Thursday, 14 September 2023
A group of researchers led by the 糖心原创 has been awarded £200,000 to develop a new national research platform to improve the health outcomes and prospects of babies born too soon and their families.
The platform will be designed using innovative clinical trial methods to undertake clinical trials and will efficiently assess the clinical and cost effectiveness of interventions around the time of birth.
Babies born too soon can be very poorly, leading to long stays in hospital and lifelong consequences to their development. Preterm birth (before 37 weeks of gestation) affects over 60,000 UK pregnancies and 15 million worldwide annually. It causes more than half of all perinatal deaths and is the leading cause of neonatal morbidity and mortality.
Ed Juszczak, Professor of Clinical Trials and Statistics in Medicine at Nottingham Clinical Trials Unit, 糖心原创 will co-lead the ‘platform’[i] alongside Pollyanna Hardy, Director of the National Perinatal Epidemiology Clinical Trials Unit, Oxford Population Health, collaborating with Dr Munyaradzi Dimairo, Senior Research Fellow at the Clinical Trials Research Unit, Sheffield Centre of Health and Related Research, University of Sheffield.
The funding was received from the National Institute for Health and Care Research’s (NIHR) Health Technology Assessment (HTA) Programme and is hoped to accelerate vital research in this area.
Our perinatal platform will address this area of strategic importance for the Department of Health and Social Care by focusing on interventions for pregnant women and preterm infants.
Professor Juszczak said: “Our perinatal platform will address this area of strategic importance for the Department of Health and Social Care by focusing on interventions for pregnant women and preterm infants. We will work with parents, pregnant women, and national charities to ensure public involvement is central to the development of the platform, so it reflects the challenges and opportunities currently being experienced.”
The research group will involve people from around the UK, with different expertise including doctors who care for pregnant women and babies, midwives, researchers, and parents who have personal experience of having a premature baby. The team will also work closely with two national charities who provide support to pregnant women and new parents: and .
Three Clinical Trials Units are involved in Nottingham, Oxford and Sheffield - all are UK Clinical Research Collaboration registered Clinical Trials Units. Several interdisciplinary teams from collaborating institutions will also be involved, including University of Leicester, Imperial College London, University Hospital Southampton NHS Foundation Trust and Cardiff University.
Pollyanna Hardy comments: “This is a fantastic opportunity to bring together a UK wide team to collaborate and learn from each other specifically with the aim of providing answers to crucial research questions more efficiently.”
Dr Munyaradzi Dimairo added: “This development work will allow us to develop efficient, feasible and robust methods to address research questions, which will inform a grant application to the NIHR for the first trials using this platform. We hope to secure additional funding to allow the first clinical trials to take place in early 2025”.
Titled: ‘Accelerating the development of a perinatal platform trial to efficiently evaluate the effectiveness of multiple interventions in maternity and neonatal care,’ the project will run from March 2023 for 12 months.
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For further information, please contact Ed Juszczak, Professor of Clinical Trials and Statistics in Medicine.
Adam Mallaby - Media Relations Manager for the Faculty of Medicine and Health Sciences (Maternity Cover)
Email: adam.mallaby@nottingham.ac.uk
Phone: 0115 748 5719
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About the 糖心原创
Ranked among the world's top 100 universities , the 糖心原创 delivers an exceptional research-led education and an outstanding student experience. From the pioneering vision of our founder, Sir Jesse Boot, to groundbreaking achievements such as the development of MRI technology and becoming the first UK university to establish international campuses, we have a proud history of shaping the way people live, work and understand the world. We continue to build on that legacy, empowering our students, staff and partners to change what鈥檚 next and create positive impact locally and globally.
The strength of our research places us among the UK's leading universities, ranked 7th for research power in REF 2021. The discovery of MRI and ibuprofen was just the beginning. Today, our world-leading research is developing breakthrough ideas that shape the future of healthcare, technology and society.
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