糖心原创

Contact

• workRoom W/C1401 West Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• suzanne.miller@nottingham.ac.uk

Biography

In 2005, Suzanne graduated from Newcastle University with a BSc in Biochemistry and Immunology (2.1). She gained a PhD entitled 'Genome-wide molecular characterisation of CNS PNET and pineoblastomas', studying the genetics and histopathology of paediatric brain tumours at the Children's Brain Tumour Research Centre, 糖心原创, UK. During this time she visited The Hospital for Sick Kids, Toronto, with an international collaboration leading to a The Lancet Oncology publication. Following a move to Prof Ian Hall's lab working on the genetics of lung function, further high profile studies were published in The Lancet Respiratory Medicine and Nature Genetics. Moving back into the rare disease field, in 2015, Suzanne was promoted to Senior Research Fellow and studied diagnostic and prognostic markers of Lymphangioleiomyomatosis (LAM), a rare lung disease, with Nottingham hosting the National Centre for this disease.

In 2023, Suzanne made the leap to management and now manages the NIHR Nottingham Biomedical Research Centre, Musculoskeletal, Surgery, Inflammation and Recovery theme. Suzanne is still research active, with current research activities including projects in (i) Sarcoma diagnostics, (ii) Models of Arthrofibrosis, (iii) The gut microbiome in health and disease, (iv) Hip fracture pathways and (v) The use of AI in Rehabilitation.

Expertise Summary

Molecular genetics, Immunohistochemistry, Microarrays, Data analysis, Statistics, Rare disease research, Biomedical research management.

Research Summary

My current research involves (i) Sarcoma diagnostics, (ii) Models of Arthrofibrosis, (iii) The gut microbiome in health and disease, (iv) Hip fracture pathways and (v) The use of AI in Rehabilitation.

Previous research involved the study of pathogenesis and progression in a rare lung disease Lymphangioleiomyomatosis (LAM) as part of Professor Simon Johnson's research team. Previously supported by the NIHR Rare Diseases Translational Research Collaboration and The LAM Foundation, USA, I have also been supported by The British Lung Foundation, UK and La Marato, Spain.

LAM is a rare lung and lymphatic disease which leads to cystic lesions in the lungs. LAM affects women and is caused by a defect in one of the two proteins associated with Tuberous Sclerosis, Tuberin and Hamartin. Utilising data collected from the current study we want to identify diagnostic and prognostic biomarkers in LAM and better understand why some women with LAM have stable disease for many years whilst others progress in a relatively short period of time. Prior to this I works in lung function genetics, with publications in Nature Communications and The Lancet Respiratory Medicine. My PhD was in the genetics of childhood brain tumour's with research published in The Lancet Oncology.

Selected Publications

• MILLER S, COVENEY C, JOHNSON J, FARMAKI AE, GUPTA N, TOBIN MD, WAIN LV, MCCORMACK FX, BOOCOCK DJ and JOHNSON SR, 2018. The European respiratory journal. 52(5),
• LIU B, HENRY AP, AZIMI S, MILLER S, LEE FK, LEE JC, PROBERT K, KOTLIKOFF MI, SAYERS I and HALL IP, 2019. PloS one. 14(9), e0221899
• PHILP, CJ, SIEBEKE, I, CLEMENTS, D, HABGOOD, A, JOHN, A, NAVARATNAM, V, HUBBARD, RB, JENKINS, G and JOHNSON, SR, 2017. American Journal of Respiratory Cell and Molecular Biology.
• BEE J, FULLER S, MILLER S and JOHNSON SR, 2017. Thorax. (In Press.)

• View all publications

Past Research

Molecular and genetic mechanisms underlying Chronic Obstructive Pulmonary Disease (COPD), specifically the involvement of Advanced Glycosylation End Product-Specific Receptor (RAGE, 6p21).

