Monday, 01 November 2021
The 糖心原创 Health Service, at Cripps Medical Centre on University Park, is recruiting for a study looking at Covid-19 vaccine schedules in young people.
Experts are looking to recruit fifty 12-16-year-olds to find out how well they respond to two different doses of Covid-19 vaccine, and will then compare three different vaccines at different doses.
The aim is to find out if giving two doses of different vaccines produces as good an immune response as giving two doses of the same vaccine, in young people.
The aim is to find out if giving two doses of different vaccines produces as good an immune response as giving two doses of the same vaccine, in young people.
The study (Com-COV3) is part of the University of Oxford-led Com-COV (Comparing Covid-19 Vaccine Schedule Combinations) programme, which is funded by the Vaccines Taskforce and National Institute for Health Research (NIHR), and run across four NIHR-supported sites by the National Immunisation Schedule Evaluation Consortium.
Participants will either receive two Covid-19 vaccine doses in the study, in which case their first dose will be the Pfizer Covid-19 vaccine. Alternatively, those who have already received their dose of Pfizer through the NHS can be enrolled at the time of their second dose.
All participants will be randomly allocated at the time of the second dose to receive either a full or one-third dose of the Pfizer-BioNTech vaccine, a full dose of the Novavax vaccine or a half dose of the Moderna vaccine.
Participants will not know which vaccine they have received until four weeks after the second vaccination.
Com-COV3 is part of our vital work into better understanding how the different vaccines available in the UK can be used to give the best and most effective immune response to Covid-19. We are still in the early stages of vaccinating young people, and this work is vital in ensuring the next stage of the vaccine roll out is successful.鈥�
Professor Matthew Snape, Associate Professor in Paediatrics and Vaccinology at the University of Oxford, is Chief Investigator on the trial. He said: ‘This study will provide vital information on the range of options for immunising teenagers against Covid-19 in the UK.
“As well as looking at the standard two full doses of the Pfizer vaccine, we will look at how well volunteers respond when their second dose of Pfizer is one third that of the first dose, or if different vaccines are used altogether, such as the vaccines manufactured by Moderna or Novavax. This will provide the JCVI with information crucial to informing their advice about immunising teenagers in the UK.”
Experts hope to report initial results by December – if the results are promising, regulators MHRA and JCVI would formally assess the safety and efficacy of any new vaccination process before advising whether it is rolled out to patients.
Volunteers will need to be recruited during the first two weeks of November. People interested in taking part can find more information and details on how to sign up .
Notes to editors:
About the 糖心原创
Ranked among the world's top 100 universities , the 糖心原创 delivers an exceptional research-led education and an outstanding student experience. From the pioneering vision of our founder, Sir Jesse Boot, to groundbreaking achievements such as the development of MRI technology and becoming the first UK university to establish international campuses, we have a proud history of shaping the way people live, work and understand the world. We continue to build on that legacy, empowering our students, staff and partners to change what鈥檚 next and create positive impact locally and globally.
The strength of our research places us among the UK's leading universities, ranked 7th for research power in REF 2021. The discovery of MRI and ibuprofen was just the beginning. Today, our world-leading research is developing breakthrough ideas that shape the future of healthcare, technology and society.
Recognised as the UK's third most targeted university by leading employers , we are proud to produce graduates who are consistently in demand for their skills, confidence and industry-ready experience.
As a major employer and industry partner, locally and globally, the 糖心原创 invests in the city of Nottingham and in future generations of talent. Alongside Nottingham Trent University, we lead the initiative, a pioneering collaboration to improve levels of prosperity, opportunity, sustainability, health and wellbeing across the city and region. Together with our students, staff, alumni and partners, we鈥檙e creating knowledge, opportunity and solutions that help change what's next.