ÌÇÐÄÔ­´´

Contact

• workAdvanced Health Research Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 846 6939
• yana.vinogradova@nottingham.ac.uk

Biography

Yana Vinogradova completed a Diploma in Applied Mathematics [MSc equivalent] at Moscow State University (MGU) and joined the Cardiology Research Centre at the Russian Academy of Medical Sciences in Moscow as a Research Fellow. After moving to the UK, she worked in the Division of Cardiology at the University of Leicester, and in the Centre for Health Service Studies (CHESS) and the Division of Health in the Community at the University of Warwick. She joined the ÌÇÐÄÔ­´´ as an expert in medical statistics in 2005. Working as a Research Fellow in the Division of Primary Care of the School of Medicine, she was awarded a PhD in Medicine by published works in 2017.

Expertise Summary

Medical statistics

Epidemiology of diseases

Drug safety studies

Large primary and secondary care databases

Teaching Summary

Yana has taught short courses on how to use statistical software in Epidemiology for Masters and PhD students.

Research Summary

Yana's research primarily involves the use of mathematical models and statistical methods to improve understanding of the dynamics and incidence of diseases, and of treatment outcomes. Her work at… read more

Selected Publications

• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2020. British Medical Journal. 371, m3873
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2019. British Medical Journal. 364, k4810
• VINOGRADOVA, Y., COUPLAND, C., HILL, T. and HIPPISLEY-COX, J., 2018. British Medical Journal. 362, k2505
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2016. Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. British Medical Journal. 353, i3305

• View all publications

• Statistical adviser to students and staff

Current Research

Yana's research primarily involves the use of mathematical models and statistical methods to improve understanding of the dynamics and incidence of diseases, and of treatment outcomes. Her work at Nottingham has largely been in the area of drug safety, focusing in particular on two aspects. The first is adherence to prescribed medications, because failure to use medicines like statins as prescribed may compromise their effectiveness. Identifying patient characteristics associated with various patterns of non-adherence is the aim of such studies. The second is identifying those drugs where prolonged exposure may be associated with increased risks of development of a serious or life-threatening condition or with generally increased mortality. Such observational studies, based on data gathered over long periods in real treatment environments, aim to clarify 'real world' outcomes among the general population, to identify slowly-developing problems such as cancers, which do not manifest themselves in the short term, and to highlight the relative safety or otherwise of different drugs - and, where possible, of different formulations of a particular drug type.

Yana is currently working on drug safety issues associated with hormone replacement therapy (HRT), used to overcome problems associated with menopause. A paper on the associations between venous thromboembolism risk and exposure to specific HRT treatments has been published and a companion study on the risks of breast cancer associated with HRT treatments is in progress.

Past Research

Yana facilitated a variety of studies as a research statistician. These included observational and trial studies in Moscow Cardiological Research Centre and Warwick University. Since joining Nottingham University, she has also worked on risk prediction modelling (QRisk) and observational studies run by the Injury Prevention group.

Future Research

Yana has developed special skills in the handling of very large data sets and has pioneered the use of multiple databases (specifically QResearch and CPRD) to facilitate more detailed research into drug types and formulations and improve the accuracy of risk estimates. Her aim is to build on what has been achieved at Nottingham to continue to deliver independently-researched drug safety information of use to patients, doctors and regulators. She also hopes to develop national and international links with researchers having similar interests. Yana also has many years of experience of medical statistics and epidemiology in many different environments and a wide interest in clinical and medical developments, so will always be seeking other areas where she might usefully contribute.

