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School of Pharmacy

Staff listing for the Molecular Therapeutics and Formulation Division 

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Maria Marlow

Associate Professor, Faculty of Science

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Biography

I am pharmacist with a PhD in drug delivery (糖心原创 1991) and post doctoral experience in tissue engineering (Massachusetts Institute of Technology 1991-1992) working with osteoblasts and biodegradable polymers. I have over 18 years experience in drug delivery in industry and have worked on many different drug delivery options and formulations throughout my career at Fisons, Astra and then AstraZeneca including oral, intravenous and inhaled dosage forms. Specifically I worked on AstraZeneca's metered dose inhaler SYMBICORT, for which I have a formulation patent. I have also developed formulations of poorly soluble candidate drugs. My industrial experience includes several scientific and line manager roles from 1996 leading multidisciplinary teams in product development and early development. My last industrial role in early development included the development of formulations for preclinical, toxicity and phase I/II studies. I have also project managed and led numerous technical improvement projects/teams including recently in 2010, the development of a new global process for suspension development and a global web based brochure for clinical supplies.

In May 2011, I made the transition back into academia and secured the first Gunn and Carter Senior Fellowship at De Montfort University working with Dr Geoff Smith on developing methodologies for studying bio-relevant physical form changes of drug products using terahertz spectroscopy and pulsed imaging. In Jan 2012, I was appointed as Associate Professor in Formulation Science and Pharmaceutical Materials in the School of Pharmacy. Currently I am the training director of the EPSRC CDT in Transformative Pharmaceutical Technologies and supervise 3 PhD students and cosupervise 7 students.

Expertise Summary

Drug delivery

Formulation science

Material characterisation

Teaching Summary

Pharmaceutics

MPharm

Fundamentals of Pharmacy- module convenor and physical/chemical stability of medicines

Pain module -controlled oral drug release and colloidal stability

MSc/BSc Pharmaceutical Sciences -Biopharmaceutics (PHAR1016) and Science in Industry (PHAR3022)

MSc Drug Discovery and Pharmaceutical Sciences -Formulations in drug discovery and development

Research Summary

My research is focused on developing drug delivery systems, in collaboration with clinicians that address an unmet clinical need. My current research projects focus on using injectable hydrogels… read more

Selected Publications

  • FAIDRA ANGELEROU MG, MARKUS R, PARASKEVOPOULOU V, FORALOSSO R, CLARKE P, ALVAREZ CV, CHENLO M, JOHNSON L, RUTLAND C, ALLEN S, BRASNETT C, SEDDON A, ZELZER M and MARLOW M, 2019. Journal of controlled release : official journal of the Controlled Release Society. 317, 118-129
  • 艩TAKA I, CADETE A, SURIKUTCHI BT, ABUZAID H, BRADSHAW TD, ALONSO MJ and MARLOW M, 2019. International journal of pharmaceutics. 565, 151-161
  • SABRI, A., OGILVIE, J., MCKENNA, J., SEGAL, J., SCURR, D. and MARLOW, M., 2020. Molecular pharmaceutics. 17(8), 2925-2937
  • SABRI, AKMAL H, CATER, ZACHARY, GURNANI, PRATIK, OGILVIE, JANE, SEGAL, JOEL, SCURR, DAVID J and MARLOW, MARIA, 2020. International journal of pharmaceutics. 119808

Current Research

My research is focused on developing drug delivery systems, in collaboration with clinicians that address an unmet clinical need. My current research projects focus on using injectable hydrogels (including supramolecular hydrogels), nanoparticles and microneedles to deliver small molecules, proteins or peptides for the treatment of cancer (skin, ovarian and brain tumours), HIV and pain. The research involves the physicochemical characterisation of these deliver systems to allow the optimisation/prediction of their in vivo performance.

Future Research

Future research is based upon using hydrogels and microneedles for long acting oligonucleotide and protein/peptide delivery and long acting injectables for globally neglected diseases

