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Ian Spendlove

Associate Professor of Cancer Immunology and Course Director for MSc Oncology, Faculty of Medicine & Health Sciences

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Teaching Summary

Our group are instrumental in the running of two very successful MSc courses in Cancer Immunology and Biotechnology and Oncology. These focus on current developments and understanding of the causes… read more

Research Summary

We have been funded by the major institutions funding the development of novel aproaches to treating Cancer and Immune regulation including; Cancer Research UK, Pancreatic Cancer Research Fund, Lewis… read more

Selected Publications

  • SHARP, T., AL-ATTAR, A., FOXLER, D.E., DING, L., VALLIM, T.Q.D.A., ZHANG, Y., NIJMEH, H.S., WEBB, T.M., NICHOLSON, A.G., ZHANG, Q., KRAJA, A., SPENDLOVE, I., OSBOURNE, J., MARDIS, E. and LONGMORE, G.D., 2008. Proceedings of the National Academy of Sciences of the United States of America. 105(50), 19932-19937
  • AITHAL, G.P., THOMAS, J.A., KAYE, P.V., LAWSON, A., RYDER, S.D., SPENDLOVE, I., AUSTIN, A.S., FREEMAN, J.G., MORGAN, L. and WEBBER, J., 2008. Gastroenterology. 135(4), 1176-1184
  • SPENDLOVE, I., AL-ATTAR, A., WATHERSTONE, O., WEBB, T.M., ELLIS, E.O., LONGMORE, G.D. and SHARP, T.V., 2008. International Journal of Cancer. 123(10), 2247-2253
  • DUNCAN, T.J., AL-ATTAR, A., ROLLAND, P., SCOTT, I.V., DEEN, S., LIU, D.T.Y., SPENDLOVE, I. and DURRANT, L.G., 2008. Clinical Cancer Research. 14(10), 3030-3035

Our group are instrumental in the running of two very successful MSc courses in Cancer Immunology and Biotechnology and Oncology. These focus on current developments and understanding of the causes of cancer and also in the identification of novel approaches to treatment and targeting of cancer. The courses are 1 year long, have a mix of didactic teaching and interactive learning to provide the essential background to a six month research project. these are taken with one of the active cancer research groups at Nottingham and cover a range of subjects including Antibody development, Tumour-DC biology, Tregs and Cancer, Drug Design, Pathology, Radiation Biology, Preclinical tumour models, Vascular biology and site specific projects including Brain tumour, Breast cancer, Haematology, Melanoma research.

Current Research

We have been funded by the major institutions funding the development of novel aproaches to treating Cancer and Immune regulation including; Cancer Research UK, Pancreatic Cancer Research Fund, Lewis Charitable trust, MRC, Bowel Cancer Trust and the Cancr Vaccines Institute. Our programmes of work are focused around the discovery of strategies employed by tumours to avoid immune recognition and in so doing identify novel mechanisms and molecules that can be targeted. These include a novel class of glycans preferentially expressed by tumours against which we have generated high affinity, high specificity monoclonal antibodies. These demonstrate some potent anti-tumour activity and novel mechanisms of action, by directly affecting membrane integrity. Another class of antibodies we have generated are similar to a the checkpoint blockade antibodies in that they regulate immune function by interfering with T cell and antigen presenting cell communication. We chimerise and humanise our own antibodies and have access to a range of orthotopic Xenograft models in which to test their efficacy. One of our humanised antibodies controls the production of IL-10 in a regulatory population of T cells, sometimes referred to as Tr1. Our clinical association has enabled us to study these relatively uncharacterised T cells in diseases including Cancer and Multiple Sclerosis where dramatic changes can be observed.

Past Research

Our Group have over 20 years research expertise in the generation of antibodies to cancer and the development of these for pre-clinical and clinical trials. We have seen many of our antibodies enter phase one clinical trials, developed the first human anti-idiotype to go into clinical trails, currently have one antibody in trial and have a pipeline of antibody-based therapeutics being evaluated by the pharmaceutical industry.

Future Research

Our continued aim is to study immune defects in disease, identify potential targets at the tumour - immune cell interface and develop novel antibodies that target these.

