糖心原创

Biobank
 

Image of Sarah Blott

Sarah Blott

Associate Professor in Animal Breeding and Genetics, Faculty of Medicine & Health Sciences

Contact

  • workGateway Building
    Sutton Bonington Campus
    Sutton Bonington
    Leicestershire
    LE12 5RD
    UK
  • work0115 951 6247
  • fax0115 951 6415

Biography

Sarah Blott has a BSc in Genetics from University College London, and an MSc and PhD in Quantitative Genetics from the University of Edinburgh. After post-doctoral positions at the University of Li猫ge, Belgium and the University of Cambridge she worked for Sygen International plc (now part of Genus plc, a leading pig and cattle breeding company) as a research scientist. From 2006-2014, she was Head of Quantitative Genetics at the Animal Health Trust. She joined the School of Veterinary Medicine and Science in 2014.

Research Summary

My research focuses on improving methods of evaluating the genetic risk of disease in animal populations and on developing new breeding strategies to reduce disease prevalence. Existing projects have… read more

Recent Publications

  • WIENER P, S脕NCHEZ-MOLANO E, CLEMENTS DN, WOOLLIAMS JA, HASKELL MJ and BLOTT SC, 2017. BMC genomics. 18(1), 609
  • ILSKA J, HASKELL MJ, BLOTT SC, S脕NCHEZ-MOLANO E, POLGAR Z, LOFGREN SE, CLEMENTS DN and WIENER P, 2017. Genetics. 206(2), 1101-1111
  • VELIE, BRANDON D, SHRESTHA, MERINA, FRAN要OIS, LIESBETH, SCHURINK, ANOUK, TESFAYONAS, YOHANNES G, STINCKENS, ANNELEEN, BLOTT, SARAH, DUCRO, BART J, MIKKO, SOFIA, THOMAS, RUTH and OTHERS, 2016. PloS one. 11(4), e0152966
  • NORTON EM, MICKELSON JR, BINNS MM, BLOTT SC, CAPUTO P, ISGREN CM, MCCOY AM, MOORE A, PIERCY RJ, SWINBURNE JE, VAUDIN M and MCCUE ME, 2016. The Journal of heredity. 107(6), 537-43

Current Research

My research focuses on improving methods of evaluating the genetic risk of disease in animal populations and on developing new breeding strategies to reduce disease prevalence. Existing projects have enabled genome-wide association studies (GWAS) to be carried out to identify genetic variants associated with musculoskeletal disorders in the horse and dog, and respiratory disease in the horse. My research group has also been responsible for the development of Estimated Breeding Values (EBVs are a measure of genetic risk calculated from pedigree and clinical or health screening data) for hip and elbow score in Kennel Club registered dogs, and we are also working with Guide Dogs UK to produce EBVs for health and behavioural traits. A second strand of research has been looking at the management of inbreeding to reduce risk of inherited disease at the population level. The impact of this research has been disseminated through the development of internet-based tools for breeders and through presentations and educational sessions for breeders, the veterinary community and other stakeholders.

Future Research

Significant genome regions associated with fracture risk in horses, and hip dysplasia in dogs have been identified. Future research will use next generation sequencing (NGS) technologies and bioinformatics analysis to prioritise genetic variants, both to improve prediction of genetic risk and to highlight variants for further follow-up in order to better understand the underlying biology. In addition, the importance of genotype-by-environment interactions will be investigated using gene-environment association studies based on high density genotyping data. Cross-disciplinary collaborations will be developed, in order to identify gene networks and regulatory mechanisms impacted by disease mutations. Possible approaches will include high-throughput gene expression analysis combined with genome association studies (eQTL), methylation and ChIP-seq analyses to elucidate epigenetic factors involved in complex disease and the use of induced pluripotent stem (iPS) cells as an in-vitro model for functional studies.

