Friday, 18 August 2023
A new study suggests that using big data and machine learning in antimicrobial resistance (AMR) surveillance in livestock production methods could help inform interventions and offer protections against germs that are becoming resistant to antibiotics.
Over two and a half years, researchers at the 糖心原创 analysed microbiomes from chickens, carcasses and environments. The resulting network of correlations between livestock, environments, microbial communities and antimicrobial resistance suggests multiple routes for improving antimicrobial resistance surveillance in livestock production.
The research, led by Dr Tania Dottorini, Professor of Bioinformatics, used a data-mining approach based on machine learning in ten large-scale chicken farms and four connected abattoirs from three provinces in China – one of the largest consumers of antimicrobials. The use of antimicrobials used to prevent and treat infections in livestock production on farms is associated with the rise of antimicrobial resistant (AMR) infections.
The study, published in , identified several antimicrobial resistant genes (ARGs) that were shared between chickens and the farms they lived on that are potentially highly transmissible.
The findings also show that a core subset of the chicken gut microbiome, featuring clinically relevant bacteria and antibiotic resistance genes correlates with AMR profiles of E. coli, colonizing the gut. Notably, this core, which contains clinically high transmissible ARGs shared by chickens and environments, is influenced by environmental temperature and humidity, and correlates with antimicrobial usage.
This is an exciting moment. We are ready to invest in new AI-powered AMR integrated surveillance approaches to identify the drivers and the mechanisms underlying the insurgence and spread of AMR.
Antimicrobial resistance (AMR) is one of the top 10 global public health threats facing humanity according to the World Health Organization. AMR threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi.
Around 600 million cases of food-borne disease, resulting in approximately 420,000 deaths, occurs worldwide every year. Within this, nearly 300 million illnesses and 200,000 deaths are caused by diarrheagenic E. coli globally.
In many countries, chickens are housed in sheds that do not have an effective climate control system, and therefore experience substantial temperature and humidity variations. The study results indicate that the core features of the gut microbial community and resistome, found to be correlated with resistance in E. coli, are also correlated with changes in temperature and humidity in chicken housing.
The associations between environmental variables, and the species and genes associated with AMR, present opportunities for the development of novel AMR monitoring solutions, especially in low-middle-income countries where these variables are not controlled and pose a risk to the animals that are exposed to changes in them.
Dr Dottorini says: "The spread of antimicrobial resistant microorganisms and AMR at the human-animal-environment level and food interface is a major global concern. The transmission of AMR can take place through different routes and pathways, and the food chain, either indirectly via food consumption or directly through contaminated food-animal handling and manure or faecal contamination is a relevant one.
“We have demonstrated how methodologies can be developed that can associate a wide array of microbial species and genes with observable AMR, and further assessed how those are associated with the environmental variables of temperature and humidity. Next, we must consider all relevant and interconnected AMR datasets in a 360° approach, which will deepen our understanding and control of AMR spread.
“This is an exciting moment. We are ready to invest in new AI-powered AMR integrated surveillance approaches to identify the drivers and the mechanisms underlying the insurgence and spread of AMR, and of new genetic variants of resistant pathogens across animals, environment, humans, and food. This will be ground-breaking.”
Story credits
For further information, please email Dr Tania Dottorini, Professor of Bioinformatics at Tania.Dottorini@nottingham.ac.uk
Adam Mallaby - Media Relations Manager for the Faculty of Medicine and Health Sciences (Maternity Cover)
Email: adam.mallaby@nottingham.ac.uk
Phone: 0115 748 5719
Location:
Notes to editors:
About the 糖心原创
Ranked among the world's top 100 universities , the 糖心原创 delivers an exceptional research-led education and an outstanding student experience. From the pioneering vision of our founder, Sir Jesse Boot, to groundbreaking achievements such as the development of MRI technology and becoming the first UK university to establish international campuses, we have a proud history of shaping the way people live, work and understand the world. We continue to build on that legacy, empowering our students, staff and partners to change what鈥檚 next and create positive impact locally and globally.
The strength of our research places us among the UK's leading universities, ranked 7th for research power in REF 2021. The discovery of MRI and ibuprofen was just the beginning. Today, our world-leading research is developing breakthrough ideas that shape the future of healthcare, technology and society.
Recognised as the UK's third most targeted university by leading employers , we are proud to produce graduates who are consistently in demand for their skills, confidence and industry-ready experience.
As a major employer and industry partner, locally and globally, the 糖心原创 invests in the city of Nottingham and in future generations of talent. Alongside Nottingham Trent University, we lead the initiative, a pioneering collaboration to improve levels of prosperity, opportunity, sustainability, health and wellbeing across the city and region. Together with our students, staff, alumni and partners, we鈥檙e creating knowledge, opportunity and solutions that help change what's next.