糖心原创

Contact

• workSouth Block, D floor
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• lesia.kurlak@nottingham.ac.uk

Biography

I am a clinical trial manager responsible for overseeing MAPS-2 (Metoclopramide for Avoiding Pneumonia after Stroke): a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke.

Research Summary

Currently, I am involved in MAPS-2 (Metoclopramide for Avoiding Pneumonia after Stroke): a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with… read more

Recent Publications

• KURLAK LO, MISTRY HD, CINDROVA-DAVIES T, BURTON GJ and BROUGHTON PIPKIN F, 2016. Journal of Physiology. 5, 1327-40
• MISTRY HD, BROUGHTON PIPKIN F and KURLAK LO, 2016. Biological trace element research. 171(1), 235
• SMITH-JACKSON, K., HENTSCHKE, M. R., POLI-DE-FIGUEIREDO, C. E., PINHEIRO DA COSTA, B. E., KURLAK, L. O., PIPKIN, F. BROUGHTON, CZAJKA, A. and MISTRY, H. D., 2015. PLACENTA. 36(5), 607-610
• KURLAK, L. O., WILLIAMS, P. J., BULMER, J. N., PIPKIN, F. BROUGHTON and MISTRY, H. D., 2015. PLACENTA. 36(5), 611-613

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Dr Lesia Kurlak, Research Fellow in Obstetrics & Gynaecology at the City Hospital Campus, has been awarded a Practical Skills Grant from the Society for Endocrinology () to participate in the 10^th Annual Human Placenta Workshop at Queen's University, Kingston, Ontario. This unique, week-long, workshop is highly specialised in content, covering a wide range of skills in placentology: it provides an exceptional opportunity to work alongside esteemed experts in the field and forge strong international collaborations.

Current Research

Currently, I am involved in MAPS-2 (Metoclopramide for Avoiding Pneumonia after Stroke): a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke.

Past Research

My past research was focussed on the pathophysiology of hypertensive diseases of pregnancy, in particular pre-eclampsia, and its associated higher risk of accelerated cardiovascular aging. Pre-eclampsia remains a common disorder in pregnancy, affecting 3-5% of all UK pregnancies. It is a pregnancy-specific and multi-systemic disorder in which a major contributing role is played by placental dysfunction. This results in systemic endothelial dysfunction which clinically manifests as hypertension with associated kidney, liver and neurological complications. Excessive generation of reactive oxygen species (ROS) initiates a cascade of events in susceptible individuals leading to maternal oxidative stress as well as endothelial cell dysfunction. The redox balance markedly influences the capacity to generate angiotensin I from angiotensinogen, and hence the potent vasoconstrictor angiotensin II.

A systematic review with meta-analyses including than 3 million women (Bellamy et al), has found that women with a history of pre-eclampsia have a 3.7 higher risk of hypertension and 1.8 increased risk of stroke in later life. The severity of pre-eclampsia is associated with the severity of cardiovascular diseases later in life.

The renin-angiotensin system, which plays a major role in the pathogenesis of hypertension also affects platelet function through its main mediator angiotensin II.

I have previously also studied platelet activation in newborn infants and adults to investigate whether measureable differences in aggregation are related to the physical properties of the outer plasma membrane of these blood cells. Membrane fluidity was analysed using the characteristic of fluorescence anisotropy; whilst the fatty acid composition of platelet membrane was assessed by Gas Chromatography - Mass Spectroscopy (GCMS).

