糖心原创

School of Pharmacy

Image of Sue-Mian Then

Sue-Mian Then

Research Director for School of Pharmacy,

Contact

Biography

Dr Sue-Mian Then obtained both of her bachelor's and PhD's degrees from Universiti Kebangsaan Malaysia (UKM). She worked as a research fellow at the UKM Medical Molecular Biology Institute (UMBI) from 2007-2012 and joined the 糖心原创 Malaysia (UNM) in July 2012 and has been working until present. She is now an Associate Professor of the university since 2015. She also obtained her Post Graduation Certificate in Higher Education (PGCHE) in July 2016. She is currently the lead for animal ethics for the campus, she is involved in the local review and facilitates researchers from the campus to obtain their animal ethics approval from Animal Welfare and Ethics Review Board (AWERB), UK.

Her research interest is in elucidating mechanism of action of natural compounds, neuroscience, pharmacogenetics and Science, Technology, Engineering and Mathematics (STEM) education. Her research grants includes investigation of gamma-tocotrienol (gT3), a vitamin E isomer from palm oil as a potential anti-cancer treatment for neuroblastoma; development of mobile genetic detector to detect genes (HLA-B*15:02 and HLA-B*58:01) to prevent severe drug-induced adverse reaction.

She serves as the Research Director for the School of Pharmacy from Sept 2021 onwards. She is also one of the nominated members to the UNM Research Integrity and Research Ethics Committee (RIREC) from Dec 2021 and was recently appointed as the RIREC Chair from Dec 2024 until present.

Teaching Summary

Module Convener for:

LIFE1058 Human Anatomy and Histology

LIFE1051 Fundamentals of Neuroscience

Co-Convener:

LIFE3087 Tropical Medicine and Beyond

I also contribute lectures to other modules such as LIFE1052 Human Physiology, LIFE1055 Human Diseases, LIFE2088 Pharmacological Basis of Therapeutics, LIFE2103 Professional Skilss for Biomedical Sciences, PHAR3036 Central Nervous System, LIFE3108 Toxicology and Pharmacogenetics. As personal tutor, I guide my tutee with their LIFE1054 Core Skills in Biomedical Sciences assignments.

I'm interested in utilising collaborative learning and peer learning to help improved students' understanding and appreciation of histology for LIFE1058 Human Anatomy and Histology by designing a cross-campus collaborative revision activity near the end of semester to aid in the students' revision. The outcome of this approach has been positive with our students demonstrated marked academic improvement.This work has been presented in HEA seminar and has been published.

Research Summary

Area of research

Research Interest

1. Basic Neuroscience: Oxidative stress and tocotrienol signaling in neurons

2. Pharmacogenomics: Development of a rapid protocol for detection of HLA-B*15:02 and HLA-B*58:01 alleles to prevent drug-induced adverse reaction.

3. Using online plateform/ tools to deliver Science, Technology, Engineering & Mathematics (STEM) education / Biotechnology education amongst Malaysian school children.

4. Gravitational and Space Biology of Eukaryotic Cells and C elegans

Citation index

Total Citation

1. Web of Knowledge: Total citation=393, H-index=10

2. Scopus: Total citation = 494, H-index=12

3. Google Scholar: Total citation=677, H-index=12

Research projects

1. Formatting potential treatment for drug resistance high-risk neuroblastoma: Enhancing apoptotic cell death by increased interaction of gamma-tocotrienol with p53 DNA-binding domain to displace FOXO3 transcription factor (Principle Investigator), MOHE FRGS, RM151,500.00, 2021-2024.

2. Introducing a STEM-based Educational Toolkit and Prototype called "The Gene Detective" as Biotechnology Enrichment Module to promote interest and love for biotechnology (Principle Investigator), MOHE PRGS, RM146,000.00, 2019-2022.

3. The Gene Detective: Understanding DNA and diseases. (Principle Investigator), Biochemistry Society Education Outreach Grant, 拢950.00

4. Re-innovating a Combined Treatment of Tocotrienol and Doxorubicin by Elucidating the Interaction between Apoptosis and Autophagy in Colorectal Cancer Cells (Co-Investigator), MOHE FRGS, RM183,000.00, 2020-2023.

