糖心原创

Contact

• workRoom A60 Veterinary Academic Building
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6435
• fax0115 951 6440
• michael.a.jones@nottingham.ac.uk

Biography

Michael Jones obtained a BSc (Hons) in Microbiology from the University of Sheffield. He carried out postgraduate research at the University of East Anglia obtaining an MSc (1991) and PhD (1994). He then spent three and a half years as a research fellow at the University of Aberdeen, Institute for Medical Sciences, studying stretch activated channels. He then moved to work at the Institute for Animal Health, Compton Laboratory in 1997 where he worked on host pathogen interactions during bacterial gastrointestinal disease in farm animals , vaccine development and host genetics. His research links molecular biology, bacterial physiology and host immune responses to infection.

In 2006 Dr Jones moved to help establish the School of Veterinary Medicine and Science where he was a foundation lecturer. Dr Jones planned, implemented and convenes the microbiology components of the BVM BVS and BVMedSci course. During this time he has obtained his PGCHE and an MA in higher education from the 糖心原创 and has carried on his research on intestinal pathogens and host interactions.

His current research is focused on the zoonotic pathogens Salmonella and Campylobacter, AMR and Bacteriophage in the farm environment and as bio-controls and .

In addition he has supported the development of undergraduate research projects and placements resulting in projects in the following areas: understanding the micro-flora of zoological species, AMR and molecular detection of zoonotic pathogens..

Dr Jones acknowledges and would like to thanks the following for their support: DEFRA, BBSRC, FSA, EU, Novartis and Intervet in his research.

Expertise Summary

Research expertise:

• Foodbourne bacterial pathogens in particular Campylobacter and Salmonella. He has worked in public health since 1994 and has been actively researching animal health since 1997.
• Understanding the immune response to Salmonella and how Salmonella stereotypes come to define these responses.
• The role Bacteriophage in the farm environment and risk from AMR and virulence gene transfer.
• Antibiotic resistance in the environment and the interplay between specific drivers and risk of development.
• The application fo Bacteriophage to control pathogens and reduce AMR.

Teaching and associated expertise:

• Planning and implementation of Veterinary Microbiology delivery within the Nottingham BVMS course.
• AMR teaching and stewardship. Dr Jones is part of the Vet Schools Council AMR advisory group.

Safety and Biological Safety.

• Dr Jones is School of Veterinary Medicine and Sciences Safety Coordinator.
• Biological safety Dr Jones has over 20 years experience in Biological Safety and as a Biological Safely advisor. He is also chair of the campus genetic modification scientific committee (GMSCd).

Teaching Summary

Dr Jones convenes the microbiology integrated module. He lectures in veterinary microbiology and molecular biology in years 2 and 3 of the BVMS course. The course has an innovative integrated… read more

Research Summary

His current research is directed at understanding the host interactions of bacteria disease and routes to control these infections.

His research interests developed from the study of bacterial physiology through to the molecular and immunological mechanisms involved in colonization and disease.

The main focus of his work is on the following genera of bacteria, Campylobacter, Salmonella and Mycobacterium.

Research on Campylobacter includes investigations into phase variation, the physiology and immunology of colonization of the chicken and the development of vaccines. This work is being carried out in collaboration with Departments of Food Sciences and Bimolecular sciences and Mathematics at the 糖心原创, the universities of Leicester and Cambridge.

The studies on Salmonella are investigating the molecular basis of host specificity and virulence of Salmonella serovars Gallinarum, Pullorum and Enteritidis. This work is in collaboration with Paul Barrow at the 糖心原创, the Roslin and the Sanger Institutes.

Work on Mycobacterium has focused on understanding the interaction of Mycobacterium avium in poultry. With work focusing on immune responses and the physical interaction of these bacteria with the host cells.

The overall aim of the research program is to improve the understanding of the nature of infectious diseases to identify and improved routes for control of important animal and zoonotic diseases.

Selected Publications

• BAYLISS, C.D., BIDMOS, F.A., ANJUM, A., MANCHEV, V.T., RICHARDS, R.L., GROSSIER, J., WOOLDRIDGE, K.G., KETLEY, J.M., BARROW, P.A., JONES, M.A. and TRETYAKOV, M.V., 2012. Nucleic Acids Research. 40(13), 82152
• SETTA, A., BARROW, P.A., KAISER, P. and JONES, M.A., 2012. Comparative Immunology, Microbiology and Infectious Diseases. 35(5), 397-410
• KARLYSHEV A.V., THACKER G., JONES M.A., CLEMENTS M.O. and WREN B.W., 2014. FEBS Open Bio. 4, 468-72
• SETTA, A., BARROW, P., KAISER, P. and JONES, M., 2012. Veterinary Immunology and Immunopathology. (In Press.)

