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School of Medicine
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People

Raheela Khan

Emeritus Professor, Faculty of Medicine & Health Sciences

Contact

Teaching Summary

I am actively involved in several areas of undergraduate and postgraduate teaching.

I am Module convenor for:

  • A12U2G (Urogenital) module of Graduate Entry Medicine.
  • A12REP (Reproduction) module of the BSc in Medical Physiology and Therapeutics which runs in Part I of the course.
  • A13LIP (Lipid signalling) as co-convenor

Research Summary

My current research is centred around reproductive physiology in the human. The main interest of my group is on signalling mechanisms that maintain gestational quiescence and the switch to labour. I… read more

Selected Publications

  • PATEL, S.K., JACKSON, L., WARREN, A.Y., ARYA, P., SHAW, R.W. and KHAN, R.N., 2013. Journal of Cellular and Molecular Medicine. 17(1), 134-146
  • PEARSON, T., ZHANG, J., ARYA, P., WARREN, A.Y., ORTORI, C., FAKIS, A., KHAN, R.N. and BARRETT, D.A., 2010. Journal of Hypertension. 28(12), 2429-2437
  • ASHER, V., WARREN, A., SHAW, R., SOWTER, H., BALI, A. and KHAN, R., 2011. Cancer Cell International. 11, 6
  • KHAN, R.N., MATHAROO-BALL, B. and SHAW, R.W., 2010. Reproductive Sciences. 17(1), 78-84

Current Research

My current research is centred around reproductive physiology in the human. The main interest of my group is on signalling mechanisms that maintain gestational quiescence and the switch to labour. I am interested in the role of inflammatory pathways in pregnancy. This research is currently funded by the Wellcome Trust, Medical Research Council and Action Medical Research. In particular we are studying the role of eicosanoids in normal pregnancy and preeclampsia, the contribution of a purinergic receptor to the release of the cytokine interleukin-1beta in pregnancy as well as investigation of the inflammasome in coordinating inflammatory pathways coupled to cytokine release.

In recent years, we have begun exploring the role ion channels play in the aetiology of ovarian cancer. Our cancer studies have expanded to include oesophageal cancer with emphasis on oestrogen receptor expression and function in this malignancy.

Current grant funding:

2011-2013. The purinergic P2X7 receptor: regulation of uterine function in labour and preterm labour. RN Khan (PI), AJ Douglas, ST Woolley. Action Medical Research, project grant

2010-2012. Mechanisms underlying non-prostanoid eicosanoid modulation of vascular function in normal and pre-eclamptic pregnancies. RN Khan (PI), DA Barrett, F Broughton Pipkin. British Heart Foundation, project grant2009-2012. Proinflammatory mediators as modulators of decidual calcium channel expression and function. RN Khan (PI), N Chapman. The Wellcome Trust, project grant

Past Research

My past research has involved investigation of ipn cahnenls in thecontrol of pregnancy.

208-2011. Understanding how how NF-kappaB regulates expression and repression of the Galphas GTPbinding protein in the myometrium. N Chapman, D Anumba, N Europe-Finner. RN Khan (CoI). Medical Research Council, project grant (36 months)

2007-2009. The possible role of phospholipase C delta in the regulation of uterine contractility. J Lymn, RN Khan (CoI), SJ Hill. Action Medical Research, project grant (24 months)

2005-2008. Ion channel characterization in the human fetoplacental unit. RN Khan. British Heart Foundation, PhD studentship (36 months)

2004-2007. Mechanisms underlying the modulatory actions of cytochrome P450-derived eicosanoids in human myometrium. RN Khan (PI), DA Barrett. BBSRC, project grant (36 months)

Future Research

The intention for future research is to apply some of our experimental findings for translation to the antenatal clinic, either through idnetification and validation of potentially novel drug targets through which to manage pregnancies complicated by preterm birth either through tocolysis, early detection of preterm birth using novel biomarkers. We also aim to perform largescale genomic and metabolomic investigations designed to increase knowledge of causal factors in preterm birth.

