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Nikos Evangelou

Clinical Professor of Neurology, Faculty of Medicine & Health Sciences

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Biography

I did my undergraduate studies in Greece and the UK and trained as a Neurologist in Oxford and Nottingham. I gained my DPhil in Oxford studying axonal damage in MS with MRI and histopathology.

Since 2003, I have been a Consultant Neurologist at Nottingham University Hospital. In 2012 I became clinical lead for the department of Neurology, at the Nottingham University Hospital.

In 2011, I joined the University as a Clinical Associate Professor in Neurology and was appointed as a Clinical Professor of Neurology in 2023.

Expertise Summary

I lead a translational group of clinicians and scientists aiming to better understand the pathophysiology of neurological diseases such as Multiple Sclerosis, Parkinson's, Dementia and traumatic brain injury. I have participated in most major clinical trials in MS. Clinically, I run regular general neurology clinics, but my clinical expertise lies in Multiple Sclerosis and headache management.

My team is interested in clinical trials in MS and I am the Co-Principle Investigator of a large study to compare in many sites in the UK and USA escalation vs. highly effective treatment in MS.

Our current MRI research focuses in facilitating the early recognition of demyelinating disorders and quick diagnosis of MS through the demonstration of the pathogenic central vein in demyelinating lesions. We work on 3T and 7T MRI scanners at the medical school and SPMMR centre. We are currently the DECISIVE study, an NIHR funded multicentre trial and found that the detection of central vein is as good for MS diagnosis as the invasive lumbar puncture detecting oligoclonal bands.

I work with the SPMIC and Prof Brookes on OPM- MEG and study how MEG in naturalistic condition involving patients standing, sitting and moving can help understand brain activation and connectivity.

In addition, we study remyelination and lesion activity in the grey and white matter in vivo using mainly high resolution MRI imaging.

Working with academic neuropsychologists and with the help of the NIHR, we also run a programme grant (NEUROMS) where we try to understand how best to screen for cognitive deficits in MS.

Teaching Summary

Current supervisor for 4 PhD students

2 Post doctoral students

4 academic clinical fellows in Neurology

BMedsci supervisor for Clinical Neuroscience and Psychiatry

Research Summary

Clinical trials

DELIVER MS :

I am also participating in a number of commercial and non-commercial trials as principle investigator in Nottingham.

Neuroimaging

Investigations trying to understand brain disorders (MS and brain injury) and symptoms (cognition impairment, fatigue) through MRI and clinical trials 鈥嬧�媔ncluding:

Central veins in MS diagnosis

The Role of MEG in Assessment and Diagnosis In mTBI (MEGAbIT)

Neuropsychology of MS

Member of the research team of NEUROMS, an NIHR programme grant for the neuropsychological evaluation and rehabilitation in Multiple sclerosis

Selected Publications

  • TALLANTYRE, E.C., DIXON, J.E., DONALDSON, I., OWENS, T., MORGAN, P.S., MORRIS, P.G. and EVANGELOU, N., 2011. Neurology. 76(6), 534-539
  • TALLANTYRE, E.C., B脴, L., AL-RAWASHDEH, O., OWENS, T., POLMAN, C.H., LOWE, J. and EVANGELOU, N., 2009. Brain: a Journal of Neurology. 132(5), 1190-1199
  • GILMORE, CP, DONALDSON, I, BO, L, OWENS, T, LOWE, J and EVANGELOU, N, 2009. Journal Of Neurology Neurosurgery And Psychiatry. 80(2), 182-187
  • TALLANTYRE, E.C., BROOKES, M.J., DIXON, J.E., MORGAN, P.S., EVANGELOU, N. and MORRIS, P.G., 2008. Neurology. 70(22), 2076-2078