• View all publications

Dr Jones convenes the microbiology integrated module. He lectures in veterinary microbiology and molecular biology in years 2 and 3 of the BVMS course. The course has an innovative integrated delivery and is based around body systems, so delivery of specific pathogens is related to both anatomy and physiology of specific body systems.

Past Research

Previously Dr Jones worked as a research fellow in the University of Aberdeen where he worked on stretch activated channels and was part of the team which identified double membrane spanning MscL channel in E. coli.

Dr Jones then moved to the Institute for Animal Health to work on Type-III secretion systems in Salmonella.

He then established the IAH Campylobacter research group. This group was the first to identify defined lines of poultry resistant to Campylobacter colonisation, in vivo gene transcripts from bacteria in the GI tract and to show a pro-inflammatory avian immune responses to the commensal Campylobacter.

The work has been carried on to evaluate infection models for Campylobacter and to investigate the potential for vaccines against this important foodborne pathogen.

Future Research

Alongside the current research Dr Jones also has interests in Antimicrobial resistance and novel control of bacteria. He is also collaborating with Professor Jamie Leigh well established group in developing novel areas of streptococcal research.

• COOK R., HOOTON S., TREVARDI U, KING E., DODD CER, HOBMAN JL, STEKEL DJ, JONES MA, MILLARD AD and MILLARD AD, 2021. Microbiome. 9, 65
• SLAWOMIR MICHNIEWSKI,, BRANKO RIHTMAN,, RYAN COOK,, MICHAEL A. JONES, WILLIAM H. WILSON, DAVID J. SCANLAN and ANDREW MILLARD, 2021. ISME Communications. 58
• RYAN COOK, NATHAN BROWN, TAMSIN REDGWELL, BRANKO RIHTMAN, MEGAN BARNES, MARTHA CLOKIE, DOV J. STEKEL, JON HOBMAN, MICHAEL A. JONES and ANDREW MILLARD, 2021. PHAGE. 2(4), 214-223
• SWIFT BMC, BENNETT M, WALLER K, DODD C, MURRAY A, GOMES RL, HUMPHREYS B, HOBMAN JL, JONES MA, WHITLOCK SE, MITCHELL LJ, LENNON RJ and ARNOLD KE, 2018. The Science of the total environment. 649, 12-20 (In Press.)
• TANG Y, FOSTER N, JONES MA and BARROW PA, 2018. Infection and immunity. 86(8),
• AIDLEY J, RAJOPADHYE S, AKINYEMI N M, LANGO-SCHOLEY L, JONES M A and BAYLISS C D, 2017. MBio.
• PSIFIDI A, FIFE M, HOWELL J, VAN DIEMEN PM, KUO R, SMITH J, HOCKING PM, SALMON N, JONES MA, HUME DA, BANOS G, STEVENS MP and KAISER P, 2016. BMC Genomics. 17(1), 293
• LEA LANGO-SCHOLEY, JACK AIDLEY, ALEXANDRA WOODACRE, MICHAEL A. JONES and CHRISTOPHER D. BAYLISS, 2016. PLoS One. 11(7),
• KANJI A, JONES MA, MASKELL DJ and GRANT AJ, 2015. Microb Pathog. 89, 93-99
• KARLYSHEV A.V., THACKER G., JONES M.A., CLEMENTS M.O. and WREN B.W., 2014. FEBS Open Bio. 4, 468-72
• BAYLISS, C.D., BIDMOS, F.A., ANJUM, A., MANCHEV, V.T., RICHARDS, R.L., GROSSIER, J., WOOLDRIDGE, K.G., KETLEY, J.M., BARROW, P.A., JONES, M.A. and TRETYAKOV, M.V., 2012. Nucleic Acids Research. 40(13), 82152
• SETTA, A., BARROW, P., KAISER, P. and JONES, M., 2012. Veterinary Immunology and Immunopathology. (In Press.)
• SETTA, A., BARROW, P.A., KAISER, P. and JONES, M.A., 2012. Comparative Immunology, Microbiology and Infectious Diseases. 35(5), 397-410