COPD is a chronic disorder of the lungs which causes airway obstruction. This disease is a major cause of morbidity and mortality worldwide. It is estimated that 3 million people in the UK have COPD, which causes 30,000 deaths in the UK each year. Genome-wide association studies have shown an association with RAGE and lung function (Repapi et al., 2010. Nature Genetics 42, 36-44). By characterising the membrane and soluble forms of RAGE, we hope to idenitify RAGE's involvement in COPD in the hope of developing novel therapies for this debilitating and progressive disease.

Future Research

Since 2023, I moved into Biomedical Research Management. I manage the Musculoskeletal, Surgery, Inflammation and Recovery theme of the NIHR Nottingham Biomedical Research Centre (BRC).

• BABAEI-JADIDI R, CLEMENTS D, WU Y, CHEN K, MILLER S, PLATE M, LIM K, RUE R, KRYMSKAYA VP, CHAMBERS R, RAWLINS EL, XU Y and JOHNSON SR, 2025. Nature communications. 16(1), 8996
• VALDES AM, IKRAM A, TAYLOR LA, ZHENG A, KOURAKI A, KELLY A, ASHRAF W, VIJAY A, MILLER S, NIGHTINGALE J, SELBY NM and OLLIVERE BJ, 2024. Frontiers in Immunology.
• KOURAKI A, ZHENG A, MILLER S, KELLY A, ASHRAF W, BAZZANI D, BONADIMAN A, TONIDANDEL G, BOLZAN M, VIJAY A, NIGHTINGALE J, MENNI C, OLLIVERE BJ and VALDES AM, 2024. iScience.
• VIJAY A, KELLY A, MILLER S, MARSHALL M, ALONSO A, KOURAKI A, PROBERT C, SIMPSON E and VALDES AM, 2024. Nutrients. 3326
• JOPETH RAMIS, ROBERT MIDDLEWICK, FRANCESCO PAPPALARDO, JENNIFER T. CAIRNS, IAIN D. STEWART, ALISON E. JOHN, SHAMS-UN-NISA NAVEED, RAMASWAMY KRISHNAN, SUZANNE MILLER, DOMINICK E. SHAW, CHRISTOPHER E. BRIGHTLING, LEE BUTTERY, FELICITY ROSE, GISLI JENKINS, SIMON R. JOHNSON and AMANDA L. TATLER, 2022. ERJ.
• DEBBIE CLEMENTS, SUZANNE MILLER, ROYA BABAEI-JADIDI, MIKE ADAM, STEVEN S. POTTER and SIMON R. JOHNSON, 2022. Am J Physiol Lung Cell Mol Physiol. 322(2), L283-L293
• ROYA BABAEI-JADIDI, ARUNDHATI DONGRE, SUZANNE MILLER, MARCOS CASTELLANOS URIBE, IAIN D. STEWART, ZOE M THOMPSON, ABDOLRAHMAN S. NATERI, PETER BRADDING, SEAN T. MAY and DEBBIE CLEMENTS, 2021. American Journal of Respiratory and Critical Care Medicine.
• CHERNBUMROONG, S, JOHNSON, J, GUPTA, N, MILLER, S, MCCORMACK, F, GARIBALDI, J M and JOHNSON, S, 2021. European Respiratory Journal.
• CARMEN HERRANZ, FRANCESCA MATEO, ALEXANDRA BAIGES, GORKA RUIZ DE GARIBAY, ALEXANDRA JUNZA, SIMON R JOHNSON, SUZANNE MILLER, NADIA GARCIA, JORDI CAPELLADES, ANTONIO GOMEZ, AUGUST VIDAL, LUIS PALOMERO, MARIA MOLINA MOLINA, ANTONIO ROMAN, OSCAR YANES and MIQUEL A PUJANA, 2021. EMBO Mol Med.