5. Examining the heritability of autobiographical memory to understand the causes of overgeneral memory in depression (Co-Investigator), MOHE FRGS, RM94,000.00. 2020-2022.

Recent Publications

  • KAYATRI GOVINDARAJU, YIN YING MAK, FONG KAI LEE, CLAUDIA C. BAUER, KUAN HON LIM, ROBIN S. BON, CIN KONG, SUE-MIAN THEN and KANG NEE TING, 2024. Phytochemistry Letters. 59, 24-35
  • WEI LEIK NG, NORITA HUSSEIN, CHIRK JENN NG, NADEEM QURESHI, YEW KONG LEE, ZHENLI KWAN, BOON PIN KEE, SUE-MIAN THEN, TUN FIRZARA ABDUL MALIK, FATIMAH ZAHRAH MOHD ZAIDAN and SITI UMI FAIRUZ AZMI, 2024. PLoS One. 19(1), e0296498
  • THEN, SUE-MIAN, KOKOLSKI, MARIE, MBAKI, YVONNE, MERRICK, DEBORAH and ANDERSON, SUSAN, 2023. ANATOMIA HISTOLOGIA EMBRYOLOGIA. 52(1), 21-30
  • YIN YING MAK, FONG KAI LEE, MEI KEE LEE, YVONNE MBAKI, SUE MIAN THEN, CHEE SUM ALVIN YAP, SHIN YEE FUNG, CIN KONG, KUAN HON LIM and KANG NEE TING, 2023. In: British Journal of PharmacologyVolume 180: Abstracts of the 19th World Congress of Basic & Clinical Pharmacology 2023. 546-548

Past Research

Title of Research Projects

1. Development of a portable screening kit to detect HLA-B*1502 and HLA-B*5801 to prevent Carbamazepine, Phenytoin, Oxocarzepine and Allopurinol induced-Steven Johnson Syndrome (Principle Investigator), MOSTI eScience, RM300,000.00. 2014-2016

2. Establishing pre-clinical evidence of gamma-tocotrienol as potential anti-tumor therapeutic agent against neuroblastoma by targeting the BH3 domain of the Bcl-2 family proteins involved in apoptosis signaling pathway in an animal model (Principle Investigator), MOHE FRGS, RM147,040.00. 2014-2017

3. RNA Interference-Mediated Silencing Effects of Genes Involved in Longevity, DNA Repair and Locomotion of Caenorhabditis Elegans Exposed to Microgravity and Orbital Forces (Co-researcher), Geran Pembangunan Sains Angkasa dan Mikrogravity, ANGKASA, MOSTI, RM 520,000.00. 2012-2015

4. Interrogating the role of gamma-tocotrienol as potential anti-tumor therapeutic agent through the apoptosis signalling pathway in human neuroblastoma cell line by in silico molecular target and molecular functional study (Principal Investigator), FRGS MOHE, RM 135,750.00 2012-2013

5. Development and validation of an in-house fast screening protocol and kit for HLA-B*1502 and Cw*0801 polymorphism to prevent Carbamazepine induced- Steven Johnson Syndrome (SJS) (Principal Investigator), Malaysia Neuroscience Society Grant, RM20,000.00 2011-2013

6. Elucidating the possible mechanism of action of gamma-Tocotrienol's Cellular Transport and Signalling pathway Modulate by Gamma-Tocotrienol (Principal Investigator), Geran Galakan Penyelidik Muda UKM (UKM-GGPM-TKP-072-2010), RM 50,000.00 2010-2012

7. Gene Silencing Effects of Bcl-2, Bax, p53, p 38, ERK and PKC in Oxidative Stress-Induced Neurons: Potential Modulatory Role of Palm Oil Y-Tocotrienol in neuronal apoptosis (Principal Investigator), FRGS MOHE, RM78,000.00 2010-2012

8. A System Biology Approach to 糖心原创 Alzheimer's disease: Neural Stem Cell Diffrenentiation, Pathophysiology in An Alzheimner's disease (AD) Mouse Model and response to neural stem cell transplantation (Co-researcher & Project Manager), Geran Arus Perdana UKM (UKM-AP-TKP-08-2009), RM690,000.00 2009-2011

Future Research

1. The readiness of Malaysian parents with secondary school children to embrace non-traditional method learning of science using mobile device and online tool.