• ROSHIER A.L., FOSTER N. and JONES M.A., 2011. Veterinary students' usage and perception of video teaching resources. BMC Medical Education. 10, 1
• DHAWI, A A, ELAZOMI, A, JONES, M A, LOVELL, M A, LI, H, EMES, R D and BARROW, P A, 2011. Veterinary microbiology.
• HARVEY, P.C., WATSON, M., HULME, S., JONES, M.A., LOVELL, M., BERCHIERI, A., YOUNG, J., BUMSTEAD, N. and BARROW, P., 2011. Infection and Immunity. 79(10), 4105-21
• CONLAN, A.J.K., LINE, J.E., HIETT, K., COWARD, C., VAN DIEMEN, P.M., STEVENS, M.P., JONES, M.A., GOG, J.R. and MASKELL, D.J., 2011. Interface: Journal of the Royal Society. 8(65), 1720-1735
• FIFE, M.S., HOWELL, J.S., SALMON, N., HOCKING, P.M., VAN DIEMEN, P.M., JONES, M.A., STEVENS, M.P. and KAISER, P., 2011. Animal Genetics. 42(2), 134-140
• HITCHCOCK A, HALL S.J., MYERS J.D., MULHOLLAND F., JONES M.A. and KELLY D.J., 2010. Microbiology. 156, 2994-3010
• BUCKLEY, A.M., WANG, J., HUDSON, D.L., GRANT, A.J., JONES, M.A., MASKELL, D.J. and STEVENS, M.P., 2010. Vaccine. 28(4), 1094-1105
• HOWARD, S.L., JAGANNATHAN, A., SOO, E.C., HUI, J.P., AUBRY, A.J., AHMED, I., KARLYSHEV, A., KELLY, J.F., JONES, M.A., STEVENS, M.P., LOGAN, S.M. and WREN, B.W., 2009. Infection and Immunity. 77(6), 2544-2556
• THOMSON, N.R., CLAYTON, D.J., WINDHORST, D., VERNIKOS, G., DAVIDSON, S., CHURCHER, C., QUAIL, M.A., STEVENS, M., JONES, M.A., WATSON, M., BARRON, A., LAYTON, A., PICKARD, D., KINGSLEY, R.A., BIGNELL, A., CLARK, L., HARRIS, B., ORMOND, D. and ABDELLA, Z, 2008. Genome Research. 18(10), 1624-1637
• COWARD, C., VAN DIEMEN, P.M., CONLAN, A.J.K., GOG, J.R., STEVENS, M.P., JONES, M.A. and MASKELL, D.J., 2008. Competing isogenic Campylobacter strains exhibit variable population structures in vivo. Applied and environmental microbiology. 74(12), 3857-67
• CHAPPELL, L., KAISER, P., BARROW, P. A., JONES, M. A., JOHNSTON, C. and WIGLEY, P., 2008. The immunobiology of avian systemic salmonellosis. Veterinary Immunology and Immunopathology. [epub preprint],
• KAISER, P, HOWELL, J, FIFE, M, SADEYEN, J-R, SALMON, N, ROTHWELL, L, YOUNG, J, VAN DIEMEN, P, STEVENS, S, POH, T.-Y, JONES, M, BARROW, P, WIGLEY, P, HE, H, , SWAGGERTY, C and KOGUT, M, 2008. ntegrated Immunogenomics in the Chicken: Deciphering the Immune Response to Identify Disease Resistance Genes. In: PINARD, M.-H. (JOUY-EN-JOSAS), GAY, C. (BELTSVILLE), PASTORET, P.-P. (BRUSSELS), DODET, B. (LYON) and , eds., Developments in Biologicals 132. Karger, Basel. (In Press.)
• ATACK, J.M., HARVEY, P., JONES, M.A. and KELLY, D.J., 2008. The Campylobacter jejuni thiol peroxidases Tpx and Bcp both contribute to aerotolerance and peroxide-mediated stress resistance but have distinct substrate specificities. Journal of bacteriology. 190(15), 5279-90
• SMITH, C., ABUOUN, A., CAWTHRAW, S., HUMPHREY, T., ROTHWELL, L., KAISER, P., BARROW, P. A. and JONES M. A., 2008. FEMS Immunology and Medical Microbiology.
• ASHGAR S.S., OLDFIELD N.J., WOOLDRIDGE K.G., JONES M.A., IRVING G.J., TURNER D.P. and ALA'ALDEEN D.A., 2007. Journal of Bacteriology. 189(5), 1856-1865
• JONES, M.A., HULME, S.D., BARROW, P.A, and WIGLEY, P., 2007. Avian Pathology. 36(3), 199-203
