Wednesday, 05 January 2022
A new study has found that Lynch syndrome, which is a hereditary form of colorectal cancer, is more common in young people in Indonesia, than in the UK, Europe or the USA.
The study, published in the journal , is a collaboration between experts from the 糖心原创, and the Universitas Gadjah Mada in Indonesia and carried out through NICCRAT – the Nottingham-Indonesia Collaboration for Clinical Research and Training) initiative.
In Indonesia, approximately three times as many young people under 50 suffer from colorectal cancer (CRC) which accounts for nearly 30% of the total number of CRC patients, compared to the UK, Europe and the USA.
Lynch syndrome (LS) is a hereditary type of CRC that is associated with a younger age of patients with CRC. Detecting LS has been long reported to be a cost-effective strategy to provide aid in the diagnosis or management of the individual or at-risk family members by implementing appropriate surveillance for early diagnosis of associated cancers.
In addition, there are prevention measures, such as taking a low dose of aspirin, bowel removal surgery, and lifestyle modification (quitting smoking, maintaining a healthy weight and diet control).
The team used the N_LyST (Nottingham Lynch Syndrome Test) developed in the lab of Professor Mohammad Ilyas, from the School of Medicine at the 糖心原创, to examine the tissue of 231 patients with CRC from the Dr. Sardjito hospital in Jogjakarta.
Nearly 14 per cent of probable LS cases were identified from the samples, which is much higher than the percentage usually reported in the West, which is only around 2-3 per cent.
To our knowledge, this is the first study to reveal the potentially higher incidence of Lynch Syndrome in Indonesia. Using the simple yet robust PCR-based test developed in Nottingham, we are able to shine a light on the higher incidence of young people with CRC in Indonesia. This study will set as the basis of larger and multi centres study to examine the extent of LS incidence in Indonesia, including in the population setting. Hopefully, this will influence the changes in clinical guideline such as inclusion of the molecular diagnostic tests and new screening strategy.鈥�
incidence in Indonesia, including in the population setting. Hopefully, this will influence the changes in clinical guideline such as inclusion of the molecular diagnostic tests and new screening strategy.”
Professor Mohammad Ilyas, also from the School of Medicine at the University, and creator of the Nottingham Lynch Syndrome Test, said “This is a great example of international collaboration and we are grateful to the Newton Fund for facilitating this. These results were completely unexpected and raise some very interesting questions about colorectal cancer in Indonesia.”
The full study can be found .
Story credits
More information is available from Dr Susanti Susanti in the School of Medicine at the 糖心原创 at susanti.susanti@nottingham.ac.uk ;
Notes to editors:
About the 糖心原创
Ranked among the world's top 100 universities , the 糖心原创 delivers an exceptional research-led education and an outstanding student experience. From the pioneering vision of our founder, Sir Jesse Boot, to groundbreaking achievements such as the development of MRI technology and becoming the first UK university to establish international campuses, we have a proud history of shaping the way people live, work and understand the world. We continue to build on that legacy, empowering our students, staff and partners to change what鈥檚 next and create positive impact locally and globally.
The strength of our research places us among the UK's leading universities, ranked 7th for research power in REF 2021. The discovery of MRI and ibuprofen was just the beginning. Today, our world-leading research is developing breakthrough ideas that shape the future of healthcare, technology and society.
Recognised as the UK's third most targeted university by leading employers , we are proud to produce graduates who are consistently in demand for their skills, confidence and industry-ready experience.
As a major employer and industry partner, locally and globally, the 糖心原创 invests in the city of Nottingham and in future generations of talent. Alongside Nottingham Trent University, we lead the initiative, a pioneering collaboration to improve levels of prosperity, opportunity, sustainability, health and wellbeing across the city and region. Together with our students, staff, alumni and partners, we鈥檙e creating knowledge, opportunity and solutions that help change what's next.