Past Research

Neuropathology og Multiple Sclerosis

  • SINNECKER, TIM, CLARKE, MARGARETA A, MEIER, DOMINIK, ENZINGER, CHRISTIAN, CALABRESE, MASSIMILIANO, DE STEFANO, NICOLA, PITIOT, ALAIN, GIORGIO, ANTONIO, SCHOONHEIM, MENNO M, PAUL, FRIEDEMANN, PAWLAK, MIKOLAJ A, SCHMIDT, REINHOLD, KAPPOS, LUDWIG, MONTALBAN, XAVIER, ROVIRA, ALEX, EVANGELOU, NIKOS and WUERFEL, JENS, 2019. Evaluation of the Central Vein Sign as a Diagnostic Imaging Biomarker in Multiple Sclerosis. JAMA neurology.
  • ONTANEDA, DANIEL, TALLANTYRE, EMMA, KALINCIK, TOMAS, PLANCHON, SARAH M and EVANGELOU, NIKOS, 2019. Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis. The Lancet. Neurology.
  • SINNECKER, TIM, CLARKE, MARGARETA, MEIER, DOMINIK, ENZINGER, CHRISTIAN, CALABRESE, MASSIMILIANO, DE STEFANO, NICOLA, PITIOT, ALAIN, GIORGIO, ANTONIO, SCHOONHEIM, MENNO M., PAUL, FRIEDEMANN, PAWLAK, MIKOLAJ, KAPPOS, LUDWIG, ROVIRA, ALEX, EVANGELOU, NIKOLAOS and WURFEL, JENS, 2019. Evaluation of the "Three Lesions with a Central Vein Sign" Criteria for the Differentiation between Multiple Sclerosis and its Imaging Mimics NEUROLOGY. 92(15),
  • CADAVID, DIEGO, MELLION, MICHELLE, HUPPERTS, RAYMOND, EDWARDS, KEITH R., CALABRESI, PETER A., DRULOVIC, PLENA, GIOVANNONI, GAVIN, HARTUNG, HANS-PETER, ARNOLD, DOUGLAS L., FISHER, ELIZABETH, RUDICK, RICHARD, MI, SHA, CHOI, YI, LI, JIE, ZHANG, YIWEI, CHENG, WENTING, XU, LEI, ZHU, BING, GREEN, SUSAN M., CHANG, IH, DEYKIN, AARON and SHEIKH, SARAH, I, 2019. LANCET NEUROLOGY. 18(9), 845-856
  • 2018. European Radiology. (In Press.)
  • PAPATHANASIOU A, ABDEL-FAHIM R and EVANGELOU N, 2018. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 39(10), 1795-1796
  • GERALDES R, CICCARELLI O, BARKHOF F, DE STEFANO N, ENZINGER C, FILIPPI M, HOFER M, PAUL F, PREZIOSA P, ROVIRA A, DELUCA GC, KAPPOS L, YOUSRY T, FAZEKAS F, FREDERIKSEN J, GASPERINI C, SASTRE-GARRIGA J, EVANGELOU N and , 2018. Nature reviews. Neurology. 14(4), 213
  • SAMARAWEERA A, CLARKE M and EVANGELOU N, 2017. Journal of neuroimaging. 27(1), 114-121
  • BARRATT EL, TEWARIE PK, CLARKE MA, HALL EL, GOWLAND PA, MORRIS PG, FRANCIS ST, EVANGELOU N and BROOKES MJ, 2017. Human brain mapping. 38(5), 2441-2453
  • MCKEE JB, COTTRIALL CL, ELSTON J, EPPS S, EVANGELOU N, GERRY S, KENNARD C, KONG Y, KOELEWYN A, KUEKER W, LEITE MI, PALACE J and CRANER M, 2017. Multiple sclerosis (Houndmills, Basingstoke, England). 1352458517742979 (In Press.)
  • CRONIN MJ, WHARTON S, AL-RADAIDEH A, CONSTANTINESCU C, EVANGELOU N, BOWTELL R and GOWLAND PA, 2016. Magma (New York, N.Y.). 29(3), 543-57
  • MISTRY, NIRAJ, ABDEL-FAHIM, RASHA, SAMARAWEERA, AMAL, MOUGIN, OLIVIER, TALLANTYRE, EMMA, TENCH, CHRISTOPHER, JASPAN, TIM, MORRIS, PETER, MORGAN, PAUL S. and EVANGELOU, NIKOS, 2016. MULTIPLE SCLEROSIS JOURNAL. 22(10), 1289-1296