• PITTMAN, M.S., ELVERS, K. T., LEE, L., JONES, M. A., POOLE, R. K., PARK, S. F. and KELLY, D. J., 2007. Molecular Microbiology. 63(2), 575-590
• SMITH, C.K., KAISER, P., ROTHWELL, L., HUMPHREY, T., BARROW, P.A. and JONES, M.A., 2005. Infection and Immunity. 73(4), 2094-2100
• WOODALL, C.A., JONES, M.A., BARROW, P.A., HINDS, J., MARSDEN, G.L., KELLY, D.J., DORRELL, N., WREN, B.W. and MASKELL, D.J., 2005. Infection and Immunity. 73(8), 5278-5285
• BOYD, Y., HERBERT, E.G., MARSTON, K.L., JONES, M.A. and BARROW, P.A., 2005. Immunogenetics. VOL 57(NUMBER 3-4), 248-253
• GRANT, A. J., COWARD, C., JONES, M. A., WOODALL, C. A., BARROW, P. A. and MASKELL, D. J., 2005. Applied and Environmental Microbiology. VOL 71(NUMB 12), 8031-8041
• JONES, M.A., MARSTON, K.L., WOODALL, C.A., MASKELL, D.J., LINTON, D., KARLYSHEV, A.V., DORRELL, N., WREN, B.W. and BARROW, P.A., 2004. Infection and Immunity. 72(7), 3769-76
• VELAYUDHAN, J., JONES, M. A., BARROW, P. A. and KELLY, D. J., 2004. Infection and Immunity. VOL 72(PART 1), 260-268
• TURNER, A.K., BARBER,L. Z., WIGLEY,P., MUHAMMAD, S., JONES, M.A., LOVELL, M.A., HULME, S. and BARROW, P.A., 2003. Infection and Immunity. 71(6), 3392-3401
• JONES, M.A., T脰TEMEYER, S., MASKELL, D.J., BRYANT, C.E. and BARROW, P.A., 2003. Infection and Immunity. 71(5), 2626-2633
• BARROW, P.A., ADAMS, P., MIDDLETON, A., LOVELL, M.A., MARSTON, K., BUMSTEAD, M. and JONES, M.A., 2003. Salmonella in the chicken intestine behave differently to those grown in vitro and show stationary-phase characteristics. In: The Society for General Microbiology Ordinary Meeting.
• WIGLEY, P., JONES, M. A. and BARROW, P. A., 2002. Avian Pathology. VOL 31(PART 5), 501-506
• JONES, M.A., FOSTER, N., PAGE, K., HULME, S.D. and BARROW, P.A., 2002. Salmonella enterica serovar Typhimurium F98 modulation of NO production is not host cell dependent and is inv/spa dependent. In: The International Symposium on Salmonella and Salmonellosis.. 203-204
• JONES, M.A., WIGLEY, P., PAGE, K.L., HULME, S.D. and BARROW, P.A., 2002. The role of Type-III secretion in the virulence of Salmonella enterica serovar Gallinarum and Salmonella enterica serovar Pullorum. In: International Symposium on Salmonella and Salmonellosis. 145-149
• HARVEY, P., MUHAMMAD, S., JONES, M. and BARROW, P.A., 2002. Microarray analysis of Salmonella gene expression: identification of genes with a role in growth suppression in stationary phase. In: The international Symposium on Salmonella and Salmonellosis.. 217-218
• MUHAMMAD, S., JONES, M.A. and BARROW, P.A., 2002. Bacterial energetics in rpoS expression and stability in stationary-phase growth of Salmonella Typhimurium. In: International Symposium on Salmonella and Salmonellosis.. 219-220
• MCLAGGAN, D., JONES, M. A., GOUESBET, G., LEVINA, N., LINDEY, S., EPSTEIN, W. and BOOTH, I. R., 2002. Molecular Microbiology. VOL 43(PART 2), 521-536
• JONES, M. A., WIGLEY, P., PAGE, K. L., HULME, S. D. and BARROW, P. A., 2001. Infection and Immunity. VOL 69(PART 9), 5471-5476
• HOSIE, A. H. F., ALLAWAY, D., JONES, M. A., WALSHAW, D. L., JOHNSTON, A. W. B. and POOLE, P. S., 2001. Molecular Microbiology. VOL 40(PART 6), 1449-1460