糖心原创

Contact

• workApplied Health Research Building
  University Park
  Nottingham
  NG7 2RD
  UK
• Kirsty.Sprange@nottingham.ac.uk

Biography

Kirsty is Assistant Professor of Clinical Trials at the 糖心原创 Clinical Trials Unit (NCTU) www.nctu.ac.uk. She has over 17 years' experience working in clinical research including design and delivery of randomised controlled trials, feasibility and pilot studies as well as qualitative methodology including fidelity assessment and process evaluation. She has worked in the unit since 2014 in a range of roles including Trial Manager, Senior Trial Manager and now her current Assistant Professor post. Prior to joining the NCTU she worked for the Sheffield Clinical Trials Research Unit (CTRU) in the School of Health and Related Research (ScHARR) as a Research Associate. Prior to that she worked for the Healthcare Innovation and Technology Evaluation Centre (HITEC) based at Derby Hospitals NHS Foundation Trust where she carried out systematic reviews, evidence reviews and technical evaluations of assistive technologies and medical devices for the Centre for Evidence-based Purchasing (CEP) part of the Purchasing and Supply Chain (PASA) and the National Institute for Health and Clinical Excellence (NICE).

Her main research interest is in adult and child mental health in which she is co-applicant on several large multi-centre NIHR HTA funded trials as well as smaller projects in the UK (JtD, PRIDE, STADIA, SATURN, SPARX, RE-MIND). She has a specific interest in older adults and dementia, particularly occupational therapy based interventions exploring self-management for maintaining independent living as well as mental and physical wellbeing. She also has a strong interest in fidelity assessment of complex intervention and qualitative research.

Teaching Summary

I currently lead the Qualitative Methods in Clinical Trials Course and the Online Introduction to Clinical Trials Course as part of the NCTU Short Course programme. In addition I also co-lead the… read more

Research Summary

Moppett I, Costa M, Sprange K, Karantana A, Stanworth S, James M, Partlett C, Juszczak E, Acheson A, Sugavanam A, Shah A, Sinclair R, Welch N. The clinical benefits and cost-effectiveness and safety… read more

Selected Publications

• KIRSTY SPRANGE, GAIL A MOUNTAIN, KATY SHORTLAND, CLAIRE CRAIG, DANIEL BLACKBURN, PETER BOWIE, KIRSTY HARKNESS and MAGGIE SPENCER, 2015. Pilot and Feasibility Studies. 1(42),
• SPRANGE, KIRSTY, MOUNTAIN, GAIL A., BRAZIER, JOHN, COOK, SARAH P., CRAIG, CLAIRE, HIND, DANIEL, WALTERS, STEPHEN J., WINDLE, GILL, WOODS, ROBERT, KEETHARUTH, ANJU D., CHATER, TIM and HORNER, KATH, 2013. TRIALS. 14(302),
• HIND, D, ROBERTS, C, SPRANGE, K, GOSSAGE-WORRALL, R, COOPER, C and WALTERS, S, 2013. Trials. 14((Suppl 1)),
• SPRANGE, K and CLIFT, M, 2012. Journal of the Royal Society of Medicine. 105(S4-S11),

• View all publications

I currently lead the Qualitative Methods in Clinical Trials Course and the Online Introduction to Clinical Trials Course as part of the NCTU Short Course programme. In addition I also co-lead the Fundamental of Clinical Trials course (/nctu/short-courses/).

I currently co-supervise two PhD students through the Joan Browne Legacy Fund and the Mental Health Mission (MHM) Children and Young People's Mental Health Workstream.

I have provided supervision and/or mentorship for NIHR Clinical Trials Fellowships, Pre-doctoral Fellowships and NIHR DSE Fellowships.

Current Research

Moppett I, Costa M, Sprange K, Karantana A, Stanworth S, James M, Partlett C, Juszczak E, Acheson A, Sugavanam A, Shah A, Sinclair R, Welch N. The clinical benefits and cost-effectiveness and safety of haematopoietic interventions for patients with anaemia following major emergency surgery: a phase IV, multicentre, multi-arm randomised controlled trial: Peri-op Iron and EPO Intervention 糖心原创 - POP-I, NIHR Health Technology Assessment Programme. NIHR133467, Start date July 2022 (48 months), 拢2,146,909. Trial methodologist Co-applicant.