  • FILIPPI, MASSIMO, ROCCA, MARIA A., CICCARELLI, OLGA, DE STEFANO, NICOLA, EVANGELOU, NIKOS, KAPPOS, LUDWIG, ROVIRA, ALEX, SASTRE-GARRIGA, JAUME, TINTORE, MAR, FREDERIKSEN, JETTE L., GASPERINI, CLAUDIO, PALACE, JACQUELINE, REICH, DANIEL S., BANWELL, BRENDA, MONTALBAN, XAVIER and BARKHOF, FREDERIK, 2016. LANCET NEUROLOGY. 15(3), 292-303
  • CRONIN, MATTHEW JOHN, WHARTON, SAMUEL, AL-RADAIDEH, ALI, CONSTANTINESCU, CRIS, EVANGELOU, NIKOS, BOWTELL, RICHARD and GOWLAND, PENNY ANNE, 2016. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE. 29(3), 543-557
  • SATI P, OH J, CONSTABLE RT, EVANGELOU N, GUTTMANN CR, HENRY RG, KLAWITER EC, MAINERO C, MASSACESI L, MCFARLAND H, NELSON F, ONTANEDA D, RAUSCHER A, ROONEY WD, SAMARAWEERA AP, SHINOHARA RT, SOBEL RA, SOLOMON AJ, TREABA CA, WUERFEL J, ZIVADINOV R, SICOTTE NL, PELLETIER D, REICH DS and , 2016. Nature reviews. Neurology. (In Press.)
  • RODR脥GUEZ CRUZ PM, MATTHEWS L, BOGGILD M, CAVEY A, CONSTANTINESCU CS, EVANGELOU N, GIOVANNONI G, GRAY O, HAWKINS S, NICHOLAS R, OPPENHEIMER M, ROBERTSON N, ZAJICEK J, ROTHWELL PM and PALACE J, 2016. JAMA neurology. 73(8), 954-60
  • RICE CM, MARKS DI, BEN-SHLOMO Y, EVANGELOU N, MORGAN PS, METCALFE C, WALSH P, KANE NM, GUTTRIDGE MG, MIFLIN G, BLACKMORE S, SARKAR P, REDONDO J, OWEN D, COTTRELL DA, WILKINS A and SCOLDING NJ, 2015. Trials. 16, 463
  • MOUGIN O., ABDEL-FAHIM R., DINEEN R., PITIOT A., EVANGELOU N. and GOWLAND P., 2015. Magnetic resonance in medicine. (In Press.)
  • SAMARAWEERA AP, COHEN SN, AKAY EM and EVANGELOU N, 2015. Multiple sclerosis (Houndmills, Basingstoke, England). 22(1), 122-4
  • SORMANI MP and EVANGELOU N, 2015. Neurology. 85(13), 1096-7
  • JURY艃CZYK M, WEINSHENKER B, AKMAN-DEMIR G, ASGARI N, BARNES D, BOGGILD M, CHAUDHURI A, D'HOOGHE M, EVANGELOU N, GERALDES R, ILLES Z, JACOB A, KIM HJ, KLEITER I, LEVY M, MARIGNIER R, MCGUIGAN C, MURRAY K, NAKASHIMA I, PANDIT L, PAUL F, PITTOCK S, SELMAJ K, DE S脠ZE J, SIVA A, TANASESCU R, VUKUSIC S, WINGERCHUK D, WREN D, LEITE I and PALACE J, 2015. Journal of neurology. 263(1), 140-9
  • MCKEE JB, ELSTON J, EVANGELOU N, GERRY S, FUGGER L, KENNARD C, KONG Y, PALACE J and CRANER M, 2015. BMJ open. 5(11), e009200
  • MISTRY N, ABDEL-FAHIM R, SAMARAWEERA A, MOUGIN O, TALLANTYRE E, TENCH C, JASPAN T, MORRIS P, MORGAN PS and EVANGELOU N, 2015. Multiple sclerosis (Houndmills, Basingstoke, England). 22(10), 1289-96
  • SORMANI, MARIA PIA and EVANGELOU, NIKOS, 2015. NEUROLOGY. 85(13), 1096-1097
  • KITLEY J, EVANGELOU N, K脺KER W, JACOB A, LEITE MI and PALACE J, 2014. Journal of the neurological sciences. 339(1-2), 223-5
  • STROMAN, P. W., WHEELER-KINGSHOTT, C., BACON, M., SCHWAB, J. M., BOSMA, R., BROOKS, J., CADOTTE, D., CARLSTEDT, T., CICCARELLI, O., COHEN-ADAD, J., CURT, A., EVANGELOU, N., FEHLINGS, M. G., FILIPPI, M., KELLEY, B. J., KOLLIAS, S., MACKAY, A., PORRO, C. A., SMITH, S., STRITTMATTER, S. M., SUMMERS, P. and TRACEY, I., 2014. NEUROIMAGE. 84, 1070-1081
  • WHEELER-KINGSHOTT, C. A., STROMAN, P. W., SCHWAB, J. M., BACON, M., BOSMA, R., BROOKS, J., CADOTTE, D. W., CARLSTEDT, T., CICCARELLI, O., COHEN-ADAD, J., CURT, A., EVANGELOU, N., FEHLINGS, M. G., FILIPPI, M., KELLEY, B. J., KOLLIAS, S., MACKAY, A., PORRO, C. A., SMITH, S., STRITTMATTER, S. M., SUMMERS, P., THOMPSON, A. J. and TRACEY, I., 2014. NEUROIMAGE. 84, 1082-1093
  • OWENS T, EVANGELOU N and WHYNES DK, 2013. The European journal of health economics : HEPAC : health economics in prevention and care. 14(2), 315-21
  • TANASESCU R, EVANGELOU N and CONSTANTINESCU CS, 2013. Neuropsychiatric disease and treatment. 9, 539-53
  • MISTRY, N., DIXON, J., TALLANTYRE, E., TENCH, C., ABDEL-FAHIM, R., JASPAN, T., MORGAN, P.S., MORRIS, P. and EVANGELOU, N., 2013. JAMA Neurology. 70(5), 623-628
  • MATTHEWS, L, MARASCO,R, JENKINSON,M, KUKER,W, LUPPE,S, LEITTE,M, GIORGIO,A, DE STEFANO,N, ROBERTSON,N, JOHANSEN-BERG,H, EVANGELOU,N and PALACE,J, 2013. Neurology. 80(14), 1330-7
  • STROMAN PW, WHEELER-KINGSHOTT C, BACON M, SCHWAB JM, BOSMA R, BROOKS J, CADOTTE D, CARLSTEDT T, CICCARELLI O, COHEN-ADAD J, CURT A, EVANGELOU N, FEHLINGS MG, FILIPPI M, KELLEY BJ, KOLLIAS S, MACKAY A, PORRO CA, SMITH S, STRITTMATTER SM, SUMMERS P and TRACEY I, 2013. NeuroImage. 84, 1070-81
  • MOUGIN, O. E., ABDEL-FAHIM, R., HALL, E., PITIOT, A., GOWLAND, P. and EVANGELOU, N., 2013. Cortical lesion classification in multiple sclerosis using 3D interleaved phase sensitive inversion recovery imaging and an inherent null point image MULTIPLE SCLEROSIS JOURNAL. 19(11), 422-422
  • TAYLOR TR, EVANGELOU N, PORTER H and LENTHALL R, 2012. Clinical Radiology. 67(1), 24-7
  • FILLIPI,M, ROCCA,M, BARKHOF F, BR脺CK W, CHEN JT, COMI G, DELUCA G, DE STEFANO N, ERICKSON BJ, EVANGELOU N, FAZEKAS F, GEURTS JJ, LUCCHINETTI C, MILLER DH, PELLETIER D, POPESCU BF and LASSMANN H, 2012. Lancet Neurol.. 11(4), 349-360
  • EVANGELOU,N, 2012. Mult Scler. 18(12), 1680-81
  • MISTRY N, TALLANTYRE EC, DIXON JE, GALAZIS N, JASPAN T, MORGAN PS, MORRIS P and EVANGELOU N, 2011. Multiple Sclerosis (Houndmills, Basingstoke, England). 17(11), 1313-23
  • TALLANTYRE, E.C., DIXON, J.E., DONALDSON, I., OWENS, T., MORGAN, P.S., MORRIS, P.G. and EVANGELOU, N., 2011. Neurology. 76(6), 534-539
  • DIXON JE, SIMPSON A, MISTRY N, EVANGELOU N and MORRIS PG, 2011. European Journal Of Radiology. 82(5), 719-27
  • TALLANTYRE, EC, MORGAN, PS, DIXON, JE, AL-RADAIDEH, A, BROOKES, MJ, MORRIS, PG and EVANGELOU, N, 2010. Journal Of Magnetic Resonance Imaging. 32(4), 971-977
  • TALLANTYRE, EC, BO, L, AL-RAWASHDEH, O, OWENS, T, POLMAN, CH, LOWE, JS and EVANGELOU, N, 2010. Multiple Sclerosis. 16(4), 406-411
  • TALLANTYRE, E.C., B脴, L., AL-RAWASHDEH, O., OWENS, T., POLMAN, C.H., LOWE, J. and EVANGELOU, N., 2009. Brain: a Journal of Neurology. 132(5), 1190-1199
  • GILMORE, C.P., DELUCA, G.C., BO, L., OWENS, T., LOWE, J., ESIRI, M.M. and EVANGELOU, N., 2009. Brain Pathology. 19(4), 642-649
  • BAIRD, W, JACKSON, R, FORD, H, EVANGELOU, N, BUSBY, M, BULL, P and ZAJICEK, J, 2009. Journal Of Medical Ethics. 35(2), 92-96
  • GILMORE, CP, DONALDSON, I, BO, L, OWENS, T, LOWE, J and EVANGELOU, N, 2009. Journal Of Neurology Neurosurgery And Psychiatry. 80(2), 182-187
  • GILMORE, CP, JACOB, A and EVANGELOU, N, 2009. A Case Of Neuromyelitis Optica With Gadolinium-Enhancing Brain Lesions And Parinaud Syndrome
  • GILMORE, CP, GEURTS, JJG, EVANGELOU, N, BOT, JCJ, VAN SCHIJNDEL, RA, POUWELS, PJW, BARKHOF, F and BO, L, 2009. Multiple Sclerosis. 15(2), 180-188
  • TALLANTYRE, E.C., BROOKES, M.J., DIXON, J.E., MORGAN, P.S., EVANGELOU, N. and MORRIS, P.G., 2008. Neurology. 70(22), 2076-2078
  • GILMORE, CP, BO, L, OWENS, T, LOWE, J, ESIRI, MM and EVANGELOU, N, 2006. Brain Pathology. 16(3), 202-208
  • DELUCA, GC, WILLIAMS, K, EVANGELOU, N, EBERS, GC and ESIRI, MM, 2006. Brain. 129, 1507-1516
  • BURWICK, RM, RAMSAY, PP, HAINES, JL, HAUSER, SL, OKSENBERG, JR, PERICAK-VANCE, MA, SCHMIDT, S, COMPSTON, A, SAWCER, S, CITTADELLA, R, SAVETTIERI, G, QUATTRONE, A, POLMAN, CH, UITDEHAAG, BMJ, ZWEMMER, JNP, HAWKINS, P, OLLIER, WER, WEATHERBY, S, ENZINGER, C, FAZEKAS, F, SCHMIDT, H, SCHMIDT, R, HILLERT, J, MASTERMAN, T, HOGH, P, NIINO, M, KIKUCHI, S, MACIEL, P, SANTOS, M, RIO, ME, KWIECINSKI, H, ZAKRZEWSKA-PNIEWSKA, B, EVANGELOU, N, PALACE, J and BARCELLOS, LF, 2006. Apoe Epsilon Variation In Multiple Sclerosis Susceptibility And Disease Severity - Some Answers
  • NIEPEL, G, TENCH, CR, MORGAN, PS, EVANGELOU, N, AUER, DP and CONSTANTINESCU, CS, 2006. Journal Of Neurology. 253(7), 896-902
  • EVANGELOU, N, DELUCA, GC, OWENS, T and ESIRI, MM, 2005. Brain. 128, 29-34
  • GILMORE, CP, DELUCA, GC, BO, L, OWENS, T, LOWE, J, ESIRI, MM and EVANGELOU, N, 2005. Archives Of Neurology. 62(12), 1859-1862
  • LIN, X, TENCH, CR, EVANGELOU, N, JASPAN, T and CONSTANTINESCU, CS, 2004. Journal Of Neuroimaging. 14(3), 20S-26S
  • EVANGELOU, N, LITTLEWOOD, T, ANSLOW, P and CHAPEL, H, 2003. Journal Of Clinical Pathology. 56(4), 308-309
  • PRICE, CJS, EVANGELOU, N and GREGORY, R, 2002. Amyloid Neuropathy Presenting As Thoraco-Abdominal Parathesia
  • EVANGELOU, N, KONZ, D, ESIRI, MM, SMITH, S, PALACE, J and MATTHEWS, PM, 2001. Brain. 124, 1813-1820
  • EVANGELOU, N, KONZ, D, ESIRI, MM, SMITH, S, PALACE, J and MATTHEWS, PM, 2000. Brain. 123, 1845-1849
  • EVANGELOU, N, ESIRI, MM, SMITH, S, PALACE, J and MATTHEWS, PM, 2000. Annals Of Neurology. 47(3), 391-395
  • EVANGELOU, N, JACKSON, M, BEESON, D and PALACE, J, 1999. Journal Of Neurology Neurosurgery And Psychiatry. 67(2), 203-205

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