• MILLER S, STEWART ID, CLEMENTS D, SOOMRO I, BABAEI-JADIDI R and JOHNSON SR, 2020. The journal of pathology. Clinical research. (In Press.)
• CLEMENTS D, MILLER S and JOHNSON SR, 2020. Medical hypotheses. 141, 109703 (In Press.)
• LEONARDO BOTTOLO, SUZANNE MILLER and SIMON R JOHNSON, 2020. Thorax. 75(8), 679-688
• LIU B, HENRY AP, AZIMI S, MILLER S, LEE FK, LEE JC, PROBERT K, KOTLIKOFF MI, SAYERS I and HALL IP, 2019. PloS one. 14(9), e0221899
• MILLER S, COVENEY C, JOHNSON J, FARMAKI AE, GUPTA N, TOBIN MD, WAIN LV, MCCORMACK FX, BOOCOCK DJ and JOHNSON SR, 2018. The European respiratory journal. 52(5),
• PHILP, CJ, SIEBEKE, I, CLEMENTS, D, HABGOOD, A, JOHN, A, NAVARATNAM, V, HUBBARD, RB, JENKINS, G and JOHNSON, SR, 2017. American Journal of Respiratory Cell and Molecular Biology.
• BEE J, FULLER S, MILLER S and JOHNSON SR, 2017. Thorax. (In Press.)
• KHEIRALLAH AK, MILLER S, HALL IP and SAYERS I, 2016. Advances in genetics. 93, 57-145
• MILLER S, HENRY AP, HODGE E, KHEIRALLAH AK, BILLINGTON CK, RIMINGTON TL, BHAKER SK, OBEIDAT M, MEL脡N E, MERID SK, SWAN C, GOWLAND C, NELSON CP, STEWART CE, BOLTON CE, KILTY I, MALARSTIG A, PARKER SG, MOFFATT MF, WARDLAW AJ, HALL IP and SAYERS I, 2016. PloS one. 11(10), e0164041
• WAIN LV, SHRINE N, MILLER S, JACKSON VE, NTALLA I, TOBIN MD and HALL IP, 2015. The Lancet Respiratory Medicine.
• SOLER ARTIGAS M, WAIN LV, MILLER S, KHEIRALLAH AK, HUFFMAN JE, NTALLA I, SHRINE N, OBEIDAT M, TROCHET H, MCARDLE WL, ALVES AC, HUI J, ZHAO JH, JOSHI PK, TEUMER A, ALBRECHT E, IMBODEN M, RAWAL R, LOPEZ LM, MARTEN J, ENROTH S, SURAKKA I, POLASEK O, LYYTIK脛INEN LP, GRANELL R, HYSI PG, FLEXEDER C, MAHAJAN A, BEILBY J, BOSS脡 Y, BRANDSMA CA, CAMPBELL H, GIEGER C, GL脛SER S, GONZ脕LEZ JR, GRALLERT H, HAMMOND CJ, HARRIS SE, HARTIKAINEN AL, HELI脰VAARA M, HENDERSON J, HOCKING L, HORIKOSHI M, HUTRI-K脛H脰NEN N, INGELSSON E, JOHANSSON 脜, KEMP JP, KOLCIC I, KUMAR A, LIND L, MEL脡N E, MUSK AW, NAVARRO P, NICKLE DC, PADMANABHAN S, RAITAKARI OT, RIED JS, RIPATTI S, SCHULZ H, SCOTT RA, SIN DD, STARR JM, , VI脩UELA A, V脰LZKE H, WILD SH, WRIGHT AF, ZEMUNIK T, JARVIS DL, SPECTOR TD, EVANS DM, LEHTIM脛KI T, VITART V, K脛H脰NEN M, GYLLENSTEN U, RUDAN I, DEARY IJ, KARRASCH S, PROBST-HENSCH NM, HEINRICH J, STUBBE B, WILSON JF, WAREHAM NJ, JAMES AL, MORRIS AP, JARVELIN MR, HAYWARD C, SAYERS I, STRACHAN DP, HALL IP and TOBIN MD, 2015. Nature communications. 6, 8658
