糖心原创

School of Medicine
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Tim Harrison

Professor and Honorary Consultant, Faculty of Medicine & Health Sciences

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Research Summary

We have explored the therapeutic benefit of increasing the dose of inhaled steroids to prevent the development of asthma exacerbations.

We are currently exploring the mechanisms for therapy resistant asthma and looking at new therapeutic options for these patients

Selected Publications

  • BATEMAN, ERIC D., BUHL, ROLAND, O'BYRNE, PAUL M., HUMBERT, MARC, REDDEL, HELEN K., SEARS, MALCOLM R., JENKINS, CHRISTINE, HARRISON, TIM W., QUIRCE, SANTIAGO, PETERSON, STEFAN and ERIKSSON, GOERAN, 2015. Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 135(6), 1457-1464

Past Research

We have explored the absorption and systemic effects of inhaled steroids in asthma and COPD and explored the effect of lung function.

Future Research

We are now able to evaluate airway inflammation using multi-flow exhaled NO meters, induced sputum and various airway challenges. research exploring asthma phenotypes and the development of the new treatments are of interest.

Airway phenotyping includes human airway smooth muscle and epithelial cell culture for in-vitro work.

  • MARTIN, M J, WILSON, E, GERRARD-TARPEY, W, MEAKIN, G, HEARSON, G, MCKEEVER, T M, SHAW, D E and HARRISON, T W, 2016. Thorax.
  • HODGSON D, ANDERSON J, REYNOLDS C, OBORNE J, MEAKIN G, BAILEY H, SHAW D, MORTIMER K and HARRISON T, 2016. Chest. 149(4), 1052-60
  • 2016. Physiological reports. 4(18),
  • BEASLEY R, PAVORD I, PAPI A, REDDEL HK, HARRISON T, MARKS GB, HANCOX RJ and WEATHERALL M, 2016. The European respiratory journal. 47(3), 981-4
  • ANDERSON JR, MORTIMER K, PANG L, SMITH KM, BAILEY H, HODGSON DB, SHAW DE, KNOX AJ and HARRISON TW, 2016. PloS one. 11(8), e0160257
  • 2016. Thorax. (In Press.)
  • JOHN ME, COCKCROFT JR, MCKEEVER TM, COWARD WR, SHALE DJ, JOHNSON SR, THORNTON JG, HARRISON TW, KNOX AJ and BOLTON CE, 2015. International journal of chronic obstructive pulmonary disease. 10, 211-21
  • HODGSON D, ANDERSON J, REYNOLDS C, MEAKIN G, BAILEY H, PAVORD I, SHAW D and HARRISON T, 2015. Thorax. 70(6), 559-65
  • BATEMAN, ERIC D., BUHL, ROLAND, O'BYRNE, PAUL M., HUMBERT, MARC, REDDEL, HELEN K., SEARS, MALCOLM R., JENKINS, CHRISTINE, HARRISON, TIM W., QUIRCE, SANTIAGO, PETERSON, STEFAN and ERIKSSON, GOERAN, 2015. Development and validation of a novel risk score for asthma exacerbations: The risk score for exacerbations JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 135(6), 1457-1464
  • MARTIN MJ and HARRISON TW, 2015. Respiratory medicine. 109(9), 1105-13
  • SLATER M, RIVETT DW, WILLIAMS L, MARTIN M, HARRISON T, SAYERS I, BRUCE KD and SHAW D, 2014. Thorax. 69, 673-674
  • ROGERS NK, CLEMENTS D, DONGRE A, HARRISON TW, SHAW D and JOHNSON SR, 2014. PloS one. 9(2), e90565
  • WILSON E, MCKEEVER T, HARGADON B, HEARSON G, ANDERSON J, HODGSON D, BAILEY H, MEAKIN G, THOMAS M, PAVORD ID, HARRISON T and SHAW D, 2014. The European respiratory journal. (In Press.)
