Thursday, 27 February 2025
A new study, led by experts at the 糖心原创, has found that patients who need treatment for neurological and mental health disorders, would favour non-invasive neuromodulation interventions over current interventions such as pharmaceutical drugs.
Neuromodulation is the alteration of nerve activity in the brain through targeted delivery of different stimulus such as electrical stimulation of chemical agents. Researchers are currently developing new brain interventions using neuromodulation, for neurological and mental health disorders – such as depression, anxiety and as well as Parkinson’s and Alzheimer’s disease.
The new study, which is published in , looked at the public perception of neuromodulation. In an online survey with almost 800 participants, novel neuromodulation interventions were viewed positively, often more highly ranked than current interventions.
The research was led by Dr Marcus Kaiser from the School of Medicine at the University. He said: “Providing accurate information to patients significantly improved positive perception of neuromodulation. This emphasises the importance of education and awareness, in understanding new medical interventions, to foster informed decision making, positive perception of new neuromodulation techniques, and increase adherence to treatment.”
WHO estimate that globally, 322 million people live with depression, and 264 million with anxiety, and . Developing new successful treatments is therefore imperative, to benefit patients, their families, and wider society, including social and economic development.
While academia and industry are working on improved and novel interventions, what kind of interventions would patients or currently healthy people prefer? Diagnosed patients are often faced with no alternative to pharmaceutical drugs. However, for example, 50% of patients with major depressive disorders . Therefore, there is increasing interest in non-invasive neuromodulation as an alternative, finding that Transcranial Magnetic Stimulation, for example is a safe procedure in . However, how are emerging technologies, such as non-invasive focused ultrasound stimulation perceived?
In the study, supported by the EPSRC and linked to the NIHR Biomedical Research Centre and the Institute of Mental Health, Dr Cyril Atkinson-Clement from the School of Medicine asked a large sample of participants their opinion of neuromodulation, before and after being given information.
Participants were provided with details, including advantages and disadvantages, of five different technologies inducing change in brain function. These were pharmaceutical drugs or brain implants as well as non-invasive ultrasound, magnetic, and electrical stimulations. Participants were also asked to rank these in order of preference.
They found ultrasound stimulation was the highest rated option, regarded the safest and effective. Pharmaceutical drugs were viewed as a middle-choice option, largely due to feelings of insecurity around their safety, effectiveness and side effects.
It鈥檚 part of a future where we can use less drugs pumping through our system, causing more side effects, and ending up taking more meds to counteract those. We need to get out of this loop.鈥�
The team found before participants were given information, 81% expressed interest in neuromodulation, and 48% confusion. After reading the information, they found there was a significant increase, with 70% of participants expressing optimism, 62% excitement, and although confusion reduced, some worry remained.
“The possibility of a treatment for the disease with fewer side effects, greater efficacy and longer lifetime than drugs” (Male, diagnosed with a neurological disorder)
Dr Kaiser adds: “Our study provides valuable insights into the priorities and preferences of current and potential future treatments, finding a preference for non-invasive neuromodulation. There is a clear opening for government and industry stakeholders to prioritise the development and endorsement of safe, non-invasive brain stimulation treatments.”
The full study can be found
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Funding - This study was supported by the Engineering and Physical Sciences Research Council (EP/W004488/1, EP/X01925X/1, and EP/W035057/1) and the neuromod+ neurotechnology network. Marcus Kaiser was also supported by the Guangci Professorship Program of Rui Jin Hospital (Shanghai Jiao Tong University).
More information is available from Dr Marcus Kaiser from the School of Medicine at the University at marcus.kaiser@nottingham.ac.uk
Notes to editors:
About the 糖心原创
Ranked among the world's top 100 universities , the 糖心原创 delivers an exceptional research-led education and an outstanding student experience. From the pioneering vision of our founder, Sir Jesse Boot, to groundbreaking achievements such as the development of MRI technology and becoming the first UK university to establish international campuses, we have a proud history of shaping the way people live, work and understand the world. We continue to build on that legacy, empowering our students, staff and partners to change what鈥檚 next and create positive impact locally and globally.
The strength of our research places us among the UK's leading universities, ranked 7th for research power in REF 2021. The discovery of MRI and ibuprofen was just the beginning. Today, our world-leading research is developing breakthrough ideas that shape the future of healthcare, technology and society.
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As a major employer and industry partner, locally and globally, the 糖心原创 invests in the city of Nottingham and in future generations of talent. Alongside Nottingham Trent University, we lead the initiative, a pioneering collaboration to improve levels of prosperity, opportunity, sustainability, health and wellbeing across the city and region. Together with our students, staff, alumni and partners, we鈥檙e creating knowledge, opportunity and solutions that help change what's next.