糖心原创

School of Pharmacy

Image of Giuseppe Mantovani

Giuseppe Mantovani

Associate Professor in Biomedical Polymers, Director of PGR Studies, Faculty of Science

Contact

Biography

I gained my degree in Industrial Chemistry at the University of Bologna (Italy) in 1998. This included a 12 months research project in organic synthetic methodologies working at the sulphur-mediated total synthesis of enantiopure conduritols starting from reduced sugars, in Prof. V. Cere's group.In Nov 2002 I was awarded my PhD in Chemistry (Corso di Perfezionamento in Scienze degli Idrocarburi) from the Scuola Normale Superiore of Pisa (Italy) working on the design and synthesis of novel transition-metal catalysts based on iminopyridine ligands for the olygomerisation of ethylene to alpha-olefins (research sponsored by ENI spa) in Dr. C. Bianchini's group at the ICCOM-CNR institute in Florence.Shortly afterwards I joined the group of Prof. D. M. Haddleton at the University of Warwick as a post-doctoral research assistant. In the 2003-2005 period I held a Marie Curie Post-doctoral Fellowship awarded by the European Commission.In Warwick I've been involved in a number of different projects mainly focused on the use of controlled radical polymerisation techniques (mainly transition metal-mediated living radical polymerisation, TMM-LRP, often termed ATRP) for:

  • Design and synthesis of novel protein biohybrid materials obtained by site-specific conjugation of precision alpha-functional polymers to appropriate (poly)peptides.
  • Design and synthesis of well-defined functional glycopolymers and study of their ability of recognising specific protein receptors (lectins)
  • Grafting of functional macromolecules to surfaces (glass, cellulose, crosslinked polystyrene beads) via "grafting to" and "grafting from" approaches.
  • 4) Combination of Cu(I)-catalysed Living Radical Polymerisation (LRP) with other synthetic techniques (i.e. "click" chemistry).

In Jan 2009 I was appointed Lecturer in Lecturer in Biologics Delivery in the School of Pharmacy at Nottingham.

Past Research (Keywords)Gycomic and Bioresponsive Materials Science, Macromolecular and Bioconjugation Chemistry, Tandem Organometallic Catalysis, Total Synthesis.

Research Summary

The development of materials able to inform, interrogate, and instruct biological systems is emerging as one of the fastest growing and exciting fields in science. These information-rich materials… read more

Selected Publications

  • GENG, J., LINDQVIST, J., MANTOVANI, G. and HADDLETON, D.M., 2008. Angewandte Chemie International Edition. 47(22), 4180-4183
  • GENG, JIN, MANTOVANI, GIUSEPPE, TAO, LEI, NICOLAS, JULIEN, CHEN, GAOJIAN, WALLIS, RUSSELL, MITCHELL, DANIEL A, JOHNSON, BENJAMIN R G, EVANS, STEPHEN D and HADDLETON, DAVID M, 2007. Journal of the American Chemical Society. 129(49), 15156-63
  • TAO, LEI, MANTOVANI, GIUSEPPE, LECOLLEY, FRANCOIS and HADDLETON, DAVID M, 2004. Alpha-aldehyde terminally functional methacrylic polymers from living radical polymerization: application in protein conjugation "pegylation". Journal of the American Chemical Society. 126(41), 13220-1
  • LADMIRAL, VINCENT, MANTOVANI, GIUSEPPE, CLARKSON, GUY J, CAUET, SOLENE, IRWIN, JACOB L and HADDLETON, DAVID M, 2006. Synthesis of neoglycopolymers by a combination of "click chemistry" and living radical polymerization. Journal of the American Chemical Society. 128(14), 4823-30

Current Research

The development of materials able to inform, interrogate, and instruct biological systems is emerging as one of the fastest growing and exciting fields in science. These information-rich materials have been studied for a plethora of different applications which span to nanomedicine to the development of advanced diagnostics. It is very clear that progress in these fields relies on the development and understanding of these materials, as well as our ability to achieve very fine control over their preparation. My research lies at the interface of organic/macromolecular synthesis and materials/soft matter science with particular emphasis in the development of bioresponsive polymers, neoglycopolymer probes for lectin receptors recognition and polymer-(poly)peptide biohybrid materials. Precision polymer synthesis is often carried out by combining controlled radical polymerisation (CRP) techniques and orthogonal ('click') methodologies.

Selected Recent Publications

Mastrotto, F., A. F. Breen, G. Sicilia, S. Murdan, A. D. Johnstone, G. E. Marsh, C. Grainger-Boultby, N. A. Russell, C. Alexander, and G. Mantovani. 2016. 'One-pot RAFT and fast polymersomes assembly: a 'beeline' from monomers to drug-loaded nanovectors', Polymer Chemistry, 7: 6714-24.

