糖心原创

Contact

• workBiodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• Jacqueline.Shields@nottingham.ac.uk

Biography

Jacqui studied for a Bachelor's degree in Pathology and Microbiology at the University of Bristol completing a PhD in the area of tumour microcirculation and lymphatic vessels in the lab of Professor Dave Bates at Bristol. This is really where her interest in the tumour microenvironment began. In 2005, she moved to Lausanne, Switzerland and the laboratory of Professor Melody Swartz, at the Institute of Bioengineering, EPFL for her post-doctoral training to further specialize in lymphatic functionality, and how this could relate to tumour progression.

In Mid 2011, she was appointed as a Group Leader at the Medical Research Council Cancer Unit, University of Cambridge, where she started a new research programme and gained tenure in 2019. In April 2022, she moved to King's College London and her lab is continuing a programme of research to advance understanding of how the tumour stroma operates to help a tumour develop and evolve. Jacqui was appointed Professor in Cancer Immunology at the 糖心原创 in January 2024. Her group are especially interested in the mechanisms by which these non-cancerous cells are able to shut off the immune responses to avoid our defenses, and how they may use this information to improve therapy responses.

Expertise Summary

The Stromal Immunology Lab focuses on detangling the mechanisms by which stromal cells such as fibroblasts and endothelial cells modulate immunity, with the ultimate aim of developing new therapeutic approaches

One of our focuses is understanding how these stromal populations regulate immune suppressive networks within the tumour microenvironment, revealing the mechanisms by which effective immune responses are lost to instead promote disease. To do this, we consider the intimate relationship between the tumour and connected lymph node niches utilizing GEMMs, proteomic and genomic approaches, and functional assays.

Recent Publications

• NOWICKI-OSUCH, K., ZHUANG, L., CHEUNG, T. S., BLACK, E. L., MASQUE-SOLER, N., DEVONSHIRE, G., REDMOND, A. M., FREEMAN, A., DI PIETRO, M., PILONIS, N., JANUSZEWICZ, W., O'DONOVAN, M., TAVARE, S., SHIELDS, J. D. and FITZGERALD, R. C., 2023. Cancer Discov. 13(6), 1346-1363
• MAZZAGLIA, C., SHENG, Y., RODRIGUES, L. N., LEI, I. M., SHIELDS, J. D. and HUANG, Y. Y. S., 2023. Biofabrication. 15(2),
• RIEDEL, A., HELAL, M., PEDRO, L., SWIETLIK, J. J., SHORTHOUSE, D., SCHMITZ, W., HAAS, L., YOUNG, T., DA COSTA, A. S. H., DAVIDSON, S., BHANDARE, P., WOLF, E., HALL, B. A., FREZZA, C., OSKARSSON, T. and SHIELDS, J. D., 2022. Cancer Immunol Res. 10(4), 482-497
• MUNIR, H., JONES, J. O., JANOWITZ, T., HOFFMANN, M., EULER, M., MARTINS, C. P., WELSH, S. J. and SHIELDS, J. D., 2021. Nat Commun. 12(1), 683