  • WIENER P, S脕NCHEZ-MOLANO E, CLEMENTS DN, WOOLLIAMS JA, HASKELL MJ and BLOTT SC, 2017. BMC genomics. 18(1), 609
  • ILSKA J, HASKELL MJ, BLOTT SC, S脕NCHEZ-MOLANO E, POLGAR Z, LOFGREN SE, CLEMENTS DN and WIENER P, 2017. Genetics. 206(2), 1101-1111
  • VELIE, BRANDON D, SHRESTHA, MERINA, FRAN要OIS, LIESBETH, SCHURINK, ANOUK, TESFAYONAS, YOHANNES G, STINCKENS, ANNELEEN, BLOTT, SARAH, DUCRO, BART J, MIKKO, SOFIA, THOMAS, RUTH and OTHERS, 2016. PloS one. 11(4), e0152966
  • NORTON EM, MICKELSON JR, BINNS MM, BLOTT SC, CAPUTO P, ISGREN CM, MCCOY AM, MOORE A, PIERCY RJ, SWINBURNE JE, VAUDIN M and MCCUE ME, 2016. The Journal of heredity. 107(6), 537-43
  • BLOTT S, 2015. Foal Immunodeficiency Syndrome. In: SPRAYBERRY KA and ROBINSON NE, eds., Robinson's Current Therapy in Equine Medicine 7th. Chapter 116. Elsevier. Pages 490-491
  • S脕NCHEZ-MOLANO, ENRIQUE, PONG-WONG, RICARDO, CLEMENTS, DYLAN N, BLOTT, SARAH C, WIENER, PAMELA and WOOLLIAMS, JOHN A, 2015. Genomic prediction of traits related to canine hip dysplasia Frontiers in genetics. 6,
  • EVANS, KATY M, LEWIS, THOMAS W, ASHER, LUCY, BLYTHE, SIMON, BOTTOMLEY, MATTHEW, TOOTILL, LISA, ROBERTS, RENA, WHITESIDE, HELEN, ENGLAND, GARY CW and BLOTT, SARAH C, 2015. Journal of Veterinary Behavior: Clinical Applications and Research. 10(6), 459-464
  • WIENER, PAMELA, ILSKA, JOANNA J, LOFGREN, SARAH E, S脕NCHEZ-MOLANO, ENRIQUE, CLEMENTS, DYLAN N, WOOLLIAMS, JOHN A, BLOTT, SARAH C and HASKELL, MARIE J, 2015. Dissecting genetic and non-genetic influences on dog personality Journal of Veterinary Behavior: Clinical Applications and Research. 10(5), 438
  • LEWIS, TW, ABHAYARATNE, BM and BLOTT, SC, 2015. Trends in genetic diversity for all Kennel Club registered pedigree dog breeds Canine genetics and epidemiology. 2(1), 1
  • LEWIS, TW, ABHAYARATNE, BM and BLOTT, SC, 2015. Selected highlights from other journals: Effect on genetic diversity of inbreeding in pedigree dogs Veterinary Record. 177(17), 441-441
  • BLOTT SC, SWINBURNE JE, SIBBONS C, FOX-CLIPSHAM LY, HELWEGEN M, HILLYER L, PARKIN TDH, NEWTON JR and VAUDIN M, 2014. BMC Genomics. 15, 147
  • WELSH CE, LEWIS TW, BLOTT SC, MELLOR DJ, STIRK AJ and PARKIN TDH, 2014. Veterinary journal (London, England : 1997). 200(2), 253-6
  • CORBIN LJ, KRANIS A, BLOTT SC, SWINBURNE JE, VAUDIN M, BISHOP SC and WOOLLIAMS JA, 2014. Genetics, selection, evolution : GSE. 46, 9
  • S脕NCHEZ-MOLANO E, WOOLLIAMS JA, BLOTT SC and WIENER P, 2014. Journal of animal breeding and genetics = Zeitschrift f眉r Tierz眉chtung und Z眉chtungsbiologie. 131(2), 134-45
  • LOFGREN SE, WIENER P, BLOTT SC, S脕NCHEZ-MOLANO E, WOOLLIAMS JA, CLEMENTS DN and HASKELL MJ, 2014. Management and personality in Labrador Retriever dogs Applied Animal Behaviour Science. 156, 44-53