We support a range of students from MSc, MRes and PhD to post doctoral fellows. We have active research projects in;

Understanding CD55-CD97 mediated regulation of IL-10 at the T-cell-DC interface. We have unique resources to enable us to characterise the profile of these cells, identify the pathways by which they are regulated and target these to regulate their induction and function.

Antibody development to tumour specific Glycans in a humanised Rat model (OmniRat, carrying the Human IgG locus)

Characterisation of anti-tetraspanin antibodies. A small class of molecules with roles in immune regulation, against which there are few reagents available. We have developed a novel strategy to overcome this shortfall and have a panel of anti-tetraspanin antibodies requiring characterisation.

  • MALECKA A, WANG Q, SHAH S, SUTAVANI R, SPENDLOVE I, RAMAGE J, GREENSMITH J, FRANKS H, GOUGH MJ, SAALBACH A, PATEL PM and JACKSON AM, 2016. Journal of leukocyte biology. 100(2), 381-389
  • WILLIAMS NC, JOHNSON MA, SHAW DE, SPENDLOVE I, VULEVIC J, SHARPE GR and HUNTER KA, 2016. Medicine and science in sports and exercise. 48(5 Suppl 1), 456-7
  • WILLIAMS NC, JOHNSON MA, SHAW DE, SPENDLOVE I, VULEVIC J, SHARPE GR and HUNTER KA, 2016. The British journal of nutrition. 116(5), 798-804
  • DINGJAN T, SPENDLOVE I, DURRANT LG, SCOTT AM, YURIEV E and RAMSLAND PA, 2015. Molecular immunology. 67(2 Pt A), 75-88
  • CHUA JX, VANKEMMELBEKE M, MCINTOSH RS, CLARKE PA, MOSS R, PARSONS T, SPENDLOVE I, ZAITOUN AM, MADHUSUDAN S and DURRANT LG, 2015. Clinical cancer research : an official journal of the American Association for Cancer Research. 21(13), 2963-74
  • WANG, Q., FRANKS, H.A., LAX, S.J., EL REFAEE, M., MALECKA, A., SHAH, S., SPENDLOVE, I., GOUGH, M.J., SEEDHOUSE, C., MADHUSUDAN, S., PATEL, P.M. and JACKSON, A.M., 2013. Journal of Immunology. 190(7), 3246-3255
  • NOBLE, P., SPENDLOVE, IAN, HARDING, S., PARSONS, T. and DURRANT, L. G., 2013. PLOS ONE.
  • NOBLE P, SPENDLOVE I, HARDING S, PARSONS T and DURRANT LG, 2013. PloS one. 8(2), e54892
  • SUTAVANI RV, BRADLEY RG, RAMAGE JM, JACKSON AM, DURRANT LG and SPENDLOVE I, 2013. Journal of immunology (Baltimore, Md. : 1950). 191(12), 5895-903
  • DURRANT LG, NOBLE P and SPENDLOVE I, 2012. Clinical And Experimental Immunology. 167(2), 206-15
  • KHOO EYH, STEVENSON MC, LEVERTON E, CROSS R, ERIKSSON JW, POUCHER SM, SPENDLOVE I, MORRIS PG, MACDONALD IA, MANSELL P and AITHAL GP, 2012. Digestive diseases and sciences. 57(11), 3017-25
  • POPPLE, A., DURRANT, L.G., SPENDLOVE, I., ROLLAND, P., SCOTT, I.V., DEEN, S. and RAMAGE, J.M., 2012. British Journal of Cancer. 106(7), 1306-1313
  • KHOO, E. Y., STEVENSON, M. C., LEVERTON, E., CROSS, R., ERIKSSON, J. W., POUCHER, S. M., SPENDLOVE, I., MORRIS, P. G., MACDONALD, I. A., MANSELL, P. and AITHAL, G. P., 2012. Dig Dis Sci. 57(11), 3017-25
