEEDHOUSE CH and PALLIS M, 2018. Oncotarget. 8(67), 111405-111418
• GRUNDY, MARTIN, BALAKRISHNAN, SAHANA, FOX, MATTHEW, SEEDHOUSE, CLAIRE H and RUSSELL, NIGEL H, 2018. Genetic biomarkers predict response to dual BCL-2 and MCL-1 targeting in acute myeloid leukaemia cells. Oncotarget. 9(102), 37777-37789
• YU, NING, SEEDHOUSE, CLAIRE, RUSSELL, NIGEL and PALLIS, MONICA, 2018. Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737 LEUKEMIA & LYMPHOMA. 59(10), 2447-2453
• ALI, REEM, AL-KAWAZ, ABDULBAQI, TOSS, MICHAEL S., GREEN, ANDREW R., MILIGY, ISLAM M., MESQUITA, KATIA A., SEEDHOUSE, CLAIRE, MIRZA, SAMEER, BAND, VIMLA, RAKHA, EMAD A. and MADHUSUDAN, SRINIVASAN, 2018. CANCER RESEARCH. 78(24), 6818-6827
• SHAFIEE MN, MONGAN N, SEEDHOUSE C, CHAPMAN C, DEEN S, ABU J and ATIOMO W, 2017. Acta obstetricia et gynecologica Scandinavica. 96(5), 556-562
• SHAFIEE, MOHAMAD NASIR, SEEDHOUSE, CLAIRE, MONGAN, NIGEL, CHAPMAN, CAROLINE, DEEN, SUHA, ABU, JAFARU and ATIOMO, WILLIAM, 2016. MOLECULAR AND CELLULAR ENDOCRINOLOGY. 424(C), 94-101
• PALLIS, M, BURROWS, F, RYAN, J, GRUNDY, M, SEEDHOUSE, C, ABDUL-AZIZ, A, MONTERO, J and LETAI, A, 2016. Oncotarget.
• PALLIS M, BURROWS F, RYAN J, GRUNDY M, SEEDHOUSE C, ABDUL-AZIZ A, MONTERO J, LETAI A and RUSSELL N, 2016. Oncotarget. 8(10), 16220-16232
• SHAW, B. E., LEE, F., KRISHNAMURTHY, S., BYRNE, J. L., SEEDHOUSE, C., MAYOR, N. P., MALDONADO-TORRES, H., SAUDEMONT, A., MARSH, S. G. E., MADRIGAL, J. A. and RUSSELL, N. H., 2015. BONE MARROW TRANSPLANTATION. 50(2), 237-243
• SHAFIEE, MOHAMAD NASIR, ABD MALIK, DAHLIA, YUNOS, RYIA ILLANI MOHD, ATIOMO, WILLIAM, OMAR, MOHD HASHIM, GHANI, NUR AZURAH ABDUL, HATTA, AHMAD ZAILANI, SEEDHOUSE, CLAIRE, CHAPMAN, CAROLINE and MOKHTAR, NORFILZA MOHD, 2015. GYNECOLOGICAL ENDOCRINOLOGY. 31(4), 286-290
• ALBARAKATI, NADA, ABDEL-FATAH, TAREK M. A., DOHERTY, RACHEL, RUSSELL, ROSLIN, AGARWAL, DEVIKA, MOSELEY, PAUL, PERRY, CHRISTINA, ARORA, ARVIND, ALSUBHI, NOUF, SEEDHOUSE, CLAIRE, RAKHA, EMAD A., GREEN, ANDREW, BALL, GRAHAM, CHAN, STEPHEN, CALDAS, CARLOS, ELLIS, IAN O. and MADHUSUDAN, SRINIVASAN, 2015. MOLECULAR ONCOLOGY. 9(1), 204-217
• SHAFIEE, MOHAMAD NASIR, KHAN, GULAFSHANA, ARIFFIN, RINA, ABU, JAFARU, CHAPMAN, CAROLINE, DEEN, SUHA, NUNNS, DAVID, BARRETT, DAVID A., SEEDHOUSE, CLAIRE and ATIOMO, WILLIAM, 2014. GYNECOLOGIC ONCOLOGY. 132(1), 248-253
• SEEDHOUSE, CLAIRE H., MILLS, KEN I., AHLUWALIA, SOPHIE, GRUNDY, MARTIN, SHANG, SHILI, BURNETT, ALAN K., RUSSELL, NIGEL H. and PALLIS, MONICA, 2014. LEUKEMIA RESEARCH. 38(1), 131-137
• ABBOTTS, RACHEL, JEWELL, ROSALYN, NSENGIMANA, JEREMIE, MALONEY, DAVID J., SIMEONOV, ANTON, SEEDHOUSE, CLAIRE, ELLIOTT, FAYE, LAYE, JON, WALKER, CHRISTY, JADHAV, AJIT, GRABOWSKA, ANNA, BALL, GRAHAM, PATEL, POULAM M., NEWTON-BISHOP, JULIA, WILSON, DAVID M., III and MADHUSUDAN, SRINIVASAN, 2014. ONCOTARGET. 5(10), 3273-3286
• SULTANA, R., ABDEL-FATAH, T., ABBOTTS, R., HAWKES, C., ALBARAKATI, N., SEEDHOUSE, C., BALL, G., CHAN, S., RAKHA, E.A., ELLIS, I.O. and MADHUSUDAN, S., 2013. Cancer Research. 73(5), 1621-1634
• SULTANA R, ABDEL-FATAH T, PERRY C, MOSELEY P, ALBARAKTI N, MOHAN V, SEEDHOUSE C, CHAN S and MADHUSUDAN S, 2013. PloS one. 8(2), e57098
• PALLIS M, BURROWS F, WHITTALL A, BODDY N, SEEDHOUSE C and RUSSELL N, 2013. BMC pharmacology & toxicology. 14(1), 32 (In Press.)
• ABDEL-FATAH, TAREK, SULTANA, REBEKA, ABBOTTS, RACHEL, HAWKES, CLAIRE, SEEDHOUSE, CLAIRE, CHAN, STEPHEN and MADHUSUDAN, SRINIVASAN, 2013. INTERNATIONAL JOURNAL OF CANCER. 132(12), 2778-2786
• WANG, QUNWEI, FRANKS, HESTER A., LAX, STEPHANIE J., EL REFAEE, MOHAMED, MALECKA, ANNA, SHAH, SABARIA, SPENDLOVE, IAN, GOUGH, MICHAEL J., SEEDHOUSE, CLAIRE, MADHUSUDAN, SRINIVASAN, PATEL, POULAM M. and JACKSON, ANDREW M., 2013. JOURNAL OF IMMUNOLOGY. 190(7), 3246-3255
• PALLIS, MONICA, BURROWS, FRANCIS, WHITTALL, ABIGAIL, BODDY, NICHOLAS, SEEDHOUSE, CLAIRE and RUSSELL, NIGEL, 2013. BMC PHARMACOLOGY & TOXICOLOGY. 14,
• SULTANA, R., MCNEILL, D.R., ABBOTTS, R., MOHAMMED, M.Z., ZDZIENICKA, M.Z., QUTOB, H., SEEDHOUSE, C., LAUGHTON, C.A., FISCHER, P.M., PATEL, P.M., WILSON, D.M. and MADHUSUDAN, S., 2012. International Journal of Cancer. 131(10), 2433-2444
• PALLIS M, ABDUL-AZIZ A, BURROWS F, SEEDHOUSE C, GRUNDY M and RUSSELL N, 2012. British journal of haematology. 159(2), 191-203
• JAWAD M, YU N, SEEDHOUSE C, TANDON K, RUSSELL NH and PALLIS M, 2012. BMC cancer. 12, 431
• GRUNDY M, SEEDHOUSE C, RUSSELL NH and PALLIS M, 2011. Bmc Cancer. 11, 254
• JAWAD, M., SEEDHOUSE, C., MONY, U., GRUNDY, M., RUSSELL, N.H. and PALLIS, M., 2010. Leukemia. 24(1), 74-80
• GRUNDY, M., SEEDHOUSE, C., SHANG, S., RICHARDSON, J., RUSSELL, N. and PALLIS, M., 2010. Molecular Cancer Therapeutics. 9(3), 661-672
• SEEDHOUSE, C., GRUNDY, M., SHANG, S., RONAN, J., PIMBLETT, H., RUSSELL, N. and PALLIS, M., 2009. Clinical Cancer Research. 15(23), 7291-7298
• SEEDHOUSE, C.H., PALLIS, M., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2009. British Journal of Haematology. 147(5), 653-661
• MONY, U., JAWAD, M., SEEDHOUSE, C., RUSSELL, N. and PALLIS, M., 2008. Leukemia. 22(7), 1395-1401
• SEEDHOUSE,, GRUNDY,, WHITE,, LI,, FISHER,, YAKUNINA,, MOORMAN,, HOY,, RUSSELL,, BURNETT, and PALLIS,, 2007. Clinical Cancer Research. 13(23), 7059-7066
• CONNELLY-SMITH,, PATTINSON,, GRUNDY,, SHANG,, SEEDHOUSE,, RUSSELL, and PALLIS,, 2007. Experimental Hematology.
• SHANG,, SEEDHOUSE,, RUSSELL, and PALLIS,, 2007. Leukemia Research.
• SEEDHOUSE, CLAIRE and RUSSELL, NIGEL, 2007. British Journal of Haematology. 137(6), 513-29
• SEEDHOUSE, C.H, HUNTER, H.M., LLOYD-LEWIS, B., MASSIP, A-M., PALLIS, M., CARTER, G.I., GRUNDY, M., SHANG, S. and RUSSELL, N.H., 2006. Leukemia. 20(12), 2130-2136
• JAWAD, M., SEEDHOUSE, C.H., RUSSELL, N. and PLUMB, M., 2006. Blood. 108(12), 3916-3918
• BRADBURY, D., CLARKE, D., SEEDHOUSE, C., CORBETT, L., STOCKS, J. and KNOX, A., 2005. Journal of Biological Chemistry. 280(34), 29993-30000
• FERN, L., PALLIS, M., CARTER, G.I., SEEDHOUSE, C., RUSSELL, N. and BYRNE, J., 2004. British Journal of Haematology. 126(1), 63-71
• SEEDHOUSE, C., FAULKNER, R., ASHRAF, N., DAS-GUPTA, E. and RUSSELL, N., 2004. Clinical Cancer Research. 10(8), 2675-2680
• FAULKNER, R. D., SEEDHOUSE, C. H., DAS-GUPTA, E. P. and RUSSELL, N. H., 2004. British Journal of Haematology. VOL 124(NUMBER 2), 160-165
• HUNTER, H. M., PALLIS, M., SEEDHOUSE, C. H., GRUNDY, M., GRAY, C. and RUSSELL, N. H., 2004. British Journal of Haematology. VOL 127(NUMBER 1), 26-33
• SEEDHOUSE, C. H., DAS-GUPTA, E. P. and RUSSELL, N. H., 2003. Leukemia. 17(1), 83-88
• PALLIS, M., SEEDHOUSE, C., GRUNDY, M. and RUSSELL, N., 2003. Leukemia Research. VOL 27(NUMBER 9), 803-805
• PALLIS, M., TURZANSKI, J., GRUNDY, M., SEEDHOUSE, C. and RUSSELL, N., 2003. British Journal of Haematology. VOL 120(PART 6), 1009-1016
• SEEDHOUSE, C., BAINTON, R., LEWIS, M., HARDING, A., RUSSELL, N. and DAS-GUPTA, E., 2002. Blood. 100(10), 3761-3766
• DAS-GUPTA, E. P., SEEDHOUSE, C. H. and RUSSELL, N. H., 2001. British Journal of Haematology. VOL 114(PART 2), 307-312
• SEEDHOUSE, C H, MARGISON, G P, HENDRY, J H, HAJEER, A and EMBLETON, M J, 2001. Biochemical and biophysical research communications. 280(3), 595-604
• DAS-GUPTA EP, SEEDHOUSE CH and RUSSELL NH, 2000. Hematological Oncology. 18(3), 99-110