  • S脕NCHEZ-MOLANO E, WOOLLIAMS JA, PONG-WONG R, CLEMENTS DN, BLOTT SC and WIENER P, 2014. BMC genomics. 15(1), 833 (In Press.)
  • WELSH CE, LEWIS TW, BLOTT SC, MELLOR DJ, LAM KH, STEWART BD and PARKIN TDH, 2013. Veterinary journal (London, England : 1997). 198(3), 611-5
  • LEWIS TW, BLOTT SC and WOOLLIAMS JA, 2013. BMC genetics. 14, 16
  • CORBIN LJ, BLOTT SC, SWINBURNE JE, VAUDIN M, BISHOP SC and WOOLLIAMS JA, 2012. Animal genetics. 43(3), 337-9
  • CORBIN LJ, BLOTT SC, SWINBURNE JE, SIBBONS C, FOX-CLIPSHAM LY, HELWEGEN M, PARKIN TDH, NEWTON JR, BRAMLAGE LR, MCILWRAITH CW, BISHOP SC, WOOLLIAMS JA and VAUDIN M, 2012. Mammalian genome : official journal of the International Mammalian Genome Society. 23(3-4), 294-303
  • HARTLEY C, BARNETT KC, PETTITT L, FORMAN OP, BLOTT S and MELLERSH CS, 2012. Veterinary ophthalmology. 15(5), 327-32
  • HARTLEY C, DONALDSON D, SMITH KC, HENLEY W, LEWIS TW, BLOTT S, MELLERSH C and BARNETT KC, 2012. Veterinary ophthalmology. 15(5), 315-26
  • DE RISIO L, LEWIS T, FREEMAN J, DE STEFANI A, MATIASEK L and BLOTT S, 2011. Veterinary journal (London, England : 1997). 188(3), 286-90
  • LEWIS TW, ILSKA JJ, BLOTT SC and WOOLLIAMS JA, 2011. Veterinary journal (London, England : 1997). 189(2), 227-33
  • WOOLLIAMS JA, LEWIS TW and BLOTT SC, 2011. Veterinary journal (London, England : 1997). 189(2), 169-76
  • LEWIS T, SWIFT S, WOOLLIAMS JA and BLOTT S, 2011. Veterinary journal (London, England : 1997). 188(1), 73-6
  • LEWIS TW, WOOLLIAMS JA and BLOTT SC, 2010. PloS one. 5(10), e13610
  • LEWIS TW, BLOTT SC and WOOLLIAMS JA, 2010. PloS one. 5(10), e12797
  • CORBIN LJ, BLOTT SC, SWINBURNE JE, VAUDIN M, BISHOP SC and WOOLLIAMS JA, 2010. Animal genetics. 41 Suppl 2, 8-15
  • LEWIS T, RUSBRIDGE C, KNOWLER P, BLOTT S and WOOLLIAMS JA, 2010. Veterinary journal (London, England : 1997). 183(3), 345-7
  • BONHOMME M, CHEVALET C, SERVIN B, BOITARD S, ABDALLAH J, BLOTT S and SANCRISTOBAL M, 2010. Genetics. 186(1), 241-62
  • CLIFFE KM, DAY AE, BAGGA M, SIGGENS K, QUILTER CR, LOWDEN S, FINLAYSON HA, PALGRAVE CJ, LI N, HUANG L, BLOTT SC and SARGENT CA, 2010. Animal genetics. 41(6), 619-29
  • LEWIS TW, WOOLLIAMS JA and BLOTT SC, 2010. Optimisation of breeding strategies to reduce the prevalence of inherited disease in pedigree dogs Animal Welfare. 19(S), 93-98
  • QUILTER CR, GILBERT CL, OLIVER GL, JAFER O, FURLONG RA, BLOTT SC, WILSON AE, SARGENT CA, MILEHAM A and AFFARA NA, 2008. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 147B(7), 1126-37
  • GERBER V, SWINBURNE JE, BLOTT SC, NUSSBAUMER P, RAMSEYER A, KLUKOWSKA-R脰TZLER J, DOLF G, MARTI E, BURGER D and LEEB T, 2008. DTW. Deutsche tier盲rztliche Wochenschrift. 115(7), 271-5
  • FOURY A, GEVERINK NA, GIL M, GISPERT M, HORT脫S M, FONT I FURNOLS M, CARRION D, BLOTT SC, PLASTOW GS and MORM脠DE P, 2007. Animal : an international journal of animal bioscience. 1(7), 973-82