  • ALENEZI SA, KHAN R, SNELL L, ABOELDALYL S and AMER S, 2023. Int J Mol Sci. 24(13), 10976
  • GRIFFIN M, KHAN R, BASU S and SMITH S, 2020. Cancers. 12(10):3068(10), 3068
  • AMER SA, ALZANATI NG, WARREN A, TARBOX R and KHAN R, 2019. The Journal of endocrinology. 241(1), 99-109
  • MUIR R, LIU G, KHAN R, SHMYGOL A, QUENBY S, QUENBY S, GIBSON RA, MULHAUSLER B and ELMES M, 2018. Sci Rep. 8(1), 3389
  • AL KHYATT W, TUFARELLI C, KHAN R and IFTIKHAR SY, 2018. BMC Cancer. 18(1), 121
  • ELMORSY, E., AL-GHAFARI, A., AGGOUR, A.M., KHAN, R. and AMER, S., 2017. Toxicology in Vitro. 44, 190-195
  • ELMORSY, E., AL-GHAFARI, A., AGGOUR, A.M., MOSAD, S.M., KHAN, R. and AMER, S., 2017. Toxicology Letters. 272, 94-100
  • RONAN MUIR, JEAN BALLAN, BETHAN CLIFFORD, SARAH MCMULLEN, RAHEELA KHAN, ANATOLY SHMYGOL, SIOBHAN QUENBY and MATTHEW ELMES, 2016. Clinical Science. 130
  • CADAGAN, DAVID, KHAN, RAHEELA and AMER, SAAD, 2016. REPRODUCTIVE BIOLOGY. 16(1), 53-60
  • OFINRAN O, BOSE U, HAY D, ABDUL S and TUFARELLI C, 2016. Mol Med Rep. 14(6), 5725-5731
  • CADAGAN, D., KHAN, R. and AMER, S., 2016. Reproductive Biology. 16(1), 53-60
  • KHAN, R.N. and HAY, D.P., 2015. Human Reproduction Update. 21(3), 388-405
  • MANETA, E., WARREN, A.Y., HAY, D.P. and KHAN, R.N., 2015. Frontiers in Physiology. 6(JUN),
  • MUIR R, BALLAN J, CLIFFORD B, MCMULLEN S, KHAN R, SHMYGOL A, QUENBY S and ELMES M, 2015. Clinical science (London, England : 1979). 130(3), 183-92
  • ALI, T.Y., PIPKIN, F.B. and KHAN, R.N., 2014. PLoS ONE. 9(12),
  • CADAGAN, D., KHAN, R. and AMER, S., 2014. Molecular Genetics and Metabolism Reports. 1(1), 254-263
  • PATEL, S.K., JACKSON, L., WARREN, A.Y., ARYA, P., SHAW, R.W. and KHAN, R.N., 2013. Journal of Cellular and Molecular Medicine. 17(1), 134-146
  • INNAMAA A, JACKSON L, ASHER V, VAN SCHALKWYK G, WARREN A, KEIGHTLEY A, HAY D, BALI A, SOWTER H and KHAN R, 2013. Clinical and Translational Oncology. (In Press.)
  • WEBSTER, S.J., WAITE, S.L., COOKSON, V.J., WARREN, A., KHAN, R., GANDHI, S.V., EUROPE-FINNER, G.N. and CHAPMAN, N.R., 2013. Journal of Biological Chemistry. 288(9), 6704-6716
  • PANG V, COUNILLON L, LAGADIC-GOSSMANN D, POET M, LACROIX J, SERGENT O, KHAN R and RAUCH C, 2012. Cell Biochemistry and Biophysics. 63, 47-57
  • ASHER, V., WARREN, A., SHAW, R., SOWTER, H., BALI, A. and KHAN, R., 2011. Cancer Cell International. 11, 6
  • KHAN R, 2011. Principles and new developments in molecular biology. In: SHAW RW, LUESLEY D and MONGA AK, eds., Gynaecology 4th. Churchill Livingstone. 156-165
  • ALCOCK, J., WARREN, A.Y., GOODSON, Y.J., HILL, S.J., KHAN, R.N. and LYMN, J.S., 2010. Biology of Reproduction. 84(4), 646-653
  • PEARSON, T., ZHANG, J., ARYA, P., WARREN, A.Y., ORTORI, C., FAKIS, A., KHAN, R.N. and BARRETT, D.A., 2010. Journal of Hypertension. 28(12), 2429-2437
  • RASHID, FARHAN, WARAICH, NASEEM, BHATTI, IMRAN, SAHA, SHOPAN, KHAN, RAHEELA N, AHMED, JAVED, LEEDER, PAUL C, LARVIN, MIKE and IFTIKHAR, SYED Y, 2010. World Journal of Surgical Oncology. 8, 1
  • KHAN, R.N., MATHAROO-BALL, B. and SHAW, R.W., 2010. Reproductive Sciences. 17(1), 78-84
  • RASHID, FARHAN, KHAN, RAHEELA N and IFTIKHAR, SYED Y, 2010. World Journal of Surgical Oncology. 8, 9
  • ALI, T., BROUGHTON PIPKIN, F. and KHAN, R.N., 2010. Investigating the effects of acidic pH on placental residual arteries Proc Physiol Soc. 19, C26
  • JONES K, KHAN, R.N. and DENT, K., 2010. Pre-eclampsia Student British Medical Journal. 18, c2212
  • ASHER V, KHAN R, WARREN A, SHAW R, VAN SCHALKWYK G, BALI A and SOWTER HM, 2010. Diagnostic Pathology. 5, 78
  • ASHER V, KHAN RN, SHAW RW, BALI A and SOWTER H, 2010. Eag potassium channel as a new prognostic marker in ovarian cancer In: British International Congress, Belfast.
