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School of Pharmacy

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Jonathan Burley

Associate Professor in Pharmaceutical Nanotechnology, Faculty of Science

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Biography

In 1998 I gained a MChem (First Class Honours) in Chemistry at , , and remained there to complete a DPhil in Inorganic Chemistry in 2001, under the supervision of . I then spent two years working as a post-doc in the at , Illinois, USA, in the laboratory of Dr John F Mitchell. I returned to the UK in 2003 to take up a Junior Research Fellowship at , , where I ran an independent research program in the Inorganic Chemistry sector. I moved to the at in 2006, as a lecturer in pharmaceutical technologies. In 2007 I was appointed to a lectureship in pharmaceutical nanotechnology here in the at .

Research Summary

My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc.… read more

Recent Publications

  • TRES, FRANCESCO, TREACHER, KEVIN, BOOTH, JONATHAN, HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2016. MOLECULAR PHARMACEUTICS. 13(3), 1166-1175
  • TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. POLYMER. 89, 41-49
  • TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Molecular pharmaceutics. 12(5), 1512-1522
  • SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. International Journal of Pharmaceutics. 494(2), 643-650

Current Research

My research interests focus on measuring and understanding change in pharmaceutical materials. This includes changes that occur with time, temperature, position in sample, addition of solvent, etc. Phenomena of interest include , , hydration, dehydration, mapping of components in tablets and other drug delivery vehicles, formation of salts and co-crystals, etc.

A number of experimental techniques are employed, including , , (powder and single crystal), thermal methods etc. Experimental data are often complex (multi-variate) and are interpreted with appropriate statistical methods including .

Current projects include investigations of:

  • transitions from one solid form to another (polymorphism) on heating, important for formulating medicines
  • rapid spatial mapping of tablets and complex drug delivery vehicles, for quality control of medicines and understanding controlled release
  • new spectroscopic methods including Transmission Raman Spectroscopy, various new applications in pharmacy
  • formation and stabilisation of amorphous materials, to produce new highly soluble medicines

Biography

  • 2007-present Lecturer in Pharmaceutical Nanotechnology, 糖心原创
  • 2006-2007 Lecturer in Pharmaceutical Technology, De Montfort University, Leicester
  • 2006-2003 Junior Research Fellow, Jesus College and Chemistry Department, University of Cambridge
  • 2003-2001 Post-doctoral researcher, Materials Science Division, Argonne National Laboratory, USA
  • 2001-1998 DPhil, Department of Chemistry, University of Oxford
  • 1998-1994 MChem, University of Oxford