  • PHOEBE MCCRORIE, JONATHAN ROWLINSON, DAVID J. SCURR, MARIA MARLOW and RUMAN RAHMAN, 2022. Pharmaceutics. 14(3), 571
  • SURIKUTCHI, BHANU TEJA, OBENZA-OTERO, REBECA, RUSSO, EMANUELE, ZELZER, MISCHA, GOLAN CANCELA, IRENE, A. COSTOYA, JOSE, CRECENTE CAMPO, JOSE, JOSE ALONSO, MARIA and MARLOW, MARIA, 2022. Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration INTERNATIONAL JOURNAL OF PHARMACEUTICS. 622,
  • YANG, BIN, LLEDOS, MARINA, AKHTAR, RIAZ, CICCONE, GIUSEPPE, JIANG, LONG, RUSSO, EMANUELE, RAJPUT, SUNIL, JIN, CHUNYU, ANGELEREOU, MARIA GALINI FAIDRA, ARNOLD, THOMAS, RAWLE, JONATHAN, VASSALLI, MASSIMO, MARLOW, MARIA, ADAMS, DAVE J. and ZELZER, MISCHA, 2021. CHEMICAL SCIENCE. 12(42), 14260-14269
  • ANGELEROU, M.G.F., MARKUS, R., PARASKEVOPOULOU, V., FORALOSSO, R., CLARKE, P., ALVAREZ, C.V., CHENLO, M., JOHNSON, L., RUTLAND, C., ALLEN, S., BRASNETT, C., SEDDON, A., ZELZER, M. and MARIA MARLOW, 2020. Journal of Controlled Release. S0168-3659(19)30568-1
  • SABRI, A. H., CATER, Z., OGILVIE, J., SCURR, D. J., MARLOW, M. and SEGAL, J., 2020. Journal of Drug Delivery Science and Technology. 58,
  • SABRI, A., OGILVIE, J., MCKENNA, J., SEGAL, J., SCURR, D. and MARLOW, M., 2020. Molecular pharmaceutics. 17(8), 2925-2937
  • SABRI, AKMAL H, CATER, ZACHARY, GURNANI, PRATIK, OGILVIE, JANE, SEGAL, JOEL, SCURR, DAVID J and MARLOW, MARIA, 2020. International journal of pharmaceutics. 119808
  • SABRI, AKMAL H., CATER, ZACHARY, OGILVIE, JANE, SCURR, DAVID J., MARLOW, MARIA and SEGAL, JOEL, 2020. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 58,
  • JOHNSON, LITTY, ANGELEROU, MARIA GALINI FAIDRA, SURIKUTCHI, BHANU TEJA, ALLEN, STEPHANIE, ZELZER, MISCHA and MARLOW, MARIA, 2019. MOLECULAR PHARMACEUTICS. 16(1), 462-467
  • HUSSAIN AL-MAYAHY, M., SABRI, A.H., RUTLAND, C.S., HOLMES, A., MCKENNA, J., MARLOW, M. and SCURR, D.J., 2019. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 139, 33-43
  • SABRI AH, OGILVIE J, ABDULHAMID K, SHPADARUK V, MCKENNA J, SEGAL J, SCURR DJ and MARLOW M, 2019. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. (In Press.)
  • 艩TAKA I, CADETE A, SURIKUTCHI BT, ABUZAID H, BRADSHAW TD, ALONSO MJ and MARLOW M, 2019. International journal of pharmaceutics. 565, 151-161
  • PHAN H, MINUT RI, MCCRORIE P, VASEY C, LARDER RR, KRUMINS E, MARLOW M, RAHMAN R, ALEXANDER C and TARESCO V, 2019. Journal of Polymer Science Part A Polymer Chemistry. 57, 1801-1810
  • SABRI, AKMAL H, KIM, YUJIN, MARLOW, MARIA, SCURR, DAVID J, SEGAL, JOEL, BANGA, AJAY K, KAGAN, LEONID and LEE, JONG BONG, 2019. Advanced drug delivery reviews.
  • MCCRORIE, PHOEBE, TARESCO, VINCENZO, XU, ZEYUAN, RITCHIE, ALISON, CLARKE, PHILIP A., MARLOW, MARIA and RAHMAN, RUMAN, 2019. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH-GRADE GLIOMAS NEURO-ONCOLOGY. 21, 275-275
  • MCCRORIE, PHOEBE, TARESCO, VINCENZO, RITCHIE, ALISON, CLARKE, PHILLIP, SCURR, DAVID, MARLOW, MARIA and RAHMAN, RUMAN, 2019. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH GRADE GLIOMAS NEURO-ONCOLOGY. 21, 87-87