2. A 糖心原创 of Malaysian Secondary School Students' to Embrace Non-Traditional Method Learning of Science, Technology, Engineering and Mathematics (STEM) using online learning.

  • KAYATRI GOVINDARAJU, YIN YING MAK, FONG KAI LEE, CLAUDIA C. BAUER, KUAN HON LIM, ROBIN S. BON, CIN KONG, SUE-MIAN THEN and KANG NEE TING, 2024. Phytochemistry Letters. 59, 24-35
  • WEI LEIK NG, NORITA HUSSEIN, CHIRK JENN NG, NADEEM QURESHI, YEW KONG LEE, ZHENLI KWAN, BOON PIN KEE, SUE-MIAN THEN, TUN FIRZARA ABDUL MALIK, FATIMAH ZAHRAH MOHD ZAIDAN and SITI UMI FAIRUZ AZMI, 2024. PLoS One. 19(1), e0296498
  • THEN, SUE-MIAN, KOKOLSKI, MARIE, MBAKI, YVONNE, MERRICK, DEBORAH and ANDERSON, SUSAN, 2023. ANATOMIA HISTOLOGIA EMBRYOLOGIA. 52(1), 21-30
  • YIN YING MAK, FONG KAI LEE, MEI KEE LEE, YVONNE MBAKI, SUE MIAN THEN, CHEE SUM ALVIN YAP, SHIN YEE FUNG, CIN KONG, KUAN HON LIM and KANG NEE TING, 2023. In: British Journal of PharmacologyVolume 180: Abstracts of the 19th World Congress of Basic & Clinical Pharmacology 2023. 546-548
  • LI YIN PANG, SUE-MIAN THEN, KUAN HON LIM, KANG NEE TING and SHIN-YEE FUNG, 2023. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health. In: DINESH CHANDRA AGRAWAL and MURALIKRISHNAN DHANASEKARAN, eds., Mushrooms with Therapeutic Potentials. Springer. 189鈥�219
  • PANG, LI-YIN, LEE, MEI-KEE, KONG, BOON HONG, FUNG, SHIN-YEE, NG, SZU TING, TAN, CHON SENG, THEN, SUE-MIAN, LIM, KUAN-HON, ROBERTS, RICHARD and TING, KANG-NEE, 2022. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS. 24(3), 1-14
  • MAK, YIN-YING, LOONG, BI-JUIN, MILLNS, PAUL, BAUER, CLAUDIA C., BON, ROBIN S., MBAKI, YVONNE, LEE, FONG-KAI, LIM, KUAN-HON, KONG, CIN, THEN, SUE-MIAN and TING, KANG-NEE, 2022. PHYTOTHERAPY RESEARCH.
  • SOON, BEE HONG, ABU, NADIAH, MURAD, NOR AZIAN ABDUL, THEN, SUE-MIAN, ABU BAKAR, AZIZI, FADZIL, FARIZAL, THANABALAN, JEGAN, HASPANI, MOHD SAFFARI MOHD, TOH, CHARNG JENG, KUMAR, RAMESH, JAAFAR, AINUL SYAHRILFAZLI, AZLI, ANIS NABILLAH MOHD, AZAHAR, MOHD SYAKIR MOHD, PARAMASVARAN, SANMUGARAJAH, PALANIANDY, KAMALANATHAN, TAMIL, AZMI MOHD and JAMAL, RAHMAN, 2022. PERSONALIZED MEDICINE. 19(1), 25-39
  • ADELIYA TEMIRBEK and SUE-MIAN THEN, 2022. Neuroscience Research Notes. 5(3), 147
  • GAN, KOK BENG, CHONG, KIM SOON, NAWOOR, ANUSHA DEVI, THEN, SUE-MIAN, ABDUL MURAD, NOR AZIAN and A. JAMAL, A. RAHMAN, 2020. IEEE ACCESS. 8, 225306-225323
  • KARL VERN TAN, SANDY HWEI SAN LOH, DEBORAH BRIGGS, IAN KERR and SUE-MIAN THEN, 2020. Journal of Oil Palm Research. 32(4), 630-638
