糖心原创

Clinical Epidemiology
 

Linda Fiaschi

Principal Research Fellow, Faculty of Medicine & Health Sciences

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Biography

Linda Fiaschi took her B.Sc., M.Sc. in Electronic Engineering with Biomedical Specialization at the University of Pisa, Italy, before going onto do her PhD in Computer Science (Bioinformatics) at the 糖心原创.

Expertise Summary

Data enabled trials, electronic health records, large routine health data management and analysis, perinatal epidemiology, pregnancy longitudinal data, medical data mining, programming, Bioinformatics, diseases association studies, genetic data analysis, medical signal processing,

ORCID: https://orcid.org/0000-0002-3780-5895

Google Scholar: https://scholar.google.com/citations?user=ucE-TBQAAAAJ&hl=en&oi=ao

Teaching Summary

Dr Fiaschi is tutor on the module 'Data Organisation and Management in Epidemiology' (DOME) delivered on the Master in Public Health degree. She supervises MPH dissertations, BMedSci projects, PhD… read more

Research Summary

Linda Fiaschi is currently working on the GBS3 Trial (https://www.gbs3trial.ac.uk/home.aspx ), leading the routine data acquisition, management and linkage of several different electronic health… read more

Recent Publications

  • FIASCHI, L, NELSON-PIERCY, C, DEB, S, KING, R and TATA, L J, 2019. BJOG : an international journal of obstetrics and gynaecology.
  • DHALWANI, N.N., SZATKOWSKI, L., COLEMAN, T., FIASCHI, L. and TATA, L.J., 2018. Nicotine & Tobacco Research. Accepted Manuscript Online: 31 January 2018,
  • BANNISTER J, SZATKOWSKI L, SHARKEY D, TAN S, FIASCHI L and BAN L, 2018. Journal of pediatric gastroenterology and nutrition. (In Press.)
  • FIASCHI, LINDA, HOUSLEY, GEMMA, NELSON-PIERCY, CATHERINE, GIBSON, JACK, RAJI, AYOKUNNU, DEB, SHILPA and TATA, LAILA J, 2018. International journal of clinical practice. e13261

Dr Fiaschi is tutor on the module 'Data Organisation and Management in Epidemiology' (DOME) delivered on the Master in Public Health degree. She supervises MPH dissertations, BMedSci projects, PhD students and she is personal tutor for medical students. She also obtained the Fellowship status with Advance HE.

Current Research

Linda Fiaschi is currently working on the GBS3 Trial (https://www.gbs3trial.ac.uk/home.aspx ), leading the routine data acquisition, management and linkage of several different electronic health datasets involved in the trial.

This is a multi-centre prospective two-group parallel cluster randomised controlled superiority trial with internal pilot, feasibility evaluation, qualitative study and parallel economic modelling. The GBS3 trial will test whether routine testing of women for Group B Streptococcus (GBS) colonisation either in late pregnancy or during labour reduces the occurrence of early-onset neonatal sepsis, compared to the current risk factor based strategy.

This trial, the first adequately powered RCT of GBS screening in the world, is commissioned by the NIHR, following a research prioritisation process led by the Department of Health and Social Care, to address an important absence of evidence required by the UK National Screening Committee (NSC).

Previous Trials:

PROTECT-CH trial (https://www.protect-trial.net/): a UK-wide clinical trial to identify treatments that can protect care home residents from developing COVID-19.

Past Research

Linda Fiaschi's past research project involved the assessment of risk factors, complications, drug safety and management of nausea, vomiting and hyperemesis in pregnancy. This was a Rosetrees Trust funded project which made use of some of the largest primary and secondary care datasets in the UK.

Other previous research projects involved looking at the computerisation of general practices in the United Kingdom. This Wellcome Trust funded project is known as Assessment of drug safety and the impact of illness in pregnancy using routinely collected primary care data:

  • The project proposes to build a large nationally-representative database of pregnancy information using a unique household identifier, linking the records of mothers to their children.
  • Databases are used to assess the impact of chronic and infectious illnesses and associated drug treatments on pregnancy, and as an early warning system for new drugs.
  • Resource will be used to find out the impacts, in terms of obstetric complications, adverse pregnancy outcomes and adverse childhood outcomes, of gestational exposures to commonly used medications.