Sprange K, Hall C, Juszczak E, Martin J, Murray E, Gardner, Willis A, Montgomery A. REcruitment in Mental health trials: broadening the 'net', opportunities for INclusivity through online methoDs (RE-MIND 糖心原创), NIHR CTU Support Funding Award. Jan 2022 (12 months). 拢72,944. Lead applicant.

Papaioannou D, Sprange K, O'Cathain A, Moody G, Robling M, Corneliuse V. Recording HArms in Behavioural change Intervention Trials (RHABIT), NIHR CTU Support Funding Award. 拢79,015. Jan 2022 (12 months). Co-Applicant, supervisor for qualitative element.

Partlett C, Sprange K, Linsell, L, Gamble C, Julious S, Cook A. Blinding of Trial Statisticians (BOTS), NIHR CTU Support Funding Award. 拢67,374. Jan 2021 (18 months). Co-applicant and qualitative lead.

Ryder S, Clifton-Brown A, Enki SG, Guha IN, Hutton C, Jones K, Rennick-Egglestone S, Sprange K, Willott S, Wragg A. Does knowledge of liver fibrosis affect high risk drinking behaviour (KLIFAD)? A feasibility randomised controlled trial. NIHR Research for Patient Benefit (RfPB). NIHR201146 (26278). Start date Sept 2020 (24 months). 拢219,073. Trial methodology lead, expertise in trial management and delivery.

Karantana K, Costa M, Davis T, James M, Jerosch-Herold C, Montgomery A, Ogollah R, Rodrigues J, Trickett R, Sprange K, Widdowson L. POINT: A multi-centre randomised trial of surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults. NIHR Health Technology Assessment Programme. NIHR127292. Start date Sept 2019 (48 months). 拢1,403,829. Trial methodology lead, expertise in trial management and delivery.

Hollis C, Cortese S, Hall C, James M, Jarvis C, Liang H, Malik O, Montgomery AA, Ogollah R, Sayal K, Sharma A, Sprange K and Kyriakopoulos M. Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN study): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus guanfacine for ADHD in children and young people with a co-existing tic disorder. NIHR Health Technology Assessment Programme. NIHR128472. Start date Oct 2021 (48 months). 拢1,628,868. Trial methodology lead, expertise in trial management and delivery.

Sayal K, Montgomery AA, Sprange K, James M, Thomson L, Lang A, Ewart C, Reynolds S, Marshall T, Gledhill J, Dubicka B, Bhardwaj A. STAndardised DIagnostic Assessment for children and adolescents with emotional difficulties (STADIA): a multi-centre randomised controlled trial. NIHR Health Technology Assessment Programme. 16/96/09. Start date Nov 2018 (48 months). 拢1,481,137. Trial methodology lead, expertise in trial management and delivery.

Mountain G, Orrell M, Bowie P, Sprange K, Walters S, Craig C, Cooper C, Berry K, Blackburn D, Moniz-Cook ED, Young T. Journeying through dementia; randomised controlled trial of clinical and cost effectiveness. NIHR Health Technology Assessment Programme. 14/140/80. Start date Sept 2015 (42 months) 拢2,017,925. Fidelity assessment and qualitative study lead.

