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Winfried Amoaku

Clinical Assoc Prof & Reader in Ophthalmology & Visual Sciences, Faculty of Medicine & Health Sciences

Contact

  • workRoom B Floor Eye and ENT Centre, University Hospital, QMC
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 951 5151
  • fax0115 962 7765

Expertise Summary

My research complements my clinical practice: age-related macular degeneration (AMD) (the commonest cause of blindness in the western world). It focuses on the pathogenesis and treatments of AMD and other chronic eye diseases (clinical and laboratory). Current treatments are suboptimal. As the population ages the prevalence of AMD will increase. My research aims to improve disease outcome. There are no suitable animal or inv vitro models for AMD. My laboratory is the first to have cultured, in vitro, human inner choroidal endothelial cells (the site of the disease) for experiments into the disease. We are currently in the process of determining genomic differences between these cells and other endothelial cells in the eye and from other locations (eg HUVEC) in order to determine molecular targeting. Some of our work has been in collaboration with a laboratory in Kings' College, London who have expertise in microarrays and supporting validating technologies. AMD seems less common in the African. Genetic and environmental factors which contribute to these differences require elucidation. On going collaborations with Queen's University of Belfast, University of Iowa and Utah, The University of Ghana Medical School are looking at genetic differences between the African and Caucasians in the pathogenesis of AMD.

Research Summary

The effects of diabetes on proliferating human tenon's capsule fibroblast. To determine the proliferative potential of human tenon's fibroblasts in diabetics and compare that to normals Investigate… read more

Selected Publications

  • WEI, R, STEWART, EA and AMOAKU, WM, 2013. BMC Research Notes. 6(46),

Current Research

The effects of diabetes on proliferating human tenon's capsule fibroblast. To determine the proliferative potential of human tenon's fibroblasts in diabetics and compare that to normals Investigate the collagen and protein synthesis by tenon's fibroblasts in normals and diabetics. 糖心原创 of cytokine growth factor activity in the aqueous humour of diabetics and non-diabetics. To determine how different growth factors modify tenon's fibroblasts growth and synthetic capabilities in diabetics and normals.

My current research complements my clinical practice: age-related macular degeneration (AMD) (the commonest cause of blindness in the western world). It focuses on the pathogenesis and treatments of AMD and other chronic eye diseases (clinical and laboratory). Current treatments are suboptimal. As the population ages the prevalence of AMD will increase. My research aims to improve disease outcome. There are no suitable animal or inv vitro models for AMD. My laboratory is the first to have cultured, in vitro, human inner choroidal endothelial cells (the site of the disease) for experiments into the disease. We are currently in the process of determining genomic differences between these cells and other endothelial cells in the eye and from other locations (eg HUVEC) in order to determine molecular targeting. Some of our work has been in collaboration with a laboratory in Kings' College, London who have expertise in microarrays and supporting validating technologies. AMD seems less common in the African. Genetic and environmental factors which contribute to these differences require elucidation. On going collaborations with Queen's University of Belfast, University of Iowa and Utah, The University of Ghana Medical School are looking at genetic differences between the African and Caucasians in the pathogenesis of AMD. Non-infective intraocular inmflammations also continue to give clinical challenges to treatment. Finding safer treatments will be beneficial.

Past Research

The effects of ionising radiation on the eye. The effects of ionising radiation on corneal cells in vitro. This is to determine the relative importance of corneal epithelium, stroma and endothelium in the initiation and progress of radiation keratopathy and how to modify these changes. (This is in collaboration with Radiobiology/Oncology Departments of the City Hospital, Nottingham) The effects of ionising radiation on the vitreous body.

Future Research

The next steps would be find particular molecules which will selectively target particular endothelial cells in the eye. That way we should be able to ensure selectivity of action in particular diseases.

