糖心原创

Contact

• workRoom B87 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 748 6436
• Robert.Owen@nottingham.ac.uk
• publications.owen.world

Biography

Nottingham Research Fellow 2023 - my fellowship 'Harnessing Geometry', will research how we can incorporate our ability to control cell behaviour using the shape of their environment within clinically translatable medical devices manufactured by additive manufacturing, focussing initially on bone repair.

Prior to this I was a research Fellow in Biomaterials Development and Additive Manufacturing within the United Kingdom Regenerative Medicine 2 (UKRMP2) platform. My research involved the fabrication of defined-geometry microparticles using multi-photon polymerisation to explore the roles of pore architecture on mesenchymal stem cell differentiation. I was also involved in the 'Next Generation Biomaterials Discovery' programme grant incorporating machine learning tools to enhance image analysis of high-throughput screening biomaterial discovery platforms such as the TopoChip and polymer microarrays.

Additionally, I was involved in the design and delivery of the '' Laboratory at the 糖心原创, purpose built for bioprinting.

Before joining the 糖心原创, I was an EPSRC Doctoral Prize Fellow 2018 within the INSIGNEO Institute for in silico Medicine at the University of Sheffield having received a Master's degree in Biomaterial Science and Tissue Engineering in 2014 and a PhD in 2017 under the supervision of Dr. Gwendolen C Reilly and Dr. Frederik Claeyssens.

Expertise Summary

Bone tissue engineering and in vitro modelling of bone.

• Polymer synthesis, in particular for modification of materials for use in microstereolithography (MSL).
• Materials characterisation, including SEM, micro-computed tomography, FTIR and contact angle assessment.
• Advanced mechanical characterisation of synthetic and biological materials.
• Range of polymeric scaffold manufacture techniques, including single and two-photon stereolithorgaphy.
• Extensive cell culture experience in 2D and 3D, including mesenchymal progenitor (MP)/osteoblast-lineage cell lines, primary MP culture and their differentiation into osteoblastic and chondrogenic lineages, and culture of primary monocytes and their differentiation into osteoclasts.
• Cell culture assay techniques including viability and cell number, differentiation by enzyme upregulation, histological staining, immunohistochemistry, fluorescence and confocal microscopy, ELISA, and qPCR.
• High-throughput image analysis using machine learing and artificial intelligence.
• Competent user of statistical analysis software such as GraphPad Prism, as well office IT applications.

Teaching Summary

I attained AFHEA status in February 2021 in recognition of my contribution to teaching.

Recent Publications

• BORG, STEPHANIE A, BUCKLEY, HARRIET, OWEN, ROBERT, MARIN, ANA CAMPOS, LU, YONGTAU, EYLES, DARRYL, LACROIX, DAMIEN, REILLY, GWENDOLEN C, SKERRY, TIM M and BISHOP, NICK J, 2018. PloS one. 13(1), e0190675
• BHASKAR, BIRRU, OWEN, ROBERT, BAHMAEE, HOSSEIN, RAO, PARCHA SREENIVASA and REILLY, GWENDOLEN C, 2018. Applied biochemistry and biotechnology. 1-9
• OWEN, ROBERT and REILLY, GWENDOLEN C, 2018. Frontiers in bioengineering and biotechnology. 6,
• PASHNEH-TALA, SAMAND, OWEN, ROBERT, BAHMAEE, HOSSEIN, REKVSTYTE, S, MALINAUSKAS, MANGIRDAS and CLAEYSSENS, FREDERIK, 2018. Frontiers in Physics. 6,

• View all publications

• BORG, STEPHANIE A, BUCKLEY, HARRIET, OWEN, ROBERT, MARIN, ANA CAMPOS, LU, YONGTAU, EYLES, DARRYL, LACROIX, DAMIEN, REILLY, GWENDOLEN C, SKERRY, TIM M and BISHOP, NICK J, 2018. PloS one. 13(1), e0190675
• BHASKAR, BIRRU, OWEN, ROBERT, BAHMAEE, HOSSEIN, RAO, PARCHA SREENIVASA and REILLY, GWENDOLEN C, 2018. Applied biochemistry and biotechnology. 1-9
• OWEN, ROBERT and REILLY, GWENDOLEN C, 2018. Frontiers in bioengineering and biotechnology. 6,
• PASHNEH-TALA, SAMAND, OWEN, ROBERT, BAHMAEE, HOSSEIN, REKVSTYTE, S, MALINAUSKAS, MANGIRDAS and CLAEYSSENS, FREDERIK, 2018. Frontiers in Physics. 6,
• SHERBORNE, COLIN, OWEN, ROBERT, REILLY, GWENDOLEN C and CLAEYSSENS, FREDERIK, 2018. Light-based additive manufacturing of PolyHIPEs: Controlling the surface porosity for 3D cell culture applications Materials & Design. 156, 494-503
• BHASKAR, BIRRU, OWEN, ROBERT, BAHMAEE, HOSSEIN, WALLY, ZENA, SREENIVASA RAO, PARCHA and REILLY, GWENDOLEN C, 2018. Journal of Biomedical Materials Research Part A. 106(5), 1334-1340
• OWEN, ROBERT, 2017. Tissue Engineering an In Vitro Model of Osteoporosis
• BAUD'HUIN, MARC, LAMOUREUX, FRAN脟OIS, JACQUES, CAMILLE, CALLEJA, LIDIA RODRIGUEZ, QUILLARD, THIBAUT, CHARRIER, C脡LINE, AMIAUD, J脡ROME, BERREUR, MARTINE, BROUNAIS-LEROYER, B脡N脡DICTE, OWEN, ROBERT and OTHERS, 2017. Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis Bone. 94, 10-21
• ANTONINI, LEONARDO MARASCA, KOTHE, VIN脥CIUS, REILLY, GWENDOLEN C, OWEN, ROBERT, MARCUZZO, JOSSANO SALDANHA and DE FRAGA MALFATTI, C脡LIA, 2017. Effect of Ti6Al4V surface morphology on the osteogenic differentiation of human embryonic stem cells Journal of Materials Research. 32(20), 3811-3821
• WANG, AI-JUAN, PATERSON, THOMAS, OWEN, ROBERT, SHERBORNE, COLIN, DUGAN, JAMES, LI, JUN-MING and CLAEYSSENS, FREDERIK, 2016. Photocurable high internal phase emulsions (HIPEs) containing hydroxyapatite for additive manufacture of tissue engineering scaffolds with multi-scale porosity Materials Science and Engineering: C. 67, 51-58
• OWEN, ROBERT, SHERBORNE, COLIN, PATERSON, THOMAS, GREEN, NICOLA H, REILLY, GWENDOLEN C and CLAEYSSENS, FREDERIK, 2016. Journal of the mechanical behavior of biomedical materials. 54, 159-172
• OWEN, ROBERT, SHERBORNE, COLIN, REILLY, GWENDOLEN C and CLAEYSSENS, FREDERIK, 2015. Data in brief. 5, 616-620