Loczenski Rose, Vanessa, Saif Shubber, S. Sajeesh, Sebastian G. Spain, Sanyogitta Puri, Stephanie Allen, Dong-Ki Lee, G. Sebastiaan Winkler, and Giuseppe Mantovani. 2015. 'Phosphonium Polymethacrylates for Short Interfering RNA Delivery: Effect of Polymer and RNA Structural Parameters on Polyplex Assembly and Gene Knockdown', Biomacromolecules, 16: 3480-90.

Magennis, E. Peter, Francisco Fernandez-Trillo, Cheng Sui, Sebastian G. Spain, David J. Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer, and Cameron Alexander. 2014. 'Bacteria-instructed synthesis of polymers for self-selective microbial binding and labeling', Nat. Mater., 13: 748-55.

  • PETCH, JOSHUA E., GURNANI, PRATIK, YILMAZ, GOKHAN, MASTROTTO, FRANCESCA, ALEXANDER, CAMERON, HEEB, STEPHEN, CAMARA, MIGUEL and MANTOVANI, GIUSEPPE, 2021. ACS Applied Materials & Interfaces.
  • BRUNATO, S., MASTROTTO, F., BELLATO, F., GAROFALO, M., GOEDDENHENTICH, T., MANTOVANI, G., ALEXANDER, C., GROSS, S., SALMASO, S. and CALICETI, P., 2020. Macromolecular Bioscience. (In Press.)
  • ALEJANDRO NIETO-ORELLANA, MARCO DI ANTONIO, CLAUDIA CONTE, FRANCO H FALCONE, CYNTHIA BOSQUILLON, NICK CHILDERHOUSE, GIUSEPPE MANOTVANI and SNOW STOLNIK, 2017. Polymer Chemistry. 8, 2210-2220
  • ROSE, VANESSA LOCZENSKI, MASTROTTO, FRANCESCA and MANTOVANI, GIUSEPPE, 2017. POLYMER CHEMISTRY. 8(2), 353-360
  • MAGENNIS EP, FRANCINI N, MASTROTTO F, CATANIA R, REDHEAD M, FERNANDEZ-TRILLO F, BRADSHAW D, CHURCHLEY D, WINZER K, ALEXANDER C and MANTOVANI G, 2017. PloS one. 12(7), e0180087
  • BRAZZALE, C., MASTROTTO, F., MOODY, P., WATSON, P. D., BALASSO, A., MALFANTI, A., MANTOVANI, G., CALICETI, P., ALEXANDER, C., JONES, A. T. and SALMASO, S., 2017. Nanoscale. 9, 11137-11147
  • MASTROTTO, F., BREEN, A. F., SICILIA, G., MURDAN, S., JOHNSTONE, A. D., MARSH, G. E., GRAINGER-BOULTBY, C., RUSSELL, N. A., ALEXANDER, C. and MANTOVANI, G., 2016. POLYMER CHEMISTRY. 7(44), 6714-6724
  • KAKDE, DEEPAK, POWELL, LEAGH G., BANSAL, KULDEEP K., HOWDLE, STEVE, IRVINE, DEREK, MANTOVANI, GIUSEPPE, MILLAR, GAVIN, DAILEY, LEA ANN, STONE, VICKI, JOHNSTON, HELINOR J. and ALEXANDER, CAMERON, 2016. JOURNAL OF CONTROLLED RELEASE. 244, 214-228
  • KAKDE, DEEPAK, TARESCO, VINCENZO, BANSAL, KULDEEP K., MAGENNIS, E. PETER, HOWDLE, STEVEN M., MANTOVANI, GIUSEPPE, IRVINE, DEREK J. and ALEXANDER, CAMERON, 2016. JOURNAL OF MATERIALS CHEMISTRY B. 4(44), 7119-7129
  • TARESCO, VINCENZO, SUKSIRIWORAPONG, JIRAPHONG, CREASEY, RHIANNON, BURLEY, JONATHAN C., MANTOVANI, GIUSEPPE, ALEXANDER, CAMERON, TREACHER, KEVIN, BOOTH, JONATHAN and GARNETT, MARTIN C., 2016. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY. 54(20), 3267-3278
  • BANSAL, K. K., KAKDE, D., PURDIE, L., IRVINE, D. J., HOWDLE, S. M., MANTOVANI, G. and ALEXANDER, C., 2015. Polymer Chemistry. 6(40), 7196-7210
  • LOCZENSKI ROSE V, SHUBBER S, SAJEESH S, SPAIN SG, PURI S, ALLEN S, LEE DK, WINKLER GS and MANTOVANI G, 2015. Biomacromolecules. 16(11), 3480-90
  • GALLON E, MATINI T, SASSO L, MANTOVANI G, ARMI脩AN DE BENITO A, SANCHIS J, CALICETI P, ALEXANDER C, VICENT MJ and SALMASO S, 2015. Biomacromolecules. 16(7), 1924-37