Memberships of Committees & Professional Bodies

  • Member, Royal Society of Chemistry

Teaching

  • B31C07: Pharmaceutical Technology
  • Laboratory studies in Pharmaceutics
  • TRES, FRANCESCO, TREACHER, KEVIN, BOOTH, JONATHAN, HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2016. MOLECULAR PHARMACEUTICS. 13(3), 1166-1175
  • TARESCO, V., CREASEY, R. G., KENNON, J., MANTOVANI, G., ALEXANDER, C., BURLEY, J. C. and GARNETT, M. C., 2016. POLYMER. 89, 41-49
  • TRES F, PATIENT JD, WILLIAMS PM, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2015. Molecular pharmaceutics. 12(5), 1512-1522
  • SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. International Journal of Pharmaceutics. 494(2), 643-650
  • SHABAN KHALED, JONATHAN BURLEY, MORGAN ALEXANDER, JING YANG and CLIVE ROBERTS, 2015. Journal of Controlled Release. 217, 308-314
  • MASON, LAURA MICHELLE, DOLORES CAMPINEZ, MARIA, PYGALL, SAMUEL R., BURLEY, JONATHAN C., GUPTA, PRANAV, STOREY, DAVID E., CARABALLO, ISIDORO and MELIA, COLIN D., 2015. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 94, 485-492
  • BEECH, K. E., BIDDLECOMBE, J. G., VAN DER WALLE, C. F., STEVENS, L. A., RIGBY, S. P., BURLEY, J. C. and ALLEN, S., 2015. European Journal of Pharmaceutics and Biopharmaceutics. 96, 247-254
  • TRES, FRANCESCO, COOMBES, STEVEN R., PHILLIPS, ANDREW R., HUGHES, LESLIE P., WREN, STEPHEN A. C., AYLOTT, JONATHAN W. and BURLEY, JONATHAN C., 2015. MOLECULES. 20(9), 16404-16418
  • BEECH, KAREN E., BIDDLECOMBE, JAMES G., VAN DER WALLE, CHRISTOPHER F., STEVENS, LEE A., RIGBY, SEAN P., BURLEY, JONATHAN C. and ALLEN, STEPHANIE, 2015. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 96, 247-254
  • BUANZ, ASMA, PRIOR, TIMOTHY J., BURLEY, JONATHAN C., RAIMI-ABRAHAM, BAHIJJA TOLULOPE, TELFORD, RICHARD, HART, MICHAEL, SEATON, COLIN C., DAVIES, PHILIP J., SCOWEN, IAN J., GAISFORD, SIMON and WILLIAMS, GARETH R., 2015. CRYSTAL GROWTH & DESIGN. 15(7), 3249-3256
  • NANUBOLU, JAGADEESH BABU and BURLEY, JONATHAN C., 2015. CRYSTENGCOMM. 17(28), 5280-5287
  • SHABAN A. KHALED, JONATHAN C. BURLEY, MORGAN R. ALEXANDER and CLIVE J. ROBERTS, 2014. International Journal of Pharmaceutics. 461(1-2), 105鈥�111
  • JONATHAN C. BURLEY, ADEYINKA AINA, PAVEL MATOUSEK and CHRISTOPHER BRIGNELL, 2014. Analyst. 139, 74-78
  • MEGARRY, A. J., BOOTH, J. and BURLEY, J., 2014. Journal of Pharmaceutical Sciences. (In Press.)
  • TRES F, TREACHER K, BOOTH J, HUGHES LP, WREN SAC, AYLOTT JW and BURLEY JC, 2014. Journal of controlled release : official journal of the Controlled Release Society. 188, 53-60
  • ALGAHTANI, MOHAMMED S., SCURR, DAVID J., HOOK, ANDREW L., ANDERSON, DANIEL G., LANGER, ROBERT S., BURLEY, JONATHAN C., ALEXANDER, MORGAN R. and DAVIES, MARTYN C., 2014. JOURNAL OF CONTROLLED RELEASE. 190, 115-126
  • YAA ASANTEWAA, JONATHAN AYLOTT, JONATHAN C BURLEY, NASHIRU BILLA and CLIVE J ROBERTS, 2013. Pharmaceutics. 5, 69-80
  • ALKHALIL, A, NANUBOLU, JB and BURLEY, JC, 2012. Rsc Advances. 2(1), 209-216
  • BRADLEY JP, PICKARD CJ, BURLEY JC, MARTIN DR, HUGHES LP, COSGROVE SD and BROWN SP, 2012. Journal Of Pharmaceutical Sciences. 101(5), 1821-30
