糖心原创

School of Pharmacy

Staff listing for the Biomolecular Science and Medicinal Chemistry Division 

Image of Michael Stocks

Michael Stocks

Professor of Medicinal Chemistry and Drug Discovery, Faculty of Science

Contact

Biography

I am a synthetic medicinal chemist with a PhD in organic chemistry under the supervision of Professor Philip Kocienski (University of Southampton 1991). I have over 20 years' experience in Medicinal Chemistry in the pharmaceutical industry through my career at Fisons, Astra and then AstraZeneca. I have worked in most areas of medicinal chemistry concentrating recent efforts on GPCR-based drug discovery projects most recently delivering AstraZeneca's beta-2 and muscarinic M3 inhalation projects into clinical development. I was appointed as project leader for designing and delivering chemical libraries (both targeted and diversity based) to enhance the AstraZeneca compound collection, a program that lasted for 4 years. During this time I worked with contract research organisations in China, Russia and India and recruited 2 industrial post-doctoral fellows to discover both new multi-component reactions delivering drug-like molecules as well as exploring the synthesis of new 3-dimesional scaffolds for use in medicinal chemistry. I have been co-author and inventor on over 50 publications and patent applications and recently co-authored a new "primer" book in medicinal chemistry: Stocks, Alcaraz and Griffen: On medicinal Chemistry.

In April 2012, I made the transition into academia and was appointed as Associate Professor in Medicinal Chemistry in the Division of Medicinal Chemistry and Structural Biology.

Research Summary

My research interests are focused on early stage drug discovery designing and synthesising new chemical scaffolds to interact with biological targets generating both high-quality tool compounds and… read more

Selected Publications

  • GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. European Journal of Medicinal Chemistry. 208, 112778
  • SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. ACS Omega.
  • SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Frontiers in Chemistry. 8, 204

Current Research

My research interests are focused on early stage drug discovery designing and synthesising new chemical scaffolds to interact with biological targets generating both high-quality tool compounds and lead-like compounds to probe biological targets and provide the starting points for successful drug discovery programs.

  • Utilising synthetic and physical chemistry to address and overcome drug discovery issues such as; hit and lead optimisation, absorption, metabolism and compound selectivity.
  • Conformational analysis and structure-based drug design.
  • Fragment based drug design - designing and optimising high-quality fragments and libraries.
  • Combining synergistic pharmacology's within a single small molecule.

Expertise areas:

Drug Discovery, Design, Medicinal Chemistry, Lead Optimisation & Identification, Multi-parameter Optimization, Inhalation and Oral delivery, Fragment & Structure Based Drug Design, ADME , Synthetic Chemistry.

  • GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. European Journal of Medicinal Chemistry. 208, 112778
  • SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. ACS Omega.
  • SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Frontiers in Chemistry. 8, 204
  • ADLERE, ILZE, CASPAR, BIRGIT, ARIMONT, MARTA, DEKKERS, SEBASTIAN, VISSER, KIRSTEN, STUIJT, JEFFREY, DE GRAAF, CHRIS, STOCKS, MICHAEL, KELLAM, BARRIE, BRIDDON, STEPHEN, WIJTMANS, MAIKEL, DE ESCH, IWAN, HILL, STEPHEN and LEURS, ROB, 2019. Molecular Pharmacology. mol.119.117663
  • BOSQUILLON, C, PANDUGA, V and STOCKS, M J, 2019. Understanding the mechanisms controlling inhaled drug retention in the lungs using human bronchial epithelial cell layers In: BRITISH JOURNAL OF PHARMACOLOGY. 3009
  • FENN, SAMUEL, DUBERN, JEAN-FREDERIC, STOCKS, MICHAEL, ELMSLEY, JONAS and CAMARA, MIGUEL, 2019. Identification of a nitrite reductase in Pseudomonas aeruginosa as a potential antimicrobial target Access Microbiology. 1(1A), 635
  • SOUKARIEH, F., OTON, E.V., DUBERN, J.-F., GOMES, J., HALLIDAY, N., DE PILAR CRESPO, M., RAM脥REZ-PRADA, J., INSUASTY, B., ABONIA, R., QUIROGA, J., HEEB, S., WILLIAMS, P., STOCKS, M.J. and C脕MARA, M., 2018. Molecules. 23,
  • CITOSSI, FRANCESCA, SMITH, THOMAS, LEE, JONG BONG, SEGAL, JOEL, GERSHKOVICH, PAVEL, STOCKS, MICHAEL JOHN, BRADSHAW, TRACEY D, KELLAM, BARRIE and MARLOW, MARIA, 2018. Molecular Pharmaceutics. acs.molpharmaceut.7b01106
  • SKILLING, KATHRYN J., STOCKS, MICHAEL J., KELLAM, BARRIE, ASHFORD, MARIANNE, BRADSHAW, TRACEY, BURROUGHS, LAURENCE and MARLOW, MARIA, 2018. ChemMedChem.
  • CONROY, SEAN, KINDON, NICHOLAS D., GLENN, JACQUELINE, STODDART, LEIGH A., LEWIS, RICHARD JAMES, HILL, STEPHEN J., KELLAM, BARRIE and STOCKS, MICHAEL JOHN, 2018. Journal of Medicinal Chemistry. 61(7), 3089-3113
  • SOU, TOMAS, KUKAVICA-IBRULJ, IRENA, SOUKARIEH, FADI, HALLIDAY, NIGEL, LEVESQUE, ROGER C, WILLIAMS, PAUL, STOCKS, MICHAEL, CAMARA, MIGUEL, FRIBERG, LENA E and BERGSTROM, CHRISTEL A S, 2018. Journal of pharmaceutical sciences.
  • SOUKARIEH, FADI, WILLIAMS, PAUL, STOCKS, MICHAEL JOHN and CAMARA, MIGUEL., 2018. Journal of Medicinal Chemistry. Ahead of Print
  • LEE, JONG BONG, ZGAIR, ATHEER, MALEC, JED, KIM, TAE HWAN, KIM, MIN GI, ALI, JOSEPH, QIN, CHAOLONG, FENG, WANSHAN, CHIANG, MANTING, GAO, XIZHE, VORONIN, GREGORY, GARCES, AIMIE E, LAU, CHUN LONG, CHAN, TING-HOI, HUME, AMY, MCINTOSH, TECASHANELL M, SOUKARIEH, FADI, AL-HAYALI, MOHAMMED, CIPOLLA, ELENA, COLLINS, HILARY M, HEERY, DAVID M, SHIN, BEOM SOO, YOO, SUN DONG, KAGAN, LEONID, STOCKS, MICHAEL J, BRADSHAW, TRACEY D, FISCHER, PETER M and GERSHKOVICH, PAVEL., 2018. Journal of Controlled Release. 286, 10-19
  • GARCES, AIMIE E and STOCKS, MICHAEL J, 2018. Journal of Medicinal Chemistry. Ahead of Print
  • SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LI, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Journal of Medicinal Chemistry. acs.jmedchem.6b01801
  • PANDUGA V, STOCKS MJ and BOSQUILLON C, 2017. International journal of pharmaceutics. (In Press.)
  • KINDON, NICHOLAS, ANDREWS, GLEN, BAXTER, ANDREW, CHESHIRE, DAVID, HEMSLEY, PAUL, JOHNSON, TIMOTHY, LIU, YU-ZHEN, MCGINNITY, DERMOT, MCHALE, MARK, METE, ANTONIO, REUBERSON, JAMES, ROBERTS, BRYAN, STEELE, JOHN, TEOBALD, BARRY, UNITT, JOHN, VAUGHAN, DEBORAH, WALTERS, IAIN and STOCKS, MICHAEL J., 2017. ACS Medicinal Chemistry Letters. acsmedchemlett.7b00315
