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School of Pharmacy

Staff listing for the Biomolecular Science and Medicinal Chemistry Division 

Lodewijk Dekker

Associate Professor, Faculty of Science

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Biography

I was educated at Utrecht University, the Netherlands, where I completed my PhD in Molecular Neurobiology in 1989 in the Institute for Molecular Biology and the Rudolf Magnus Institute of Pharmacology in Utrecht. During this period I investigated the role of protein phosphorylation in synaptic function. I then undertook postdoctoral research at the Novartis Institute for Medical Research, the Imperial Cancer Research Fund and University College in London. My research was in the area of cell signaling and focused largely on the Protein Kinase C pathway. In 2001 I joined Ionix Pharmaceuticals Ltd in Cambridge as Head of Molecular Biology and then became Head of Molecular Pharmacology and Associate Director of Pharmacology. In this capacity I was project leader of an early stage drug discovery project targeting voltage gated sodium channels to develop novel analgesics. In 2005 I joined the School of Pharmacy in Nottingham as Senior Lecturer in the Division of Medicinal Chemistry and Structural Biology. My research has yielded scientific publications which to date have been cited in excess of 4000 times (h-index: 34 (ISI)).

Research Summary

Our group operates in the field of molecular medicine and we use cell biology, biochemistry, molecular pharmacology and chemistry to understand and explore novel as yet unexplored drug targets.… read more

Selected Publications

  • ABD EL-ALEEM SA and DEKKER LV, 2018. Journal of Molecular Histology. 49(5), 531-543
  • KAREEM HAMED B, PATHAK M, MANNA R, FISCHER PM, EMSLEY J and DEKKER LV, 2017. Journal of Thrombosis and Haemostasis. 15(9), 1818-1828
  • DISNEY AJ, KELLAM B and DEKKER LV, 2016. ChemMedChem. 11(9), 972-9
  • LIU Y, MYRVANG HK and DEKKER LV, 2015. British journal of pharmacology. 172(7), 1664-1676

Current Research

Our group operates in the field of molecular medicine and we use cell biology, biochemistry, molecular pharmacology and chemistry to understand and explore novel as yet unexplored drug targets. Specific interests centre on the exploration of protein-protein and protein-DNA interactions relevant to cancer.

Our current research projects include

Chemical biology approaches to understand the function of S100 protein interactions.

S100 proteins are small adaptor proteins that have been implicated in many cellular processes. They do so by interacting with key partners such as for instance the annexins. Read about this in our recent review (). We aim to explore the function of these protein interactions using a combination of biochemical, chemical biological and cell biological approaches.

Protein Kinase C-delta protein interactions

Protein Kinase C-delta has been implicated in breast cancer metastasis. The activity of PKC-d is regulated by cofactors such as diacylglycerol. In addition, protein interactions contribute to the regulation of PKC-d. We aim to explore how protein interactions regulate PKC-d in breast cancer cells with a view to understand its role in metastasis.

Coagulation proteases

Coagulation proteases are important in haemostasis but have recently also been proposed as drug targets in various diseases. In collaboration with Profs Emsley and Fischer we try to understand the enzyme activity of co-agulation proteases. By investigating the precise molecular interactions between Factor XII and its natural product inhibitor CTI we are gaining insight into the structure of the catalytic site of this enzyme that may help in developing new specific inhibitors ().

Novel kinase probes

We are interested in developing novel probes to measure kinase activity and kinase expression for screening and diagnostic applications (with Prof Barrie Kellam).

Our research is or has been supported by grants from Cancer Research UK, the Breast Cancer Campaign, the Association for International Cancer Research, Pancreatic Cancer UK, British Heart Foundation and the Biotechnology and Biological Sciences Research Council. We publish in reputable journals such as Journal of Medicinal Chemistry and British Journal of Pharmacology. We are always looking for new members of our group to experience the excitement of research and make discoveries. Places for students are available on all the above projects. Please get in touch to discuss if you are interested in joining. For international students there are scholarship schemes to receive support, please follow for up to date information.

  • PATHAK M, MANNA R, LI C, KAIRA BG, HAMAD BK, BELVISO BD, BONTURI CR, DREVENY I, FISCHER PM, DEKKER LV, OLIVA MLV and EMSLEY J, 2019. Acta crystallographica. Section D, Structural biology. 75(Pt 6), 578-591
  • ABD EL-ALEEM SA and DEKKER LV, 2018. Journal of Molecular Histology. 49(5), 531-543
  • AHMED M, CHAUDHARI K, BABAEI-JADIDI R, DEKKER LV and NATERI AS, 2017. Stem cells (Dayton, Ohio). 35(4), 839-850
  • KAREEM HAMED B, PATHAK M, MANNA R, FISCHER PM, EMSLEY J and DEKKER LV, 2017. Journal of Thrombosis and Haemostasis. 15(9), 1818-1828
  • DISNEY AJ, KELLAM B and DEKKER LV, 2016. ChemMedChem. 11(9), 972-9
  • WOODHAM AW, SANNA AM, TAYLOR JR, SKEATE JG, DA SILVA DM, DEKKER LV and KAST WM, 2016. Virology journal. 13(1), 187
  • LIU Y, MYRVANG HK and DEKKER LV, 2015. British journal of pharmacology. 172(7), 1664-1676
  • PATHAK M, WILMANN P, AWFORD J, LI C, HAMAD BK, FISCHER PM, DREVENY I, DEKKER LV and EMSLEY J, 2015. Journal of Thrombosis and Haemostasis. 13(4), 580-591
  • REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2014. Bioorganic and Medicinal Chemistry. 22(19), 5378-5391
  • MYRVANG, H.K., GUO, X., LI, C. and DEKKER, L.V., 2013. FEBS Letters. 587(19), 3210-3215
  • ECCLES ET AL, 2013. Breast Cancer research. 15(5), R92
  • REDDY, T.R.K., LI, C., FISCHER, P.M. and DEKKER, L.V., 2012. ChemMedChem. 7(8), 1435-1446
  • MOHAMMED, M.Z., VYJAYANTI, V.N., LAUGHTON, C.A., DEKKER, L.V., FISCHER, P.M., WILSON, D.M., ABBOTTS, R., SHAH, S., PATEL, P.M., HICKSON, I.D. and MADHUSUDAN, S., 2011. British Journal of Cancer. 104(4), 653-663
  • REDDY, T.R.K., LI, C., GUO, X., MYRVANG, H.K., FISCHER, P.M. and DEKKER, L.V., 2011. Journal of Medicinal Chemistry. 54(7), 2080-2094
  • REDDY, T.R.K., LI, C., FISCHER, P.M. and DEKKER, L.V., 2011. Preparation of pyrrole derivatives as S100 protein binding interaction inhibitors for treatment of cancer and other diseases WO2011092505 A1 WO2011-GB50137 GB2010-1596 WO 2011092505 08/04/2011 00:00:00
  • LI, C., REDDY, T.R.K., FISCHER, P.M. and DEKKER, L.V., 2010. ASSAY and Drug Development Technologies. 8(1), 85-95
  • SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2010. International Journal of Biochemistry and Cell Biology. 42(10), 1736-1743
  • REDDY, T.R.K., LI, C., GUO, X., FISCHER, P.M. and DEKKER, L.V., 2010. Structure-based design, synthesis, and SAR exploration of pyrrole-2-one analogues as inhibitors of the annexin A2-S100A10 protein interaction: potential anti-angiogenesis therapeutics. Journal of Pharmacy and Pharmacology. 62(10), 1373-1374
  • PACLET, M.H., DAVIDSON-MONCADA, J., LOPEZ-LLUCH, G., SHAO, D. and DEKKER, L.V., 2009. Protein Kinase C as an effector of lipid-derived second messengers. In: LARIJANI, B., WOSCHOLSKI, R. and ROSSER, C.A., eds., Lipid signalling protocols 462. Humana Press Inc, Totowa, USA. 253-263
  • DEKKER, L.V., 2008. Novel approaches to drug discovery in signal transduction The Biotechnology Journal. 3(4), 428-429
  • DEKKER, LODEWIJK V, DANIELS, ZOE, HICK, CAROLINE, ELSEGOOD, KATHRYN, BOWDEN, SARAH, SZESTAK, TADGE, BURLEY, J RUSSELL, SOUTHAN, ANDY, CRONK, DAVID and JAMES, IAIN F, 2005. European Journal of Pharmacology. 528(1-3), 52-8
  • BROWN, SEAN G, THOMAS, ALISON, DEKKER, LODEWIJK V, TINKER, ANDREW and LEANEY, JOANNE L, 2005. American Journal of Physiology: Cell Physiology. 289(3), C543-56
  • RENAULT, MARIE-ANGE, JALVY, SANDRA, POTIER, MYL脙篓NE, BELLOC, ISABELLE, GENOT, ELISABETH, DEKKER, LODEWIJK V, DESGRANGES, CLAUDE and GADEAU, ALAIN-PIERRE, 2005. Journal of Biological Chemistry. 280(4), 2708-13
  • DEKKER,L.V. and CRONK,D., 2005. Nav1.8 as a drug target for pain. In: COWARD,K. and BAKER,M.D., eds., Sodium channels, pain and analgesia Birkh脙陇user Publishing Ltd, Basel, CHE. 123-144
  • PACLET, M.-H., DAVIS, C., KOTSONIS, P., GODOVAC-ZIMMERMANN, J., SEGAL, A.W. and DEKKER, L.V., 2004. Biochemical Journal. 377(2), 469-477
  • BIRCH, PHILLIP J, DEKKER, LODEWIJK V, JAMES, IAIN F, SOUTHAN, ANDREW and CRONK, DAVID, 2004. Drug Discovery Today. 9(9), 410-8
  • DEKKER,L.V., 2004. Introduction. In: Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA. 1-7
  • DEKKER, L.V., ed., 2004. Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA.
  • DEKKER,L.V., 2004. Protein Kinase C isotype function in neutrophils. In: Protein Kinase C 2nd. Kluwer Academic/Plenum Publishers, New York, USA. 165-190
  • SHAO, D., SEGAL, A.W. and DEKKER, L.V., 2003. FEBS Letters. 550(1-3), 101-106
  • DAVIDSON-MONCADA, J.K., LOPEZ-LLUCH, G., SEGAL, A.W. and DEKKER, L.V., 2002. Biochemical Journal. 363(1), 95-103
  • L脫PEZ-LLUCH, G., BIRD, M.M., CANAS, B., GODOVAC-ZIMMERMAN, J., RIDLEY, A., SEGAL, A.W. and DEKKER, L.V., 2001. Biochemical Journal. 357(1), 39-47
  • SCHURINGA, J J, DEKKER, L V, VELLENGA, E and KRUIJER, W, 2001. Journal of Biological Chemistry. 276(29), 27709-15
  • LEANEY, J L, DEKKER, L V and TINKER, A, 2001. Journal of Physiology. 534(Pt. 2), 367-79
  • DEKKER, L. V. and SEGAL, A. W., 2000. Science. ISSU 5455, 982-984

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