  • SUE-MIAN THEN, FAZLINA NORDIN, KHAIRUL-BARIAH AHMAD AMIN NOORDIN, HAFIDZAH MUNAJAT, NOOR-HAMIDAH HUSSIN, MAHA ABDULLAH, DAVID KLAUS, LOUIS STODIECK and RAHMAN JAMAL, 2020. Spaceflight altered the gene and protein expression of the membrane transporter proteins in Jurkat cells Asia-Pacific Journal of Mol. Medicine. 9(1), 1
  • MAK, Y. Y., LEE, F. K., LIM, K. H., KONG, C., MBAKI, Y., THEN, S. M. and TING, K. N., 2020. Investigating calcium channels modulatin of a novel phenylethylamine compound in Caenorhabditis elegans NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 393(SUPPL 1), 11-12
  • CHAI, BOON KHENG, AL-SHAGGA, MUSTAFA, PAN, YAN, THEN, SUE-MIAN, TING, KANG NEE, LOH, HWEI-SAN and MOHANKUMAR, SURESH K, 2019. Lipids. 54(6-7), 369-379
  • THEN SUE-MIAN and RAYMOND AZMAN ALI, 2019. Neuroscience Research Notes.
  • LEE, F., MAK, Y., LIM, K., KONG, C., MBAKI, Y., THEN, S. and TING, K., 2019. Vasorelaxation effects of a newly discovered phenylethylamine (FK244) in hypertensive rat isolated aortae BRITISH JOURNAL OF PHARMACOLOGY. 176(16), 2993-2993
  • MAK, Y., LEE, F., LIM, K., KONG, C., MBAKI, Y., THEN, S. and TING, K., 2019. FK244 (N-phenethyl-1,2,3,4-tetrahydronaphthalen-2-amine), a newly discovered phenylethylamine as a calcium channel blocker BRITISH JOURNAL OF PHARMACOLOGY. 176(16), 2992-2992
  • CHONG, K. S., DEVI, N. A., THEN, S. M. and GAN, K. B., 2019. DEVELOPMENT OF A FLUORESCENCE DETECTION SYSTEM FOR HIGH-RESOLUTION MELTING ANALYSIS USING SILICON PHOTOMULTIPLIER JOURNAL OF ENGINEERING SCIENCE AND TECHNOLOGY. 14(2), 951-964
  • GAURI, SAMLA, GAN, KOK BENG and THEN, SUE-MIAN, 2019. MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROCESSING SYSTEMS. 25(4), 1379-1385
  • MEI-KEE LEE, KUAN-HON LIM, PAUL MILLNS, SURESH KUMAR MOHANKUMAR, SZU-TING NG, CHON-SENG TAN, SUE-MIAN THEN and YVONNE MBAKI, 2018. Phytomedicine. 42, 172-179
  • ZAM ZUREENA MOHD RANI, NOR AZIAN ABDUL MURAD, THEN SUE-MIAN, SUTHASHINI PANJA BERNAM, ASMAA ABDULLAH, SABERI SAIMUN, SRI NORAIMA OTHMAN, RAYMOND AZMAN ALI and RAHMAN JAMAL, 2018. HLA-B*15:02 screening in epileptic patients using a high resolution melting-real time PCR (HRM-QPCR) method. Neurology Asia. 23(2), 137 鈥� 144
  • LEE, MEI-KEE, MILLNS, PAUL, MBAKI, YVONNE, NG, SZU-TING, TAN, CHON-SENG, LIM, KUAN-HON, THEN, SUE-MIAN, MOHANKUMAR, SURESH KUMAR and TING, KANG-NEE, 2018. DATA IN BRIEF. 18, 1322-1326
  • CHONG, KIM SOON, DEVI, NAWOOR ANUSHA, GAN, KOK BENG and THEN, SUE-MIAN, 2018. Design and development of polymerase chain reaction thermal cycler using proportional-integral temperature controller MALAYSIAN JOURNAL OF FUNDAMENTAL AND APPLIED SCIENCES. 14(2), 213-218