  • BUCHAN JC, AMOAKU W, BARNES B, CASSELS-BROWN A, CHANG BY, HARCOURT J, SHICKLE D, SPENCER AF, VERNON SA and MACEWEN C, 2018.
  • FULTON J, MAZUMDER B, WHITCHURCH JB, MONTEIRO CJ, COLLINS HM, CHAN CM, CLEMENTE MP, HERNANDEZ-QUILES M, STEWART EA, AMOAKU WM, MORAN PM, MONGAN NP, PERSSON JL, ALI S and HEERY DM, 2017. Cell death & disease. 8(3), e2677
  • BOXELL EM, AMOAKU WM and BRADLEY C, 2017. BMJ Open. 7(2), e012790
  • WILDE C, POOSTCHI A, MEHTA RL, MACNAB HK, HILLMAN JG, VERNON SA and AMOAKU WM, 2017. Eye (Lond). 31(7), 1042-1050
  • BUCHAN JC, AMOAKU W, BARNES B, CASSELS-BROWN A, CHANG BY, HARCOURT J, SHICKLE D, SPENCER AF, VERNON SA and MACEWEN C, 2017. Eye (Lond).. 31(11), 1519-1522
  • AMOAKU WM, 2017. 31(11), 1513-1514
  • HILL S, DENNICK R and AMOAKU WM, 2017. Int J Med Educ.. 8, 389-395
  • KELKAR AS, FOGLA R, KELKAR J, KOTHARI AA, MEHTA H and AMOAKU W, 2017. Indian J Ophthalmol. 65(12), 1450-1453
  • WILDE C, LAKSHMANAN A, PATEL M, MORALES MU, DHAR-MUNSHI S and AMOAKU WM, 2016. Eye (London, England). 30(6), 817-24
  • STEWART EA, SAKER S and AMOAKU WM, 2016. Experimental eye research. 151, 75-81
  • MEHTA H, M脺LLER S, EGAN CA, DEGLI ESPOSTI S, TUFAIL A, SIM DA, HOLZ FG, BROWNING AC, AMOAKU WM, CHARBEL ISSA P and GILLIES MC, 2016. The British journal of ophthalmology.
  • LINNARSSON D, ZUO L, CHUANG CC, LI G, GAO F, MEKJAVIC PJ, DUA H, AMOAKU W, MACDONALD IA, EIKEN O and MEKJAVIC IB, 2016. Journal of applied physiology (Bethesda, Md. : 1985). 121(1), 350-1
  • MORALES M, SAKER S, WILDE C, PELLIZZARI C, PALLIKARIS A, NOTAROBERTO N, RUBINSTEIN M, RUI C, LIMOLI P, SMOLEK MK and AMOAKU WM, 2016. Transl Vis Sci Technol. 5(6), 6
  • KELKAR AS, KELKAR JA, BARVE PM, MULAY A, SHARMA S and AMOAKU W, 2016. Post-clear corneal phacoemulsification endophthalmitis: profile and management outcomes at a tertiary eye care center in western India. J Ophthalmic Inflamm Infect. 6(1), 48
  • STEWART, ELIZABETH A., WEI, RUOXIN, BRANCH, MATTHEW J., SIDNEY, LAURA E. and AMOAKU, WINFRIED M., 2015. EXPERIMENTAL EYE RESEARCH. 138, 114-123
  • AMOAKU, W. M., CHAKRAVARTHY, U., GALE, R., GAVIN, M., GHANCHI, F., GIBSON, J., HARDING, S., JOHNSTON, R. L., KELLY, S., LOTERY, A., MAHMOOD, S., MENON, G., SIVAPRASAD, S., TALKS, J., TUFAIL, A. and YANG, Y., 2015. EYE. 29(6), 721-731
  • SIVAPRASAD, S., AMOAKU, W. M. and HYKIN, P., 2015. EYE. 29(12), 1633-1638
  • AMOAKU, W. M. K., SAKER, S. and STEWART, E. A., 2015. EYE. 29(9), 1115-1130
  • CASTILLO, MAYRET M., MOWATT, GRAHAM, ELDERS, ANDREW, LOIS, NOEMI, FRASER, CYNTHIA, HERNANDEZ, RODOLFO, AMOAKU, WINFRIED, BURR, JENNIFER M., LOTERY, ANDREW, RAMSAY, CRAIG R. and AZUARA-BLANCO, AUGUSTO, 2015. OPHTHALMOLOGY. 122(2), 399-406
  • SIVAPRASAD S, AMOAKU WM, HYKIN P and , 2015. Eye (London, England). 29(12), 1640
  • JAWAID I, HILL SC and AMOAKU WM, 2015. Eye (London, England). 30(2), 326
  • AMOAKU WM, CHAKRAVARTHY U, GALE R, GAVIN M, GHANCHI F, GIBSON J, HARDING S, JOHNSTON RL, KELLY SP, LOTERY A, MAHMOOD S, MENON G, SIVAPRASAD S, TALKS J, TUFAIL A and YANG Y, 2015. Eye (London, England). 29(10), 1397-8
  • WILDE C, PATEL M, LAKSHMANAN A, MORALES MA, DHAR-MUNSHI S and AMOAKU WM, 2015. European journal of ophthalmology. 26(2), 128-34
  • AMOAKU WM, SAKER S and STEWART EA, 2015. Eye (London, England). 29(9), 1115-30
  • AMOAKU WM, GALE RP, LOTERY AJ, MENON G, SIVAPRASAD S, PETRILLO J and QUINN J, 2015. PloS one. 10(6), e0128403
  • WILDE C, PATEL M, LAKSHMANAN A, AMANKWAH R, DHAR-MUNSHI S, AMOAKU W and , 2015. Eye (London, England). 29(5), 602-9; quiz 610
  • AMOAKU WM, CHAKRAVARTHY U, GALE R, GAVIN M, GHANCHI F, GIBSON J, HARDING S, JOHNSTON RL, KELLY SP, LOTERY A, MAHMOOD S, MENON G, SIVAPRASAD S, TALKS J, TUFAIL A and YANG Y, 2015. Eye (London, England). 29(6), 721-31
  • SAKER S, MORALES M, JHITTAY H, WEN Y and AMOAKU W, 2015. Documenta ophthalmologica. Advances in ophthalmology. 130(3), 231-40
  • MORALES MU, SAKER S and AMOAKU WM, 2015. BMJ case reports. 2015,
  • SAKER S, STEWART EA, BROWNING AC, ALLEN CL and AMOAKU WM, 2014. Experimental eye research. 121, 161-7
  • AMOAKU, W., CACKETT, P., TYAGI, A., MAHMOOD, U., NOSEK, J., MENNIE, G. and RUMNEY, N., 2014. EYE. 28(9), 1150-1150
  • TUFAIL, A., PATEL, P. J., SIVAPRASAD, S., AMOAKU, W., BROWNING, A. C., COLE, M., GALE, R., GEORGE, S., LOTERY, A. J., MAJID, M., MCKIBBIN, M., MENON, G., YANG, Y., ANDREWS, C., BRITTAIN, C. and OSBORNE, A., 2014. EYE. 28(3), 365-365
  • STEWART, E. A. and AMOAKU, W. M., 2014. ACTA OPHTHALMOLOGICA. 92,
  • CASTILLO MM, MOWATT G, ELDERS A, LOIS N, FRASER C, HERN脕NDEZ R, AMOAKU W, BURR JM, LOTERY A, RAMSAY CR and AZUARA-BLANCO A, 2014. Ophthalmology. 122(2), 399-406
  • MOWATT G, HERN脕NDEZ R, CASTILLO M, LOIS N, ELDERS A, FRASER C, AREMU O, AMOAKU W, BURR J, LOTERY A, RAMSAY C and AZUARA-BLANCO A, 2014. Health technology assessment (Winchester, England). 18(69), 1-254
  • CASTILLO MM, MOWATT G, LOIS N, ELDERS A, FRASER C, AMOAKU W, BURR JM, LOTERY AJ, RAMSAY CR and AZUARA-BLANCO A, 2014. Eye (London, England). 28(12), 1399-406
  • KELKAR A, GANDHI P, AMOAKU W, KELKAR J, KELKAR S, RAUT P and SHAH R, 2014. Case reports in ophthalmology. 5(2), 207-11
  • WEI, R, STEWART, EA and AMOAKU, WM, 2013. BMC Research Notes. 6(46),
  • TUFAIL A, PATEL PJ, SIVAPRASAD S, AMOAKU W, BROWNING A, COLE M, GALE R, GEORGE S, LOTERY A, MAJID M, MCKIBBIN M, MENON G, YANG Y, ANDREWS C, BRITTAIN C and OSBORNE A, 2013. Eye (London, England). 27(6), 742-6
  • TUFAIL A,, NARENDRAN N, PATEL PJ,, SIVAPRASAD S, AMOAKU W, BROWNING AC, OSOBA O, GALE R, GEORGE S, LOTERY AJ, MAJID M, MCKIBBIN M, MENON G, ANDREWS C, BRITTAIN C and OSBORNE A, 2013. Ophthalmology. (In Press.)
  • PALMER JM and AMOAKU WM, 2013. Eye.
  • BROWNING, A.C., HALLIGAN, E.P., STEWART, E.A., SWAN, D.C., DOVE, R., SAMARANAYAKE, G.J. and AMOAKU, W.M., 2012. British Journal of Ophthalmology. 96(1), 128-132
  • ALEXANDER P, MUSHTAQ F, OSMOND C and AMOAKU W, 2012. Eye (London, England). 26(5), 678-83
  • SHAH M and AMOAKU WMK, 2012. Acta ophthalmologica. 90(6), e491-3
  • AMOAKU W, BLAKENEY S, FREEMAN M, GALE R, JOHNSTON R, KELLY SP, MCLAUGHLAN B, SAHU D, VARMA D and ACTION ON AMD GROUP, 2012. Eye (London, England). 26 Suppl 1, S2-21
  • SHAH M and AMOAKU WMK, 2012. Eye (London, England). 26(9), 1194-8
  • STEWART EA, SAMARANAYAKE GJ, BROWNING AC, HOPKINSON A and AMOAKU WM, 2011. Experimental Eye Research. 93(5), 761-6
  • HOLZ, F.G., AMOAKU, W., DONATE, J., GUYMER, R.H., KELLNER, U., SCHLINGEMANN, R.O., WEICHSELBERGER, A. and STAURENGHI, G., 2011. Ophthalmology. 118(4), 663-671
