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Rian Griffiths

Assistant Professor, Faculty of Science

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Biography

Dr Griffiths graduated with an MSci in Chemistry from the University of Birmingham in 2010, discovering a passion for mass spectrometry during her final year project. She went on to complete a PhD under the supervision of Professor Josephine Bunch, investigating routes to controlling lipid adduct formation in complex biological samples via matrix-assisted laser desorption/ionisation (MALDI) mass spectrometry. In 2014 she secured a Research Fellow post in Professor Helen Cooper's laboratory (School of Biosciences, University of Birmingham) where she developed liquid extraction surface analysis (LESA) mass spectrometry methods for the direct analysis of intact proteins, both denatured and folded, and non-covalent protein complexes from biological samples such as dried blood spots and thin tissue sections. In January 2019 she moved to Nottingham for a Research Fellow position in Professor Morgan Alexander's laboratory. In October 2019 she became an independent Anne McLaren Fellow.

Expertise Summary

Dr Griffiths has experience with a wide range of surface-sampling mass spectrometry and imaging approaches including matrix-assisted laser desorption/ionisation (MALDI), liquid extraction surface analysis (LESA), Flowprobe and secondary ion mass spectrometry (SIMS). Her research has encompassed the analysis of small molecule metabolites, lipids, intact proteins and non-covalent protein complexes. Ion mobility separation, a surface compatible separation approach, is also one of her particular interests. This offers the benefits of molecular separation and improved sensitivity.

Research Summary

Dr Griffiths' research focuses on surface sampling mass spectrometry of biological analytes such as protein, lipids and metabolites. Her research sits at a nexus of chemical, biological and physical… read more

Recent Publications

Current Research

Dr Griffiths' research focuses on surface sampling mass spectrometry of biological analytes such as protein, lipids and metabolites. Her research sits at a nexus of chemical, biological and physical sciences and is highly interdisciplinary. Dr Griffiths is interested in developing methods for the direct analysis of biological samples that have an application in improving human health and understanding disease. Specific examples include the analysis of Mycobacterial lipids from colonies grown on agar plates, metabolite analysis from bacteria colonised surfaces and proteins from thin tissue sections.

  • O J HALE, E K SISLEY, R L GRIFFITHS, I B STYLES and H J COOPER, 2020. Journal of the American Society for Mass Spectrometry. 3(4), 873-879
  • R L GRIFFITHS, J W HUGHES, S E ABBATIELLO, M W BELFORD, I B STYLES and H J COOPER, 2020. Analytical Chemistry. 92(4), 2885-2890
  • R L GRIFFITHS, K I KOCUREK and H J COOPER, 2020. Liquid Extraction Surface Analysis (LESA) High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins. In: GIUSEPPE PAGLIA and GIUSEPPE ASTARITA, eds., Ion Mobility-Mass Spectrometry Springer. 191-201
  • CONNER AN, JARVIS JR, ALDERWICK L and GRIFFITHS RL, 2019. Rapid communications in mass spectrometry : RCM. (In Press.)
  • GRIFFITHS RL, KONIJNENBERG A, VINER R and COOPER HJ, 2019. Analytical chemistry. 91(14), 9330
  • GRIFFITHS RL, KONIJNENBERG A, VINER R and COOPER HJ, 2019. Analytical chemistry. 91(11), 6962-6966
  • J HAVLIKOVA, E C RANDALL, R L GRIFFITHS, J SWALES, R J A GOODWIN, J BUNCH and H J COOPER, 2019. Analytical Chemistry. 91(22), 14198鈥�14202
  • GRIFFITHS RL, SIMMONDS AL, SWALES JG, GOODWIN RJA and COOPER HJ, 2018. Analytical chemistry. 90(22), 13306-13314
  • LOPEZ-CLAVIJO AF, GRIFFITHS RL, GOODWIN RJA and COOPER HJ, 2018. Journal of the American Society for Mass Spectrometry. 29(11), 2218-2226
  • KOCUREK KI, GRIFFITHS RL and COOPER HJ, 2018. Journal of mass spectrometry : JMS. 53(7), 565-578
  • GRIFFITHS RL, RANDALL EC, RACE AM, BUNCH J and COOPER HJ, 2017. Analytical chemistry. 89(11), 5683-5687
  • GRIFFITHS RL, KOCUREK KI and COOPER HJ, 2017. Current opinion in chemical biology. 42, 67-75
  • GRIFFITHS RL, CREESE AJ, RACE AM, BUNCH J and COOPER HJ, 2016. Analytical chemistry. 88(13), 6758-66
  • GRIFFITHS RL and COOPER HJ, 2015. Analytical chemistry. 88(1), 606-9
  • GRIFFITHS RL, DEXTER A, CREESE AJ and COOPER HJ, 2015. The Analyst. 140(20), 6879-85
  • SARSBY J, GRIFFITHS RL, RACE AM, BUNCH J, RANDALL EC, CREESE AJ and COOPER HJ, 2015. Analytical chemistry. 87(13), 6794-800
  • MARTIN NJ, GRIFFITHS RL, EDWARDS RL and COOPER HJ, 2015. Journal of the American Society for Mass Spectrometry. 26(8), 1320-7
  • FONVILLE, J.M., CARTER, C.L., PIZARRO, L., STEVEN, R.T., PALMER, A.D., GRIFFITHS, R.L., LALOR, P.F., LINDON, J.C., NICHOLSON, J.K., HOLMES, E. and BUNCH, J., 2013. Analytical Chemistry. 85(3), 1415-1423
  • SINGHAL R, CARRIGAN JB, WEI W, TANIERE P, HEJMADI RK, FORDE C, LUDWIG C, BUNCH J, GRIFFITHS RL, JOHNSON PJ, TUCKER O, ALDERSON D, G脺NTHER UL and WARD DG, 2013. Journal of proteomics. 80, 207-15
  • GRIFFITHS RL, SARSBY J, GUGGENHEIM EJ, RACE AM, STEVEN RT, FEAR J, LALOR PF and BUNCH J, 2013. Analytical chemistry. 85(15), 7146-53
  • PALMER AD, GRIFFITHS R, STYLES I, CLARIDGE E, CALCAGNI A and BUNCH J, 2012. Journal of mass spectrometry : JMS. 47(2), 237-41
  • GRIFFITHS RL and BUNCH J, 2012. Rapid communications in mass spectrometry : RCM. 26(13), 1557-66
  • FONVILLE JM, CARTER CL, PIZARRO L, STEVEN RT, PALMER AD, GRIFFITHS RL, LALOR PF, LINDON JC, NICHOLSON JK, HOLMES E and BUNCH J, 2012. Analytical chemistry. 85(3), 1415-23

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