  • BURLEY, J.C., ALKHALIL, A., BLOOMFIELD, M. and MATOUSEK, P., 2012. Analyst. 137(13), 3052-3057
  • GARETH R. WILLIAMS, JOHN CROWDER, JONATHAN C. BURLEY and ANDREW M. FOGG, 2012. Journal of Material Chemistry. 22, 13600-13611
  • NANUBOLU JB and BURLEY JC, 2012. Molecular pharmaceutics. 9(6), 1544-58
  • MEGARRY, A J, BOOTH, J and BURLEY, J, 2011. Carbohydrate research. 346(8), 1061-4
  • BURLEY, J.C., O'HARE, D. and WILLIAMS, G.R., 2011. Analytical Methods. 3(4), 814-821
  • CHUAH LH, BILLA N, ROBERTS CJ, BURLEY JC and MANICKAM S, 2011. Pharmaceutical Development And Technology. 1-9
  • ALKHALIL, A, NANUBOLU, JB, ROBERTS, CJ, AYLOTT, JW and BURLEY, JC, 2011. Crystal Growth & Design. 11(2), 422-430
  • WEBBER, A.L., MASIERO, S., PIERACCINI, S., BURLEY, J.C., TATTON, A.S., IUGA, D., PHAM, T.N., SPADA, G.P. and BROWN, S.P., 2011. Journal of the American Chemical Society. 133(49), 19777-19795
  • BOUHROUM, ABDENNOUR, BURLEY, JONATHAN C, CHAMPNESS, NEIL R, TOON, RICHARD C, JINKS, PHILIP A, WILLIAMS, PHILIP M and ROBERTS, CLIVE J, 2010. International Journal of Pharmaceutics. 391(1-2), 98-106
  • AINA, A., HARGREAVES, M.D., MATOUSEK, P. and BURLEY, J.C., 2010. Analyst. 135(9), 2328-2333
  • AL-DULAIMI, S., AINA, A. and BURLEY, J., 2010. CrystEngComm. 12(4), 1038-1040
  • BURLEY, JONATHAN C, GILMOUR, RYAN, PRIOR, TIMOTHY J and DAY, GRAEME M, 2008. Acta crystallographica. Section C, Crystal structure communications. 64(Pt 1), o10-4
  • LLINAS, A., BURLEY, J.C., PRIOR, T.J., GLEN, R.C. and GOODMAN, J.M., 2008. Crystal Growth & Design. VOL 8(NUMB 1), 114-118
  • FRISCI膯, TOMISLAV, F脕BI脕N, L脕SZL脫, BURLEY, JONATHAN C, REID, DAVID G, DUER, MELINDA J and JONES, WILLIAM, 2008. Chemical Communications. 1644-6
  • LLIN脌S, A., BOX, K.J., BURLEY, J.C., GLEN, R.C. and GOODMAN, J.M., 2007. Journal of Applied Crystallography. 40(2), 379-381
  • LLIN脌S, A., BURLEY, J.C., BOX, K.J., GLEN, R.C. and GOODMAN, J.M., 2007. Journal of Medicinal Chemistry. 50(5), 979-983
  • BURLEY, J.C., MOTHERWELL, W.D.S., MAARANEN, J. and RINGWALD, M., 2007. Acta Crystallographica. Section E: Structure Reports Online. 63(1), M238-M240
  • BURLEY, JONATHAN C, DUER, MELINDA J, STEIN, ROBIN S and VRCELJ, RANKO M, 2007. European Journal of Pharmaceutical Sciences. 31(5), 271-6
  • FRI艩膶I膯, T., F脕BI脕N, L., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Chemical Communications. 48, 5009-5011
  • LLINAS, A., FABIAN, L., BURLEY, J.C., VAN DE STREEK, J. and GOODMAN, G.M., 2006. Acta Crystallographica. Section E: Structure Reports Online. 62(9), O4196-O4199
  • HAYNES, D.A., VAN DE STREEK, J., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Acta Crystallographica. Section E: Structure Reports Online. 62(3), O1170-O1172
  • BURLEY, JONATHAN C and PRIOR, TIMOTHY J, 2006. Acta Crystallographica. Section C: Crystal Structure Communications. 62(Pt 2), m63-6
  • DAY, G.M., VAN DE STREEK, J., BONNET, A., BURLEY, J.C., JONES, W. and MOTHERWELL, W.D.S., 2006. Crystal Growth and Design. 6(10), 2301-2307
  • BURLEY, J.C., VAN DE STREEK, J. and STEPHENS, P.W., 2006. Acta Crystallographica. Section E: Structure Reports Online. 62(2), O797-O799
