糖心原创

Contact

• workRoom B Floor, B207C BioDiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 823 1306
• a.nateri@nottingham.ac.uk
• /ccs/people/a.nateri

Biography

After graduating with a BSc in Human Genetics from Ahvaz/ Tehran University and an MSc in Cell & Molecular Genetics from the University of Essex, Dr Nateri completed a PhD on the genetic engineering of Picornavirus under the supervision of Prof Glyn Stanway in 2001. After receiving the Cancer Research UK Postdoctoral fellowship, he joined the Adult Stem Cell laboratory under the supervision of Prof Axel Behrens at the London Research Institute (previously known as ICRF), where his research into exploring the links between transcription, signalling & diseases, identified FBXW7 E3-Ligase and TCF4/b-catenin as novel interacting protein to modulate the activity of AP-1 transcription factor, c-Jun, and highlighted their critical role in cell biology and cancer development and progression (Science. 2004; 303:1374-8, Nature. 2005; 437:281-5).

Dr Nateri was appointed Assistant Professor at the 糖心原创's School of Medicine and joined the Centre for Cancer Sciences (previously known as the Division of Preclinical Oncology) in 2007 and was awarded the New Investigator Research Grant (NIRG) from MRC in 2008.

He currently leads the Cancer Genetics & Stem Cell laboratory as an Associate Professor with a grant portfolio of over 拢2.5m from MRC, CRUK and NC3Rs and international funders. Key collaborations include Hubrecht Institute and Crick Institute on research programmes in molecular mechanism, modelling early detection and identifying drugs targeting cellular heterogeneity and signalling arise from complex genetic, epigenetic, secretome, and metabolic modifications under the influence of the tumour microenvironment in gastrointestinal (GI) neoplastic & non-neoplastic disorders.

His affiliation with professional bodies includes membership on the Evaluation Committee for the Cyprus Research and Innovation Foundation (RIF) (2018-present), the French National Institute of Health and Medical Research (INSERM) (2019-present), and the Qatar National Research Fund (QNRF) (2016-present).

Expertise Summary

糖心原创ing molecular and cellular oncology and applying cross-platforms of early and advanced patient-derived based technologies (Organoids, Explants, and Mini-rings) to target cancer stem-like cells and the tumour microenvironment for early detection, detect markers to identify cancer metastasis risks and drug resistance and to develop potentially better drug treatment options and personalized medicine applications.

Teaching Summary

I'm teaching postgraduate MSc courses (Molecular Oncology, Cancer Immunology and Biotechnology, and Stem Cell Technology and Regenerative Medicine) and undergraduates courses (Cancer Science,… read more

Research Summary

My research group are broadly interested in two research themes:

1. Molecular and Cellular Oncology 鈹� Adult stem cell fate/ niche control and signals integration in inflammation, colorectal, pancreatic, and leukemic cancers biology with focuses on;

• F-box E3 ligases linked with epigenetic modifiers HP1BP3 and epithelial-mesenchymal transition (EMT) mediator ZEB2 and Wnt/FLWYCH1 signalling.
• Functional genomics using CRISPR/Cas9-based screening.
• Bioengineering, extracellular matrix and cellular metabolism with a focus on the SPOCK protein family.

2. The discovery of new cancer drugs 鈹� focuses on developing approaches and methods to screen effectively and investigate microenvironment components, including stromal and cancer stem-like cells, the evolution of drug resistance, and leverage drug response data for precision medicine applications using tumour patient-derived organoid, explant, and mini-ring platforms.

