糖心原创

GI and Liver Diseases Medical and Surgical Research
 

Image of Aloysious D Aravinthan

Aloysious D Aravinthan

Associate Professor in Hepatology, Faculty of Medicine & Health Sciences

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Biography

Dr. Aravinthan is an Associate Professor in Hepatology at the 糖心原创 and an Honorary Consultant Hepatologist at Nottingham University Hospitals NHS Trust. He completed his postgraduate training in Hepatology at Cambridge University Hospitals NHS Trust, UK, and Toronto General Hospital/University of Toronto, Canada. His doctoral thesis, awarded by the University of Cambridge, focused on the role of hepatocyte senescence in the progression of chronic liver disease.

He received the prestigious Sheila Sherlock Research Award from the British Association for the 糖心原创 of the Liver in 2014 and the Sheila Sherlock Travelling Fellowship from the Royal College of Physicians in 2015. His research continues to focus on the systemic impact and therapeutic manipulation of cellular senescence in liver disease, the therapeutic potential of mammalian Target of Rapamycin (mTOR) in liver disease progression, and the epidemiology and natural history of rare liver diseases and liver cancer.

Research Summary

Exploring the systemic impact and therapeutic manipulation of cellular senescence in liver disease Evaluating the therapeutic potential of mammalian Target of Rapamycin (mTOR) in liver disease… read more

Selected Publications

  • ARAVINTHAN AD and ALEXANDER GJ, 2016. Journal of hepatology. 65(4), 825-834
  • ARAVINTHAN AD, BRUNI SG, DOYLE AC, THEIN HH, GOLDARACENA N, ISSACHAR A, LILLY LB, SELZNER N, BHAT M, SREEHARSHA B, SELZNER M, GHANEKAR A, CATTRAL MS, MCGILVRAY ID, GREIG PD, RENNER EL, GRANT DR and SAPISOCHIN G, 2017. Annals of surgical oncology. 24(7), 1843-1851
  • ARAVINTHAN AD, DOYLE AC, ISSACHAR A, DIB M, PERETZ D, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, GRANT DR, SELZNER N, LILLY LB and RENNER EL, 2016. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(12), 3512-3521
  • ARAVINTHAN AD and ALEXANDER GJ, 2015. Journal of hepatology. 63(2), 532-533

