糖心原创

Contact

• workRoom C209f Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8231854
• judith.ramage@nottingham.ac.uk

Biography

Dr Judith Ramage is an Associate Professor within the School of Medicine, at the 糖心原创

She graduated from Glasgow University with a BSc in Immunology. She then went on to study Immunolgoical T cell memory for her PhD in Professor Hill Gastons laboratory, initially at Birmingham University then at Cambridge University.

She moved to The 糖心原创 for her first postdoc within the group of Professor Lindy Durrant to study the molecular mechanisms of Cancer vaccine targeting.

In 2005 Dr Ramage designed and set up the only Msc in the Country focusing on tumour Immunology (MSc Cancer Immunology and Biotechnology). She is the course director of this course as well as the module convenor of the cancer vaccine module. Dr Ramage is also the teaching lead for the Division of Cancer and Stem cells.

Her work has specifically focused on the study of the avidity of T cell responses to self antigens as well examining the methods of altering both positive and negative co-stimulatory molecules on tumour targets and the ability of T cells to transmigrate into the tumour.

Teaching Summary

Cancer Immunotherapy module Convenor

I initiated, designed and setup the only Cancer Immunology course in the UK. This course was established to met the rapid growth of cancer immunotherapy. The course is extremely popular with over 80 applicants per years. The course is intended to advance the students' knowledge of tumour immunology and to appreciate the contribution of immunological mechanisms to the development of anti-cancer therapies. We take on a maximum of 15 students per year. Students are trained to carry out critical evaluation of scientific papers and to develop the ability to report and interpret results. In addition they carry out a 6 month research project. The course attracts high calibre students and this is demonstrated through the grades achieved by the students on the course. Graduates have progressed to PhD study in laboratories around the world, in leading Immuno-Biotech companies, including Medimmune and the NIH laboratories headed by Steve Rosenberg. Indeed we have found this to be a good source of obtaining high calibre PhD students for the school.

Research Summary

Dr Ramage is a T cell tumour immunologist whose current areas of research are:

1. understanding the mechanisms of antigen specific T cell migration into tumours

2. generating monoclonal antibodies to tetraspanins expressed on T cells

Recent Publications

• SHAHD TALHOUNI, WAKKAS FADHIL, NIGEL P. MONGAN, LARA FIELD, KELLY HUNTER, SOGAND MAKHOUS, ALEXANDRE MACIEL-GUERRA, NAYANDEEP KAUR, AUSRINE NESTARENKAITE, ARVYDAS LAURINAVICIUS, BENJAMIN E. WILLCOX, TANIA DOTTORINI, IAN SPENDLOVE, ANDREW M. JACKSON, MOHAMMAD ILYAS and JUDITH M. RAMAGE, 2023. Front. Immunol.. 14,
• ANDREA M. GRIESINGER, KENT RIEMONDY, NITHYASHRI ESWARAN, ANDREW M. DONSON, NICHOLAS WILLARD, ERIC W. PRINCE, SIMON ML. PAINE, GEORGIA BOWES, JOHN RHEAUME, REBECCA J. CHAPMAN, JUDITH RAMAGE, ANDREW JACKSON, RICHARD G. GRUNDY, NICHOLAS K. FOREMAN and TIMOTHY A. RITZMANN, 2023. iScience.
• VANKEMMELBEKE, MIREILLE, MCINTOSH, RICHARD S, CHUA, JIA XIN, KIRK, THOMAS, DANIELS, IAN, PATSALIDOU, MARILENA, MOSS, ROBERT, PARSONS, TINA, SCOTT, DAVID, HARRIS, GEMMA, RAMAGE, JUDITH M, SPENDLOVE, IAN and DURRANT, LINDY G, 2020. Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement. Cancer research.
• MARIA CHASAMPALIOTI, ANDREW R. GREEN, IAN O. ELLIS, EMAD A. RAKHA, ANDREW M. JACKSON, IAN SPENDLOVE and JUDITH M RAMAGE, 2018. Breast Cancer Research and Treatment.

• View all publications

• SHAHD TALHOUNI, WAKKAS FADHIL, NIGEL P. MONGAN, LARA FIELD, KELLY HUNTER, SOGAND MAKHOUS, ALEXANDRE MACIEL-GUERRA, NAYANDEEP KAUR, AUSRINE NESTARENKAITE, ARVYDAS LAURINAVICIUS, BENJAMIN E. WILLCOX, TANIA DOTTORINI, IAN SPENDLOVE, ANDREW M. JACKSON, MOHAMMAD ILYAS and JUDITH M. RAMAGE, 2023. Front. Immunol.. 14,
• ANDREA M. GRIESINGER, KENT RIEMONDY, NITHYASHRI ESWARAN, ANDREW M. DONSON, NICHOLAS WILLARD, ERIC W. PRINCE, SIMON ML. PAINE, GEORGIA BOWES, JOHN RHEAUME, REBECCA J. CHAPMAN, JUDITH RAMAGE, ANDREW JACKSON, RICHARD G. GRUNDY, NICHOLAS K. FOREMAN and TIMOTHY A. RITZMANN, 2023. iScience.
• VANKEMMELBEKE, MIREILLE, MCINTOSH, RICHARD S, CHUA, JIA XIN, KIRK, THOMAS, DANIELS, IAN, PATSALIDOU, MARILENA, MOSS, ROBERT, PARSONS, TINA, SCOTT, DAVID, HARRIS, GEMMA, RAMAGE, JUDITH M, SPENDLOVE, IAN and DURRANT, LINDY G, 2020. Engineering the human Fc-region enables direct cell killing by cancer glycan-targeting antibodies without the need for immune effector cells or complement. Cancer research.
• MARIA CHASAMPALIOTI, ANDREW R. GREEN, IAN O. ELLIS, EMAD A. RAKHA, ANDREW M. JACKSON, IAN SPENDLOVE and JUDITH M RAMAGE, 2018. Breast Cancer Research and Treatment.
• MACHADO, L R, MOSELEY, P, MOSS, R, DEEN, S, NOLAN, C, SPENDLOVE, I, RAMAGE, J M, CHAN, S Y T and DURRANT, L, 2017. Oncotarget.
• MALECKA A, WANG Q, SHAH S, SUTAVANI R, SPENDLOVE I, RAMAGE J, GREENSMITH J, FRANKS H, GOUGH MJ, SAALBACH A, PATEL PM and JACKSON AM, 2016. Journal of leukocyte biology. 100(2), 381-389
• XUE, W, 2016. OncoImmunoloy.
• OELKRUG C and RAMAGE JM, 2014. Clinical and experimental immunology. 178(1), 1-8
• SUTAVANI, R.V., BRADLEY, R.G., RAMAGE, J.M., JACKSON, A.M., DURRANT, L.G. and SPENDLOVE, I., 2013. Journal of Immunology. 191(n/a), n/a
• POPPLE, A., DURRANT, L.G., SPENDLOVE, I., ROLLAND, P., SCOTT, I.V., DEEN, S. and RAMAGE, J.M., 2012. British Journal of Cancer. 106(7), 1306-1313
• PUDNEY, V.A., METHERINGHAM, R.L., GUNN, B., SPENDLOVE, I., RAMAGE, J.M. and DURRANT, L.G., 2010. European Journal of Immunology. 40(3), 899-910
• CAPASSO, M., DURRANT, L.G., STACEY, M., GORDON, S., RAMAGE, J. and SPENDLOVE, I., 2006. The Journal of Immunology. 177(2), 1070-1077
• RAMAGE, J.M., SPENDLOVE, I., REES, R., MOSS, R.S. and DURRANT, L.G., 2006. Cancer Immunology & Immunotherapy. 55(8), 1004-1010
• SPENDLOVE, I., RAMAGE, J.M., BRADLEY, R., HARRIS, C. and DURRANT, L.G., 2006. Cancer Immunology & Immunotherapy. 55(8), 987-995
• WATSON, N. F. S., RAMAGE, J. M., MADJD, Z., SPENDLOVE, I., ELLIS, I. O., SCHOLEFIELD, J. H. and DURRANT, L. G., 2006. International Journal of Cancer. VOL 118(NUMB 1), 6-10
• DURRANT, L. G. and RAMAGE, J. M., 2005. Expert Opinion on Biological Therapy. VOL 5(NUMB 4), 555-564
• RAMAGE, J.M., METHERINGHAM, R., CONN, A., SPENDLOVE, I., MOSS, R.S., PATTON, D.T., MURRAY, J.C., REES, R.C. and DURRANT, L.G., 2004. International Journal of Cancer. 110(2), 245-250
• RAMAGE, J.M, METHERINGHAM, R., MOSS, R., SPENDLOVE, I., REES, R. and DURRANT, L.G., 2004. Vaccine. 22(13-14), 1728-1731
• RAMAGE, J M, YOUNG, J L, GOODALL, J C and GASTON, J S, 1999. T cell responses to heat-shock protein 60: differential responses by CD4+ T cell subsets according to their expression of CD45 isotypes. The Journal of Immunology. 162(2), 704-10
• RAMAGE, J M and GASTON, J S, 1999. Rheumatology. 38(7), 631-5
• YOUNG, J L, RAMAGE, J M, GASTON, J S and BEVERLEY, P C, 1997. European Journal of Immunology. 27(9), 2383-90