  • SAMLA GAURI, KOK BENG GAN and SUE-MIAN THEN, 2017. International Journal of Nanoelectronics and Materials. 10(1), 75-92
  • SAMLA GAURI, KOK BENG GAN and SUE-MIAN THEN, 2017. Microsystem Technologies. 23(10), 4435鈥�4440
  • BEE HONG SOON, NOR AZIAN ABDUL MURAD, SUE-MIAN THEN, AZIZI ABU BAKAR, FARIZAL FADZIL, JEGAN THANABALAN, MOHD SAFFARI MOHD HASPANI, CHARNG JENG TOH, AZMI MOHD TAMIL, ROSLAN HARUN, WAN ZURINAH WAN NGAH and RAHMAN JAMAL, 2017. Frontiers in Physiology: Oxidant Physiology. 8, 231
  • LING FEI TEE, HUI-MIN NEOH, SUE-MIAN THEN, NOR AZIAN MURAD, MOHD FAIROS ASILLAM, MOHD HELMY HASHIM and RAHMAN JAMAL, 2017. Life Sciences in Space Research. 15, 11-17
  • NOR AZIAN ABDUL MURAD, SUE-MIAN THEN, MOHD RIDHWAN ABDUL RAZAK, CONJEEVARAM RAJENDRARAO THAMBIDORAI, SRI NORAIMA OTHMAN, ROSNIZA MOHAMAD HUSSAIN, MOHAN NALLUSAMY, SYED ZULKIFLI SYED ZAKARIA, ISA MOHAMED ROSE, ZARINA ABDUL LATIFF and RAHMAN JAMAL, 2017. Asia Pacific Journal of Molecular Medicine. 7(1), 2
  • CHONG, K. S., GAN, K. B. and THEN, SUE-MIAN., 2017. Development of a Portable Low-cost Real-time PCR System 2017 INTERNATIONAL CONFERENCE ON ROBOTICS, AUTOMATION AND SCIENCES (ICORAS).
  • JEN-KIT TAN, SUE-MIAN THEN, MUSALMAH MAZLAN, RAHMAN JAMAL and WAN ZURINAH WAN NGAH, 2016. Nutrition & Cancer.
  • JEN-KIT TAN, SUE-MIAN THEN, MUSALMAH MAZLAN, RAJA NOOR ZALIHA RAJA ABDUL RAHMAN, RAHMAN JAMAL and WAN ZURINAH WAN NGAH, 2016. Journal of Nutritional Biochemistry. 31, 28-37
  • ZAM ZUREENA MOHD RANA, NOR AZIAN MURAD, SUE-MIAN THEN, SP BERNAM, A ABDULLAH, SABERI SAIMUN, SN OTHMAN, AZMAN ALI RAYMOND and RAHMAN JAMAL, 2015. Public Health Genomics. 18 (Suppl), 1-51
  • PEK LENG NG, NOR FADILAH RAJAB, SUE-MIAN THEN, YASMIN ANUM MOHD YUSOF, WAN ZURINAH WAN NGAH, KAR YONG PIN and MEE LEE LOOI, 2014. JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B. 15(8), 692-700
  • SUE-MIAN THEN, NURUL-FAIZAH JUSOH, ROSLAN HARUN, SHEILA NATHAN, NATHANIEL J. SZEWCZYK, LOUIS STODIECK and RAHMAN JAMAL, 2014. Asia Pacific Journal of Molecular Medicine. 4(1), 1
  • TZE SEAN KHOO, NOOR HAMIDAH HUSSIN, SUE-MIAN THEN and RAHMAN JAMAL, 2013. DIFFERENTIATION. 85(3), 110-118
  • LAI KUAN LEE, SUZANA SHAHAR, NOR FADILAH RAJAB, NOOR AINI MOHD YUSOFF, RAHMAN JAMAL and SUE-MIAN THEN, 2013. JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 24(5), 803-808
  • SUE-MIAN THEN, ZAM ZUREENA MOHD RANI, AZMAN ALI RAYMOND and RAHMAN JAMAL, 2013. Pharmacogenomics screening of HLA-B*1502 in epilepsy patients: How we do it in the UKM Medical Centre, Malaysia NEUROLOGY ASIA. 18, 27-29
  • ROSDINOM RAZALI, ZANARIAH MAT SAHER, ELINDA TUNAN, WAN ZURINAH WAN NGAH, SUE-MIAN THEN, SURIATI MOHAMED SAINI, ABDUL HAMID ABDUL RAHMAN and SHAMSUL AZHAR SHAH, 2013. Apolipoprotein E Genotypes and Behavioural and Psychological Symptoms of Dementia (BPSD) in Malaysian Patients with Dementia SAINS MALAYSIANA. 42(3), 409-416
  • SUZANA SHAHAR, LAI KUAN LEE, NOR FADILAH RAJAB, CHENG LEONG LIM, NUR AMIRA HARUN, MOHD FAIRUL NIZAL MD NOH, SUE-MIAN THEN and RAHMAN JAMAL, 2013. NUTRITIONAL NEUROSCIENCE. 16(1), 6-12
  • NORFILZA M. MOKHTAR, NOR AZIAN MURAD, SUE-MIAN THEN and RAHMAN JAMAL, 2013. In: Genomic Expression Profiles: From Molecular Signatures to Clinical Oncology Translation. InTech.
  • HUI-XIN TEH, SUE-MIAN THEN, INDAH MAISARAH SHANI, MUSALMAH MAZLAN, WAN ZURINAH WAN NGAH and RAHMAN JAMAL, 2013. Asia Pacific Journal of Molecular Medicine. 3(2), 1
  • SUE-MIAN THEN, CORAL SANFELIU, GAPOR MAT TOP, WAN ZURINAH WAN NGAH and MUSALMAH MAZLAN, 2012. NUTRITION & METABOLISM. 9,
  • DONNA HERMAWATI, SUE-MIAN THEN, TRI INDAH WINARNI, RAHMAN JAMAL and SULTANA MH FARADZ, 2012. Are GSTM1 Null and GSTT1 Null Risk Factor of Autism Spectrum Disorder? a Preliminary 糖心原创 Media Medika Indonesiana. 46(2), 69-74
  • SUE-MIAN THEN, ZAM ZUREENA MOHD RANI, AZMAN ALI RAYMOND, SAFRINA RATNANINGRUM and RAHMAN JAMAL, 2011. Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY. 29(3), 290-293
  • DONNA HERMAWATI, SUE-MIAN THEN, TRI INDAH WINARNI, SULTANA MH FARADZ and RAHMAN JAMAL, 2011. Lower erythrocyte GST activity in autism spectrum disorder (ASD) patients compared to normal controls Asian Pacific Journal of Molecular Medicine. 1, 1
  • ZARINA ABDUL LATIFF, WAI CHUAN LIM, KHAIRUL-BARIAH AMIN NOORDIN, OTHMAN, Z., SUE-MIAN THEN, ROSLAN HARUN, ZAKARIA, S. and RAHMAN JAMAL, 2010. Screening of Fragile X syndrome (FRAXA) using both clinical checklist and PCR Preliminary experience in a developing country JOURNAL OF MEDICAL GENETICS. 47, S51-S51
  • SUE-MIAN THEN, WAN ZURINAH WAN NGAH, GAPOR MAT TOP and MUSALMAH MAZLAN, 2010. Sains Malaysiana. 39(1), 145-156
  • SUE-MIAN THEN, MUSALMAH MAZLAN, GAPOR MAT TOP and WAN ZURINAH WAN NGAH, 2009. CELLULAR AND MOLECULAR NEUROBIOLOGY. 29(4), 485-496
  • MUSALMAH MAZLAN, SUE-MIAN THEN, GAPOR MAT TOP and WAN ZURINAH WAN NGAH, 2006. JOURNAL OF THE NEUROLOGICAL SCIENCES. 243(1-2), 5-12
  • SUE-MIAN THEN, MUSALMAH MAZLAN, GAPOR MAT TOP and WAN ZURINAH WAN NGAH, 2004. Neuroprotective effects of gamma-tocotrienol and alpha-tocopherol against H2O2-induced oxidative stress in astrocytes culture FREE RADICAL BIOLOGY AND MEDICINE. 36, S88-S88

School of Pharmacy

糖心原创
University Park
Nottingham, NG7 2RD

For all enquiries please visit: