ÌÇÐÄÔ­´´

Contact

• workRoom B1B26a Block B
  Malaysia Campus
  Jalan Broga
  43500 Semenyih
  Selangor Darul Ehsan
  Malaysia
• work+6 (03) 8725 3444
• Pan.Yan@nottingham.edu.my

Biography

1999-2004, Bachelor of Lab Science and technology, Shanghai Second Medical University, Shanghai China

2005-2009, Doctor of Philosophy in Pharmacology, International Medical University, Kuala Lumpur, Malaysia

2006, Certificate in Good Clinical Practice, International Medical University, Kuala Lumpur, Malaysia

2016, Fellow of The Higher Education Academy

Teaching Summary

Module convener: Pharmacological Basis of Therapeutics; Toxicology and Pharmacogenetics

Co-teaching: Human Physiology; Asthma, Allergy and Immune disease; Core skills in BMS; Structure Function and Analysis of Protein; Renal and Endocrine Diseases; BMS final year project

Tutoring & Supervising: Final Year Projects, postgraduate research studies

Research Summary

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids.… read more

Recent Publications

• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2022. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B. Drug metabolism letters.
• ABU-BAKAR, A'EDAH, TAN, BOON HOOI, HALIM, HASSERI, RAMLI, SALFARINA, PAN, YAN and ONG, CHIN ENG, 2022. Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current drug metabolism.
• SHAROEN YU MING LIM, JASON SIAU EE LOO, MUSTAFA ALSHAGGA, MOHAMMED ABDULLAH ALSHAWSH, CHIN ENG ONG and YAN PAN, 2022. Toxicology Reports. 9, 759-768
• CHONG CL, FANG CM, PUNG SY, ONG CE, PUNG YF, KONG C and PAN Y, 2021. Bionanosci. (IF: 0.277)

• View all publications

Current Research

Cytochrome P450 (CYP) enzymes are a superfamily of mono-oxygenases responsible for metabolising a wide spectrum of xenobiotics including drugs as well as endogenous compounds such as fatty acids. Accumulation of drugs or toxins in human body may result in serious adverse toxic effects. The hydrophilicity of the metabolite is usually increased after being oxidised by CYP, which facilitates the elimination of foreign compounds from human body. However, the activities of CYPs can be inhibited or induced by various types of chemicals. As a result, drugs or food have potential to decrease or increase the elimination of co-administrated drugs, leading to adverse drug reactions or treatment failures.

My current research interest is to investigate the modulatory effects of commonly used traditional herbs on the activities of several most important human CYP isoforms (CYP2C9, CYP2C19, CYP2D6 and CYP3A4) by in vitro evaluation. Moreover, CYPs exhibit polymorphisms. Lower or no activities of CYPs are expressed in the population carrying polymorphic genes. These people are not able to metabolise a certain group of drugs, and they are more prone to adverse drug reactions. Thus, I am also interested in investigating the activities of CYP variants and the mechanisms involved.

Moreover, my on-going project is also investigating effects of ZnO nanoparticles on CYP activities as well as their toxicological effects using cells and C. elegans.

Future Research

In addition to in vitro investigation, I am keen to correlate in vitro with in vivo findings by performing clinical studies.

• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2022. Role of P34S, G169R, R296C, and S486T Substitutions in Ligand Access and Catalysis for Cytochrome P450 2D6 Allelic Variants CYP2D6*14A and CYP2D6*14B. Drug metabolism letters.
• ABU-BAKAR, A'EDAH, TAN, BOON HOOI, HALIM, HASSERI, RAMLI, SALFARINA, PAN, YAN and ONG, CHIN ENG, 2022. Cytochromes P450: Role in Carcinogenesis and Relevance to Cancers. Current drug metabolism.
• SHAROEN YU MING LIM, JASON SIAU EE LOO, MUSTAFA ALSHAGGA, MOHAMMED ABDULLAH ALSHAWSH, CHIN ENG ONG and YAN PAN, 2022. Toxicology Reports. 9, 759-768
• CHONG CL, FANG CM, PUNG SY, ONG CE, PUNG YF, KONG C and PAN Y, 2021. Bionanosci. (IF: 0.277)
• CHIENG JIN YU, YASOTHA SUGUMARAN and PAN YAN, 2021. Borneo Journal of Medical Sciences. 15(1), 11-20
• LIM, SHAROEN YU MING, CHIENG, JIN YU and PAN, YAN, 2021. ALL LIFE. 14(1), 1-33
• PAN YAN, TYE KEAN HONG and MUSTAFA ALSHAGGA, 2021. Bangladesh Journal of Medical Science. 20(2), 11-16
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN and ONG, CHIN ENG, 2021. In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6. Drug metabolism and personalized therapy.
• DONG, AMELIA NATHANIA, TAN, BOON HOOI, PAN, YAN and ONG, CHIN ENG, 2021. The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 24, 94-112
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN and ONG, CHIN ENG, 2021. In vitro inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6 Drug Metabolism and Personalized Therapy. 36(4), 259-270
• LIM, SHAROEN YU MING, ALSHAGGA, MUSTAFA AHMED, ALSHAWSH, MOHAMMED ABDULLAH, ONG, CHIN ENG and PAN, YAN, 2021. In vitro effects of 95% khat ethanol extract (KEE) on human recombinant cytochrome P450 (CYP)1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2 and CYP3A5 Drug Metabolism and Personalized Therapy. 37(1),
• AMNA SHAH, ONG CHIN ENG and PAN YAN, 2021. Current Drug Metabolism. 22(9), 698-708
• CHONG, ZHI XIONG, HO, WAN YONG, YAN, PAN and ALSHAGGA, MUSTAFA AHMED, 2020. Evaluation of Khat (Catha edulis) Use as a Risk Factor of Cancer: A Systematic Review. Asian Pacific journal of cancer prevention : APJCP. 21(4), 881-895
• CHIENG, JIN YU, ARAVAN, LOGARUBAN, ARIMUTHU, DURGA A., TAN, WENDY AI YING, NAIDU, THARANI and PAN, YAN, 2020. INFECTIOUS DISEASES IN CLINICAL PRACTICE. 28(1), 27-33
• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2020. CURRENT MOLECULAR PHARMACOLOGY. 13(3), 233-244
• LIM, S. Y. M., ALSHAGGA, M., ONG, C. E., CHIENG, J. Y. and PAN, Y., 2020. Cytochrome P450 4B1 (CYP4B1) as a target in cancer treatment HUMAN & EXPERIMENTAL TOXICOLOGY. 39(6), 785-796
• CHIENG JIN YU, CHIANG YOONG FEI and PAN YAN, 2020. Gastroenterology and Hepatology Letters. 2(2),
• CHIENG JIN YU, YASOTHA SUGUMARAN, MUSTAFA ALSHAGGA and PAN YAN, 2020. Demographic and Clinical Characteristics of Inflammatory Bowel Disease (IBD) in the Patients Attending A Public Hospital In Central Malaysia – A Descriptive ÌÇÐÄÔ­´´ From A Single Centre Vietnam Journal of Public Health. 6(2),
• CHAI, BOON KHENG, AL-SHAGGA, MUSTAFA, PAN, YAN, THEN, SUE-MIAN, TING, KANG NEE, LOH, HWEI-SAN and MOHANKUMAR, SURESH K, 2019. Lipids. 54(6-7), 369-379
• PAN, YAN, ONG, CHIN ENG, PUNG, YUH FEN and CHIENG, JIN YU, 2019. XENOBIOTICA. 49(7), 863-876
• LIM, SHAROEN YU MING, AZIDIN, ATHIRA RAFHANA BINTI, UNG, YEE TZE, AL-SHAGGA, MUSTAFA, ALSHAWSH, MOHAMMED ABDULLAH, MOHAMED, ZAHURIN, ONG, CHIN ENG and PAN, YAN, 2019. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 44(3), 423-431
• TAN BH, AHEMAD N, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2019. Asia Pacific Journal of Molecular Biology and Biotechnology. 27(1), 43-55
• DONG, AMELIA NATHANIA, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN and ONG, CHIN ENG, 2019. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 392(8), 1015-1029
• CHAI, BOON KHENG, AL-SHAGGA, MUSTAFA, PAN, YAN, THEN, SUE-MIAN, TING, KANG NEE, LOH, HWEI-SAN and MOHANKUMAR, SURESH K., 2019. LIPIDS. 54(6-7), 369-379
• THEN RU FAH, TAN YI JUN, PAN YAN and CHIENG JIN YU, 2019. Appropriateness Of Proton Pump Inhibitors Prescription In Patients Admitted To A Malaysian Tertiary Hospital International Journal of Public Health Research. 9(1),
• CHIN ENG ONG, AMELIA DONG, BOON HOOI TAN and PAN YAN, 2019. Cytochromes P450, Cardiovascular Homeostasis and Diseases. In: PETER GRUNWALD, ed., Pharmaceutical Biocatalysis: fundamentals, enzyme inhibitors, and enzymes in health and diseases Singapore: Jenny Stanford Publishing Pte.Ltd.. 567-587
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN, YIAP, BEOW CHIN and ONG, CHIN ENG, 2018. Cytochrome P450 2C9-natural antiarthritic interactions: evaluation of inhibition magnitude and prediction from in vitro data. Biopharmaceutics & drug disposition.
• TAN, BOON HOOI, AHEMAD, NAFEES, PAN, YAN, PALANISAMY, UMA DEVI, OTHMAN, IEKHSAN, YIAP, BEOW CHIN and ONG, CHIN ENG, 2018. Cytochrome P450 2C9-natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data BIOPHARMACEUTICS & DRUG DISPOSITION. 39(4), 205-217
• DONG, AMELIA NATHANIA, PAN, VAN, PALANISAMY, UMA DEVI, YIAP, BEOW CHIN, AHEMAD, NAFEES and ONG, CHIN ENG, 2018. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. 186(1), 132-144
• YAN, PAN, ENG, ONG CHIN and YU, CHIENG JIN, 2018. CURRENT DRUG METABOLISM. 19(11), 917-929
• DONG, AMELIA NATHANIA, TAN, BOON HOOI, PAN, YAN and ONG, CHIN ENG, 2018. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 45(10), 991-1001
• UNG, YEE TZE, ONG, CHIN ENG and PAN, YAN, 2018. Current High-Throughput Approaches of Screening Modulatory Effects of Xenobiotics on Cytochrome P450 (CYP) Enzymes. High-throughput. 7(4),
• OZTURK, MESUT, ASLAN, SERDAR, SAGLAM, DILEK, BEKCI, TUMAY and BILGICI, MELTEM CEYHAN, 2018. EURASIAN JOURNAL OF MEDICINE. 50(1), 56-58
• TAN, BOON HOOI, PAN, YAN, DONG, AMELIA NATHANIA and ONG, CHIN ENG, 2017. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 20, 319-328
• PAN, YAN and ONG, ENG CHIN, 2017. XENOBIOTICA. 47(10), 923-932
• LAU, PUI SHEN, LEONG, KENNY VOON GAH, ONG, CHIN ENG, DONG, AMELIA NATHANIA HUI MIN and PAN, YAN, 2017. BIOCHEMICAL GENETICS. 55(1), 48-62
• ONG CHIN ENG, PAN YAN and MAK JOON WAH, 2017. The roles of cytochrome P450 in vascular biology and cardiovascular homeostasis International Journal of Clinical and Experimental Medicine. 10(1), 1624-1636
• MUN CHIENG TAN, OOI CHUAN NG, RAY YEE PAUL YAP, YAN PAN and JIN YU CHIENG, 2017. Colorectal cancer screening using immunochemical fecal occult blood test Malaysian Journal of Public Health Medicine. 17(1), 33-37
• CHIENG JIN YU, AHMAD AMIRUL HAFIZ BIN HARIS, ANG SHIH YUAN and PAN YAN, 2017. Assessment of the level of knowledge of colorectal cancer among public at outpatient clinics in Serdang Hospital: a survey based study The Medical Journal of Malaysia. 72(6), 333-339
• PAN YAN, CHIA JIE HSU, RHUN YIAN KOH, CHIN ENG ONG and JIN YU CHIENG, 2016. The All Results Journals: Biol. 7(1), 1-12
• PAN YAN and CHIENG JIN YU, 2016. CELIAC DISEASE IN EAST AND SOUTHEAST ASIAN COUNTRIES: CURRENT STATUS AND CHALLENGES. Vietnam Journal of Medicine and Pharmacy. 11(2), 76-86
• CHIENG JY, PAN Y and LOONG YY, 2015. Prevalence Of Helicobacter Pyloric Infection Among Patients Attending Gastroenterology Endoscopy Unit At Serdang Hospital Malaysian Journal of Medicine and Health Sciences (MJMHS). 11(1), 11-17
• LAU PS, LEONG KVG, ONG CE and PAN Y, 2015. In: Golden Helix Symposia 2015.
• DONG AN, ONG CE, PAN Y, PALANISAMY UD and ISMAIL R, 2015. In: Golden Helix Symposia 2015.
• PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, ONG CE, 2014. Journal of Natural Medicines. 68(2), 402-6
• ONG CE, PAN Y, 2014. TANG: HUMANITAS MEDICINE. 4(3), 17.1-17.8
• ONG CE and PAN Y, 2014. Tang. 4(3), 17.1-17.8
• PAN Y, PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2014. Phytomedicine. 21(12), 1645-1650
• TAN BH, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2014. In vitro modulatory effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 2C9 activity In: 24th Singapore Pharmacy Congress.
• DONG AN, PAN Y, PALANISAMY UD, ISMAIL R and ONG CE, 2014. Functional characterization of cytochrome P450 2D6 (CYP2D6) allelic variants CYP2D6*2 and CYP2D6*17 In: Pharmacology & Physiology International Scientific Congress.