  • DJUKANOVI膯 R, HARRISON T, JOHNSTON SL, GABBAY F, WARK P, THOMSON NC, NIVEN R, SINGH D, REDDEL HK, DAVIES DE, MARSDEN R, BOXALL C, DUDLEY S, PLAGNOL V, HOLGATE ST, MONK P and INTERCIA STUDY GROUP, 2014. American journal of respiratory and critical care medicine. 190(2), 145-54
  • SELVARAJAH S, NEGM OH, HAMED MR, TUBBY C, TODD I, TIGHE PJ, HARRISON T and FAIRCLOUGH LC, 2014. Mediators of inflammation. 2014, 820304
  • MCKEEVER T, HARRISON TW, HUBBARD R and SHAW D, 2013. Chest. 144(6), 1788-1794
  • BATEMAN ED, HARRISON TW, QUIRCE S, REDDEL HK, BUHL R, HUMBERT M, JENKINS CR, PETERSON S, OSTLUND O, O'BYRNE PM, SEARS MR and ERIKSSON GS, 2011. Respiratory Research. 12, 38
  • REDDEL, H.K., JENKINS, C., QUIRCE, S., SEARS, M.R., BATEMAN, E.D., O'BYRNE, P.M., HUMBERT, M., BUHL, R., HARRISON, T., BRUSSELLE, G.G., THOR脡N, A., SJ脰BRING, U., PETERSON, S., 应STLUND, O. and ERIKSSON, G.S., 2011. European Respiratory Journal. 38(3), 584-593
  • HODGSON, DAVID, MORTIMER, KEVIN and HARRISON, TIM, 2010. Budesonide/formoterol in the treatment of asthma. Expert review of respiratory medicine. 4(5), 557-66
  • O'BYRNE, P.M., REDDEL, H.K., ERIKSSON, G., 脰STLUND, O., PETERSON, S., SEARS, M.R., JENKINS, C., HUMBERT, M., BUHL, R., HARRISON, T.W., QUIRCE, S. and BATEMAN, E.D., 2010. European Respiratory Journal. 36(2), 269-276
  • BATEMAN, E.D., REDDEL, H.K., ERIKSSON, G., PETERSON, S., OSTLUND, O., SEARS, M.R., JENKINS, C., HUMBERT, M., BUHL, R., HARRISON, T.W., QUIRCE, S. and O'BYRNE, P.M., 2010. Journal of Allergy and Clinical Immunology. 125(3), 600-608.e6
  • EDWARDS, S J, VON MALTZAHN, R, NAYA, I P and HARRISON, T, 2010. International journal of clinical practice. 64(5), 619-27
  • COOPER, S., OBORNE, J., HARRISON, T. and TATTERSFIELD, A., 2009. Respiratory Medicine. 103(6), 813-819
  • DALBY,, POWLANOWSKI,, LARSSON,, BORGSTROM,, EDSBACKER, and HARRISON,, 2009. The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: A randomized controlled trial. Respiratory Research. 10(1), 104
  • OBORNE, J., MORTIMER, K., HUBBARD, R.B., TATTERSFIELD, A.E. and HARRISON, T.W., 2009. American Journal of Respiratory and Critical Care Medicine. 180(7), 598-602
  • SOVANI, M.P., WHALE, C.I., OBORNE, J., COOPER, S., MORTIMER, K., EKSTR脰M, T., TATTERSFIELD, A.E. and HARRISON, T.W., 2008. British Journal of General Practice. 58(546), 37-43
  • WHALE, CHRISTOPHER I, SOVANI, MILIND P, MORTIMER, KEVIN J, HARRISON, TIMOTHY W and TATTERSFIELD, ANNE E, 2008. Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease: a dose-response study. British journal of clinical pharmacology. 65(6), 841-7
  • MORTIMER, KEVIN J, TATTERSFIELD, ANNE E, TANG, YUFEI, WU, KAI, LEWIS, SARAH, HOCHHAUS, GUNTHER and HARRISON, TIM W, 2007. British Journal of Clinical Pharmacology. 64(4), 439-44
  • WHALE, C.I., SOVANI, M.P., MORTIMER, K., OBORNE, J., COOPER, S., HARRISON, T. W. and TATTERSFIELD, A.E., 2006. British Journal of Clinical Pharmacology. 62(2), 153-7