  • KINDON N, DAVIS A, DOUGALL I, DIXON J, JOHNSON T, WALTERS I, THOM S, MCKECHNIE K, MEGHANI P and STOCKS MJ, 2017. Bioorganic & medicinal chemistry letters. 27(21), 4849-4853
  • MICHAEL J. STOCKS, SEAN CONROY and BARRIE KELLAM, 2016. Journal of Medicinal Chemistry.
  • MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. CHEMICAL COMMUNICATIONS. 51(29), 6384-6387
  • SCHWEHM, CAROLIN, LI, JIN, SONG, HONGMEI, HU, XIAO, KELLAM, BARRIE and STOCKS, MICHAEL J., 2015. ACS Medicinal Chemistry Letters. 6, 324-328
  • STOCKS, MICHAEL, 2015. ChemMedChem. 10, 926-928
  • STONE, ERICA L., CITOSSI, FRANCESCA, SINGH, RAJINDER, KAUR, BALVINDER, GASKELL, MARGARET, FARMER, PETER B., MONKS, ANNE, HOSE, CURTIS, STEVENS, MALCOLM F.G., LEONG, CHEE-ONN, STOCKS, MICHAEL, KELLAM, BARRIE, MARLOW, MARIA and BRADSHAW, TRACEY D., 2015. Bioorganic & Medicinal Chemistry. 23, 6891-6899
  • MARLOW, MARIA, AL-AMEEDEE, MOHAMMED, SMITH, THOMAS, WHEELER, SIMON and STOCKS, MICHAEL J., 2015. Chem. Commun.. 51, 6384-6387
  • MICHAEL J STOCKS, LILIAN ALCARAZ, ANDREW BAILEY, ROGER BONNERT, ELAINE CADOGAN, JADEEN CHRISTIE, JOHN DIXON, STEPHEN CONNOLLY, ANTHONY COOK, STUART PAINE, 2014. ACS Med Chem Lett.
  • BRIOCHE, JULIEN, COURANT, THIBAUT, ALCARAZ, LILIAN, STOCKS, MICHAEL, FURBER, MARK, ZHU, JIEPING and MASSON, G脡RALDINE, 2014. Advanced Synthesis & Catalysis. 356, 1719-1724
  • SCHWEHM, CAROLIN, LEWIS, WILLIAM, BLAKE, ALEXANDER J., KELLAM, BARRIE and STOCKS, MICHAEL J., 2014. Acta Crystallographica Section C Structural Chemistry. 70, 1161-1168
  • STOCKS, MICHAEL J, ALCARAZ, LILIAN, BAILEY, ANDREW, BONNERT, ROGER, CADOGAN, ELAINE, CHRISTIE, JADEEN, DIXON, JOHN, CONNOLLY, STEPHEN, COOK, ANTHONY, FISHER, ADRIAN, FLAHERTY, ALICE, HUMPHRIES, ALEXANDER, INGALL, ANTHONY, JORDAN, STEPHEN, LAWSON, MANDY, MULLEN, ALEX, NICHOLLS, DAVID, PAINE, STUART, PAIRAUDEAU, GARRY and YOUNG, ALAN, 2014. ACS Med. Chem. Lett.. 5, 416-421
  • ALCARAZ, L., BAILEY, A., CADOGAN, E., CONNOLLY, S., JEWELL, R., JORDAN, S., KINDON, N., LISTER, A., LAWSON, M., MULLEN, A., DAINTY, I., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J., THORNE, P. and YOUNG, A., 2012. Bioorganic & Medicinal Chemistry Letters. 22(1), 689-95
  • SU Y, BOUMA MJ, ALCARAZ L, STOCKS M, FURBER M, MASSON G and ZHU J, 2012. Chemistry (weinheim an der bergstrasse, germany). 18(40), 12624-7
  • CONNOLLY, S., ALCARAZ, L., BAILEY, A., CADOGAN, E., CHRISTIE, J., COOK, A.R., FISHER, A.J., HILL, S., HUMPHRIES, A., INGALL, A.H., KANE, Z., PAINE, S., PAIRAUDEAU, G., STOCKS, M.J. and YOUNG, A., 2011. Bioorganic & Medicinal Chemistry Letters. 21(15), 4612-4616
  • STOCKS, M.J., ALCARAZ, L., BAILEY, A., BONNERT, R., CADOGAN, E., CHRISTIE, J., CONNOLLY, S., COOK, A., FISHER, A., FLAHERTY, A., HILL, S., HUMPHRIES, A., INGALL, A., JORDAN, S., LAWSON, M., MULLEN, A., NICHOLLS, D., PAINE, S., PAIRAUDEAU, G., ST-GALLAY, S. and YOUNG, A., 2011. Bioorganic & Medicinal Chemistry Letters. 21(13), 4027-4031
  • EDMAN, K, FURBER, M, HEMSLEY, P, JOHANSSON, C, PAIRAUDEAU, G, PETERSEN, J, STOCKS, M, TERVO, A, WARD, A, WELLS, E and WISSLER, L, 2011. Chemmedchem. 6(5), 769-773
  • ROBERTS, B, LIPTROT, D, LUKER, T, STOCKS, MJ, BARBER, C, WEBB, N, DODS, R and MARTIN, B, 2011. Tetrahedron Letters. 52(29), 3793-3796