• IYEN, B., VINOGRADOVA, Y., AKYEA, R. K., WENG, S., QURESHI, N. and KAI, J., 2022. Journal of Endocrinological Investigation. Published Online: 13 January 2022,
• AKYEA, R.K., VINOGRADOVA, Y., QURESHI, N., PATEL, R.S., KONTOPANTELIS, E., NTAIOS, G., ASSELBERGS, F.W., KAI, J. and WENG, S.F., 2021. Stroke. 52(2), 396–405
• VINOGRADOVA, Y., DENING, T., HIPPISLEY-COX, J., TAYLOR, L., MOORE, M. and COUPLAND, C., 2021. Hormone replacement therapy and dementia risk: nested case-control studies using CPRD and QResearch East Midlands Research into Ageing Network (EMRAN) Discussion Paper Series. 38(26 February 2021),
• IYEN, B., WENG, S., VINOGRADOVA, Y., AKYEA, R.K., QURESHI, N. and KAI, J., 2021. BMC Public Health. 21(1), 576
• VINOGRADOVA, Y., DENING, T., HIPPISLEY-COX, J., TAYLOR, L., MOORE, M. and COUPLAND, C., 2021. British Medical Journal. 374, n2182
• PERSSON, M.S.M., HARMAN, K.E., VINOGRADOVA, Y., LANGAN, S.M., HIPPISLEY-COX, J., THOMAS, K.S. and GRAN, S., 2020. British Journal of Dermatology. Published Online First: 9 March 2020,
• PERSSON, M.S.M., HARMAN, K.E., VINOGRADOVA, Y., LANGAN, S.M., HIPPISLEY-COX, J., THOMAS, K.S. and GRAN, S., 2020. BMJ Open. 10(7), e035934
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2020. British Medical Journal. 371, m3873
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2019. British Medical Journal. 364, k4810
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2018. British Journal of General Practice. 68(supplement 1), bjgp18X696629
• VINOGRADOVA, Y., COUPLAND, C., HILL, T. and HIPPISLEY-COX, J., 2018. British Medical Journal. 362, k2505
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2018. British Medical Journal. 350, h2135
• LITTLE, I., VINOGRADOVA, Y., ORTON, E., KAI, J. and QURESHI, N., 2017. BMJ Open. 7(3), e012665
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2016. Discontinuation and restarting in patients on statin therapy: a cohort study using a primary care database. British Medical Journal. 353, i3305
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2015. British Medical Journal. 350, h2135
• VINOGRADOVA, Y., COUPLAND, C., BRINDLE, P. and HIPPISLEY-COX, J., 2015. BMJ Open. 5(10), e008701
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2015. British Medical Journal. 350, h3308
• COUPLAND, C., HILL, T., BRINDLE, P., VINOGRADOVA, Y. and HIPPISLEY-COX, J., 2015. In: Proceedings of the 44th annual scientific meeting, Society for Academic Primary Care, Oxford University, 8-10 July 2015.
• VINOGRADOVA, Y., LEWIS, N. and HAWKEY, C., 2015. Trends in the use of non-steroidal anti-inflammatory drugs and aspirin and the use of proton pump inhibitors for gastro-duodenal protection in the UK: a cross-sectional study using the CPRD database. (Poster Presentation, Abstract number: 0123) In: Proceedings of 44nd Annual Scientific Meeting of the Society for Academic Primary Care, 8-10 July 2015.
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2014. BMJ Open. 4(4), e004499
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. British Medical Journal. 346(7894), f114
• LYONS, R.A., KENDRICK, D., TOWNER, E.M. L., COUPLAND, C., HAYES, M., CHRISTIE, N., SLENEY, J., JONES, S. J., KIMBERLEE, R., RODGERS, S.E., TURNER, S., BRUSSONI, M., VINOGRADOVA, Y., SARVOTHAM, T. and MACEY, S., 2013. PLoS ONE. 8(4), e60158
• KENDRICK, D., VINOGRADOVA, Y., COUPLAND, C., MULVANEY, C.A, CHRISTIE, N., LYONS, R.A. and TOWNER, E.L., 2013. Injury Prevention. 19, 370-381
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. British Journal of Cancer. 109(3), 795-806
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. BMJ. 346, f1518
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2013. Primary Health Care Research and Development. 14(Supplement 1), 19
• VINOGRADOVA Y, COUPLAND C and HIPPISLEY-COX J, 2012. BMJ Open. 2(1), e000548
