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Ross Denton

Professor of Organic Chemistry, Faculty of Science

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Biography

Ross began his research career here at Nottingham where he carried out his PhD studies with Professor J.C. Anderson (2001-2004). At the beginning of 2005 he moved to the Scripps Research Institute, La Jolla, USA to carry out postdoctoral research with Professor K.C. Nicolaou. In mid 2007 he returned to the UK to take up a further postdoctoral position with Professor S.V. Ley CBE, FRS at Cambridge.

Ross returned to The 糖心原创 to begin his independent research career as a Lecturer in Organic Chemistry (fixed-term) in September 2008. In June 2009 he was appointed to a permanent lectureship. He was promoted to Associate Professor in 2016 and to Professor in 2020. He was the recipient of the 2019 SCI Organic Process Chemistry Prize and the 2020 Royal Society of Chemistry Bader Prize.

Ross' research group is based in the GlaxoSmithKline Laboratory for Sustainable Chemistry and his research team focus on the design and development of new catalysis and synthesis methods.

Ross is the Deputy Head of the Synthesis and Catalysis Research Theme, the leader of the MiSynth CDT Research Theme and the Postgraduate Admissions Tutor for the School of Chemistry.

For more details about Ross' research group please visit his personal webpages:

Research Summary

Our research involves the design and development of new reactions, synthesis methods, and catalysts that allow us (and others) to make valuable small organic molecules such as natural products and… read more

Recent Publications

  • BEDDOE, RHYDIAN H., EDWARDS, DANIEL C., GOODMAN, LOUIS, SNEDDON, HELEN F. and DENTON, ROSS M., 2020. CHEMICAL COMMUNICATIONS. 56(48), 6480-6483
  • JORDAN, ANDREW, DENTON, ROSS M and SNEDDON, HELEN F, 2020. Development of a More Sustainable Appel Reaction Figshare.
  • BEDDOE, RHYDIAN H., ANDREWS, KEITH G., MAGNE, VALENTIN, CUTHBERTSON, JAMES D., SASKA, JAN, SHANNON-LITTLE, ANDREW L., SHANAHAN, STEPHEN E., SNEDDON, HELEN F. and DENTON, ROSS M., 2019. SCIENCE. 365(6456), 910-+
  • BEDDOE, RHYDIAN, SNEDDON, HELEN and DENTON, ROSS, 2019. Oxygen-18 enrichment of alcohols by a modified Mitsunobu esterification reaction ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 257,

Current Research

Our research involves the design and development of new reactions, synthesis methods, and catalysts that allow us (and others) to make valuable small organic molecules such as natural products and pharmaceuticals more efficiently and sustainably. This activity is underpinned by a core interest in organophosphorus and organosilicon chemistry.

At present we have projects running on amination reactions, amidation reactions, novel bioisosteres and building blocks for drug discovery, fluorination chemistry, alcohol activation and total synthesis.

