糖心原创

Contact

• workBoots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• Sonia.Pedro@nottingham.ac.uk

Biography

I attained a Bachelor's and Master's degree in Biochemistry from the University of Aveiro, in Portugal by 2016. I then joined the CICECO - Aveiro Institute of Materials to conduct research (in a fellowship) and pursue my PhD focused on enhancing the pharmaceuticals' performance and delivery, until 2023. The research was centered around the topic "Deep eutectic solvent formulations for the development of drug delivery systems" and shown to improve the therapeutic action of antimicrobial agents by designing novel formulations. During this time, I participated in a project aimed at understanding how these formulations impact drug solubility at the ISIS Neutron and Muon Source, Rutherford Appleton Laboratory in Oxford. In 2023, I undertook a short-term postdoctoral internship to design novel material-based systems. I joined the 糖心原创 in 2024 as a Research Fellow in the School of Pharmacy to conduct research on preserved human corneal tissue and on the development of delivery systems.

Expertise Summary

Extraction and purification of biomolecules using aqueous biphasic systems; Improvement of solubility, stability and therapeutic action of active pharmaceutical ingredients; Preparation and characterization of material-based systems; Antimicrobial testing and antibiotic efficacy; Preparation, sample analysis and manipulation of different biological matrices; High performance chromatography (pharmaceuticals' quantification and troubleshooting (C18 reverse phase columns)).

Research Summary

My research is focused on the study of dry-preserved human tissue for transplantation and on the development of new and more effective strategies for therapeutic agents, which may ultimately stand… read more

Recent Publications

• SONIA. N. PEDRO, BRUNO F. VALENTE, CARLA VILELA, HELENA OLIVEIRA, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2023. Materials Today Bio. 22, 100733
• SONIA. N. PEDRO, ANA T. P. C. GOMES, CARLA VILELA, CARLA VITORINO, ROSA FERNANDES, ADELAIDE ALMEIDA, HELENA M. AMARAL, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2023. Advanced Therapeutics. 2200235
• MARIELA M. NOLASCO, SONIA. N. PEDRO, CARLA VILELA, PEDRO D. VAZ, PAULO RIBEIRO-CLARO, SVEMIR RUDI膯, STEWART F. PARKER, CARMEN S. R. FREIRE, MARA G. FREIRE and ARMANDO J. D. SILVESTRE, 2022. Frontiers in Physics. 10, 834571
• SONIA. N. PEDRO, ANA T. P. C. GOMES, PARASTU OSKOEI, HELENA OLIVEIRA, ADELAIDE ALMEIDA, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2022. International Journal of Pharmaceutics. 616, 121566

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Current Research

My research is focused on the study of dry-preserved human tissue for transplantation and on the development of new and more effective strategies for therapeutic agents, which may ultimately stand out as more effective treatment options for a widespread number of biomedical applications.

Past Research

2017-2023: Development of new drug formulations, based on deep eutectic solvents (DES), that can simultaneously improve water-solubility, permeation and/or stability of existing drugs, particularly antimicrobial agents. These were designed and developed as new drug formulations containing DES, from simple aqueous solutions to biopolymer-based materials systems (semi-solid and solid dosage forms), for different therapeutic routes.

2011-2016: Concentration and purification of cancer biomarkers envisaging an early diagnosis using ionic liquid-based aqueous biphasic systems.

• SONIA. N. PEDRO, BRUNO F. VALENTE, CARLA VILELA, HELENA OLIVEIRA, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2023. Materials Today Bio. 22, 100733
• SONIA. N. PEDRO, ANA T. P. C. GOMES, CARLA VILELA, CARLA VITORINO, ROSA FERNANDES, ADELAIDE ALMEIDA, HELENA M. AMARAL, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2023. Advanced Therapeutics. 2200235
• MARIELA M. NOLASCO, SONIA. N. PEDRO, CARLA VILELA, PEDRO D. VAZ, PAULO RIBEIRO-CLARO, SVEMIR RUDI膯, STEWART F. PARKER, CARMEN S. R. FREIRE, MARA G. FREIRE and ARMANDO J. D. SILVESTRE, 2022. Frontiers in Physics. 10, 834571
• SONIA. N. PEDRO, ANA T. P. C. GOMES, PARASTU OSKOEI, HELENA OLIVEIRA, ADELAIDE ALMEIDA, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, 2022. International Journal of Pharmaceutics. 616, 121566
• MATHEUS M PEREIRA, SONIA. N. PEDRO, MARIA V. QUENTAL, AMINOU MOHAMADOU, JO脙O A. P. COUTINHO and MARA G. FREIRE, 2022. 10(29), 9275-9281
• SONIA. N. PEDRO, CARMEN S. R. FREIRE, ARMANDO J. D. SILVESTRE and MARA G. FREIRE, 2021. Encyclopedia. 1(3), 942-963
• SONIA. N. PEDRO, CARMEN S. R. FREIRE, ARMANDO J. D. SILVESTRE and MARA G. FREIRE, 2021. Chapter 7- Advances brought by ionic liquids in the development of polymer-based drug delivery systems. In: Application of Ionic Liquids in Drug Delivery Springer. 113-135
• SONIA. N. PEDRO, CARMEN S. R. FREIRE, ARMANDO J. D. SILVESTRE and MARA G. FREIRE, 2020. 21, 8298
• SONIA. N. PEDRO, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and MARA G. FREIRE, 2019. 16(5), 497-506
• MATHEUS M PEREIRA, S脫NIA. N. PEDRO, JOANA GOMES, T脗NIA E. SINTRA, S脫NIA P. M VENTURA, JO脙O A. P. COUTINHO, MARA G. FREIRE and AMINOU MOHAMADOU, 2019. Fluid Phase Equilibria. 20(13),
• MATHEUS M PEREIRA, S脫NIA. N. PEDRO, MARIA V. QUENTAL, 脕LVARO S. LIMA, JO脙O A. P. COUTINHO and MARA G. FREIRE, 2015. Journal of Biotechnology. 206, 17-25
• SONIA. N. PEDRO, MARIA M. S. MENDES, BRUNO N. NEVES, ISABEL F. ALMEIDA, PAULO COSTA, IN脢S CORREIA-S脕, CARLA VILELA, MARA G. FREIRE, ARMANDO J. D. SILVESTRE and CARMEN S. R. FREIRE, Pharmaceutics. 14(4), 827
• SONIA. N. PEDRO, CARMEN S. R. FREIRE, ARMANDO J. D. SILVESTRE and MARA G. FREIRE, Encyclopedia. 1, 324鈥�339
• MARIA V. QUENTAL, MARIA A. FERREIRA, SONIA. N. PEDRO, SHAHLA SHAHRIARI, AMINOU MOHAMADOU, JO脙O A. P. COUTINHO and MARA G. FREIRE, Green Chemistry. 20(13), 2978-2983