• KENDRICK, D., VINOGRADOVA, Y., COUPLAND, C., CHRISTIE, N., LYONS, R.A., TOWNER, E.L. and ON BEHALF OF THE UK BURDEN OF INJURIES STUDY GROUP,, 2012. British Journal of General Practice. 62, 76-77
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2012. Primary Health Care Research and Development. 13(Supplement 1), 47
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. Exposure to Cyclo-oxygenase-2 Inhibitors and risk of Cancer: nested case-control studies Journal of Epidemiology and Community Health. 65(Supplement 1), A44-A45
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. British Journal of General Practice. 61(592), e742-e748
• KULIKOV, Y.I., VINOGRADOVA, Y., MILES, A.W. and GIDDINS, G., 2011. Journal of Hand Surgery (European Volume). 36(3), 210-214
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. BMC Cancer. 11(September), 409
• VINOGRADOVA, Y., COUPLAND, C. and HIPPISLEY-COX, J., 2011. British Journal of Cancer. 105(3), 452-459
• BECK, C.R., MCKENZIE, B.C., HASHIM, A.B., HARRIS, R.C., ZANUZDANA, A., AGBOADO, G., ORTON, E., BÉCHARD-EVANS, L., MORGAN, G., STEVENSON, C., WESTON, R., MUKAIGAWARA, M., ENSTONE, J., AUGUSTINE, G., BUTT, M., KIM, S., PULESTON, R., DABKE, G., HOWARD, R., O'BOYLE, J., O'BRIEN, M., AHYOW, L., DENNESS, H., FARMER, S., FIGUREROA, J., FISHER, P., GREAVES, F., HAROON M, HAROON, S., HIRD, C., ISBA, R., ISHOLA, D.A., KERAC, M., PARISH, V., ROBERTS, J., ROSSER, J., THEAKER, S., WALLACE, D., WIGGLESWORTH, N., LINGARD, L., VINOGRADOVA, Y., HORIUCHI, H., PENALVER, J. and NGUYEN-VAN-TAM, J.S., 2011. PLoS One. 6(12), e29249
• AVERY, A.J., RODGERS, S., CANTRILL, J., ARMSTRONG, S., BOYD, M., CRESSWELL, K., EDEN, M., ELLIOTT, R., FRANKLIN, M., HIPPISLEY-COX, J., HOWARD, R., KENDRICK, D., MORRIS, C.J., MURRAY, S.A., PRESCOTT, R.J., PUTMAN, K., SWANWICK, G., TUERSLEY, L., TURNER, T., VINOGRADOVA, Y. and SHEIKH, A., 2010. The PINCER trial: A cluster randomised trail comparing the effectiveness of a Pharmacist led IT intervention with simple feedback in reducing rates of clinically important errors in medicines management in general practices (PS024). A Report to the Department of Health Patient Safety Research Portfolio. February 2010
• VINOGRADOVA, Y., COUPLAND, C., HIPPISLEY-COX, J., WHYTE, S. and PENNY, C., 2010. British Journal of Psychiatry. 197(4), 272-277
• VINOGRADOVA, Y., LEIGHTON, M., HIPPISLEY-COX, J. and HAWKEY, C.J., 2010. Continuing Undue Risks in UK Prescribing of Non-Steroidal Anti-Inflammatory Drugs In: Proceedings of Digestive Disease Week, 1-5 May 2010; New Orleans.
• VINOGRADOVA, Y., HIPPISLEY-COX, J., AVERY, A., KENDRICK, D., RODGERS, S., ARMSTRONG, S. and EDEN, M., 2010. Primary Health Care Research & Development. 11(Supplement 1), S44
• LEIGHTON, M., VINOGRAVADA, Y., SHONDE, A., ATHERTON, J.C., LOGAN, R.F.A., AVERY, A., KENDRICK, D., HIPPISLEY-COX, J. and HAWKEY, C.J., 2009. Diagnostic Precision of Primary Care Electronic Database for ÌÇÐÄÔ­´´ of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin Gut. 58(Supplement 1), A139-A139
• VINOGRAVADA, Y., LEIGHTON, M., AVERY, A., LOGAN, R.F.A., KENDRICK, D., ATHERTON, J.C., HIPPISLEY-COX, A.S.J. and HAWKEY, C.J., 2009. Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients Gut. 58(Supplement 1), A36-A36
• VINOGRADOVA, Y., LEIGHTON, M., AVERY, A., LOGAN, R.F., KENDRICK, D., ATHERTON, J.C., SHONDE, A., HIPPISLEY-COX, J, and HAWKEY, C.J., 2009. 408 Increased Aspirin Use and Upper Gastrointestinal Bleeding Rates in Socially Deprived Patients Gastroenterology. 136(5, Supplement 1), A-69
• LEIGHTON, M., VINOGRADOVA, Y., SHONDE, A., ATHERTON, J.C., LOGAN, R.F., AVERY, A., KENDRICK, D., HIPPISLEY-COX, J. and HAWKEY, C.J., 2009. T1973 Diagnostic Precision of Primary Care Electronic Database for ÌÇÐÄÔ­´´ of Gastrointestinal Bleeding and Its Ability to Detect the Influence of Aspirin Gastroenterology. 136(5, Supplement 1), A-612
• VINOGRADOVA, Y., HIPPISLEY-COX, J. and COUPLAND, C., 2009. British Journal of General Practice. 59(567), e329-e338