• View all publications

• NOWICKI-OSUCH, K., ZHUANG, L., CHEUNG, T. S., BLACK, E. L., MASQUE-SOLER, N., DEVONSHIRE, G., REDMOND, A. M., FREEMAN, A., DI PIETRO, M., PILONIS, N., JANUSZEWICZ, W., O'DONOVAN, M., TAVARE, S., SHIELDS, J. D. and FITZGERALD, R. C., 2023. Cancer Discov. 13(6), 1346-1363
• MAZZAGLIA, C., SHENG, Y., RODRIGUES, L. N., LEI, I. M., SHIELDS, J. D. and HUANG, Y. Y. S., 2023. Biofabrication. 15(2),
• RIEDEL, A., HELAL, M., PEDRO, L., SWIETLIK, J. J., SHORTHOUSE, D., SCHMITZ, W., HAAS, L., YOUNG, T., DA COSTA, A. S. H., DAVIDSON, S., BHANDARE, P., WOLF, E., HALL, B. A., FREZZA, C., OSKARSSON, T. and SHIELDS, J. D., 2022. Cancer Immunol Res. 10(4), 482-497
• MUNIR, H., JONES, J. O., JANOWITZ, T., HOFFMANN, M., EULER, M., MARTINS, C. P., WELSH, S. J. and SHIELDS, J. D., 2021. Nat Commun. 12(1), 683
• JONES, J. O., MOODY, W. M. and SHIELDS, J. D., 2021. Mol Oncol. 15(10), 2600-2633
• SCHUIJS, M. J., PNG, S., RICHARD, A. C., TSYBEN, A., HAMM, G., STOCKIS, J., GARCIA, C., PINAUD, S., NICHOLLS, A., ROS, X. R., SU, J., ELDRIDGE, M. D., RIEDEL, A., SERRAO, E. M., RODEWALD, H. R., MACK, M., SHIELDS, J. D., COHEN, E. S., MCKENZIE, A. N. J., GOODWIN, R. J. A., BRINDLE, K. M., MARIONI, J. C. and HALIM, T. Y. F., 2020. Nat Immunol. 21(9), 998-1009
• MUNIR, H., MAZZAGLIA, C. and SHIELDS, J. D., 2020. Adv Drug Deliv Rev. 161-162, 75-89
• MAHATA, B., PRAMANIK, J., VAN DER WEYDEN, L., POLANSKI, K., KAR, G., RIEDEL, A., CHEN, X., FONSECA, N. A., KUNDU, K., CAMPOS, L. S., RYDER, E., DUDDY, G., WALCZAK, I., OKKENHAUG, K., ADAMS, D. J., SHIELDS, J. D. and TEICHMANN, S. A., 2020. Nat Commun. 11(1), 3588
• DAVIDSON, S., EFREMOVA, M., RIEDEL, A., MAHATA, B., PRAMANIK, J., HUUHTANEN, J., KAR, G., VENTO-TORMO, R., HAGAI, T., CHEN, X., HANIFFA, M. A., SHIELDS, J. D. and TEICHMANN, S. A., 2020. Cell Rep. 31(7), 107628
• PEDRO, L., HARMER, Q., MAYES, E. and SHIELDS, J. D., 2019. Small. 15(20), e1900224
• SHORTHOUSE, D., RIEDEL, A., KERR, E., PEDRO, L., BIHARY, D., SAMARAJIWA, S., MARTINS, C. P., SHIELDS, J. and HALL, B. A., 2018. Nat Commun. 9(1), 3011
• MULIADITAN, T., CARON, J., OKESOLA, M., OPZOOMER, J. W., KOSTI, P., GEORGOULI, M., GORDON, P., LALL, S., KUZEVA, D. M., PEDRO, L., SHIELDS, J. D., GILLETT, C. E., DIEBOLD, S. S., SANZ-MORENO, V., NG, T., HOSTE, E. and ARNOLD, J. N., 2018. Nat Commun. 9(1), 2951
• LAKINS, M. A., GHORANI, E., MUNIR, H., MARTINS, C. P. and SHIELDS, J. D., 2018. Nat Commun. 9(1), 948
• RIEDEL, A., SHORTHOUSE, D., HAAS, L., HALL, B. A. and SHIELDS, J., 2016. Nat Immunol. 17(9), 1118-27
• SHIELDS, J. D., KOURTIS, I. C., TOMEI, A. A., ROBERTS, J. M. and SWARTZ, M. A., 2010. Science. 328(5979), 749-52
• MITEVA, D. O., RUTKOWSKI, J. M., DIXON, J. B., KILARSKI, W., SHIELDS, J. D. and SWARTZ, M. A., 2010. Circ Res. 106(5), 920-31