Selected Publications

• SHEEMA ALMOZYAN, ROYA BABAEI-JADIDI, ABRAR ALJOHANI, SEPIDEH YOUSSEFI, WILLIAM DALLEYWATER, PRERNA KADAM, BRADLEY SPENCER-DENE, EMAD RAKHA, MOHAMMAD ILYAS and ABDOLRAHMAN SHAMS NATERI, 2024. Cancer Communications.
• ROYA BABAEI-JADIDI, HOSSEIN KASHFI, WALLA ALELWANI, ASHKAN KARIMI BAKHTIARI, SHAHAD W. KATTAN, OMNIAH A. MANSOURI, ABHIK MUKHERJEE, DILEEP N. LOBO and ABDOLRAHMAN S. NATERI, 2022. Oncogenesis.
• ALMUSAWI S, AHMED M and NATERI AS, 2021. Clinical and Translational Medicine. 1-23
• ROYA BABAEI-JADIDI, ARUNDHATI DONGRE, SUZANNE MILLER, MARCOS CASTELLANOS URIBE, IAIN D. STEWART, ZOE M THOMPSON, ABDOLRAHMAN S. NATERI, PETER BRADDING, SEAN T. MAY and DEBBIE CLEMENTS, 2021. American Journal of Respiratory and Critical Care Medicine.

• View all publications

Essex Council SMART prize 2000

CRUK - Hardiman Redon prize 2006

Attending and presenting at several national institutes & international conferences, e.g. Cancer conferences in Germany, Greece and China, May 2018, Dec 2019, etc.

I'm teaching postgraduate MSc courses (Molecular Oncology, Cancer Immunology and Biotechnology, and Stem Cell Technology and Regenerative Medicine) and undergraduates courses (Cancer Science, Biochemistry and Medicine) across multiple modules for:

Oncogenes & Tumour Suppressor Genes

Gene Expression & Transcriptional Regulation

The Ubiquitin-Proteasome Pathway and E3-Ligases in Cancer

Investigating Cancer Genome

Genome Editing Technology in functional gene screening and drug discovery.

Preclinical Cancer Models

Precision Medicine in Cancer

Past Research

My group previously focused on exploring the molecular mechanism for tumour initiation and cell-based functional gene analysis. We combined the basic and translational research in a cell and tissue-specific manner (physiology and related disease pathology). We were studying transgenic animal tumour models, primary mouse organoids and HSC cells cultures, using an ex-vivo lentiviral-based Cre/LoxP system, proteomic and the screening of protein-protein interactions, and gene arrays.

We aimed; 1) to develop strategies to expand adult stem cells in vitro and obtain insights into the development and the pathological events that lead to cancer. 2) to understand the molecular mechanism of the links between signalling and cancer-associated gene expression regulation via transcription and post-translation modifications that control the heterogeneity of normal and cancer stem-like cell /progenitor cells. 3) to develop transgenic and tissue-specific genetically modified animal models for tumour growth and metastasis formation.

Future Research

My research group are broadly interested in two research themes:

1) Molecular and Cellular Oncology 鈹� Adult stem cell fate/ niche control and signals integration in inflammation, colorectal, pancreatic, and leukemic cancers biology with focuses on;

• F-box E3 ligases linked with epigenetic modifiers HP1BP3 and epithelial-mesenchymal transition (EMT) mediator ZEB2 and Wnt/FLWYCH1 signalling.
• Functional genomics using CRISPR/Cas9-based screening.
• Bioengineering, extracellular matrix and cellular metabolism with a focus on the SPOCK protein family.

2) The discovery of new cancer drugs 鈹� focuses on developing approaches and methods to screen effectively and investigate microenvironment components, including stromal and cancer stem-like cells, the evolution of drug resistance, and leverage drug response data for precision medicine applications using tumour patient-derived organoid, explant, and mini-ring platforms.