Previous projects:

FP6 Marie Curie Fellowship (2006-2009 at 糖心原创, UK): Novel Guidelines for the Analysis of Single Nucleotide Polymorphisms in Disease association Studies

FP6-IST Marie Curie Industry Host Fellowship (2004-2005 at Philips in Aachen, Germany): Criteria for personalized analysis of biomedical signals during ambulatory monitoring

  • FIASCHI, L, NELSON-PIERCY, C, DEB, S, KING, R and TATA, L J, 2019. BJOG : an international journal of obstetrics and gynaecology.
  • DHALWANI, N.N., SZATKOWSKI, L., COLEMAN, T., FIASCHI, L. and TATA, L.J., 2018. Nicotine & Tobacco Research. Accepted Manuscript Online: 31 January 2018,
  • BANNISTER J, SZATKOWSKI L, SHARKEY D, TAN S, FIASCHI L and BAN L, 2018. Journal of pediatric gastroenterology and nutrition. (In Press.)
  • FIASCHI, LINDA, HOUSLEY, GEMMA, NELSON-PIERCY, CATHERINE, GIBSON, JACK, RAJI, AYOKUNNU, DEB, SHILPA and TATA, LAILA J, 2018. International journal of clinical practice. e13261
  • FIASCHI L, NELSON-PIERCY C, GIBSON J, SZATKOWSKI L and TATA LJ, 2017. Paediatric and perinatal epidemiology. 32(1), 40-51
  • FIASCHI, L., NELSON-PIERCY, C. and TATA, L.J., 2016. Human Reproduction.
  • DHALWANI, N.N., SZATKOWSKI, L., COLEMAN, T., FIASCHI, L. and TATA, L.J., 2015. Pediatrics. 135(5), 859-867
  • BAN L, FLEMING KM, DOYLE P, SMEETH L, HUBBARD RB, FIASCHI L and TATA LJ, 2015. PloS ONE. 10(7), e0131130
  • BAN L, LAILA JT, HUMES DJ, FIASCHI L and CARD T, 2015. Alimentary Pharmacology & Therapeutics. 42(7), 855-66
  • BAN L, TATA LJ, FIASCHI L and CARD T, 2014. Gastroenterology. 146(1), 76-84
  • BAN L, GIBSON JE, WEST J, FIASCHI L, SOKAL R, SMEETH L, DOYLE P, HUBBARD RB and TATA LJ, 2014. BJOG: An International Journal of Obstetrics & Gynaecology.
  • BAN L, WEST J, GIBSON JE, FIASCHI L, SOKAL R, DOYLE P, HUBBARD R, SMEETH L and TATA LJ, 2014. PloS ONE. 9(6), e100996
  • DHALWANI NN, SZATKOWSKI L, COLEMAN T, FIASCHI L and TATA LJ, 2014. The British journal of general practice : the journal of the Royal College of General Practitioners. 64(626), e554-60
  • DHALWANI NN, TATA LJ, COLEMAN T, FIASCHI L and SZATKOWSKI L, 2014. Journal of public health (Oxford, England). First published online: 21 October 2014, doi: 10.1093/pubmed/fdu060
  • DHALWANI NN, FIASCHI L, WEST J and TATA LJ, 2013. Human reproduction (Oxford, England). 28(4), 960-8
  • SULTAN, A.A., TATA, L.J., WEST, J., FIASCHI, L., FLEMING, K.M., NELSON-PIERCY, C. and GRAINGE, M.J., 2013. Blood. 121(19), 3953-3961
  • BAN, L., GIBSON, J. E., WEST, J., FIASCHI, L., SOKAL, R., SMEETH, L., DOYLE, P., HUBBARD, R. and TATA, L. J., 2013. Risks of major congenital anomaly in the children of women with clinically diagnosed depression: a population-based cohort study from the United Kingdom BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 120, 2-3
  • BAN, L., TATA, L.J., WEST, J., FIASCHI, L. and GIBSON, J.E., 2012. PLoS ONE. 7(8), e43462
  • BAN LU, JACK E GIBSON, JOE WEST, LINDA FIASCHI and LAILA J TATA, 2012. British Journal of General Practice. 62(8), e671-e678
  • FIASCHI LINDA, GARIBALDI JONATHAN M and KRASNOGOR NATALIO, 2009. Multiple-Test Analysis of Sequences of SNPs for Determining Susceptibility to Pre-eclampsia. In: FRANCESCO MASULLI, ALESSIO MICHELI and ALESSANDRO SPERDUTI, eds., Computational Intelligence and Bioengineering: Essays in Memory of Antonina Starita 196. IOS Press Amsterdam. 141-154
  • FIASCHI, LINDA, GARIBALDI, JONATHAN M. and KRASNOGOR, NATALIO, 2009. In: Computational Intelligence in Bioinformatics and Computational Biology. CIBCB '09. IEEE Symposium. 106-113

Clinical Epidemiology

The 糖心原创
School of Medicine

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