• PAN Y, MAK JW and ONG CE, 2013. Biomedical chromatography : BMC. 27(7), 859-865
• ONG CE, PAN Y, MAK JW and ISMAIL R, 2013. Expert opinion on drug metabolism & toxicology.
• ONG CE, PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R and MAK JW, 2013. Studies of in vitro modulatory effect of Labisia pumila on CYP1A2, CYP2A6 and CYP3A4 In: 10th International ISSX Meeting.
• TAN BH, PAN Y, PALANISAMY UD, OTHMAN I, YIAP BC and ONG CE, 2013. Effects of glucosamine, chondroitin and diacerein on human hepatic cytochrome P450 3A4 activity in vitro In: 13th International Congress of Toxicology.
• DONG AN, TAN BH, SIONG WL, PAN Y, PALANISAMY UD and ONG CE, 2013. Site-directed mutagenesis of human cytochromes P450 (CYPs): generation of common mutants of CYP2D6 and CYP2C19 In: International Conference on Advances in Medical Science.
• PAN Y, TIONG KH, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. Journal of ethnopharmacology. 143(2), 586-91
• PAN, Y., MAK, J.W. and ONG, C. E., 2012. Current Pharmaceutical analysis. 8, 219-224
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. In vitro effect of various herbal active constituents on cytochrome P450 2E1 In: Malaysia Pharmaceutical Society-Pharmacy Scientific Conference 2012.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2012. Evaluation of the modulatory effect of Labisia Pumila extracts on cytochrome P450 2C8 in vitro In: the 19th Microsomes and Drug Oxidations (MDO) and 12th European International Society for the ÌÇÐÄÔ­´´ of Xenobiotics (ISSX) Meeting.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. Journal of natural medicines. 65(3-4), 440-7
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. Chemico-biological interactions. 190(1), 1-8
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2011. Journal of ethnopharmacology. 133(2), 881-7
• PAN, Y., ABD-RASHID, B.A., ISMAIL, Z., ISMAIL, R., MAK, J.W. and ONG, C. E., 2011. The Protein Journal. 30(2), 581-591
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. Studies of in vitro modulatory effects of Labisia pumila on cytochrome P450 2C19 In: Malaysia Pharmaceutical Society-Pharmacy Scientific Conference 2011.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. In vitro modulatory effects of Labisia pumila on cytochrome P450 2C9 In: 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW and ONG CE, 2011. Evaluation of in vitro effects of various herbal active constituents on cytochrome P450 In: 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK PCK, ER HM and ONG CE, 2010. Journal of ethnopharmacology. 130(2), 275-83
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P, ER HM and ONG CE, 2009. Evaluation of the modulatory effect of Orthosiphon stamineus (Misai kucing) on the activity of expressed human CYP2C19 In: the 3rd Regional Conference on Molecular Medicine.
• SINGH, R., TING, J. G., PAN, Y., TEH, L. K., ISMAIL, R. and ONG, C. E., 2008. Drug Metab Pharmacokinet. 23(3), 165-74
• ONG, C. E., PAN, Y., TIONG, K.H., YIAP, B.C., TAN, E.L., POOK, P. and MAK, J.W., 2008. International e-Journal of Science, Medicine & Education. 2(Suppl 1), S6-S10
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P, ER HM and ONG CE, 2008. Effects of Centella asiatica extracts and active constituents on cytochrome P450 3A4 (CYP3A4) activity In: the Australian Health and Medical Research Congress.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P and ONG CE, 2008. Effects of Andrographis paniculata extracts on cytochrome P450 3A4 (CYP3A4) activity In: the 8th MPS Pharmacy Scientific Conference.
• PAN Y, ABD-RASHID BA, ISMAIL Z, ISMAIL R, MAK JW, POOK P and ONG CE, 2008. Effects of Andrographis paniculata extracts on cytochrome P450 2D6 (CYP2D6) acitivities In: MSPP 22nd Scientific Meeting, Faculty of Medicine.
• PAN Y, ABD-RASHID BA, ISMAIL Z, MINERS JO, BIRKETT DJ, ISMAIL R, MAK JW, POOK P and ONG CE, 2007. Effects of Hempedu bumi extracts and constituents on CYP2C9 in human liver In: the Commonwealth Pharmaceutical Association - MPS Pharmacy Scientific Conference.