• SHEEMA ALMOZYAN, ROYA BABAEI-JADIDI, ABRAR ALJOHANI, SEPIDEH YOUSSEFI, WILLIAM DALLEYWATER, PRERNA KADAM, BRADLEY SPENCER-DENE, EMAD RAKHA, MOHAMMAD ILYAS and ABDOLRAHMAN SHAMS NATERI, 2024. Cancer Communications.
• ROYA BABAEI-JADIDI, HOSSEIN KASHFI, WALLA ALELWANI, ASHKAN KARIMI BAKHTIARI, SHAHAD W. KATTAN, OMNIAH A. MANSOURI, ABHIK MUKHERJEE, DILEEP N. LOBO and ABDOLRAHMAN S. NATERI, 2022. Oncogenesis.
• ALMUSAWI S, AHMED M and NATERI AS, 2021. Clinical and Translational Medicine. 1-23
• SHEEMA ALMOZYAN, JAMES COULTON and ROYA BABAEI-JADIDI, 2021. Cells.
• ROYA BABAEI-JADIDI, ARUNDHATI DONGRE, SUZANNE MILLER, MARCOS CASTELLANOS URIBE, IAIN D. STEWART, ZOE M THOMPSON, ABDOLRAHMAN S. NATERI, PETER BRADDING, SEAN T. MAY and DEBBIE CLEMENTS, 2021. American Journal of Respiratory and Critical Care Medicine.
• HIROTA, AKIRA, ALMUSAWI, SHAIKHA, NATERI, ABDOLRAHMAN S., ORDONEZ-MORAN, PALOMA and IMAJO, MASAMICHI, 2021. ACTA BIOMATERIALIA. 132, 272-287
• ISMAEL CHATITA ADOLF, AMANY ALMARS, NAZIMA DHARSEE, TEDDY MSELLE, GOKCE AKAN, IRENE JEREMIAH NGUMA and ABDOLRAHMAN S. NATERI, 2021. Genes & Diseases. (In Press.)
• LINUS P. RWEYEMAMU, GOKCE AKAN, SMAEL C. ADOLF, ERICK P. MAGOROSA, INNOCENT J. MOSHA, NAZIMA DHARSEE, LUCY A. NAMKINGA, SYLVESTER L. LYANTAGAYE and ABDOLRAHMAN S. NATERI, 2021. BMC Womens Health.
• AHMED M, JINKS N, BABAEI-JADIDI R, KASHFI H, CASTELLANOS-URIBE M, MAY ST, MUKHERJEE A and NATERI AS, 2020. Cancers. 12(1),
• KASHFI H, JINKS N and NATERI AS, 2020. Methods in molecular biology (Clifton, N.J.). 2171, 257-269
• RAPOSO TP, ALFAHED A, NATERI AS and ILYAS M, 2020. International journal of experimental pathology. 101(3-4), 80-86
• ALMOZYAN, S. and SHAMS-NATERI, A., 2020. ANNALS OF ONCOLOGY. 31, S117-S117
• SADEGHZADE, N., NOURI, M. and SHAMS NATERI, A., 2020. BIONANOSCIENCE. 10(2), 381-388
• NINGNING LI, ROYA BABAEI-JADIDI, FEDERICA LORENZI, BRADLEY SPENCER-DENE, PHILIP CLARKE, ENRIC DOMINGO, EUGENE TULCHINSKY, ROBERT G. J. VRIES, DAVID KERR, YIHANG PAN, YULONG HE, DAVID O. BATES, IAN TOMLINSON, HANS CLEVERS and ABDOLRAHMAN S. NATERI, 2019. Oncogenesis. 8(3),
• ALMARS A, CHONDROU PS, ONYIDO EK, ALMOZYAN S, SEEDHOUSE C, BABAEI-JADIDI R and NATERI AS, 2019. Int J Mol Sci.. 20(11),
• REEM ALI, MUSLIM ALABDULLAH, ISLAM MILIGY, MAKHLIYO NORMATOVA, ROYA BABAEI-JADIDI, ABDOLRAHMAN S. NATERI, EMAD A. RAKHA, SRINIVASAN MADHUSUDAN and SRINIVASAN MADHUSUDAN, 2019. Cells. 8(10), 1271-1290
• PATEL, D., TOSS, M. SHAWKY, SHAMS-NATERI, A. and ELSHEIKH, S., 2019. HP1BP3 Expression and its Significance as a Prognostic Marker in Human Primary and Metastatic Malignant Melanoma JOURNAL OF PATHOLOGY. 249, S51-S51