• HIPPISLEY-COX, J. and VINOGRADOVA, Y., 2009. Trends in consultation rates in General Practice 1995/1996 to 2008/2009: Analysis of the QResearch® database. Final Report to the NHS Information Centre and Department of Health Published by The NHS Information Centre for Health and Social Care, part of the Government Statistical Service, September 2009.
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J., MINHAS, R., SHEIKH, A. and BRINDLE, P., 2008. BMJ. 336(7659), 1475
• VINOGRADOVA, Y. and HIPPISLEY-COX, J., 2008. Patients at high risk of pneumonia: population case-control study (Oral Presentation, Abstract number: 1073) In: Proceedings of the Society for Academic Primary Care’s Annual Scientific Meeting, National University of Ireland, Galway, 9-11 July 2008.
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J. and BRINDLE, P., 2008. Heart. 94(1), 34-39
• HIPPISLEY-COX, J., COUPLAND, C., VINOGRADOVA, Y., ROBSON, J., MAY, M. and BRINDLE, P., 2007. BMJ : British Medical Journal. 335(7611), 136-141
• VINOGRADOVA, Y., HIPPISLEY-COX, J., COUPLAND, C. and LOGAN, R.F., 2007. Gastroenterology. 133(2), 393-402
• COUPLAND, CAROL, HARCOURT, SALLY, VINOGRADOVA, YANA, SMITH, GILLIAN, JOSEPH, CAROL, PRINGLE, MIKE and HIPPISLEY-COX, JULIA, 2007. Vaccine. 25(42), 7363-71
• HIPPISLEY-COX , J., PARKER,C,, COUPLAND, C. and VINOGRADOVA, Y., 2007. Heart. 93, 1256-1262
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and PARKER, C., 2007. Archives of General Psychiatry. 64(12), 1368-1376
• PARKER, C., HIPPISLEY-COX, J., COUPLAND, C. and VINOGRADOVA, Y., 2007. British Journal of General Practice. 57(538), 371-376
• COUPLAND, C.A.C., HARCOURT, S., VINOGRADOVA, Y., SMITH, G., JOSEPH, C., PRINGLE. M. and HIPPISLEY-COX, J., 2007. Inequalities in uptake of influenza vaccine by deprivation and risk group: time trends analysis. Journal of Epidemiology & Community Health. 61(Supplement 1), A40
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and HEAPS, M., 2007. Time Series Analysis for 2001-2006 for Selected Clinical Indicators from the Quality and Outcomes Framework. QRESEARCH research highlights. Leeds: The Information Centre The Information Centre.
• TIRUVOIPATI, R., VINOGRADOVA, Y., FAULKNER, G., SOSNOWSKI, A.W., FIRMIN, R.K. and PEEK, G.J., 2007. Predictors of outcome in patients with congenital diaphragmatic hernia requiring extracorporeal membrane oxygenation. Journal of Pediatric Surgery. 42(8), 1345-50
• HIPPISLEY-COX, J., PARKER, C., VINOGRADOVA, Y. and COUPLAND, C., 2006. Health outcomes for patients with serious mental health problems: second report to the Disability Rights Commission; February 2006 Nottingham: ÌÇÐÄÔ­´´.
• VINOGRADOVA, Y., HIPPISLEY-COX, J., COUPLAND, C. and PARKER, C., 2006. Risk of malignancy in patients with mental health problems (Parallel 037) In: Proceedings of the Society for Academic Primary Care, 35th Annual Scientific Meeting; The contribution of research and education to patient- centred primary care.
• GRIMSHAW, G., STANTON, A., BLACKBURN, C., ANDREWS, K., GRIMSHAW, C., VINOGRADOVA, Y. and ROBERTSON, W., 2006. Child Care Health and Development. 29(6), 457-464
• HIPPISLEY-COX, J., VINOGRADOVA, Y., COUPLAND, C. and PARKER, C., 2006. Risk of cancer in patients with mental health problems In: 35th NAPCRG Annual Meeting.
• SZCZEPURA, A, WESTMORELAND, D, VINOGRADOVA, Y, FOX, J and CLARK, M, 2006. Evaluation of molecular techniques in prediction and diagnosis of cytomegalovirus disease in immunocompromised patients. Health Technology Assessment. 10(10), 1-176
• TIRUVOIPATI,R., BALASUBRAMANIAN,S., VINOGRADOVA,Y., FAULKNER,G., SOSNOWSKI,A., FIRMIN,R. and PEEK,G., 2006. Outcome of patients with congenital diaphragmatic hernia requiring ECMO: can we predict? Critical Care. 10(Supplement 1), P27
• HIPPISLEY-COX,J., VINOGRADOVA,Y., COUPLAND,C. and PRINGLE,M., 2005. Nottingham: ÌÇÐÄÔ­´´.