  • ROBERTS, BRYAN, LIPTROT, DAVID, LUKER, TIM, STOCKS, MICHAEL J, BARBER, CATHERINE, WEBB, NICOLA, DODS, ROBERT and MARTIN, BARRIE, 2011. ChemInform. 42, no-no
  • ROBERTS B, LIPTROT D, ALCARAZ L, LUKER T and STOCKS MJ, 2010. Organic letters. 12(19), 4280-3
  • STOCKS, MJ, ALCARAZ, L, BAILEY, A, BOWERS, K, DONALD, D, EDWARDS, H, HUNT, F, KINDON, N, PAIRAUDEAU, G, THEAKER, J and WARNER, DJ, 2010. Bioorganic & Medicinal Chemistry Letters. 20(24), 7458-7461
  • JOHNSON, TIM, CHESHIRE, DAVID R, STOCKS, MICHAEL J and THURSTON, VICKY T, 2010. ChemInform. 32, no-no
  • STOCKS MJ, WILDEN GRH, PAIRAUDEAU G, PERRY MWD, STEELE J and STONEHOUSE JP, 2009. Chemmedchem. 4(5), 800-8
  • SMITH, NM, GREAVES, MJ, JEWELL, R, PERRY, MWD, STOCKS, MJ and STONEHOUSE, JP, 2009. Synlett. 1391-1394
  • GUILE, SD, ALCARAZ, L, BIRKINSHAW, TN, BOWERS, KC, EBDEN, MR, FURBER, M and STOCKS, MJ, 2009. Journal of Medicinal Chemistry. 52, 3123-3141
  • STONEHOUSE, JP, CHEKMAREV, DS, IVANOVA, NV, LANG, S, PAIRAUDEAU, G, SMITH, N, STOCKS, MJ, SVIRIDOV, SI and UTKINA, LM, 2008. Synlett. 100-104
  • HAMZA, D, STOCKS, MJ, DECOR, A, PAIRAUDEAU, G and STONEHOUSE, JP, 2007. Synlett. 2584-2586
  • STOCKS, MJ, HAMZA, D, PAIRAUDEAU, G, STONEHOUSE, JP and THORNE, PV, 2007. Synlett. 2587-2589
  • BOURQUE, E, KOCIENSKI, PJ, STOCKS, M and YUEN, J, 2005. Synthesis-Stuttgart. 3219-3224
  • STOCKS, MJ, BARBER, S, FORD, R, LEROUX, F, ST-GALLAY, S, TEAGUE, S and XUE, YF, 2005. Bioorganic & Medicinal Chemistry Letters. 15(14), 3459-3462
  • STOCKS, MJ, CHESHIRE, DR and REYNOLDS, R, 2004. Organic Letters. 6(17), 2969-2971
  • JOHNSON, TIM, CHESHIRE, DAVID R, STOCKS, MICHAEL J and THURSTON, VICKY T, 2001. Synlett. 0646-0648
  • JAROWICKI, K, KOCIENSKI, P, NORRIS, S, OSHEA, M and STOCKS, M, 1995. Synthesis of the c16-c23 effector domain of fk-506 via copper-catalyzed metalate rearrangement of an alpha-alkoxyalkenylcuprate Synthesis-Stuttgart. 195-198
  • TEAGUE, SJ, COOPER, ME and STOCKS, MJ, 1995. Bioorganic & Medicinal Chemistry Letters. 5(20), 2341-2346
  • STOCKS, MJ, HARRISON, RP and TEAGUE, SJ, 1995. Tetrahedron Letters. 36(36), 6555-6558
  • JAROWICKI, KRZYSZTOF, KOCIENSKI, PHILIP, NORRIS, SIMON, O鈥橲HEA, MICHAEL and STOCKS, MICHAEL, 1995. Synthesis. 1995, 195-198
  • STOCKS, MJ, BIRKINSHAW, TN and TEAGUE, SJ, 1994. Bioorganic & Medicinal Chemistry Letters. 4(12), 1457-1460
  • CAFFREY, MV, CLADINGBOEL, DE, COOPER, ME, DONALD, DK, FURBER, M, HARDERN, DN, HARRISON, RP, STOCKS, MJ and TEAGUE, SJ, 1994. Bioorganic & Medicinal Chemistry Letters. 4(21), 2507-2510
  • TEAGUE, SJ and STOCKS, MJ, 1993. Bioorganic & Medicinal Chemistry Letters. 3(10), 1947-1950
  • BARTHOLOMEW, D and STOCKS, MJ, 1991. Tetrahedron Letters. 32(36), 4799-4800
  • BARTHOLOMEW, D and STOCKS, MJ, 1991. Tetrahedron Letters. 32(36), 4795-4798
  • KOCIENSKI, P, STOCKS, M, DONALD, D and PERRY, M, 1990. A synthesis of the c24-c34 segment of fk-506
  • STOCKS, M, KOCIENSKI, P and DONALD, DK, 1990. Tetrahedron Letters. 31(11), 1637-1640
  • KOCIE艃SKI, PHILIP, STOCKS, MICHAEL, DONALD, DAVID and PERRY, MATHEW, 1990. Synlett. 1990, 38-39
  • KOCIENSKI, PHILIP, STOCKS, MICHAEL and DONALD, DAVID K, 1990.
  • KOCIENSKI, P, STOCKS, M, DONALD, D, COOPER, M and MANNERS, A, 1988. Tetrahedron Letters. 29(35), 4481-4484

School of Pharmacy

糖心原创
University Park
Nottingham, NG7 2RD

For all enquiries please visit: