糖心原创

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Katrin Krumbholz

Scientific Programme Leader, Faculty of Medicine & Health Sciences

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Biography

Previous appointments:

  • 20018-current: Research Programme Leader, School of Medicine, 糖心原创, UK
  • 2009-2018: Programme Leader, Medical Research Council Institute of Hearing Research, UK
  • 2004-2009: Programme Leader Track, Medical Research Council Institute of Hearing Research, UK
  • 2002-2004: Senior Research Associate, Research Centre J眉lich, Institute of Neuroscience and Medicine, DE
  • 2001-2002: Research Associate, University Hospital M眉nster, Institute of Experimental Audiology, DE
  • 1998-2001: Research Associate, University of Cambridge, Department of Physiology Development and Neuroscience, UK

Expertise Summary

I am an expert in hearing research and non-invasive neuro-recording techniques, particularly electroencephalography (EEG) and magnetic resonance imaging (MRI). I have extensive experience in recording and analyzing cortical auditory-evoked potentials (CAEPs), auditory brainstem responses (ABRs), and auditory-evoked functional MRI data.

Research Summary

Over the past ~14 years, our research has been focussed on using non-invasive neuro-recording techniques to unravel central auditory processing mechanisms in humans. We use EEG and fMRI to… read more

Recent Publications

  • DE BOER, JESSICA and KRUMBHOLZ, KATRIN, 2018. JOURNAL OF COGNITIVE NEUROSCIENCE. 30(6), 785-798
  • FLETCHER, M. D., KRUMBHOLZ, K. and DE BOER, J., 2016. J Assoc Res Otolaryngol. 17(6), 559-575
  • DUQUE, D., WANG, X., NIETO-DIEGO, J., KRUMBHOLZ, K. and MALMIERCA, M. S., 2016. Sci Rep. 6, 24114
  • SCHONWIESNER, M., DECHENT, P., VOIT, D., PETKOV, C. I. and KRUMBHOLZ, K., 2015. Cereb Cortex. 25(10), 3278-89

Current Research

Over the past ~14 years, our research has been focussed on using non-invasive neuro-recording techniques to unravel central auditory processing mechanisms in humans. We use EEG and fMRI to investigate how basic auditory features, such as frequency, pitch and location, are represented in subcortical and cortical auditory structures, and how these representations change in hearing loss. A particular interest in on modulatory mechanisms, including lateral inhibition, efferent control and adaptation. In our past research, we have used adaptation as a tool for probing auditory neuronal tuning properties.

Past Research

- We have used high-resolution fMRI and micro-structural MRI at 3 and 7T to reveal the organization of early auditory cortex in normal-hearing humans (Besle et al., 2019; Schonwiesner et al., 2015; Langers et al., 2014a, b)

- We have used EEG adaptation to demonstrate that auditory selective attention involves neuronal gain and neuronal sharpening (de Boer & Krumbholz, 2018)

- We have used EEG to demonstrate that the auditory brainstem response to speech (speech ABR) is strongly affected by its cochlear place of origin (Nutall et al., 2015)

- We have used psychoacoustics to measure the effect of the olivo-cochlear efferent system on active cochlear gain (Fletcher et al., 2013, 2015, 2016)

- We have used EEG to investigate the mechanisms of auditory adaptation (Briley & Krumbholz, 2013; Lanting et al. 2013)

- We have used cortical auditory-evoked potentials and fields to reveal cortical representation mechanisms of musical pitch (Briley et al., 2013; Lutkenhoner et al., 2011; Seither-Preisler et al., 2006a, b), sound location and motion (Edmonds & Krumbholz, 2014; Magezi & Krumbholz, 2010; Krumbholz et al., 2007), and phonemic information (Edmonds et al., 2010; Hewson-Stoate et al., 2006)

Future Research

Our current research aims to apply non-invasive methods to investigate changes in central auditory processing that may arise in consequence of peripheral hearing damage, such as sensorineural hearing loss and auditory deafferentation. Central auditory processing changes may underlie some of the most debilitating impairments associated with such damage - tinnitus, hyperacusis and speech-in-noise difficulty, which are still poorly understood, and not efficiently addressed by current treatments. Our current research projects aim to develop methodology for measuring hearing loss-related neuronal hyper-excitability and cortical tonotopic reorganization, both of which have been suggested as possible causes of tinnitus.