  • BEDDOE, RHYDIAN H., EDWARDS, DANIEL C., GOODMAN, LOUIS, SNEDDON, HELEN F. and DENTON, ROSS M., 2020. CHEMICAL COMMUNICATIONS. 56(48), 6480-6483
  • JORDAN, ANDREW, DENTON, ROSS M and SNEDDON, HELEN F, 2020. Development of a More Sustainable Appel Reaction Figshare.
  • BEDDOE, RHYDIAN H., ANDREWS, KEITH G., MAGNE, VALENTIN, CUTHBERTSON, JAMES D., SASKA, JAN, SHANNON-LITTLE, ANDREW L., SHANAHAN, STEPHEN E., SNEDDON, HELEN F. and DENTON, ROSS M., 2019. SCIENCE. 365(6456), 910-+
  • BEDDOE, RHYDIAN, SNEDDON, HELEN and DENTON, ROSS, 2019. Oxygen-18 enrichment of alcohols by a modified Mitsunobu esterification reaction ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 257,
  • BEDDOE, RHYDIAN H., SNEDDON, HELEN F. and DENTON, ROSS M., 2018. ORGANIC & BIOMOLECULAR CHEMISTRY. 16(42), 7774-7781
  • ANDREWS, KEITH G., FAIZOVA, RADMILA and DENTON, ROSS M., 2017. NATURE COMMUNICATIONS. 8,
  • ANDREWS, KEITH G and DENTON, ROSS M, 2017. A more critical role for silicon in the catalytic Staudinger amidation: silanes as non-innocent reductants. Chemical communications (Cambridge, England).
  • ANDREWS, KEITH G. and DENTON, ROSS M., 2017. CHEMICAL COMMUNICATIONS. 53(57), 7982-7985
  • ANDREWS, KEITH G., SUMMERS, DECLAN M., DONNELLY, LIAM J. and DENTON, ROSS M., 2016. CHEMICAL COMMUNICATIONS. 52(9), 1855-1858
  • SASKA, J., LEWIS, W., PATON, R. S. and DENTON, R. M., 2016. CHEMICAL SCIENCE. 7(12), 7040-7049
  • FEARNLEY, A. F., AN, J., JACKSON, M., LINDOVSKA, P. and DENTON, R. M., 2016. CHEMICAL COMMUNICATIONS. 52(28), 4987-4990
  • TANG, XIAOPING, AN, JIE and DENTON, ROSS M., 2014. TETRAHEDRON LETTERS. 55(4), 799-802
  • AN, JIE, DENTON, ROSS M., LAMBERT, TRISTAN H. and NACSA, ERIC D., 2014. ORGANIC & BIOMOLECULAR CHEMISTRY. 12(19), 2993-3003
  • TANG, XIAOPING, CHAPMAN, CHARLOTTE, WHITING, MATTHEW and DENTON, ROSS, 2014. CHEMICAL COMMUNICATIONS. 50(55), 7340-7343
  • AN, JIE, TANG, XIAOPING, MOORE, JOSHUA, LEWIS, WILLIAM and DENTON, ROSS M., 2013. TETRAHEDRON. 69(41), 8769-8776
  • JIE AN and ROSS DENTON, 2013. 109, 167-188
  • AN, JIE and DENTON, ROSS M., 2013. ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY, VOL 109. 109, 167-188
  • DENTON, R.M. and SCRAGG, J.T., 2012. Organic & Biomolecular Chemistry. 10(29), 5629-5635
  • DENTON, ROSS M. and SCRAGG, JAMES T., 2012. A strategy for the synthesis of the fargenone/fargenin family of natural products: synthesis of the tricyclic core ORGANIC & BIOMOLECULAR CHEMISTRY. 10(29), 5629-5635
  • DENTON, R.M., AN, J., ADENIRAN, B., BLAKE, A.J., LEWIS, W. and POULTON, A.M., 2011. Journal of Organic Chemistry. 76(16), 6749-6767
  • DENTON, RM, SCRAGG, JT and SASKA, J, 2011. Tetrahedron Letters. 52(20), 2554-2556
  • LUPO, G, GESTRI, G, O'BRIEN, M, DENTON, RM, CHANDRARATNA, RAS, LEY, SV, HARRIS, WA and WILSON, SW, 2011. Proceedings Of The National Academy Of Sciences Of The United States Of America. 108(21), 8698-8703
  • DENTON, R.M., SCRAGG, J.T., GALOFR脡, A.M., GUI, X. and LEWIS, W., 2010. Tetrahedron. 66(40), 8029-8035
  • DENTON, R.M., TANG, X. and PRZESLAK, A., 2010. Organic Letters. 12(20), 4678-4681
  • DENTON, R.M., AN, J. and ADENIRAN, B., 2010. Chemical Communications. 46(17), 3025-3027
  • DENTON, RM and SCRAGG, JT, 2010. Synlett. 633-635
  • NICOLAOU, K.C., STEPAN, A.F., LISTER, T., LI, A., MONTERO, A., TRIA, G.S., TURNER, C.I., TANG, Y., WANG, J. and DENTON, R.M., 2008. J. Am. Chem. Soc. VOL 130(NUMB 39), 13110-13119