  • GYASI ME, NSIIRE A, YAYEMAIN D, DEBRAH OA, ASAMANI D, GYAPONG J and AMOAKU WMK, 2010. Ophthalmic Epidemiology. 17(6), 343-8
  • MITCHELL, J., WOLFFSOHN, J., WOODCOCK, A., ANDERSON, S.J., FFYTCHE, T., RUBINSTEIN, M., AMOAKU, W. and BRADLEY, C., 2008. American Journal of Ophthalmology. 146(3), 447-454.e2
  • BROWNING, A.C., DUA, H.S. and AMOAKU, W.M., 2008. British Journal Of Ophthalmology. 92(7), 1003-1008
  • SHANMUGANATHAN, V. A., CASELY, E. M., RAJ, D., POWELL, R. J., JOSEPH, A., AMOAKU, W. M. and DUA, H. S., 2005. British Journal of Ophthalmology. VOL 89(NUMB 6), 666-669
  • BROWNING, A.C., ALIBHAI, A., MCINTOSH, R.S., ROTCHFORD, A.P., BHAN, A. and AMOAKU, W.M., 2005. Wound Repair and Regeneration. 13(3), 295-302
  • BROWNING, A. C., CHUNG, A. K., GHANCHI, F., HARDING, S. P., MUSADIQ, M., TALKS, S. J., YANG, Y. C. and AMOAKU, W. M., 2005. Ophthalmology: the Journal of the American Academy of Ophthalmology. 112(7), 1227-1231
  • BROWNING, A.C., GRAY, T. and AMOAKU, W.M., 2005. British Journal of Ophthalmology. 89(10), 1343-1347
  • GUPTA, R., BROWNING, A.C., WU, K., SOKAL, M. and AMOAKU, W.M., 2005. American Journal of Ophthalmology. 139(3), 561-562
  • HOSSAIN, PARWEZ, SEETHO, IAN W, BROWNING, ANDREW C and AMOAKU, WINFRIED M, 2005. BMJ. 330(7481), 30-3
  • GUPTA, R., BROWNING, A. C. and AMOAKU, W. M., 2005. Eye. VOL 19(NUMB 5), 592-593
  • MITCHELL, JAN, WOLFFSOHN, JAMES S, WOODCOCK, ALISON, ANDERSON, STEPHEN J, MCMILLAN, CAROLYN V, FFYTCHE, TIMOTHY, RUBINSTEIN, MARTIN, AMOAKU, WINFRIED and BRADLEY, CLARE, 2005. Health and Quality of Life Outcomes. 3, 25
  • NTIM-AMPONSAH, C. T., AMOAKU, W. M. K., EWUSI, R. K., IDIRISURIYA-KHAIR, R., NYATEPE-COO, E. and OFOSU-AMAAH, S., 2005. Eye. VOL 19(NUMB 5), 528-534
  • BROWNING, AC, AINSWORTH, G and AMOAKU, W, 2005. Verteporforin photodynamic therapy for peripapillary choroidal neovascularisation In: Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO 2005). -
  • BROWNING, ANDREW C, AMOAKU, WINFRIED M and DUA, HARMINDA S, 2004. Journal of The Royal Society of Medicine. 97(4), 166-9
  • NTIM-AMPONSAH, C T, AMOAKU, W M K, OFOSU-AMAAH, S, EWUSI, R K, IDIRISURIYA-KHAIR, R, NYATEPE-COO, E and ADU-DARKO, M, 2004. Eye. 18(5), 491-7
  • BROWNING, A C, AMOAKU, W M, VERNON, S A, MORGAN, J and THIRKILL, C E, 2004. Lancet. 363(9417), 1305
  • BROWNING, A. C., GUPTA, R., BARBER, C., LIM, C. S. and AMOAKU, W. M., 2003. Archives of Ophthalmology. VOL 121(NUMB 10), 1506-1507
  • BROWNING, ANDREW C, ALWITRY, AMAR, HAMILTON, ROBIN, ROTCHFORD, ALAN, BHAN, ARCHANA and AMOAKU, WINFRIED M, 2002. Journal of Cataract and Refractive Surgery. 28(9), 1601-6
  • REHMAN, SHAFIQ U, AMOAKU, WINFRIED M K, DORAN, ROBERT M L, MENAGE, MITCHEL J and MORRELL, ANDREW J, 2002. Randomized controlled clinical trial of beta irradiation as an adjunct to trabeculectomy in open-angle glaucoma. Ophthalmology: the Journal of the American Academy of Ophthalmology. 109(2), 302-6
  • BROWNING, A C, MENGHER, L S, GREGSON, R M and AMOAKU, W M, 2001. Archives of Disease in Childhood. 85(5), 401-3
  • Lancet. 389(10085), 2193-2203

School of Medicine

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Medical School
Nottingham, NG7 2UH

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