Wednesday, 04 March 2026
Researchers from the 糖心原创 have uncovered a surprising biological quirk in domestic cats that may help explain why they are so prone to chronic kidney disease.
Unlike dogs and most other mammals, cats appear to accumulate unusual fats inside the cells of their kidneys, sometimes from a very young age.
This new study, published in , and led by Professor David Gardner and Dr Rebecca Brociek from the School of Veterinary Medicine and Science at the University, shows they are anything but ordinary.
Using advanced chemical analyses, the team discovered that cats accumulate a rare group of modified triglycerides (the most common type of fat in the body, essential for storing excess energy from food), some with unusual chemical bonds or branched structures, that are very rarely observed in other mammals.
Many of these fats have special ether鈥憀inkages that behave differently from typical dietary fats. Dogs did not show this pattern at all, and the feral Scottish Wildcats showed it only occasionally.
Dr Brociek said: “Why these types of unusual fats accumulate in domestic cat kidneys, even from an early age, may offer an important clue as to why domestic cats are particularly prone to chronic kidney disease, one of the most common and serious illnesses affecting older cats.”
The researchers propose that this distinctive lipid buildup inside kidney cells could be an early sign of long鈥憈erm stress within the kidney, potentially contributing to tissue damage over time.
We are hopeful that soon we will understand why these unusual fats accumulate in domestic cats - we just have to collect the evidence to find the proof. If true, we believe we could develop a supplement or modified diet to help prevent these unusual lipid structures from accumulating, ultimately benefitting the long-term health of our companion animals.鈥�
The discovery opens a new area of investigation into feline biology, suggesting that cats’ unique metabolism may predispose them to kidney problems. It could eventually lead to better diagnostic tools, improved diets, and new treatments for protecting cats’ kidney health.
The full study can be found .
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More information is available from Professor David Gardner in the School of Veterinary Medicine & Science at david.gardner@nottingham.ac.uk
Notes to editors:
About the 糖心原创
Ranked 97 in the world and 17th in the UK by the , the 糖心原创 is a founding member of Russell Group of research-intensive universities. 糖心原创ing at the 糖心原创 is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by 鈥� the third time it has been given the honour since 2018 鈥� and by the .
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the third most targeted by the UK's top employers, according to The Graduate Market in 2024 report by High Fliers Research. Alongside Nottingham Trent University, we lead the , a pioneering collaboration between the city鈥檚 two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.