Current Research

  1. Exploring the systemic impact and therapeutic manipulation of cellular senescence in liver disease
  2. Evaluating the therapeutic potential of mammalian Target of Rapamycin (mTOR) in liver disease progression
  3. Investigating the epidemiology and natural history of rare liver diseases
  4. Liver cancer
  • PRAMUDI WIJAYASIRI, STUART ASTBURY, GRACE NEEDHAM, PHILIP KAYE, MAMATHA BHAT, ANNA M PICCININI and ALOYSIOUS D ARAVINTHAN, 2025. Human Cell. 38, 70
  • SCOTT, ROBERT A, CROSS, TIMOTHY J S, CLARKE, CHRISTOPHER, KHAN, SHAHID A, RYDER, STEPHEN D, FRANKLIN, JAMES and ARAVINTHAN, ALOYSIOUS D, 2023. Outcomes of National Survey of the Practice of Hepatocellular Carcinoma Surveillance. Journal of hepatocellular carcinoma. 10, 725-731
  • BAJAJ, JASMOHAN S, CHOUDHURY, ASHOK K, XIE, QING, KAMATH, PATRICK S, TOPAZIAN, MARK, HAYES, PETER C, TORRE, ALDO, DESALEGN, HAILEMICHAEL, IDILMAN, RAMAZAN, CAO, ZHUJUN, ALVARES-DA-SILVA, MARIO R, GEORGE, JACOB, BUSH, BRIAN J, THACKER, LEROY R and WONG, FLORENCE, 2023. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium. The lancet. Gastroenterology & hepatology.
  • SUBHANI, MOHSAN, SHETH, ABHISHEK, AHMED, JAMAL, WIJAYASIRI, PRAMUDI, GARDEZI, SYED A., ENKI, DOYO, MORLING, JOANNE R., AITHAL, GURUPRASAD P., RYDER, STEPHEN D. and ARAVINTHAN, ALOYSIOUS D., 2022. Incidence and prevalence of venous thromboembolism in chronic liver disease: A systematic review and meta-analysis THROMBOSIS RESEARCH. 215, 19-29
  • PRAMUDI WIJAYASIRI, STUART ASTBURY, PHILIP KAYE, FIONA OAKLEY, GRAEME J ALEXANDER, TIMOTHY J KENDALL and ALOYSIOUS D ARAVINTHAN, 2022. CELLS. 11(14), 2221
  • TSIEN, CYNTHIA, TAN, HUEY, SHARMA, SOWMYA, PALANIYAPPAN, NAAVENTHAN, WIJAYASIRI, PRAMUDI, LEUNG, KRISTEL, HAYRE, JATINDER, MOWLEM, ELIZABETH, KANG, RACHEL, EDDOWES, PETER J, WILKES, EMILIE, VENKATACHALAPATHY, SURESH V, GUHA, INDRA N, ANTONOVA, LILIA, CHEUNG, ANGELA C, GRIFFITHS, WILLIAM JH, BUTLER, ANDREW J, RYDER, STEPHEN D, JAMES, MARTIN W, AITHAL, GURUPRASAD P and ARAVINTHAN, ALOYSIOUS D, 2021. Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine (London, England). 21(1), e32-e38
  • VENKATACHALAPATHY, SURESH VASAN, JAMES, MARTIN W, HUGGETT, MATTHEW, PARANANDI, BHARAT, PEREIRA, STEPHEN P, JOHNSON, GAVIN, ARAVINTHAN, ALOYSIOUS D and AITHAL, GURUPRASAD P, 2021. Gastrointestinal endoscopy.
  • PRAMUDI WIJAYASIRI, JATINDER HAYRE, EDWARD S. NICHOLSON, PHILIP KAYE, EMILIE A. WILKES, JONATHAN EVANS, GURUPRASAD P. AITHAL, GABRIELA JONES and FIONA PEARCE, 2021. JHEP Reports. 3(5), 100329
  • CHOW CW, HAIDER SA, RAGUNATH K, AITHAL GP, ORTIZ-FERNANDEZ-SORDO J, ORTIZ-FERNANDEZ-SORDO J, ARAVINTHAN AD and VENKATACHALAPATHY SV, 2020. World Journal of Gastrointestinal Endoscopy. 12(9), 266-275
  • DOYLE A, GORGEN A, MUADDI H, ARAVINTHAN AD, ISSACHAR A, MIRONOV O, ZHANG W, KACHURA J, BEECROFT R, CLEARY SP, GHANEKAR A, GREIG PD, MCGILVRAY ID, SELZNER M, CATTRAL MS, GRANT DR, LILLY LB, SELZNER N, RENNER EL, SHERMAN M and SAPISOCHIN G, 2019. Journal of hepatology. 70(5), 866-873
  • ARAVINTHAN AD, FATEEN W, DOYLE AC, VENKATACHALAPATHY SV, ISSACHAR A, GALVIN Z, SAPISOCHIN G, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GRANT DR, SELZNER N, LILLY LB, RENNER EL and BHAT M, 2019. Transplantation. 103(12), 2523-2530
  • GOLDARACENA, NICOLAS, JUNG, JUDY, ARAVINTHAN, ALOYSIOUS D., ABBEY, SUSAN E., KRAUSE, SANDRA, PRITLOVE, CHERYL, LYNCH, JOANNA, WRIGHT, LINDA, SELZNER, NAZIA, STUNGURIS, JENNIFER, GREIG, PAUL, GHANEKAR, ANAND, MCGILVRAY, IAN, SAPISOCHIN, GONZALO, NG, VICKY LEE, LEVY, GARY, CATTRAL, MARK and GRANT, DAVID, 2019. JOURNAL OF HEPATOLOGY. 71(5), 951-959
  • ARAVINTHAN AD and ALEXANDER GJ, 2018. Liver international : official journal of the International Association for the 糖心原创 of the Liver. 38(1), 33-34