  • BURLEY, J.C., 2005. Acta Crystallographica. Section B: Structural Science. 61(6), 710-716
  • BURLEY, J.C. and PRIOR, T.J., 2005. mu(2)-Aqua-bis(mu(2)-trifluoroaceto-k(2)O,O ')bis[bis-(pyridine-kN)(trifluoroacetato-kO) cobalt(II)] Acta Crystallographica. Section E: Structure Reports Online. 61(7), M1422-M1424
  • ALVAREZ, CARMEN SORIA, BOSS, SALLY R, BURLEY, JONATHAN C, HUMPHRY, SIMON M, LAYFIELD, RICHARD A, KOWENICKI, RICHARD A, MCPARTLIN, MARY, RAWSON, JEREMY M, WHEATLEY, ANDREW E H, WOOD, PAUL T and WRIGHT, DO, 2004. Dalton transactions (Cambridge, England : 2003). 3481-7
  • BURLEY, J.C., MITCHELL, J.F. and SHORT, S., 2004. Physical Review B: Condensed Matter. 69(5),
  • BATTLE, P.D., BURLEY, J.C., GALLON, D.J., GREY, C.P. and SLOAN, J., 2004. Journal of Solid State Chemistry. 177(1), 119-125
  • BURLEY, J.C., BATTLE, P.D., JORDAN, N.A., SLOAN, J. and WEILL, F., 2003. Journal of Solid State Chemistry. 174(1), 96-103
  • ALEXANDER, A., BATTLE, P.D., BURLEY, J.C., GALLON, D.J. and GREY, C.P., 2003. Journal of Materials Chemistry. 13(10), 2612-2616
  • SCHMIDT, H., GRAY, K. E., HINKS, D. G., ZASADZINSKI, J. F., AVDEEV, M., JORGENSEN, J. D. and BURLEY, J. C., 2003. PHYSICAL REVIEW -SERIES B-. VOL 68(PART 6), 060508(R)
  • BURLEY, J.C., MITCHELL, J.F., SHORT, S., MILLER D. and TANG, Y., 2003. Journal of Solid State Chemistry. 170(2), 339-350
  • JORGENSEN, J. D., AVDEEV, M., HINKS, D. G., BURLEY, J. C. and SHORT, S., 2003. PHYSICAL REVIEW -SERIES B-. VOL 68(PART 21), 214517
  • MITCHELL, J. F., BURLEY, J. and SHORT, S., 2003. JOURNAL OF APPLIED PHYSICS. VOL 93(PART 10), 7364-7366
  • GALLON, D. J., BATTLE, P. D., BLUNDELL, S. J., BURLEY, J. C., COLDEA, A. I., CUSSEN, E. J., ROSSEINSKY, M. J. and STEER, C., 2002. Chemistry of Materials. VOL 14(PART 9), 3976-3983
  • BURLEY, J. C., BATTLE, P. D., GALLON, D. J., SLOAN, J., GREY, C. P. and ROSSEINSKY, M. J., 2002. JOURNAL- AMERICAN CHEMICAL SOCIETY. VOL 124(PART 4), 620-628
  • BURLEY, J. C., BATTLE, P. D., GASKELL, P. J. and ROSSEINSKY, M. J., 2002. JOURNAL OF SOLID STATE CHEMISTRY. VOL 168(PART 1), 202-207
  • CUSSEN, E. J., ROSSEINSKY, M. J., BATTLE, P. D., BURLEY, J. C., SPRING, L. E., VENTE, J. F., BLUNDELL, S. J., COLDEA, A. I. and SINGLETON, J., 2001. Journal of the American Chemical Society. VOL 123(PART 6), 1111-1122
  • BATTLE, P. D., BURLEY, J. C., CUSSEN, E. J., HARDY, G. C., HAYWARD, M. A., NOAILLES, L. D. and ROSSEINSKY, M. J., 1999. Chemical Communications. NUMBER 19, 1977-1978
  • BATTLE, P. D., BURLEY, J. C., CUSSEN, E. J., DARRIET, J. and WEILL, F., 1999. Journal of Materials Chemistry. VOL 9(NUMBER 2), 479-484
  • BATTLE, P.D., BLAKE, G.R., BURLEY, J.C., CUSSEN, E.J., SLOAN, J., VENTE, J.F., DARRIET, J. and WEILL, F., 1998. Commensurate and incommensurate oxide structures related to 2H perovskite In: Materials Research Symposium Proceedings. 45-51
  • WU J., LYNN J.W., GLINKA C.J., BURLEY J.C., ZHENG H., MITCHELL J.F. and LEIGHTON C., Physical Review Letters. 94, 037201

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