  • QUILTER CR, BLOTT SC, WILSON AE, BAGGA MR, SARGENT CA, OLIVER GL, SOUTHWOOD OI, GILBERT CL, MILEHAM A and AFFARA NA, 2007. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 144B(7), 862-8
  • JOST U, KLUKOWSKA-R脰TZLER J, DOLF G, SWINBURNE JE, RAMSEYER A, BUGNO M, BURGER D, BLOTT S and GERBER V, 2007. A region on equine chromosome 13 is linked to recurrent airway obstruction in horses. Equine veterinary journal. 39(3), 236-41
  • VIITALA S, SZYDA J, BLOTT S, SCHULMAN N, LIDAUER M, M脛KI-TANILA A, GEORGES M and VILKKI J, 2006. Genetics. 173(4), 2151-64
  • KOLLERS S, BLOTT SC and ROCHA D, 2005. Animal genetics. 36(2), 177-8
  • ROBERTSON L, WILLIAMSON SL, M脡GY K, FOSTER H, BLOTT SC, GRIFFIN DK and ROCHA D, 2005. Animal genetics. 36(2), 160-1
  • PLASTOW GS, CARRI脫N D, GIL M, GARC脥A-REGUEIRO JA, I FURNOLS MF, GISPERT M, OLIVER MA, VELARDE A, GU脌RDIA MD, HORT脫S M, RIUS MA, S脕RRAGA C, D脥AZ I, VALERO A, SOSNICKI A, KLONT R, DORNAN S, WILKINSON JM, EVANS G, SARGENT C, DAVEY G, CONNOLLY D, HOUEIX B, MALTIN CM, HAYES HE, ANANDAVIJAYAN V, FOURY A, GEVERINK N, CAIRNS M, TILLEY RE, MORM脠DE P and BLOTT SC, 2005. Meat science. 70(3), 409-21
  • BLOTT S, KIM J, MOISIO S, SCHMIDT-K脺NTZEL A, CORNET A, BERZI P, CAMBISANO N, FORD C, GRISART B, JOHNSON D, KARIM L, SIMON P, SNELL R, SPELMAN R, WONG J, VILKKI J, GEORGES M, FARNIR F and COPPIETERS W, 2003. Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition. Genetics. 163(1), 253-66
  • BLOTT S, ANDERSSON L, GROENEN M, SANCRISTOBAL M, CHEVALET C, CARDELLINO R, LI N, HUANG L, LI K, PLASTOW G and HALEY C, 2003. Characterisation of genetic variation in the pig breeds of China and Europe 鈥� the PigBioDiv2 project Arch Zootec. 52, 207-217
  • QUILTER CR, BLOTT SC, MILEHAM AJ, AFFARA NA, SARGENT CA and GRIFFIN DK, 2002. Mammalian genome : official journal of the International Mammalian Genome Society. 13(10), 588-94
  • BLOTT SC, WILLIAMS JL and HALEY CS, 1999. Heredity. 82 ( Pt 6), 613-9
  • COPPIETERS W, BLOTT S, FARNIR F, GRISART B, RIQUET J and GEORGES M, 1999. From phenotype to genotype: towards positional cloning of QTL in livestock? Archives of Animal Breeding. 42, 86-92
  • ASHWORTH D, BISHOP M, CAMPBELL K, COLMAN A, KIND A, SCHNIEKE A, BLOTT S, GRIFFIN H, HALEY C, MCWHIR J and WILMUT I, 1998. Nature. 394(6691), 329
  • BLOTT SC, WILLIAMS JL and HALEY CS, 1998. Animal genetics. 29(4), 273-82
  • BLOTT SC, WILLIAMS JL and HALEY CS, 1998. Genetic variation within the Hereford breed of cattle. Animal genetics. 29(3), 202-11

Biobank

The 糖心原创
School of Veterinary Medicine and Science
Sutton Bonington Campus, Leicestershire, LE12 5RD


telephone: +44 (0) 115 951 6563
email:sv-biobank@nottingham.ac.uk