  • PEARSON, T., WARREN, A.Y., BARRETT, D.A. and KHAN, R.N., 2009. American Journal of Physiology. Endocrinology and Metabolism. 297(3), E647-E656
  • THOMSON NL, ALCOCK J, GOODSON JY, WARREN AY, HILL SJ, KHAN RN, LYMN JS, 2009. Expression and cellular localisation of tissue transglutaminase II in human myometrium Reproductive Sciences. 16(3), P802
  • ALCOCK J, WARREN AY, GOODSON JY, HILL SJ, KHAN RN, LYMN JS, 2009. Oxytocin-induced contractility in human myometrium is inhibited by inhibitors of the enzyme tissue transglutaminase Reproductive Sciences. 16(3), P758
  • ALCOCK J, GOODSON JY, WARREN AY, HILL SJ, KHAN RN, LYMN JS, 2009. Phospholipase C isoform expression in the human myometrium is differentially regulated in pregnancy Reproductive Sciences. 16(3), P757
  • ALI, T., BROUGHTON PIPKIN, F. and KHAN, R.N., 2009. Expression of two pore domain potassium channels (K2P) in the placenta Reproductive Sciences. 16(3), S595
  • ALI, T., BROUGHTON PIPKIN, F. and KHAN, R.N., 2009. Activation of two pore domain potassium channels (K2P) in arteries isolated from the placenta and myometrium Reproductive Sciences. 16(3), S594
  • RASHID F, WARREN A, LEE A, LUND JN, LEEDER PC, KHAN RN, LARVIN M and IFTIKHAR SY, 2009. Potential significance of oestrogen receptors in oesophageal cancer British Journal of Surgery. 96(S6)(1), 58
  • ALCOCK J, WARREN AY, GOODSON JY, HILL SJ, KHAN RN and LYMN JS, 2009. Oxytocin-induced contractility in human myometrium is reduced by inhibition of the enzyme tissue transglutaminase II In: SGI Annual Meeting, Glasgow, UK.
  • ALCOCK J, GOODSON JY, WARREN AY, HILL SJ, KHAN RN and LYMN JS, 2009. Phospholipase C isoform expression in the human myometrium is differentially regulated in pregnancy In: SGI Annual Meeting, Glasgow, UK.
  • THOMSON NT, ALCOCK J, GOODSON JY, WARREN AY, HILL SJ, KHAN RN and LYMN JS, 2009. Expression and cellular localisation of tissue transglutaminase II in human myometrium In: SGI Annual Meeting, Glasgow, UK.
  • WARREN, A.Y., HARVEY, L., SHAW, R.W. and KHAN, R.N., 2008. Reproductive Sciences. 15(2), 189-194
  • ALI, T., BROUGHTON PIPKIN, F. and KHAN, R.N., 2008. Expression of BKCa in arteries isolated from the maternal-fetal interface of the placenta British Journal of Surgery. 95, S3
  • ZHANG, J.H., PEARSON, T., MATHAROO-BALL, B., ORTORI, C.A., WARREN, A.Y., KHAN, R. and BARRETT, D.A., 2007. Analytical Biochemistry. 365(1), 40-51
  • WARREN, A.Y, HARVEY, L, SHAW, R.W and KHAN, R.N., 2007. Interleukin-1beta Secretion from Cord Blood Leukocytes During Labor is Mediated by P2X7 Receptor Reprod Sci. 15, 189-194 (In Press.)
  • CHANRACHAKUL, B., WARREN, A. Y., SHAW, R. W., BROUGHTON PIPKIN, F. and KHAN, R. N., 2006. Compartmentation, function and expression of L-type calcium channel in human myometrium (Abstract) Journal of The Society for Gynaecological Investigation. 13(2), 9
  • LIU, B., HILL, S.J. and KHAN, R.N., 2005. Journal of Clinical Endocrinology & Metabolism. 90(7), 4191-4197
  • WARREN, A.Y., MATHAROO-BALL, B., SHAW, R.W. and KHAN, R.N., 2005. Reproduction. 130(4), 539-544
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F., WARREN, A.Y., ARULKUMARAN, S. and KHAN, R.N., 2005. American Journal of Obstetrics and Gynecology. 192(2), 458-463
  • CHANRACHAKUL, B., SHAW, R.W., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Colocalisation between the large conductance calcium-activated potassium channel, L-type calcium channel, and alpha2 adrenergic receptor, with caveolin in pregnant human myometrial cells. (Abstract) Journal of Physiology. PC58
  • CHANRACHAKUL, B., WARREN, A.Y., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Activation of BKCa channels by isoproterenol in pregnant human myometrium through b2-adrenergic receptors. (Abstract) Journal of The Society for Gynaecological Investigation. 12(2), 287A