• KURLAK LO, MISTRY HD, CINDROVA-DAVIES T, BURTON GJ and BROUGHTON PIPKIN F, 2016. Journal of Physiology. 5, 1327-40
• MISTRY HD, BROUGHTON PIPKIN F and KURLAK LO, 2016. Biological trace element research. 171(1), 235
• SMITH-JACKSON, K., HENTSCHKE, M. R., POLI-DE-FIGUEIREDO, C. E., PINHEIRO DA COSTA, B. E., KURLAK, L. O., PIPKIN, F. BROUGHTON, CZAJKA, A. and MISTRY, H. D., 2015. PLACENTA. 36(5), 607-610
• KURLAK, L. O., WILLIAMS, P. J., BULMER, J. N., PIPKIN, F. BROUGHTON and MISTRY, H. D., 2015. PLACENTA. 36(5), 611-613
• MISTRY HD, GILL CA, KURLAK LO, SEED PT, HESKETH JE, M脡PLAN C, SCHOMBURG L, CHAPPELL LC, MORGAN L, POSTON L and SCOPE CONSORTIUM, 2015. Free radical biology & medicine. 78, 147-55
• MISTRY, H.D. and KURLAK, L.O., 2015. Selenium in fertility and reproduction. In: RONALD ROSS WATSON, ed., Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health Academic Press, Elsevier. 261-281
• MISTRY, H. D., KURLAK, L. O., WHITLEY, G. S., CARTWRIGHT, J. E., PIPKIN, F. BROUGHTON and TRIBE, R. M., 2014. PLACENTA. 35(5), 337-340
• KURLAK, LESIA, MISTRY, HITEN, MANSOUR, YOSEF, CINDROVA-DAVIES, TEREZA, BURTON, GRAHAM and PIPKIN, FIONA BROUGHTON, 2014. Effect of Hypoxia-Reoxygenation on the Renin Angiotensin System (RAS) in Human Placental Explants In Vitro. REPRODUCTIVE SCIENCES. 21(3), 114A-114A
• KURLAK, LESIA O., GREEN, AMANDA, LOUGHNA, PAMELA and PIPKIN, FIONA BROUGHTON, 2014. FRONTIERS IN PHYSIOLOGY. 5,
• KURLAK, LESIA, MISTRY, HITEN, MANSOUR, YOSEF, CINDROVA-DAVIES, TEREZA, BURTON, GRAHAM and PIPKIN, FIONA BROUGHTON, 2014. Is There a Role for Placental Angiotensin Receptors in Hypoxia Responses? REPRODUCTIVE SCIENCES. 21(3), 288A-288A
• KURLAK, L. O., MISTRY, H. D., KAPTEIN, E., VISSER, T. J. and PIPKIN, F. BROUGHTON, 2013. PLACENTA. 34(5), 395-400
• MISTRY, H. D., KURLAK, L. O. and PIPKIN, F. BROUGHTON, 2013. PLACENTA. 34(2), 182-186
• HENTSCHKE, MARTA R, POLI-DE-FIGUEIREDO, CARLOS E, PINHEIRO DA COSTA, BARTIRA E, KURLAK, LESIA O, WILLIAMS, PAULA J and MISTRY, HITEN D, 2013. Journal of lipid research. 54(10), 2658-64
• MISTRY HD, KURLAK LO, YOUNG SD, BRILEY AL, BROUGHTON PIPKIN F, BAKER PN and POSTON L, 2012. Maternal & child nutrition.
• MISTRY HD, MCCALLUM LA, KURLAK LO, GREENWOOD IA, BROUGHTON PIPKIN F and TRIBE RM, 2011. Hypertension. 58(3), 497-504
• MCCALLUM, L. A., MISTRY, H. D., KURLAK, L. O., GREENWOOD, I. A., PIPKIN, F. BROUGHTON and TRIBE, R. M., 2011. Potassium channel KCNQ/KCNE isoform expression in placentae from pre-eclamptic women vs. controls BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 118(8), 1013-1013
• MISTRY, HITEN D., MCCALLUM, LAURA A., KURLAK, LESIA O., GREENWOOD, IAIN A., PIPKIN, FIONA BROUGHTON and TRIBE, RACHEL M., 2011. HYPERTENSION. 58(3), 497-504
• MISTRY, HITEN D., KURLAK, LESIA O., PIPKIN, FIONA BROUGHTON, TRIBE, RACHEL M., TAGGERT, MICHAEL J. and CZAJKA, ANNA N., 2011. Alteration in Placental Caveolin-1 Gene Expression in Women with Pre-Eclampsia REPRODUCTIVE SCIENCES. 18(3), 355A-356A
• MISTRY, H.D., KURLAK, L.O., WILLIAMS, P.J., RAMSAY, M.M., SYMONDS, M.E. and BROUGHTON PIPKIN, F., 2010. Placenta. 31, 401-408
• WILLIAMS, P.J., KURLAK, L.O., PERKINS, A.C., BUDGE, H., STEPHENSON, T., KEISLER, D., SYMONDS, M.E. and GARDNER, D.S., 2007. Kidney International. 72(3), 279-289
• YAKUBU, D.P., MOSTYN, A., HYATT, M.A., KURLAK, L.O., BUDGE, H., STEPHENSON, T. and SYMONDS, M.E., 2007. Reproduction. 134, 823-830
• BRENNAN, K.A., GOPALAKRISHNAN, G.S., KURLAK, L., RHIND, S.M., KYLE, C.E., BROOKS, A.N., RAE, M.T., OLSON, D.M., STEPHENSON, T. and SYMONDS, M.E., 2005. Reproduction. 129(2), 151-159
• KURLAK, L O, GOPALAKRISHNAN, G, STEPHENSON, T J and SYMONDS, M E, 2003. Maternal nutrient restriction during early to mid-gestation and 11 beta hydroxysteroid dehydrogenase type 2 (11 HSD2) activity in the kidneys of juvenile offspring in sheep.: Journal of Physiology Journal of Physiology. 555P, PC119
• KURLAK, L., KEAN, L., STEPHENSON, T. and PIPKIN, F.B., 2002. Early Human Development. 66(1), 55
• KURLAK, L O, KEAN, L, STEPHENSON, T J and BROUGHTON PIPKIN, F, 2002. Does the fatty acid composition of human platelets differ between neonates and adults and is it related to membrane fluidity: Early Human Development Early Human Development. 66(1), 55-56
• KURLAK, L O, STEPHENSON, T J and BROUGHTON PIPKIN, F, 2001. Does Angiotensin II (AII) act as a proaggregatory agent in human platelets?: Journal of Obstetrics and Gynaecology Journal of Obstetrics and Gynaecology. 21(Suppl 1), S33
• KURLAK, LO and STEPHENSON, TJ, 1999. ARCHIVES OF DISEASE IN CHILDHOOD. 80(2), F148-F154
• KURLAK, L. O., STEPHENSON, T. J. and BROUGHTON PIPKIN, F., 1999. Membrane fluidity of the plasma membrane in human adult and cord platelets Journal of Physiology (Cambridge). 517P, 7P
• KURLAK, L O, STEPHENSON, T J and BROUGHTON PIPKIN, F, 1999. Membrane fluidity of the plasma membrane in human adult and cord platelets: Journal of Physiology Journal of Physiology. 517.P, 7P
• KURLAK, L O, STEPHENSON, T J and BROUGHTON PIPKIN, F, 1999. Neonatal platelet aggregation responses to collagen and arachidonic acid: Early Human Development Early Human Development. 54(1), 67
• KURLAK, L O, STEPHENSON, T J and BROUGHTON PIPKIN, F, 1997. The aggregation response of neonatal platelets to adenosine diphosphate (ADP): Early Human Development Early Human Development. 50, 219
• KURLAK, LO, RUGGINS, NR and STEPHENSON, TJ, 1994. ARCHIVES OF DISEASE IN CHILDHOOD. 71(1), F16-F19