  • FRANCINI, NORA, PURDIE, LAURA, ALEXANDER, CAMERON, MANTOVANI, GIUSEPPE and SPAIN, SEBASTIAN G., 2015. MACROMOLECULES. 48(9), 2857-2863
  • MAGENNIS EP, FERNANDEZ-TRILLO F, SUI C, SPAIN SG, BRADSHAW DJ, CHURCHLEY D, MANTOVANI G, WINZER K and ALEXANDER C, 2014. Nature Materials. 13, 748-755
  • MATINI, TERESA, FRANCINI, NORA, BATTOCCHIO, ANNA, SPAIN, SEBASTIAN G., MANTOVANI, GIUSEPPE, VICENT, MARIA J., SANCHIS, JOAQUIN, GALLON, ELENA, MASTROTTO, FRANCESCA, SALMASO, STEFANO, CALICETI, PAOLO and ALEXANDER, CAMERON, 2014. POLYMER CHEMISTRY. 5(5), 1626-1636
  • MASTROTTO, FRANCESCA, SALMASO, STEFANO, ALEXANDER, CAMERON, MANTOVANI, GIUSEPPE and CALICETI, PAOLO, 2013. JOURNAL OF MATERIALS CHEMISTRY B. 1(39), 5335-5346
  • MASTROTTO, FRANCESCA, SALMASO, STEFANO, LEE, YI LIN, ALEXANDER, CAMERON, CALICETI, PAOLO and MANTOVANI, GIUSEPPE, 2013. POLYMER CHEMISTRY. 4(16), 4375-4385
  • ROSE, VANESSA LOCZENSKI, WINKLER, G. SEBASTIAAN, ALLEN, STEPHANIE, PURI, SANYOGITTA and MANTOVANI, GIUSEPPE, 2013. EUROPEAN POLYMER JOURNAL. 49(10), 2861-2883
  • REDHEAD, M., MANTOVANI, G., NAWAZ, S., CARBONE, P., GORECKI, D.C., ALEXANDER, C. and BOSQUILLON, C., 2012. Pharmaceutical Research. 29(7), 1908-1918
  • JONES, M.W., MANTOVANI, G., BLINDAUER, C.A., RYAN, S.M., WANG, X., BRAYDEN, D.J. and HADDLETON, D.M., 2012. Journal of the American Chemical Society. 134(17), 7406-7413
  • NAWAZ, S., REDHEAD, M., MANTOVANI, G., ALEXANDER, C., BOSQUILLON, C. and CARBONE, P., 2012. Soft Matter. 8(25), 6744-6754
  • MASTROTTO, F., CALICETI, P., AMENDOLA, V., BERSANI, S., MAGNUSSON, J.P., MENEGHETTI, M., MANTOVANI, G., ALEXANDER, C. and SALMASO, S., 2011. Chemical Communications. 47(35), 9846-9848
  • JONES, MATHEW W., GIBSON, MATTHEW I., MANTOVANI, GIUSEPPE and HADDLETON, DAVID M., 2011. POLYMER CHEMISTRY. 2(3), 572-574
  • CASETTARI, L., VLLASALIU, D., MANTOVANI, G., HOWDLE, S.M., STOLNIK, S. and ILLUM, L., 2010. Biomacromolecules. 11(11), 2854-2865
  • RAWLINSON, LEE-ANNE B, RYAN, SIN脡AD M, MANTOVANI, GIUSEPPE, SYRETT, JAY A, HADDLETON, DAVID M and BRAYDEN, DAVID J, 2010. Biomacromolecules. 11(2), 443-53
  • SYRETT, J.A., MANTOVANI, G., BARTON, W.R.S., PRICE, D. and HADDLETON, D.M., 2010. Polymer Chemistry. 1(1), 102-106
  • JONES, MATHEW W, MANTOVANI, GIUSEPPE, RYAN, SINEAD M, WANG, XUEXUAN, BRAYDEN, DAVID J and HADDLETON, DAVID M, 2009. Phosphine-mediated one-pot thiol-ene "click" approach to polymer-protein conjugates. Chemical communications (Cambridge, England). 5272-4
  • SAYERS, C., MANTOVANI, G., RYAN, S., RANDEV, R., KEIPER, O., LESZCZYSZYN, O., BLINDAUER, C., BRAYDEN, D. and HADDLETON, D., 2009. SOFT MATTER. VOL 5(NUMBER 16), 3038-3046
  • KEELY, S., RYAN, S.M., HADDLETON, D.M., LIMER, A., MANTOVANI, G., MURPHY, E.P., COLGAN, S.P. and BRAYDEN, D.J., 2009. Journal of Controlled Release. 135(1), 35-43
  • RYAN, SIN脡AD M, MANTOVANI, GIUSEPPE, WANG, XUEXUAN, HADDLETON, DAVID M and BRAYDEN, DAVID J, 2008. Expert opinion on drug delivery. 5(4), 371-83
  • GENG, J., LINDQVIST, J., MANTOVANI, G. and HADDLETON, D.M., 2008. Angewandte Chemie International Edition. 47(22), 4180-4183