• DAY, F., WYATT, L., BHARDWAJ, A., DUBICKA, B., EWART, C., GLEDHILL, J., JAMES, M., LANG, A., MARSHALL, T., MONTGOMERY, A., REYNOLDS, S., SPRANGE, K., THOMSON, L., BRADLEY, E., LATHE, J., NEWMAN, K., PARTLETT, C., STARR, K. and SAYAL, K., 2022. BMJ Open. (In Press.)
• BERESFORD-DENT, JULES, SPRANGE, KIRSTY, MOUNTAIN, GAIL, MASON, CLARE, WRIGHT, JESSICA, CRAIG, CLAIRE and BIRT, LINDA, 2022. Embedding patient and public involvement in dementia research: Reflections from experiences during the 'Journeying through Dementia' randomised controlled trial DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE.
• MOUNTAIN, GAIL A., COOPER, CINDY L., WRIGHT, JESSICA, WALTERS, STEPHEN J., LEE, ELLEN, CRAIG, CLAIRE, BERRY, KATHERINE, SPRANGE, KIRSTY, YOUNG, TRACEY, MONIZ-COOK, ESME, DENING, TOM, LOBAN, AMANDA, TURTON, EMILY, BERESFORD-DENT, JULES, THOMAS, BENJAMIN D., THOMPSON, BENJAMIN J. and YOUNG, EMMA L., 2022. The Journeying through Dementia psychosocial intervention versus usual care study: a single-blind, parallel group, phase 3 trial LANCET HEALTHY LONGEVITY. 3(4), E276-E285
• MITCHELL, E. J., SPRANGE, K., TREWEEK, S. and NIXON, E., 2022. Value and engagement: what can clinical trials learn from techniques used in not-for-profit marketing? TRIALS. 23(1),
• IFLAIFEL, MAIS, PARTLETT, CHRISTOPHER, BELL, JENNIFER, COOK, ANDREW, GAMBLE, CARROL, JULIOUS, STEVEN, JUSZCZAK, EDMUND, LINSELL, LOUISE, MONTGOMERY, ALAN and SPRANGE, KIRSTY, 2022. Blinding of study statisticians in clinical trials: a qualitative study in UK clinical trials units TRIALS. 23(1),
• SUBHANI M, JONES KA, SPRANGE K, RENNICK-EGGLESTONE S, KNIGHT H, MORLING JR, ENKI DG, WRAGG A and RYDER SD, 2021. BMJ Open. e054954
• CSIPKE, EMESE, SHAFAYAT, AISHA, SPRANGE, KIRSTY, BRADSHAW, LUCY, MONTGOMERY, ALAN A., OGOLLAH, REUBEN, MONIZ-COOK, ESME and ORRELL, MARTIN, 2021. CLINICAL INTERVENTIONS IN AGING. 16, 363-378
• SPRANGE, KIRSTY, BERESFORD-DENT, JULES, MOUNTAIN, GAIL, CRAIG, CLAIRE, MASON, CLARE, BERRY, KATHERINE, WRIGHT, JESSICA, MAJID, SHAZMIN, BEN THOMAS and COOPER, CINDY L., 2021. Assessing fidelity of a community based psychosocial intervention for people with mild dementia within a large randomised controlled trial BMC GERIATRICS. 21(1),
• BERRY, KATHERINE, WRIGHT, JESSICA, SPRANGE, KIRSTY, COOPER, CINDY, COURTNEY-WALKER, REBECCA and MOUNTAIN, GAIL, 2021. The implementation of Journeying through Dementia: Strategies to run a successful pragmatic multicenter trial of a complex intervention BRAIN AND BEHAVIOR. 11(12),
• SPRANGE, KIRSTY, MOUNTAIN, GAIL and CRAIG, CLAIRE, 2021. Evaluation of intervention fidelity of a complex psychosocial intervention Lifestyle Matters: a randomised controlled trial BMJ OPEN. 11(4),