• SEYED KASHFI, SHEEMA ALMOZYAN, NICHOLAS JINKS, BON-KYOUNG KOO and ABDOLRAHMAN S. NATERI, 2018. Oncotarget.
• BELAL A. MUHAMMAD, SHEEMA ALMOZYAN, ROYA BABAEI-JADIDI, EMENIKE K. ONYIDO, ANAS SAADEDDIN, SEYED HOSSEIN KASHFI, BRADLEY SPENCER-DENE, MOHAMMAD ILYAS, ANBARASU LOURDUSAMY, AXEL BEHRENS and ABDOLRAHMAN S. NATERI, 2018. Molecular Cancer Research: Mol Cancer Res.. 12, 1977-1990
• BOLLAND, HANNAH, MCINTYRE, ALAN, SHAMS-NATERI, ABDOL, BISHOP, CLEO and SILVER, ANDREW, 2018. eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival BRITISH JOURNAL OF CANCER. 119(11), 23-23
• AHMED M, CHAUDHARI K, BABAEI-JADIDI R, DEKKER LV and NATERI AS, 2017. Stem cells (Dayton, Ohio). 35(4), 839-850
• FEDERICA聽LORENZI, ROYA聽BABAEI-JADIDI, JONATHAN聽SHEARD, BRADLEY聽SPENCER-DENE and ABDOLRAHMAN聽S聽NATERI, 2016. Molecular Therapy 鈥� Methods & Clinical Development. 3, 1-9
• SAMEERAH SHAHEEN, MEHREEN AHMED, FEDERICA LORENZI and ABDOLRAHMAN S. NATERI, 2016. Stem Cell Rev and Rep. 12(52), 1-8
• ONYIDO EK, SWEENEY E and NATERI AS, 2016. Mol Cancer.. 15(1), 1-17
• ONYIDO, EMENIKE K., SWEENEY, ELOISE and NATERI, ABDOLRAHMAN SHAMS, 2016. MOLECULAR CANCER. 15,
• 2015. Oncotarget.. 6(11), 25860929
• LI N, LORENZI F, KALAKOUTI E, NORMATOVA M, BABAEI-JADIDI R, TOMLINSON I and NATERI AS, 2015. Oncotarget. 6(11), 9240-56
• LI, NINGNING, BABAEI-JADIDI, ROYA, LORENZI, FEDERICA and NATERI, ABDOLRAHMAN S., 2015. FBXW7 ORCHESTRATES A FAILSAFE PROGRAM AGAINST COLORECTAL CANCER PROGRESSION ANTICANCER RESEARCH. 35(7), 4316-4316
• 2014. Int J Exp Pathol.. 95(6), 392-400
• IBRAHEM, SALIH, AL-GHAMDI, SALEH, BALOCH, KANWAL, MUHAMMAD, BELAL, FADHIL, WAKKAS, JACKSON, DARRYL, NATERI, ABDOLRAHMAN S. and ILYAS, MOHAMMAD, 2014. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. 95(6), 392-400
• NORMATOVA, MAKHLIYO, KATTAN, SHAHAD, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S., 2014. ATM/ATR-dependent regulation of new chromatin-associated protein NFAP7, sustains DNA-damage and carcinogenesis INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 34, S124-S124
• KATTAN, SHAHAD, NORMATOVA, MAKHLIYO, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S., 2014. Epigenetically mediated Epithelial-Mesenchymal Transition (EMT) by novel chromatin-associated protein NFAP7 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 34, S124-S124
• NATERI, ABDOLRAHMAN S., 2014. Fbxw7 tumour suppressor gene: cell fate control and signal integration in small intestine and colon INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 34, S121-S121
• IBRAHIM EE, BABAEI-JADIDI R and NATERI AS, 2013. Current protocols in stem cell biology. Chapter 1, Unit 1B.10