  • MORTIMER, K. J., TATA, L. J., SMITH, C. J. P., WEST, J., HARRISON, T. W., TATTERSFIELD, A. E. and HUBBARD, R. B., 2006. Thorax. 61(5), 405-8
  • MORTIMER, KEVIN J, HARRISON, TIM W, TANG, YUFEI, WU, KAI, LEWIS, SARAH, SAHASRANAMAN, SRIKUMAR, HOCHHAUS, GUNTHER and TATTERSFIELD, ANNE E, 2006. British Journal of Clinical Pharmacology. 62(4), 412-9
  • TATTERSFIELD, ANNE E and HARRISON, TIMOTHY W, 2006. beta-Adrenoceptor polymorphisms: focus moves to long-acting beta-agonists. American Journal of Respiratory and Critical Care Medicine. 173(5), 473-4
  • HARRISON, T.W., OBORNE, J., NEWTON, S. and TATTERSFIELD, A.E., 2004. Lancet. 363(9405), 271-275
  • PHILLIPS, K., OBORNE, J., HARRISON, T. W. and TATTERSFIELD, A. E., 2004. Thorax. 59(1), 21-25
  • PHILLIPS, K., OBORNE, J., LEWIS, S., HARRISON, T.W. and TATTERSFIELD, A.E., 2004. Thorax. 59(1), 26-30
  • TATTERSFIELD, A. E., HARRISON, T. W., HUBBARD, R. B. and MORTIMER, K., 2004. PROCEEDINGS- AMERICAN THORACIC SOCIETY. VOL 1(NUMB 3), 171-175
  • HARRISON, T.W. and TATTERSFIELD, A.E., 2003. Thorax. 58(3), 258-60
  • TATA,L., WEST,J., HARRISON,T., FARRINGTON,P., SMITH,C. and HUBBARD,R., 2003. Thorax. 58(10), 835-39
  • TATTERSFIELD, A.E. and HARRISON, T.W., 2003. Management and treatment of asthma. In: Respiratory Medicine 2.
  • TATTERSFIELD, A.E. and HARRISON, T.W., 2003. Lancet. 361, 1066-7
  • WALSH, L. J., LEWIS, S. A., WONG, C. A., COOPER, S., OBORNE, J., CAWTE, S. A., HARRISON, T., GREEN, D. J., PRINGLE, M., HUBBARD, R. and TATTERSFIELD, A.E, 2002. American Journal of Respiratory and Critical Care Medicine. 166(5), 691-695
  • HUBBARD, R.B., SMITH, C.J.P., SMEETH, L., HARRISON, T.W. and TATTERSFIELD, A.E., 2002. American Journal of Respiratory and Critical Care Medicine. 166(12), 1563-1566
  • HARRISON, T.W., WISNIEWSKI, A., HONOUR, J. and TATTERSFIELD, A. E., 2001. Thorax. 56(3), 186-91
  • TATTERSFIELD, A.E. and HARRISON, T.W., 2001. Lancet. 358, 599-601
  • TATTERSFIELD, A.E. and HARRISON, T.W., 2001. Inhaled steroids for COPD? Thorax. 56(Suppl 2), ii2-6
  • HARRISON, T.W. and TATTERSFIELD, A.E., 2001. Asthma. In: Respiratory Medicine 81-106
  • HARRISON, T.W., 2001. BioDrugs. 15(6), 405-11
  • HARRISON, T.W. and TATTERSFIELD, A.E., 1999. Thorax. 54, 753-754
  • HARRISON, T.W., TATTERSFIELD, A.E. and BENNETT, J.A., 1999. European Respiratory Journal. 13, 445-448
  • OBORNE, J., WILDING, P.J. and HARRISON, T.W., 1999. Randomised placebo controlled trial of 尾-agonist dose reduction in asthma Thorax. 54, 98-102
  • HARRISON, T W, OBORNE, J, WILDING, P J and TATTERSFIELD, A E, 1999. Thorax. 54(2), 98-102
  • BENNETT, J A, HARRISON, T W and TATTERSFIELD, A E, 1999. European Respiratory Journal. 13(2), 445-8
  • HARRISON, T W and TATTERSFIELD, A E, 1998. Respiratory Medicine. 92(12), 1359-63
  • HARRISON, T.W., 1996. A rare cause of superior vena cava obstruction (Grand Round) British Medical Journal. 313, 1324-1326

School of Medicine

糖心原创
Medical School
Nottingham, NG7 2UH

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