  • DE BOER, JESSICA and KRUMBHOLZ, KATRIN, 2018. JOURNAL OF COGNITIVE NEUROSCIENCE. 30(6), 785-798
  • FLETCHER, M. D., KRUMBHOLZ, K. and DE BOER, J., 2016. J Assoc Res Otolaryngol. 17(6), 559-575
  • DUQUE, D., WANG, X., NIETO-DIEGO, J., KRUMBHOLZ, K. and MALMIERCA, M. S., 2016. Sci Rep. 6, 24114
  • SCHONWIESNER, M., DECHENT, P., VOIT, D., PETKOV, C. I. and KRUMBHOLZ, K., 2015. Cereb Cortex. 25(10), 3278-89
  • NUTTALL, H. E., MOORE, D. R., BARRY, J. G., KRUMBHOLZ, K. and DE BOER, J., 2015. J Neurophysiol. 113(10), 3683-91
  • GILBERT, H. J., SHACKLETON, T. M., KRUMBHOLZ, K. and PALMER, A. R., 2015. J Neurosci. 35(1), 209-20
  • FLETCHER, M., DE BOER, J. and KRUMBHOLZ, K., 2015. J Assoc Res Otolaryngol. 16(2), 241-53
  • EDMONDS, B. A. and KRUMBHOLZ, K., 2014. J Assoc Res Otolaryngol. 15(1), 103-14
  • LANGERS, D. R., KRUMBHOLZ, K., BOWTELL, R. W. and HALL, D. A., 2014. Neuroimage. 100, 650-62
  • LANGERS, D. R., SANCHEZ-PANCHUELO, R. M., FRANCIS, S. T., KRUMBHOLZ, K. and HALL, D. A., 2014. Neuroimage. 100, 663-75
  • LANTING, C. P., BRILEY, P. M., SUMNER, C. J. and KRUMBHOLZ, K., 2013. J Neurophysiol. 110(4), 973-83
  • FLETCHER, M., DE BOER, J. and KRUMBHOLZ, K., 2013. Adv Exp Med Biol. 787, 65-72
  • MONAGHAN, J. J., KRUMBHOLZ, K. and SEEBER, B. U., 2013. J Acoust Soc Am. 133(4), 2288-300
  • BRILEY, P. M. and KRUMBHOLZ, K., 2013. J Neurophysiol. 110(12), 2679-88
  • BRILEY, P. M., BREAKEY, C. and KRUMBHOLZ, K., 2013. Cereb Cortex. 23(11), 2601-10
  • SUMNER, C. J. and KRUMBHOLZ, K., 2012. J Physiol. 590(16), 3645
  • DE BOER, J., THORNTON, A. R. and KRUMBHOLZ, K., 2012. J Neurophysiol. 107(5), 1301-12
  • BARRETT, D. J. and KRUMBHOLZ, K., 2012. Exp Brain Res. 222(1-2), 11-20
  • LUTKENHONER, B., SEITHER-PREISLER, A., KRUMBHOLZ, K. and PATTERSON, R. D., 2011. Hear Res. 272(1-2), 85-94
  • EDMONDS, B. A., JAMES, R. E., UTEV, A., VESTERGAARD, M. D., PATTERSON, R. D. and KRUMBHOLZ, K., 2010. Eur J Neurosci. 32(4), 684-92
  • MAGEZI, D. A. and KRUMBHOLZ, K., 2010. J Neurophysiol. 104(4), 1997-2007
  • KRUMBHOLZ, K., MAGEZI, D. A., MOORE, R. C. and PATTERSON, R. D., 2009. J Acoust Soc Am. 125(2), 1067-74
  • BALAGUER-BALLESTER, E., CLARK, N. R., COATH, M., KRUMBHOLZ, K. and DENHAM, S. L., 2009. PLoS Comput Biol. 5(3), e1000301
  • KRUMBHOLZ, K., NOBIS, E. A., WEATHERITT, R. J. and FINK, G. R., 2009. Hum Brain Mapp. 30(5), 1457-69
  • MAGEZI, D. A. and KRUMBHOLZ, K., 2008. J Acoust Soc Am. 124(5), 3095-3107
  • SCHONWIESNER, M., KRUMBHOLZ, K., RUBSAMEN, R., FINK, G. R. and VON CRAMON, D. Y., 2007. Cereb Cortex. 17(2), 492-9
  • KRUMBHOLZ, K., HEWSON-STOATE, N. and SCHONWIESNER, M., 2007. J Neurophysiol. 97(2), 1649-55