• MILLER, S., PROBERT, K., KHEIRALLAH A.K. and HALL, I. P., 2015. Developmental genetics of the COPD lung COPD Research and Practice. 1(10),
• DE KOCK L, SABBAGHIAN N, DRUKER H, WEBER E, HAMEL N, MILLER S, CHOONG CS, GOTTARDO NG, KEES UR, REDNAM SP, VAN HEST LP, JONGMANS MC, JHANGIANI S, LUPSKI JR, ZACHARIN M, BOURON-DAL SOGLIO D, HUANG A, PRIEST JR, PERRY A, MUELLER S, ALBRECHT S, MALKIN D, GRUNDY RG and FOULKES WD, 2014. Acta neuropathologica. 128(4), 583-95
• MILLER S, WARD JH, ROGERS HA, LOWE J and GRUNDY RG, 2013. Brain pathology (Zurich, Switzerland). 23(1), 19-27
• HA ROGERS, JH WARD, S MILLER, J LOWE, B COYLE and RG GRUNDY, 2013. The role of the WNT/B-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs) British Journal of Cancer. 1 - 12
• HODGE E, NELSON CP, MILLER S, BILLINGTON CK, STEWART CE, SWAN C, MALARSTIG A, HENRY AP, GOWLAND C, MEL脡N E, HALL IP and SAYERS I, 2013. Respiratory research. 14, 77
• OBEIDAT M, MILLER S, PROBERT K, BILLINGTON CK, HENRY AP, HODGE E, NELSON CP, STEWART CE, SWAN C, WAIN LV, ARTIGAS MS, MEL脡N E, USHEY K, HAO K, LAMONTAGNE M, BOSS脡 Y, POSTMA DS, TOBIN MD, SAYERS I and HALL IP, 2013. PloS one. 8(9), e74630
• SCHWALBE EC, HAYDEN JT, ROGERS HA, MILLER S, LINDSEY JC, HILL RM, NICHOLSON S, KILDAY J, ADAMOWICZ-BRICE M, STORER L, JACQUES TS, ROBSON K, LOWE J, WILLIAMSON D, GRUNDY RG, BAILEY S and CLIFFORD SC, 2013. Acta neuropathologica. 126(6), 943-6
• PICARD, D., MILLER, S., HAWKINS, C.E., BOUFFET, E., ROGERS, H.A., CHAN, T.S.Y., KIM, S., RA, Y., FANGUSARO, J., KORSHUNOV, A., TOLEDANO, H., NAKAMURA, H., HAYDEN, J.T., CHAN, J., LAFAY-COUSIN, L., HU, P., FAN, X., MURASZKO, K.M., POMEROY, S.L., LAU, C.C., NG, H., JONES, C., VAN METER, T., CLIFFORD, S.C., EBERHART, C., GAJJAR, A., PFISTER, S.M., GRUNDY, R.G. and HUANG, A., 2012. The lancet oncology. 13(8), 838-848
• MILLER S, ROGERS HA, LYON P, RAND V, ADAMOWICZ-BRICE M, CLIFFORD SC, HAYDEN JT, DYER S, PFISTER S, KORSHUNOV A, BRUNDLER M, LOWE J, COYLE B and GRUNDY RG, 2011. Neuro-oncology. 13(8), 866-79
• HUSSEIN, D., PUNJARUK, W., STORER, L.C.D., SHAW, L., OTHMAN, R.T., PEET, A., MILLER, S., BANDOPADHYAY, G., HEATH, R., KUMARI, R., BOWMAN, K.J., BRAKER, P., RAHMAN, R., JONES, G.D.D. and WATSON, S., 2010. Neuro-oncology. 13(1), 70-83
• ROGERS, H A, MILLER, S, LOWE, J, BRUNDLER, M-A, COYLE, B and GRUNDY, R G, 2009. British journal of cancer. 100(8), 1292-302