• SPRANGE, KIRSTY, BERESFORD-DENT, JULES, MOUNTAIN, GAIL, THOMAS, BEN, WRIGHT, JESSICA, MASON, CLARE and COOPER, CINDY L., 2021. Journeying through Dementia Randomised Controlled Trial of a Psychosocial Intervention for People Living with Early Dementia: Embedded Qualitative 糖心原创 with Participants, Carers and Interventionists CLINICAL INTERVENTIONS IN AGING. 16, 231-244
• HUSBANDS, SAMANTHA, ELLIOTT, DAISY, DAVIS, TIM R. C., BLAZEBY, JANE M., HARRISON, ELEANOR F., MONTGOMERY, ALAN A., SPRANGE, KIRSTY, DULEY, LELIA, KARANTANA, ALEXIA, HOLLINGWORTH, WILLIAM and MILLS, NICOLA, 2020. Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI) PILOT AND FEASIBILITY STUDIES. 6(1),
• DAVIS, T. R. C., TAN, W., HARRISON, E. F., HOLLINGWORTH, W., KARANTANA, A., MILLS, N., HEPBURN, T., SPRANGE, K., DULEY, L., BLAZEBY, J. M., BAINBRIDGE, C. G., MURALI, S. R. and MONTGOMERY, A. A., 2020. A randomised feasibility trial comparing needle fasciotomy with limited fasciectomy treatment for Dupuytren's contractures PILOT AND FEASIBILITY STUDIES. 6(1),
• COLE, MICHELLE J., TAN, WEI, FIFER, HELEN, BRITTAIN, CLARE, DULEY, LELIA, HEPBURN, TRISH, LAWRENCE, TESSA, MONTGOMERY, ALAN A., SPRANGE, KIRSTY, THANDI, SUKHWINDER, CHURCHWARD, COLIN, TRIPODO, FRANCESCO, WOODFORD, NEIL and ROSS, JONATHAN D. C., 2020. Gentamicin, azithromycin and ceftriaxone in the treatment of gonorrhoea: the relationship between antibiotic MIC and clinical outcome JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 75(2), 449-457
• MITCHELL, E. J., GODOLPHIN, P. J., MEAKIN, G. and SPRANGE, K., 2020. Do investigator meetings improve recruitment rates in clinical trials? A retrospective before-and-after study of data from nine multi-centre clinical trials TRIALS. 21(1),
• MOUNTAIN, GAIL, SPRANGE, KIRSTY and CHATTERS, ROBIN, 2020. Lifestyle Matters Randomized Controlled Trial of a Preventive Health Intervention for Older People: Qualitative Sub 糖心原创 with Participants and Intervention Facilitators CLINICAL INTERVENTIONS IN AGING. 15, 239-253
• BIGGS, KATIE, HIND, DANIEL, GOSSAGE-WORRALL, REBECCA, SPRANGE, KIRSTY, WHITE, DAVID, WRIGHT, JESSICA, CHATTERS, ROBIN, BERRY, KATHERINE, PAPAIOANNOU, DIANA, BRADBURN, MIKE, WALTERS, STEPHEN J. and COOPER, CINDY, 2020. Challenges in the design, planning and implementation of trials evaluating group interventions TRIALS. 21(1),
• ROOSHENAS L ET AL, 2019. Journal of Clinical Epidemiology. 106, 108-120
• ROSS, JONATHAN D. C., BRITTAIN, CLARE, COLE, MICHELLE, DEWSNAP, CLAIRE, HARDING, JAN, HEPBURN, TRISH, JACKSON, LOUISE, KEOGH, MATTHEW, LAWRENCE, TESSA, MONTGOMERY, ALAN A., ROBERTS, TRACY E., SPRANGE, KIRSTY, TAN, WEI, THANDI, SUKHWINDER, WHITE, JOHN, WILSON, JANET and DULEY, LELIA, 2019. LANCET. 393(10190), 2511-2520