  • ANGELEROU, MARIA G. F., FREDERIX, PIM W. J. M., WALLACE, MATTHEW, YANG, BIN, RODGER, ALISON, ADAMS, DAVE J., MARLOW, MARIA and ZELZER, MISCHA, 2019. LANGMUIR. 35(7), 2885-2885
  • YANG, BIN, ADAMS, DAVE J, MARLOW, MARIA and ZELZER, MISCHA, 2018. Surface-Mediated Supramolecular Self-assembly of Protein, Peptide and Nucleoside Derivatives: From Surface Design to Underlying Mechanism and Tailored Functions. Langmuir : the ACS journal of surfaces and colloids.
  • SABRI, A. H., COCKS, E., SHPADARUK, V., MCKENNA, J., SCURR, D. and MARLOW, M., 2018. Enhancement in imiquimod permeation through microneedle skin pretreatment BRITISH JOURNAL OF DERMATOLOGY. 179, 55-55
  • ANGELEROU, MARIA G. F., FREDERIX, PIM W. J. M., WALLACE, MATTHEW, YANG, BIN, RODGER, ALISON, ADAMS, DAVE J., MARLOW, MARIA and ZELZER, MISCHA, 2018. LANGMUIR. 34(23), 6912-6921
  • SKILLING KJ, STOCKS MJ, KELLAM B, ASHFORD M, BRADSHAW TD, BURROUGHS L and MARLOW M, 2018. ChemMedChem. 13(11), 1098-1101
  • CITOSSI F, SMITH T, LEE JB, SEGAL J, GERSHKOVICH P, STOCKS MJ, BRADSHAW TD, KELLAM B and MARLOW M, 2018. Molecular pharmaceutics. 15(4), 1578-1586
  • ANGELEROU, MARIA GALINI FAIDRA, YANG, BIN, ARNOLD, THOMAS, RAWLE, JONATHAN, MARLOW, MARIA and ZELZER, MISCHA, 2018. SOFT MATTER. 14(48), 9851-9855
  • SINJAB F, SICILIA G, SHIPP DW, MARLOW M and NOTINGHER I, 2017. Applied spectroscopy. 3702817715042 (In Press.)
  • YA艦AYAN G, XUE X, COLLIER P, CLARKE P, ALEXANDER MR and MARLOW M, 2016. Nanotechnology. 27(25), 255102
  • ANGELEROU MG, SABRI A, CREASEY R, ANGELEROU P, MARLOW M and ZELZER M, 2016. Chemical communications (Cambridge, England). 52(23), 4298-300
  • 2016. Molecular pharmaceutics. (In Press.)
  • SKILLING KJ, KELLAM B, ASHFORD M, BRADSHAW TD and MARLOW M, 2016. Soft matter. 12(43), 8950-8957
  • MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. CHEMICAL COMMUNICATIONS. 51(29), 6384-6387
  • P. BENITO-GALLO, P. GERSHKOVICH, M. MARLOW, V. ZANN and K.M. WASAN, 2015. Smart Lipid-Based Drug Delivery Systems. In: V.P. TORCHILIN, ed., Smart Pharmaceutical Nanocarriers Imperial College Press. (In Press.)
  • BENITO-GALLO, PALOMA, FRANCESCHETTO, ALESSANDRO, WONG, JONATHAN C. M., MARLOW, MARIA, ZANN, VANESSA, SCHOLES, PETER and GERSHKOVICH, PAVEL, 2015. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 93, 353-362
  • STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F.G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Bioorganic & Medicinal Chemistry. 23, 6891-6899
  • SKILLING, K. J., NDUNGU, A., KELLAM, B., ASHFORD, M., BRADSHAW, T. D. and MARLOW, M., 2014. JOURNAL OF MATERIALS CHEMISTRY B. 2(47), 8412-8417
  • K. J. SKILLING, F. CITOSSI, T. D. BRADSHAW, M. ASHFORD, B. KELLAM and M. MARLOW, 2013. SOFT MATTER. 10(2), 237-256
  • MAHBOUBIAN, A, STOLNIK, S, ARSHAD, S., MARLOW, ME and SIMTH, G, 2012. In: Drug Delivery: Through the ages. United Kingdom & Ireland Controlled Release Society: Birmingham, UK. p. 53.: Evaluating in-situ Gelation using Terahertz and Dielectric Spectroscopy,
  • GOVIND, NAYNA and MARLOW, MARIA, 2010. US 7,759,328 07/20/2010 00:00:00
  • DAVIES, M.J., BRINDLEY, A., CHEN, X., DOUGHTY, S.W., MARLOW, M. and ROBERTS, C.J., 2009. Colloids and Surfaces. B, Biointerfaces. 73(1), 97-102
