糖心原创

School of Pharmacy

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Ingrid Dreveny

Associate Professor, Faculty of Science

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Biography

I received my training as a chemist at the University of Graz. As a Masters student at the University Louis Pasteur, Strasbourg, I studied the folding and structure of synthetic peptides. This work sparked my interest and fascination for protein structure from which I pursued a Ph.D. in protein crystallography under the supervision of Christoph Kratky, working on the structure and mechanism of an unusual flavoprotein that has wide-ranging applications in industrial biocatalysis.

During my postdoctoral years at Imperial College London in the laboratory of Paul Freemont and Xiaodong Zhang I uncovered how the multi-functional molecular machine, the AAA ATPase p97, that has been associated with neurodegenerative diseases and cancer, recognizes adaptor proteins. After a brief period as research fellow in the School of Pharmacy, 糖心原创, I was appointed lecturer in protein crystallography.

Research Summary

I am interested in how macromolecular structure determines function and can help explain cellular events. My main area of expertise is macromolecular X-ray crystallography, which I combine with other… read more

Recent Publications

  • SANCHEZ-BAILON, MARIA PILAR, CHOI, SOO-YOUN, DUFFICY, ELIZABETH R., SHARMA, KARAN, MCNEE, GAVIN S., GUNNELL, EMMA, CHIANG, KELLY, SAHAY, DEBASHISH, MASLEN, SARAH, STEWART, GRANT S., SKEHEL, J. MARK, DREVENY, INGRID and DAVIES, CLARE C., 2021. NATURE COMMUNICATIONS. 12(1),
  • OLIVA, MARIA LUIZA VILELA, DREVENY, INGRID and EMSLEY, JONAS, 2020. JOURNAL OF BIOLOGICAL CHEMISTRY. 295(45), 15208-15209
  • KAIRA, BUBACARR G., SLATER, ALEXANDRE, MCCRAE, KEITH R., DREVENY, INGRID, SUMYA, UMMAY, MUTCH, NICOLA J., SEARLE, MARK and EMSLEY, JONAS, 2020. BLOOD. 136(14), 1685-1697
  • GUNNELL, EMMA A., AL-NOORI, ALAA, MUHSEN, USAMA, DAVIES, CLARE C., DOWDEN, JAMES and DREVENY, INGRID, 2020. BIOCHEMICAL JOURNAL. 477(4), 787-800

Current Research

I am interested in how macromolecular structure determines function and can help explain cellular events. My main area of expertise is macromolecular X-ray crystallography, which I combine with other biophysical and biochemical techniques. My research is aimed at:

  • Establishing protein structure - function relationships
  • Characterising protein-protein and protein-ligand interactions
  • Uncovering the molecular basis of human diseases

Current research topics include:

  • Structure and function of proteases in the ubiquitin pathway
  • Molecular mechanism of enzymes in posttranslational modification pathways
  • Protein complexes in ciliary trafficking
  • Enzymes for pharmaceutical applications

For further details please visit the Structural Biology group website.