• SHAFAYAT, A., CSIPKE, E., BRADSHAW, L., CHARLESWORTH, G., DAY, F., LEUNG, P., MONIZ-COOK, E., MONTGOMERY, A. A., MORRIS, S., MOUNTAIN, G., OGOLLAH, R., SPRANGE, K., YATES, L. and ORRELL, M., 2019. Trials. 20(1), 709
• LINCOLN, N. B., BRADSHAW, L., CONSTANTINESCU, C. S., DAY, F., DRUMMOND, A., FITZSIMMONS, D., ... and DAS NAIR, R., 2019. Clinical Rehabilitation.
• WRIGHT, JESSICA, FOSTER, ALEXIS, COOPER, CINDY, SPRANGE, KIRSTY, WALTERS, STEPHEN, BERRY, KATHERINE, MONIZ-COOK, ESME, LOBAN, AMANDA, YOUNG, TRACEY ANNE, CRAIG, CLAIRE, DENING, TOM, LEE, ELLEN, BERESFORD-DENT, JULIE, THOMPSON, BENJAMIN JOHN, YOUNG, EMMA, THOMAS, BENJAMIN DAVID and MOUNTAIN, GAIL, 2019. BMJ OPEN. 9(9),
• ROBIN CHATTERS, LOUISE NEWBOLD, KIRSTY SPRANGE, DANIEL HIND, GAIL MOUNTAIN, KATY SHORTLAND, LAUREN POWELL, REBECCA GOSSAGE-WORRALL, TIM CHATER, ANJU KEETHARUTH, ELLEN LEE and BOB WOODS, 2018. Trials. 19(121),
• MAJOR G, BRADSHAW L, BOOTA N, SPRANGE K, DIGGLE M, MONTGOMERY AA, JAWHARI A and SPILLER R, 2018. GUT.
• HULL, MARK A., SPRANGE, KIRSTY, HEPBURN, TRISH, TAN, WEI, SHAFAYAT, AISHA, REES, COLIN J., CLIFFORD, GAYLE, LOGAN, RICHARD F., LOADMAN, PAUL M., WILLIAMS, ELIZABETH A., WHITHAM, DIANE and MONTGOMERY, ALAN A., 2018. Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 x 2 factorial trial LANCET. 392(10164), 2583-2594
• HARRISON E, TAN W, MILLS N, KARANTANA A, SPRANGE K, DULEY L, ELLIOTT D, BLAZEBY J, HOLLINGWORTH W, MONTGOMERY AA and DAVIS T, 2017. Trials. 18(1), 392
• MOUNTAIN, GAIL, WINDLE, GILL, HIND, DANIEL, WALTERS, STEPHEN, KEERTHARUTH, ANJU, CHATTERS, ROBIN, SPRANGE, KIRSTY, CRAIG, CLAIRE, COOK, SARAH, LEE, ELLEN, CHATER, TIM, WOODS, R., NEWBOULD, LOUISE, POWELL, LAUREN, SHORTLAND, KATY and ROBERTS, JENNIFER, 2017. AGE AND AGEING. 46(4), 627-634
• ROBIN CHATTERS, JENNIFER ROBERTS, GAIL MOUNTAIN, SARAH COOK, GILL WINDLE, CLAIRE CRAIG and KIRSTY SPRANGE, 2017. BMJ Open.
• KIRSTY SPRANGE, GAIL A MOUNTAIN, KATY SHORTLAND, CLAIRE CRAIG, DANIEL BLACKBURN, PETER BOWIE, KIRSTY HARKNESS and MAGGIE SPENCER, 2015. Pilot and Feasibility Studies. 1(42),
• EVERARD, MARK L., HIND, DANIEL, UGONNA, KELECHI, FREEMAN, JENNIFER, BRADBURN, MIKE, COOPER, CINDY L., CROSS, ELIZABETH, MAGUIRE, CHIN, CANTRILL, HANNAH, ALEXANDER, JOHN and MCNAMARA, PAUL S., 2014. THORAX. 69(12), 1105-1112
• SPRANGE, KIRSTY, MOUNTAIN, GAIL A., BRAZIER, JOHN, COOK, SARAH P., CRAIG, CLAIRE, HIND, DANIEL, WALTERS, STEPHEN J., WINDLE, GILL, WOODS, ROBERT, KEETHARUTH, ANJU D., CHATER, TIM and HORNER, KATH, 2013. TRIALS. 14(302),
• HIND, D, ROBERTS, C, SPRANGE, K, GOSSAGE-WORRALL, R, COOPER, C and WALTERS, S, 2013. Trials. 14((Suppl 1)),
• SPRANGE, K and CLIFT, M, 2012. Journal of the Royal Society of Medicine. 105(S4-S11),