  • CHANRACHAKUL, B., WARREN, A.Y., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Isoproterenol modulates calcium (Ca2+):activated potassium (K+) channels in pregnant human myometrium through beta2 adrenergic receptors. (Abstract) Journal of Obstetrics and Gynaecology. 21(Suppl 1), S62
  • CHANRACHAKUL,B., BROUGHTON PIPKIN,F. and KHAN,R.N, 2005. ABSTRACT: Activation of Ca2+-activated K+ channels by a beta adrenergic agent in pregnant human myometrial cells. Journal of Obstetrics and Gynaecology.. 25(Suppl 1), S62
  • KHAN, R. N., HAMOUD, H., WARREN, A., WONG, L. F. and ARULKUMARAN, S., 2004. American Journal of Obstetrics and Gynecology. VOL 191(NUMBER 1), 315-321
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F. and KHAN, R.N., 2004. American Journal of Physiology : Cell Physiology. 287(6), C1747-C1752
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F. and KHAN, R.N, 2004. The large conductance calcium-activated potassium channel (BKCa) and the beta2 adrenergic receptor (AR): a direct link to uterine relaxation. Physiology News. 55, 22-23
  • LIU, B., ARULKUMARAN, S., HILL, S.J. and KHAN, R.N., 2003. Biology of Reproduction. 68(6), 2281-2288
  • CHANRACHAKUL, B., TURNER, A., MATHAROO-BALL, B., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N., 2003. Colocalization and expression of 脽2-adrenergic receptor and large conductance calcium-activated potassium channel in human myometrium Journal of Physiology. 551P, C8
  • CHANRACHAKUL, B, MATHAROO-BALL, B, TURNER, A, ROBINSON, G, BROUGHTON-PIPKIN, F, ARULKUMARAN, S and KHAN, R. N., 2003. Journal of Clinical Endocrinology and Metabolism. 88(10), 4997-5001
  • MATHAROO-BALL, B., ASHFORD, M.L.J., ARULKUMARAN, S. and KHAN, R.N., 2003. Biology of Reproduction. 68(6), 2135-2141
  • CHANRACHAKUL, B., MATHAROO-BALL, B., TURNER, A., ROBINSON, G., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N., 2003. Reproduction. 126(1), 43-48
  • CHANRACHAKUL, B., MATHROO-BALL, B., TURNER, A., ROBINSON, G., ARULKUMARAN, S., BROUGHTON PIPKIN, F. and KHAN, R.N, 2003. ABSTRACT: Localisation and expression of a-subnuit of the large conductance potassium channel in human myometrium. Journal of Obstetrics and Gynaecology, Canada. 28((Suppl 1)), S53-S54
  • CHANRACHAKUL, B., MATHROO-BALL, B.TURNER, A., ROBINSON, G., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N, 2003. ABSTRACT: Expression of b2-adrenoreceptors in pregnant women with and without labour. Journal of The Society for Gynaecological Investigation. 10(2), 190A
  • ASTLE, SHIRLEY, KHAN, RAHEELA N and THORNTON, STEVEN, 2003. BJOG. 110(6), 589-92
  • KHAN, R N, MATHAROO-BALL, B, ARULKUMARAN, S and ASHFORD, M L, 2001. Experimental Physiology. 86(2), 255-64
  • KHAN, R. N., MORRISON, J. J., SMITH, S. K. and ASHFORD, M. L. J., 1998. American Journal of Obstetrics and Gynecology. VOL 178(NUMBER 5), 1027-1034
  • KHAN, R N, SMITH, S K and ASHFORD, M L, 1998. Human Reproduction. 13(1), 208-13
  • ROWE, I C, LEE, K, KHAN, R N and ASHFORD, M L, 1997. British Journal of Pharmacology. 121(3), 531-9
  • SMITH,S.K., ASHFORD,M.I., KHAN,R.N. and MORRISON,J.J, 1997. Ca2+ -dependence and pharmacology of large-conductance potassium channels in nonlabor and labor human uterine mycoytes American Journal of Physiology. 272(Nov 1997), C1721-C1731
  • ROWE,I.C., HALL,A.C., HALES,C.N., OZANNE,S.E., ASHFORD,M.I., LEE,K. and KHAN,R.N, 1996. Ciclazindol inhibits ATP-sensitive K+ channels and stimulates insulin secretion in CRI-GI insulin-secreting cells Molecular Pharmacology. 49(4), 715-720

School of Medicine

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