  • KRUMBHOLZ, K., EICKHOFF, S. B. and FINK, G. R., 2007. J Cogn Neurosci. 19(10), 1721-33
  • SEITHER-PREISLER, A., JOHNSON, L., KRUMBHOLZ, K., NOBBE, A., PATTERSON, R., SEITHER, S. and LUTKENHONER, B., 2007. J Exp Psychol Hum Percept Perform. 33(3), 743-51
  • SEITHER-PREISLER, A., PATTERSON, R. D., KRUMBHOLZ, K., SEITHER, S. and LUTKENHONER, B., 2006. Hear Res. 218(1-2), 50-63
  • SEITHER-PREISLER, A., PATTERSON, R., KRUMBHOLZ, K., SEITHER, S. and LUTKENHONER, B., 2006. Hear Res. 213(1-2), 88-98
  • HEWSON-STOATE, N., SCHONWIESNER, M. and KRUMBHOLZ, K., 2006. Eur J Neurosci. 24(9), 2661-71
  • KRUMBHOLZ, K., SCHONWIESNER, M., VON CRAMON, D. Y., RUBSAMEN, R., SHAH, N. J., ZILLES, K. and FINK, G. R., 2005. Cereb Cortex. 15(3), 317-24
  • KRUMBHOLZ, K., SCHONWIESNER, M., RUBSAMEN, R., ZILLES, K., FINK, G. R. and VON CRAMON, D. Y., 2005. Eur J Neurosci. 21(1), 230-8
  • KRUMBHOLZ, K., BLEECK, S., PATTERSON, R. D., SENOKOZLIEVA, M., SEITHER-PREISLER, A. and LUTKENHONER, B., 2005. J Acoust Soc Am. 118(2), 946-54
  • SEITHER-PREISLER, A., KRUMBHOLZ, K., PATTERSON, R., SEITHER, S. and LUTKENHONER, B., 2004. Eur J Neurosci. 19(11), 3073-80
  • KRUMBHOLZ, K., MARESH, K., TOMLINSON, J., PATTERSON, R. D., SEITHER-PREISLER, A. and LUTKENHONER, B., 2004. J Acoust Soc Am. 115(4), 1696-704
  • LUTKENHONER, B., KRUMBHOLZ, K. and SEITHER-PREISLER, A., 2003. Neuroimage. 19(3), 935-49
  • SEITHER-PREISLER, A., KRUMBHOLZ, K. and LUTKENHONER, B., 2003. Audiol Neurootol. 8(6), 322-37
  • LUTKENHONER, B., KRUMBHOLZ, K., LAMMERTMANN, C., SEITHER-PREISLER, A., STEINSTRATER, O. and PATTERSON, R. D., 2003. Neuroimage. 18(1), 58-66
  • KRUMBHOLZ, K., PATTERSON, R. D., SEITHER-PREISLER, A., LAMMERTMANN, C. and LUTKENHONER, B., 2003. Cereb Cortex. 13(7), 765-72
  • KRUMBHOLZ, K., PATTERSON, R. D., NOBBE, A. and FASTL, H., 2003. J Acoust Soc Am. 113(5), 2790-800
  • KRUMBHOLZ, K. and NOBBE, A., 2002. J Acoust Soc Am. 112(2), 654-63
  • PRESSNITZER, D., PATTERSON, R. D. and KRUMBHOLZ, K., 2001. J Acoust Soc Am. 109(5 Pt 1), 2074-84
  • KRUMBHOLZ, K. and SCHMIDT, S., 2001. J Acoust Soc Am. 109(4), 1705-16
  • KRUMBHOLZ, K., PATTERSON, R. D. and NOBBE, A., 2001. J Acoust Soc Am. 110(4), 2096-107
  • KRUMBHOLZ, K., PATTERSON, R. D. and PRESSNITZER, D., 2000. J Acoust Soc Am. 108(3 Pt 1), 1170-80
  • WIEGREBE, L. and KRUMBHOLZ, K., 1999. J Acoust Soc Am. 105(5), 2746-56
  • KRUMBHOLZ, K. and SCHMIDT, S., 1999. J Acoust Soc Am. 105(2 Pt 1), 898-911
  • KRUMBHOLZ, K. and WIEGREBE, L., 1998. Hear Res. 124(1-2), 155-69

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糖心原创
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