Memberships of Committees & Professional Bodies

Biochemical Society; British Crystallographic Association

  • SANCHEZ-BAILON, MARIA PILAR, CHOI, SOO-YOUN, DUFFICY, ELIZABETH R., SHARMA, KARAN, MCNEE, GAVIN S., GUNNELL, EMMA, CHIANG, KELLY, SAHAY, DEBASHISH, MASLEN, SARAH, STEWART, GRANT S., SKEHEL, J. MARK, DREVENY, INGRID and DAVIES, CLARE C., 2021. NATURE COMMUNICATIONS. 12(1),
  • OLIVA, MARIA LUIZA VILELA, DREVENY, INGRID and EMSLEY, JONAS, 2020. JOURNAL OF BIOLOGICAL CHEMISTRY. 295(45), 15208-15209
  • KAIRA, BUBACARR G., SLATER, ALEXANDRE, MCCRAE, KEITH R., DREVENY, INGRID, SUMYA, UMMAY, MUTCH, NICOLA J., SEARLE, MARK and EMSLEY, JONAS, 2020. BLOOD. 136(14), 1685-1697
  • GUNNELL, EMMA A., AL-NOORI, ALAA, MUHSEN, USAMA, DAVIES, CLARE C., DOWDEN, JAMES and DREVENY, INGRID, 2020. BIOCHEMICAL JOURNAL. 477(4), 787-800
  • LI C, VOOS KM, PATHAK M, HALL G, MCCRAE KR, DREVENY I, LI R and EMSLEY J, 2019. Journal of thrombosis and haemostasis : JTH. (In Press.)
  • PADROSA, DAVID ROURA, ALAUX, RAPHAEL, SMITH, PHILLIP, DREVENY, INGRID, LOPEZ-GALLEGO, FERNANDO and PARADISI, FRANCESCA, 2019. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 7,
  • PATHAK, MONIKA, MANNA, ROSA, LI, CHAN, KAIRA, BUBACARR G., HAMAD, BADRALDIN KAREEM, BELVISO, BENNY DANILO, BONTURI, CAMILA R., DREVENY, INGRID, FISCHER, PETER M., DEKKER, LODEWIJK V., VILELA OLIVA, MARIA LUIZA and EMSLEY, JONAS, 2019. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 75, 578-591
  • RIEGLER-BERKET L, LEITMEIER A, ASCHAUER P, DREVENY I and OBERER M, 2018. Biochimica et biophysica acta. 1863(7), 679-687
  • WARD SJ, GRATTON HE, INDRAYUDHA P, MICHAVILA C, MUKHOPADHYAY R, MAURER SK, CAULTON SG, EMSLEY J and DREVENY I, 2018. The Journal of biological chemistry. 293(45), 17362-17374
  • SPILIOTOPOULOS A, BLOKPOEL FERRERAS L, DENSHAM RM, CAULTON SG, MADDISON BC, MORRIS JR, DIXON JE, GOUGH KC and DREVENY I, 2018. The Journal of biological chemistry. 294(2), 424-436
  • DREES SL, LI C, PRASETYA F, SALEEM M, DREVENY I, WILLIAMS P, HENNECKE U, EMSLEY J and FETZNER S, 2016. J Biol Chem. 291(13), 6610-24
  • PATHAK M, WILMANN P, AWFORD J, LI C, HAMAD BK, FISCHER PM, DREVENY I, DEKKER LV and EMSLEY J, 2015. Journal of Thrombosis and Haemostasis. 13(4), 580-591
  • SPILIOTOPOULOS A, OWEN JP, MADDISON BC, DREVENY I, REES HC and GOUGH KC, 2015. Journal of immunological methods. 420, 50-5
  • DREVENY, I., DEEVES, S.E., FULTON, J., YUE, B., MESSMER, M., BHATTACHARYA, A., COLLINS, H.M. and HEERY, D.M., 2014. Nucleic Acids Research. 42(2), 822-835
  • DEMPSTER S, HARPER S, MOSES JE and DREVENY I, 2014. Acta crystallographica. Section D, Biological crystallography. 70(Pt 5), 1484-90
  • HARPER S, GRATTON HE, CORNACIU I, OBERER M, SCOTT DJ, EMSLEY J and DREVENY I, 2014. Biochemistry. 53(18), 2966-78
  • PATHAK, M., WONG, S.S., DREVENY, I. and EMSLEY, J., 2013. Thrombosis and Haemostasis. 110(3), 423-433
  • RENGACHARI S, ASCHAUER P, SCHITTMAYER M, MAYER N, GRUBER K, BREINBAUER R, BIRNER-GRUENBERGER R, DREVENY I and OBERER M, 2013. The Journal of Biological Chemistry. 288(43), 31093-104
  • RENGACHARI, S., BEZERRA, G.A., RIEGLER-BERKET, L., GRUBER, C.C., STURM, C., TASCHLER, U., BOESZOERMENYI, A., DREVENY, I., ZIMMERMANN, R., GRUBER, K. and OBERER, M., 2012. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1821(7), 1012-1021
  • HARPER, S., BESONG, T.M.D., EMSLEY, J., SCOTT, D.J. and DREVENY, I., 2011. Biochemistry. 50(37), 7995-8004
  • DREVENY, I., ANDRYUSHKOVA, A.S., GLIEDER, A., GRUBER, K. and KRATKY, C., 2009. Biochemistry. 48(15), 3370-3377
  • BEURON, FABIENNE, DREVENY, INGRID, YUAN, XUEMEI, PYE, VALERIE E, MCKEOWN, CIARAN, BRIGGS, LOUISE C, CLIFF, MATTHEW J, KANEKO, YAYOI, WALLIS, RUSSELL, ISAACSON, RIVKA L, LADBURY, JOHN E and MATTHEWS, STEV, 2006. EMBO Journal. 25(9), 1967-76
  • UCHIYAMA, KEIJI, TOTSUKAWA, GO, PUHKA, MAIJA, KANEKO, YAYOI, JOKITALO, EIJA, DREVENY, INGRID, BEURON, FABIENNE, ZHANG, XIAODONG, FREEMONT, PAUL and KONDO, HISAO, 2006. Developmental Cell. 11(6), 803-16
  • PYE, VALERIE E, DREVENY, INGRID, BRIGGS, LOUISE C, SANDS, CAROLINE, BEURON, FABIENNE, ZHANG, XIAODONG and FREEMONT, PAUL S, 2006. Journal of Structural Biology. 156(1), 12-28
  • DREVENY, INGRID, KONDO, HISAO, UCHIYAMA, KEIJI, SHAW, ANTHONY, ZHANG, XIAODONG and FREEMONT, PAUL S, 2004. EMBO Journal. 23(5), 1030-9
  • YUAN, XUEMEI, SIMPSON, PETER, KONDO, HISAO, MCKEOWN, CIARAN, DREVENY, INGRID, ZHANG, XIAODONG, FREEMONT, PAUL S and MATTHEWS, STEPHEN, 2004. Journal of Biomolecular NMR. 28(3), 309-10
  • DREVENY, I, PYE, V E, BEURON, F, BRIGGS, L C, ISAACSON, R L, MATTHEWS, S J, MCKEOWN, C, YUAN, X, ZHANG, X and FREEMONT, P S, 2004. p97 and close encounters of every kind: a brief review. Biochemical Society Transactions. 32(Pt 5), 715-20
  • YUAN, XUEMEI, SIMPSON, PETER, MCKEOWN, CIARAN, KONDO, HISAO, UCHIYAMA, KEIJI, WALLIS, RUSSELL, DREVENY, INGRID, KEETCH, CATHERINE, ZHANG, XIAODONG, ROBINSON, CAROL, FREEMONT, PAUL and MATTHEWS, STEPHEN, 2004. EMBO Journal. 23(7), 1463-73
  • GLIEDER, ANTON, WEIS, ROLAND, SKRANC, WOLFGANG, POECHLAUER, PETER, DREVENY, INGRID, MAJER, SANDRA, WUBBOLTS, MARCEL, SCHWAB, HELMUT and GRUBER, KARL, 2003. Angewandte Chemie International Edition. 42(39), 4815-8
  • DREVENY, INGRID, KRATKY, CHRISTOPH and GRUBER, KARL, 2002. Protein Science. 11(2), 292-300
  • DREVENY, I, GRUBER, K, GLIEDER, A, THOMPSON, A and KRATKY, C, 2001. Structure. 9(9), 803-15

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