  • DAVIES, O.R., HEAD, L., ARMITAGE, D., PEARSON, E.A., DAVIES, M.C., MARLOW, M. and STOLNIK, S., 2008. Langmuir. 24, 7138-7146
  • DAVIES, OR, MARLOW, M and STOLNIK, S, 2008. Soft Matter. 4(8), 1597-1601
  • DAVIES, OWEN R., HEAD, LAURA, ARMITAGE, DAVID, PEARSON, ELIZABETH A., DAVIES, MARTIN C., MARLOW, MARIA and STOLNIK, SNJEZANA, 2008. LANGMUIR. 24(14), 7138-7146
  • DAVIES, M., BRINDLEY, A., CHEN, X., MARLOW, M., DOUGHTY, S.W., SHRUBB, I. and ROBERTS, C.J., 2005. Pharmaceutical Research. 22(7), 1158-1166
  • DAVIES, M, BRINDLEY, A, CHEN, XY, MARLOW, M, DOUGHTY, SW, SHRUBB, I and ROBERTS, CJ, 2005. Pharmaceutical Research. 22(7), 1158-1166
  • PATEL, N, MARLOW, M and LAWRENCE, MJ, 2003. Journal Of Colloid And Interface Science. 258(2), 345-353
  • PATEL, N, MARLOW, M and LAWRENCE, MJ, 2003. Journal Of Colloid And Interface Science. 258(2), 354-362
  • DAVIES, O. R., ARMITAGE, D., WILLIAMS, P., BRINDLEY, A., MARLOW, M. and STOLNIK, S., 2003. Characterisation of polycation modified microspheres for DNA vaccination. Journal of Pharmacy and Pharmacology. 55(Supplement), S.47
  • HARPER, GR, DAVIS, SS, DAVIES, MC, NORMAN, ME, TADROS, TF, TAYLOR, DC, IRVING, MP, WATERS, JA and WATTS, JF, 1995. Biomaterials. 16(6), 427-439
  • NORMAN ME, ELGENDY HM, SHORS EC, EL-AMIN SF and LAURENCIN CT, 1994. An In-Vitro Evaluation Of Coralline Porous Hydroxyapatite As A Scaffold For Osteoblast Growth. Clinical Materials. 17(2), 85-91
  • NORMAN, ME, WILLIAMS, P and ILLUM, L, 1993. Journal Of Biomedical Materials Research. 27(7), 861-866
  • LAURENCIN, CT, NORMAN, ME, ELGENDY, HM, ELAMIN, SF, ALLCOCK, HR, PUCHER, SR and AMBROSIO, AA, 1993. Journal Of Biomedical Materials Research. 27(7), 963-973
  • DAVIS, SS, ILLUM, L, MOGHIMI, SM, DAVIES, MC, PORTER, CJH, MUIR, IS, BRINDLEY, A, CHRISTY, NM, NORMAN, ME, WILLIAMS, P and DUNN, SE, 1993. Microspheres For Targeting Drugs To Specific Body Sites
  • ELGENDY, HM, NORMAN, ME, KEATON, AR and LAURENCIN, CT, 1993. Biomaterials. 14(4), 263-269
  • NORMAN, ME, WILLIAMS, P and ILLUM, L, 1993. Biomaterials. 14(3), 193-202
  • NORMAN, ME, WILLIAMS, P and ILLUM, L, 1992. Biomaterials. 13(12), 841-849
  • MARLOW, M, WOLLACOTT, J, FISK, J, BERRY, A and COOPER, A, Liposomes: a tool for extended release of drugs in preclinical development In: 1284-1284
  • O'NEILL, AE, STOLNIK, S, HALL, IP and MARLOW, M, Drug targeting for pulmonary delivery In: S20-S20
  • BOUGHELLAM, I, GARNETT, MC, MARLOW, M, MACIEWICZ, R, MITCHELL, J and STOLNIK, S, Biopolymer complexes for in situ formation of delivery systems In: S23-S23
  • LAURENCIN, C, ELGENDY, H, KEATON, R and NORMAN, ME, BONE BIOERODIBLE POLYMER COMPOSITES - THE DEVELOPMENT OF AN INVITRO MODEL In: 18-PMSE
  • PHAN, HIEN, MINUT, I, ROBERT, MCCRORIE, PHOEBE, VASEY, CATHERINE, LARDER, RYAN R., KRUMINS, EDUARDS, MARLOW, MARIA, RAHMAN, RUMAN, ALEXANDER, CAMERON, TARESCO, VINCENZO and PEARCE, AMANDA K., JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY.

School of Pharmacy

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