  • NICOLAOU, K.C., FREDERICK, M.O., BURTOLOSO, A.C.B., DENTON, R.M., RIVAS, F., COLE, K.P., AVERSA, R.J., GIBE, R., UMEZAWA, T. and SUZUKI, T., 2008. J. Am. Chem. Soc.. VOL 130(NUMB 23), 7466-7476
  • MUNDAY, R.H., DENTON, R.M. and ANDERSON, J.C., 2008. J. Org. Chem.. VOL 73(NUMB 20), 8033-8038
  • LEY, STEVEN V, ABAD-SOMOVILLA, ANTONIO, ANDERSON, JAMES C, AYATS, CARLES, B脛NTELI, ROLF, BECKMANN, EDITH, BOYER, ALISTAIR, BRASCA, MARIA G, BRICE, ABIGAIL, BROUGHTON, HOWARD B, BURKE, BRENDA J and C, 2008. The synthesis of azadirachtin: a potent insect antifeedant. Chemistry - A European Journal. 14(34), 10683-704
  • NICOLAOU, K. C., LISTER, T., DENTON, R. M. and GELIN, C. F., 2008. Tetrahedron. VOL 64(NUMBER 21), 4736-4757
  • LEY, SV, ABAD-SOMOVILLA, A, ANDERSON, JC, AYATS, C, BANTELI, R, BECKMANN, E, BOYER, A, BRASCA, MG, BRICE, A, BROUGHTON, HB, BURKE, BJ, CLEATOR, E, CRAIG, D, DENHOLM, AA, DENTON, RM, DURAND-REVILLE, T, GOBBI, LB, GOBEL, M, GRAY, BL, GROSSMANN, RB, GUTTERIDGE, CE, HAHN, N, HARDING, SL, JENNENS, DC, JENNENS, L, LOVELL, PJ, LOVELL, HJ, DE LA PUENTE, ML, KOLB, HC, KOOT, WJ, MASLEN, SL, MCCUSKER, CF, MATTES, A, PAPE, AR, PINTO, A, SANTAFIANOS, D, SCOTT, JS, SMITH, SC, SOMERS, AQ, SPILLING, CD, STELZER, F, TOOGOOD, PL, TURNER, RM, VEITCH, GE, WOOD, A and ZUMBRUNN, C, 2008. Chemistry-A European Journal. 14(34), 10683-10704
  • NICOLAOU, K. C., LISTER, T., DENTON, R. M. and GELIN, C. F., 2007. Cascade Reactions Involving Formal [2+2] Thermal Cycloadditions: Total Synthesis of Artochamins F, H, I, and J Angewandte Chemie International Edition. VOL 119(NUMBER 39), 7645-7649
  • NICOLAOU, K. C., LISTER, T., DENTON, R. M., MONTERO, A. and EDMONDS, D. J., 2007. Adamantaplatensimycin: A Bioactive Analogue of Platensimycin Angewandte Chemie International Edition. VOL 119(NUMBER 25), 4796-4798
  • NICOLAOU, K. C., COLE, K. P., FREDERICK, M. O., AVERSA, R. J. and DENTON, R. M., 2007. Chemical Synthesis of the GHIJK Ring System and Further Experimental Support for the Originally Assigned Structure of Maitotoxin Angewandte Chemie International Edition. VOL 119(NUMBER 46), 9031-9035
  • NICOLAOU, K.C., ORTIZ, A. and DENTON, R.M., 2007. Metathesis reactions in the synthesis of complex molecules Chemica Oggi. VOL 25(NUMB 5), 70-77
  • NICOLAOU, KC, ORTIZ, A and DENTON, RM, 2007. Metathesis Reactions In The Synthesis Of Complex Molecules Chimica Oggi-Chemistry Today. 25(5), 70-76
  • NICOLAOU, KC, COLE, KP, FREDERICK, MO, AVERSA, RJ and DENTON, RM, 2007. Angewandte Chemie-International Edition. 46(46), 8875-8879
  • NICOLAOU, KC, LISTER, T, DENTON, RM and GELIN, CF, 2007. Angewandte Chemie-International Edition. 46(39), 7501-7505
  • NICOLAOU, KC, LISTER, T, DENTON, RM, MONTERO, A and EDMONDS, DJ, 2007. Angewandte Chemie-International Edition. 46(25), 4712-4714
  • NICOLAOU, K. C., DENTON, R. M., LENZEN, A., EDMONDS, D. J., LI, A., MILBURN, R. R. and HARRISON, S. T., 2006. Stereocontrolled Synthesis of Model Core Systems of Lomaiviticins A and B Angewandte Chemie International Edition. VOL 118(NUMBER 13), 2130-2135
  • NICOLAOU, KC, DENTON, RM, LENZEN, A, EDMONDS, DJ, LI, A, MILBURN, RR and HARRISON, ST, 2006. Angewandte Chemie-International Edition. 45(13), 2076-2081
  • ANDERSON, J.C., DENTON, R.M. and WILSON, C., 2005. Organic Letters. 7(1), 123-126
  • ANDERSON, JC, DENTON, RM and WILSON, C, 2005. Organic Letters. 7(1), 123-125
  • ANDERSON, J. C., DENTON, R. M., HICKIN, H. G. and WILSON, C., 2004. Tetrahedron. VOL 60(NUMBER 10), 2327-2335

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