• KALAKOUTI ELIANA, LORENZI FEDERICA, BABAEI-JADIDI ROYA and NATERI S ABDOLRAHMAN, 2013. Internal Medicine. Volume 3(Issue 1), 120
• E. KALAKOUTI, R. BABAEI-JADIDI and A. S. NATERI, 2013. . In: R. R. RESENDE and H. ULRICH, eds., Trends in Stem Cell Proliferation and Cancer Research Springer. 277-298
• IBRAHIM, ELSAYED E, BABAEI-JADIDI, ROYA and NATERI, ABDOLRAHMAN S, 2013. The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter. Current protocols in stem cell biology. Chapter 1, Unit 1B.10
• IBRAHEM, S., ALGHAMDI, S., BALOCH, K., MOHAMED, B., FADHIL, W., JACKSON, D., NATERI, A. S. and ILYAS, M., 2013. STAT3 Exerts a Paradoxical Effect on beta-Catenin Expression and Function JOURNAL OF PATHOLOGY. 231, 26-26
• IBRAHIM, E.E., BABAEI-JADIDI, R., SAADEDDIN, A., SPENCER-DENE, B., HOSSAINI, S., ABUZINADAH, M., LI, N., FADHIL, W., ILYAS, M., BONNET, D. and NATERI, A.S., 2012. Stem Cells. 30(10), 2076-2087
• IBRAHEM, S., FADHIL, W., GELALY, B., NATERI, A., JACKSON, D. and ILYAS, M., 2012. Beta-catenin Negatively Regulates Kras Expression but Both Proteins Co-operate to Promote Cell Proliferation and Motility in Colorectal Cancer JOURNAL OF PATHOLOGY. 228, S15-S15
• KALAKOUTI, E., LI, N. and NATERI, A. S., 2012. Validation of phospho-proteomically identified human phospho-p53(S15) protein induction in colorectal cancer with FBXW7 mutation TUMOR BIOLOGY. 33, 95-95
• BABAEI-JADIDI, R., LI, N., SAADEDDIN, A., SPENCER-DENE, B., JANDKE, A., MUHAMMAD, B., IBRAHIM, E.E., MURALEEDHARAN, R., ABUZINADAH, M., DAVIS, H., LEWIS, A., WATSON, S., BEHRENS, A., TOMLINSON, I. and NATERI, A.S., 2011. Journal of Experimental Medicine. 208(2), 295-312
• AL-GHAMDI, S., ALBASRI, A., CACHAT, J., IBRAHEM, S., MUHAMMAD, B.A., JACKSON, D., NATERI, A.S., KINDLE, K.B. and ILYAS, M., 2011. PloS One. 6(6), e20919
• NATERI, ABDOLRAHMAN S, AL-GHAMDI, SALEH, ILYAS, MOHAMMAD, ALBASRI, ABDULKADER, KINDLE, KARIN B, CACHAT, JULIEN, IBRAHEM, SALIH, MUHAMMAD, BELAL A and JACKSON, DARRYL, 2011. Figure_S3.tif Figshare.
• DA COSTA, C.R., VILLADIEGO, J., SANCHO, R., FONTANA, X., PACKHAM, G., NATERI, A.S. and BEHRENS, A., 2010. Molecular and Cellular Biology. 30(15), 3842-3852
• ALGHAMDI, S., ALBASRI, S., LOBO, D., ZAITOUN, A., DURRANT, L., SETH, R., KINDLE, K., FADHIL, W., IBRAHIM, S., NATERI, A. and ILYAS, M., 2010. Cten (C-terminal Tensin-Like) Connects Kras to Integrin-linked Kinase (ILK) and is Associated with Metastasis in Colorectal Cancer. JOURNAL OF PATHOLOGY. 222, S12-S12
• ALBASRI, A., SETH, R., JACKSON, D., BENHASOUNA, A., CROOK, S., NATERI, A.S., CHAPMAN, R. and ILYAS, M., 2009. The Journal of pathology: a journal of the Pathological Society of Great Britain and Ireland. 218(1), 57-65