  • CHEN, GAOJIAN, WRIGHT, PETER M, GENG, JIN, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2008. Tunable thermoresponsive water-dispersed multiwalled carbon nanotubes. Chemical communications (Cambridge, England). 1097-9
  • WRIGHT, PM, MANTOVANI, G and HADDLETON, DM, 2008. Journal Of Polymer Science Part A-Polymer Chemistry. 46(22), 7376-7385
  • LI, F, BERTONCELLO, P, CIANI, I, MANTOVANI, G and UNWIN, PR, 2008. Advanced Functional Materials. 18(11), 1685-1693
  • GENG, JIN, MANTOVANI, GIUSEPPE, TAO, LEI, NICOLAS, JULIEN, CHEN, GAOJIAN, WALLIS, RUSSELL, MITCHELL, DANIEL A, JOHNSON, BENJAMIN R G, EVANS, STEPHEN D and HADDLETON, DAVID M, 2007. Journal of the American Chemical Society. 129(49), 15156-63
  • TAO, LEI, GENG, JIN, CHEN, GAOJIAN, XU, YINGJIAN, LADMIRAL, VINCENT, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2007. Bioconjugation of biotinylated PAMAM dendrons to avidin. Chemical communications (Cambridge, England). 3441-3
  • LADMIRAL, VINCENT, MANTOVANI, GIUSEPPE, CLARKSON, GUY J, CAUET, SOLENE, IRWIN, JACOB L and HADDLETON, DAVID M, 2006. Synthesis of neoglycopolymers by a combination of "click chemistry" and living radical polymerization. Journal of the American Chemical Society. 128(14), 4823-30
  • TAO, LEI, CHEN, GAOJIAN, MANTOVANI, GIUSEPPE, YORK, STEVE and HADDLETON, DAVID M, 2006. Modification of multi-wall carbon nanotube surfaces with poly(amidoamine) dendrons: synthesis and metal templating. Chemical communications (Cambridge, England). 4949-51
  • NICOLAS, JULIEN, SAN MIGUEL, VERONICA, MANTOVANI, GIUSEPPE and HADDLETON, DAVID M, 2006. Fluorescently tagged polymer bioconjugates from protein derived macroinitiators. Chemical communications (Cambridge, England). 4697-9
  • MANTOVANI, GIUSEPPE, LECOLLEY, FRAN脟OIS, TAO, LEI, HADDLETON, DAVID M, CLERX, JOOST, CORNELISSEN, JEROEN J L M and VELONIA, KELLY, 2005. Design and synthesis of N-maleimido-functionalized hydrophilic polymers via copper-mediated living radical polymerization: a suitable alternative to PEGylation chemistry. Journal of the American Chemical Society. 127(9), 2966-73
  • MANTOVANI, GIUSEPPE, LADMIRAL, VINCENT, TAO, LEI and HADDLETON, DAVID M, 2005. One-pot tandem living radical polymerisation-Huisgens cycloaddition process ("click") catalysed by N-alkyl-2-pyridylmethanimine/Cu(I)Br complexes. Chemical communications (Cambridge, England). 2089-91
  • TAO, LEI, MANTOVANI, GIUSEPPE, LECOLLEY, FRANCOIS and HADDLETON, DAVID M, 2004. Alpha-aldehyde terminally functional methacrylic polymers from living radical polymerization: application in protein conjugation "pegylation". Journal of the American Chemical Society. 126(41), 13220-1
  • LECOLLEY, FRAN脟OIS, TAO, LEI, MANTOVANI, GIUSEPPE, DURKIN, IAN, LAUTRU, SYLVIE and HADDLETON, DAVID M, 2004. A new approach to bioconjugates for proteins and peptides ("pegylation") utilising living radical polymerisation. Chemical communications (Cambridge, England). 2026-7

School of Pharmacy

糖心原创
University Park
Nottingham, NG7 2RD

For all enquiries please visit: