糖心原创

Contact

• workBiodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• Mattea.Finelli@nottingham.ac.uk

Biography

Education:

• DPhil in Physiology, Anatomy and Genetics - Neurosciences (University of Oxford, 2011)
• MRes in Biomedical Research (Imperial College, 2007)
• MSc in Bioengineering (SupAgro, 2007)

Research positions:

• Assistant Professor (糖心原创, 2023-present)
• Anne McLaren Fellow (糖心原创, 2020-2023)
• Honorary Research Fellow/Visiting Researcher (University of Oxford, 2018-2019)
• Postdoctoral Research Assistant (University of Oxford, 2013-2018)
• Postdoctoral Fellow (Mount Sinai School of Medicine, New York, 2011-2013)

Expertise Summary

The Finelli lab explores the multiple facets of the neurodegenerative process using a wide range of molecular and cellular approaches, as well as transcriptomics, metabolomics and proteomics. Their main research centers around the role of oxidative and nitrosative stresses and redox mechanisms in the pathophysiology of neurodegenerative conditions including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia.

Research Summary

Dr 惭补迟迟茅补 Finelli established her group in January 2020 at the 糖心原创 Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms… read more

Recent Publications

• MONAGHAN TM, UGUN-KLUSEK A, FINELLI M, GURNANI P, CHAKRABARTI L, KAO D, ALEXANDER C and POLYTARCHOU C, 2023. Gut.
• CHISHOLM KI and FINELLI MJ, 2023. BMC neuroscience.
• CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. Cellular and molecular life sciences. 78(7), 3503-3524
• FENEBERG E, GORDON D, THOMPSON AG, FINELLI MJ, DAFINCA R, CANDALIJA A, CHARLES PD, M脛GER I, WOOD MJ, FISCHER R, KESSLER BM, GRAY E, TURNER MR and TALBOT K, 2020. Neurobiology of disease.

• View all publications

Current Research

Dr 惭补迟迟茅补 Finelli established her group in January 2020 at the 糖心原创 Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms underlying neurodegenerative disease and to develop and test new therapeutic strategies for these disorders.

In particular, the Finelli lab explores the proteins present in the human brain and how these proteins change in neurodegenerative diseases including Alzheimer's disease and motor neuron disease. They also develop new tools to promote the use of stem cell technology for improved disease modeling and drug testing.

The Finelli lab uses a combination of stem cell technology, gene editing, cell phenotyping, quantitative and redox proteomics, recombinant protein- and cell-based functional assays and in vitro drug screening.

More details can be found on the .

Dr 惭补迟迟茅补 Finelli is Deputy Director of the , and founder and Project Leader of the (part of the Global Alliance of Medical Excellence Network) and of the (part of Universitas 21).

• MONAGHAN TM, UGUN-KLUSEK A, FINELLI M, GURNANI P, CHAKRABARTI L, KAO D, ALEXANDER C and POLYTARCHOU C, 2023. Gut.
• CHISHOLM KI and FINELLI MJ, 2023. BMC neuroscience.
• CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. Cellular and molecular life sciences. 78(7), 3503-3524
• FENEBERG E, GORDON D, THOMPSON AG, FINELLI MJ, DAFINCA R, CANDALIJA A, CHARLES PD, M脛GER I, WOOD MJ, FISCHER R, KESSLER BM, GRAY E, TURNER MR and TALBOT K, 2020. Neurobiology of disease.
• FINELLI MJ, 2020. Frontiers in aging neuroscience.
• FENEBERG E, CHARLES PD, FINELLI MJ, SCOTT C, KESSLER BM, FISCHER R, ANSORGE O, GRAY E, TALBOT K and TURNER MR, 2020. Brain pathology.
• WILLIAMSON MG, FINELLI MJ, SLEIGH JN, REDDINGTON A, GORDON D, TALBOT K, DAVIES KE and OLIVER PL, 2019. Human molecular genetics. 28(21), 3584-3599
• SVISTUNOVA DM, SIMON JN, REMBEZA E, CRABTREE M, YUE WW, OLIVER PL and FINELLI MJ, 2018. Free radical biology & medicine. 130, 151-162
• FINELLI MJ, APRILE D, CASTROFLORIO E, JEANS A, MOSCHETTA M, CHESSUM L, DEGIACOMI MT, GRASEGGER J, LUPIEN-MEILLEUR A, BASSETT A, ROSSIGNOL E, CAMPEAU PM, BOWL MR, BENFENATI F, FASSIO A and OLIVER PL, 2018. Human molecular genetics. 28(4), 584-597
• FINELLI MJ, PARAMO T, PIRES E, RYAN BJ, WADE-MARTINS R, BIGGIN PC, MCCULLAGH J and OLIVER PL, 2018. Molecular neurobiology. 56(3), 1558-1577
• FINELLI MJ and OLIVER PL, 2017. Mammalian genome. 28(9-10), 395-406
• LOH YE, KOEMETER-COX A, FINELLI MJ, SHEN L, FRIEDEL RH and ZOU H, 2016. Epigenetics. 12(2), 77-92
• BALESTRINI S, MILH M, CASTIGLIONI C, L脺THY K, FINELLI MJ, VERSTREKEN P, CARDON A, STRA沤I艩AR BG, HOLDER JL, LESCA G, MANCARDI MM, POULAT AL, REPETTO GM, BANKA S, BILO L, BIRKELAND LE, BOSCH F, BROCKMANN K, CROSS JH, DOUMMAR D, F脡LIX TM, GIULIANO F, HORI M, H脺NING I, KAYSERILI H, KINI U, LEES MM, MEENAKSHI G, MEWASINGH L, PAGNAMENTA AT, PELUSO S, MEY A, RICE GM, ROSENFELD JA, TAYLOR JC, TROESTER MM, STANLEY CM, VILLE D, WALKIEWICZ M, FALACE A, FASSIO A, LEMKE JR, BISKUP S, TARDIF J, AJEAWUNG NF, TOLUN A, CORBETT M, GECZ J, AFAWI Z, HOWELL KB, OLIVER KL, BERKOVIC SF, SCHEFFER IE, DE FALCO FA, OLIVER PL, STRIANO P, ZARA F, CAMPEAU PM and SISODIYA SM, 2016. Neurology. 87(1), 77-85
• FINELLI MJ, SANCHEZ-PULIDO L, LIU KX, DAVIES KE and OLIVER PL, 2015. The Journal of biological chemistry. 291(6), 2751-63
• PARSONS MJ, BRANCACCIO M, SETHI S, MAYWOOD ES, SATIJA R, EDWARDS JK, JAGANNATH A, COUCH Y, FINELLI MJ, SMYLLIE NJ, ESAPA C, BUTLER R, BARNARD AR, CHESHAM JE, SAITO S, JOYNSON G, WELLS S, FOSTER RG, OLIVER PL, SIMON MM, MALLON AM, HASTINGS MH and NOLAN PM, 2015. Cell. 162(3), 607-21
• FINELLI MJ, LIU KX, WU Y, OLIVER PL and DAVIES KE, 2015. Human molecular genetics. 24(12), 3529-44
• LIU KX, EDWARDS B, LEE S, FINELLI MJ, DAVIES B, DAVIES KE and OLIVER PL, 2015. Brain. 138(Pt 5), 1167-81
• MOORE JM, OLIVER PL, FINELLI MJ, LEE S, LICKISS T, MOLN脕R Z and DAVIES KE, 2014. PloS one. 9(8), e105933
• FINELLI MJ, WONG JK and ZOU H, 2013. The Journal of neuroscience. 33(50), 19664-76
• FINELLI MJ, MURPHY KJ, CHEN L and ZOU H, 2013. Cell reports. 3(5), 1592-606
• CARROLL B, MOHD-NAIM N, MAXIMIANO F, FRASA MA, MCCORMACK J, FINELLI M, THORESEN SB, PERDIOS L, DAIGAKU R, FRANCIS RE, FUTTER C, DIKIC I and BRAGA VM, 2013. Developmental cell. 25(1), 15-28
• OLIVER PL, FINELLI MJ, EDWARDS B, BITOUN E, BUTTS DL, BECKER EB, CHEESEMAN MT, DAVIES B and DAVIES KE, 2011. PLoS genetics. 7(10), e1002338
• BITOUN E, FINELLI MJ, OLIVER PL, LEE S and DAVIES KE, 2009. The Journal of neuroscience. 29(49), 15366-74
• HALL SE, MAO A, NICOLAIDOU V, FINELLI M, WISE EL, NEDJAI B, KANJANAPANGKA J, HARIRCHIAN P, CHEN D, SELCHAU V, RIBEIRO S, SCHYLER S, PEASE JE, HORUK R and VAIDEHI N, 2009. Molecular pharmacology. 75(6), 1325-36