  • ARAVINTHAN AD, BRUNI SG, DOYLE AC, THEIN HH, GOLDARACENA N, ISSACHAR A, LILLY LB, SELZNER N, BHAT M, SREEHARSHA B, SELZNER M, GHANEKAR A, CATTRAL MS, MCGILVRAY ID, GREIG PD, RENNER EL, GRANT DR and SAPISOCHIN G, 2017. Annals of surgical oncology. 24(7), 1843-1851
  • ARAVINTHAN AD, BARBAS AS, DOYLE AC, TAZARI M, SAPISOCHIN G, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, BHAT M, SELZNER N, GRANT DR, LILLY LB and RENNER EL, 2017. Transplant international : official journal of the European Society for Organ Transplantation. 30(11), 1140-1149
  • BARBAS AS, GOLDARACENA N, DIB MJ, AL-ADRA DP, ARAVINTHAN AD, LILLY LB, RENNER EL, SELZNER N, BHAT M, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SAPISOCHIN G, SELZNER M, GREIG PD and GRANT DR, 2017. Transplantation direct. 3(6), e158
  • ARAVINTHAN AD and ALEXANDER GJ, 2016. Journal of hepatology. 65(4), 825-834
  • ARAVINTHAN AD, DOYLE AC, ISSACHAR A, DIB M, PERETZ D, CATTRAL MS, GHANEKAR A, MCGILVRAY ID, SELZNER M, GREIG PD, GRANT DR, SELZNER N, LILLY LB and RENNER EL, 2016. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 16(12), 3512-3521
  • TACHTATZIS PM, MARSHALL A, ARAVINTHAN A, VERMA S, PENRHYN-LOWE S, MELA M, SCARPINI C, DAVIES SE, COLEMAN N and ALEXANDER GJ, 2015. PloS one. 10(7), e0134315
  • TACHTATZIS PM, MARSHALL A, ARVINTHAN A, VERMA S, PENRHYN-LOWE S, MELA M, SCARPINI C, DAVIES SE, COLEMAN N and ALEXANDER GJ, 2015. PloS one. 10(5), e0127511
  • ARAVINTHAN AD and ALEXANDER GJ, 2015. Journal of hepatology. 63(2), 532-533
  • ARAVINTHAN A, 2015. Human cell. 28(2), 51-64
  • WOODWARD JM, GKRANIA-KLOTSAS E, CORDERO-NG AY, ARAVINTHAN A, BANDOH BN, LIU H, DAVIES S, ZHANG H, STEVENSON P, CURRAN MD and KUMARARATNE D, 2015. The American journal of gastroenterology. 110(2), 320-327
  • ARAVINTHAN A, CHALLIS B, SHANNON N, HOARE M, HEANEY J and ALEXANDER GJ, 2014. Experimental cell research. 331(1), 38-45
  • ARAVINTHAN A, SHANNON N, HEANEY J, HOARE M, MARSHALL A and ALEXANDER GJ, 2014. Experimental gerontology. 60, 37-45
  • ARAVINTHAN A, MELLS G, ALLISON M, LEATHART J, KOTRONEN A, YKI-JARVINEN H, DALY AK, DAY CP, ANSTEE QM and ALEXANDER G, 2014. Cell cycle (Georgetown, Tex.). 13(9), 1489-1494
  • ARAVINTHAN A, PIETROSI G, HOARE M, JUPP J, MARSHALL A, VERRILL C, DAVIES S, BATEMAN A, SHERON N, ALLISON M and ALEXANDER GJ, 2013. PloS one. 8(9), e72904
  • ARAVINTHAN A, GELSON W, LIMBU A, BRAIS R and RICHARDSON P, 2013. World journal of hepatology. 4(12), 402-405
  • ARAVINTHAN A, SCARPINI C, TACHTATZIS P, VERMA S, PENRHYN-LOWE S, HARVEY R, DAVIES SE, ALLISON M, COLEMAN N and ALEXANDER G, 2012. Journal of hepatology. 58(3), 549-56
  • POTTER VA and ARAVINTHAN A, 2012. British journal of hospital medicine (London, England : 2005). 73(5), 265-270
  • ARAVINTHAN A, VERMA S, COLEMAN N, DAVIES S, ALLISON M and ALEXANDER G, 2012. Journal of clinical pathology. 65(6), 557-560
  • ARAVINTHAN A, NIKOLIC M, OUYANG X and LEE YM, 2012. The hidden cause of dysphagia--epiphrenic diverticulum and esophageal motility disorders. Canadian journal of gastroenterology = Journal canadien de gastroenterologie. 26(2), 68-69
  • ARAVINTHAN A, AL-NAEEB Y, ABUBACKER Z and RICHARDSON P, 2009. Gut. 58(8), 1103, 1128
  • ARAVINTHAN A, AL-NAEEB Y and RICHARDSON P, 2009. European journal of gastroenterology & hepatology. 21(4), 471-473
  • ARAVINTHAN A, SEN S and MARCUS N, 2009. Transfusion-related acute lung injury: a rare and life-threatening complication of a common procedure. Clinical medicine (London, England). 9(1), 87-89
  • KEJARIWAL D, ARAVINTHAN A, BROMLEY D and MIAO Y, 2008. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 23(3), 322-324
  • Lancet Gastrpoentrerology & Hepatology. 9(11), 997-1009

Nottingham Digestive Diseases Centre

The 糖心原创
E Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31090
email:nddcbru@nottingham.ac.uk