• SAADEDDIN, A., BABAEI-JADIDI, R., SPENCER-DENE, B. and NATERI, A.S., 2009. Molecular Cancer Research. 7(8), 1189-1196
• SANCHO, R., NATERI, A.S., DE VINUESA, A.G., AGUILERA, C., NYE, E., SPENCER-DENE, B. and BEHRENS, A., 2009. EMBO Journal. 28(13), 1843-1854
• WHELBAND, ELISABETH, KUMARI, RAJENDRA, GRABOWSKA, ANNA M., ARGENT, RICHARD H., SHAMS-NATERI, ABDOL and WATSON, SUSAN A., 2009. MOLECULAR CANCER THERAPEUTICS. 8(12),
• RUFF, C., DA COSTA, C., STAAK, N., RUMAJOGEE, P., MAKWANA, M., ACOSTA-SALTOS, A., KASWICH, M., BRECHT, S., HRISTOVA, M., NATERI, A. S., RIERA-SANS, L., MIRSKY, R., HERDEGEN, T., JESSEN, K. R., BEHRENS, A. and RAIVICH, G., 2009. Role of c-Jun and its N-terminal phosphorylation in facial nerve regeneration Society for Neuroscience Abstract Viewer and Itinerary Planner. 39,
• NATERI, ABDOLRAHMAN S, RAIVICH, GENNADIJ, GEBHARDT, CHRISTINE, DA COSTA, CLIVE, NAUMANN, HEIKE, VREUGDENHIL, MARTIN, MAKWANA, MILAN, BRANDNER, SEBASTIAN, ADAMS, RALF H, JEFFERYS, JOHN G R and KANN, OLIVE, 2007. The EMBO journal. 26(23), 4891-901
• NATERI, A.S., SPENCER-DENE, B. and BEHRENS, A., 2005. Nature. 437, 281-285
• NATERI, A S, TZAVELAS, C, BILDIRICI, L and RICKWOOD, D, 2005. Journal of immunoassay & immunochemistry. 26(3), 169-77
• NATERI, ABDOLRAHMAN S, SPENCER-DENE, BRADLEY and BEHRENS, AXEL, 2005. Nature. 437(7056), 281-5
• RAIVICH, GENNADIJ, BOHATSCHEK, MARION, DA COSTA, CLIVE, IWATA, OSUKE, GALIANO, MATTHIAS, HRISTOVA, MARIA, NATERI, ABDOLRAHMAN S, MAKWANA, MILAN, RIERA-SANS, LLU脥S, WOLFER, DAVID P and LIPP, HANS-PET, 2004. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron. 43(1), 57-67
• NATERI, ABDOLRAHMAN S, RIERA-SANS, LLU脥S, DA COSTA, CLIVE and BEHRENS, AXEL, 2004. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science. 303(5662), 1374-8
• RAIVICH, G., BOHATSCHEK, M., DA COSTA, C., IWATA, O., GALIANO, M., HRISTOVA, M., NATERI, A.S., MAKWANA, M., RIERA-SANS, L., WOLFER, D.P, LIPP, H.P., AGUZZI, A., WAGNER, E.F. and BEHRENS, A., 2004. Neuron. 43(1), 57-67
• NATERI, A.S., RIERA-SANS, L., DA COSTA, C. and BEHRENS, A., 2004. Science. 303(5662), 1374-1378
• NATERI, A.S., HUGHES, P.J. and STANWAY, G., 2002. Journal of Virology. 76(24), 13116-13122
• NATERI, ABDOLRAHMAN S, HUGHES, PAMELA J and STANWAY, GLYN, 2002. Terminal RNA replication elements in human parechovirus 1. Journal of Virology. 76(24), 13116-22
• NATERI, A S, HUGHES, P J and STANWAY, G, 2000. In vivo and in vitro identification of structural and sequence elements of the human parechovirus 5' untranslated region required for internal initiation. Journal of Virology. 74(14), 6269-77
• Molecular Cancer Research: Mol Cancer Res.