  • STEPHANIE FOAN, ANDREW M JACKSON, IAN SPENDLOVE, UWE AICKELIN, 2011. . In: PIETRO LIO, GIUSEPPE NICOSIA, THOMAS STIBOR, ed., LNCS Artificial Immune Systems: Proceedings of 10th International Conference on Artificial Immune Systems (ICARIS2011) Vol:6825. Springer. 71-76
  • BAXENDALE A, VAN HOOFF P, DURRANT LG, SPENDLOVE I, HOWDLE SM, WOODS HM, WHITAKER MJ, DAVIES OR, NAYLOR A, LEWIS AL and ILLUM L, 2011. International Journal Of Pharmaceutics. 413(1-2), 147-54
  • PUDNEY, V.A., METHERINGHAM, R.L., GUNN, B., SPENDLOVE, I., RAMAGE, J.M. and DURRANT, L.G., 2010. European Journal of Immunology. 40(3), 899-910
  • DURRANT LG, PUDNEY V, SPENDLOVE I and METHERINGHAM RL, 2010. Expert Opinion On Biological Therapy. 10(5), 735-48
  • DUNCAN TJ, AL-ATTAR A, ROLLAND P, HARPER S, SPENDLOVE I and DURRANT LG, 2010. International Journal Of Gynecological Pathology : Official Journal Of The International Society Of Gynecological Pathologists. 29(1), 8-18
  • DUNCAN, T.J., AL-ATTAR, A., ROLLAND, P., SCOTT, I.V., DEEN, S., LIU, D.T.Y., SPENDLOVE, I. and DURRANT, L.G., 2008. Clinical Cancer Research. 14(10), 3030-3035
  • ULLENHAG, G.J., SPENDLOVE, I., WATSON, N.F.S., KALLMEYER, C., PRITCHARD-JONES, K. and DURRANT, L.G., 2008. Clinical Immunology. 128(2), 148-154
  • AITHAL, G.P., THOMAS, J.A., KAYE, P.V., LAWSON, A., RYDER, S.D., SPENDLOVE, I., AUSTIN, A.S., FREEMAN, J.G., MORGAN, L. and WEBBER, J., 2008. Gastroenterology. 135(4), 1176-1184
  • SPENDLOVE, I., AL-ATTAR, A., WATHERSTONE, O., WEBB, T.M., ELLIS, E.O., LONGMORE, G.D. and SHARP, T.V., 2008. International Journal of Cancer. 123(10), 2247-2253
  • SHARP, T., AL-ATTAR, A., FOXLER, D.E., DING, L., VALLIM, T.Q.D.A., ZHANG, Y., NIJMEH, H.S., WEBB, T.M., NICHOLSON, A.G., ZHANG, Q., KRAJA, A., SPENDLOVE, I., OSBOURNE, J., MARDIS, E. and LONGMORE, G.D., 2008. Proceedings of the National Academy of Sciences of the United States of America. 105(50), 19932-19937
  • ROLLAND, P., MADJD, Z., DURRANT, L., ELLIS, I.O., LAYFIELD, R. and SPENDLOVE, I., 2007. Endocrine-Related Cancer. 14(1), 73-80
  • ROLLAND, PHIL, SPENDLOVE, IAN, MADJID, ZAHRA, RAKHA, EMAD A, PATEL, POULAM, ELLIS, IAN O and DURRANT, LINDY, 2007. International Journal of Cancer. 120(6), 1311-7
  • ABBOTT, R.J.M., SPENDLOVE, I., ROVERSI, P., FITZGIBBON, H., KNOTT, V., TERIETE, P., MCDONNELL, J.M., HANDFORD, P.A. and LEA, S.M., 2007. Journal of Biological Chemistry. 282(30), 22023-22032
  • ROLLAND, P., DEEN, S., SCOTT, I., DURRANT, L. and SPENDLOVE, I., 2007. Clinical Cancer Research. 13, 3591-3596
  • DUNCAN, T.J., ROLLAND, P, DEEN,S, SCOTT, I. V., LIU, D. T, SPENDLOVE, I and DURRANT, L. G., 2007. Clin Cancer Res.. 13, 4139-45
  • CAPASSO, M., DURRANT, L.G., STACEY, M., GORDON, S., RAMAGE, J. and SPENDLOVE, I., 2006. The Journal of Immunology. 177(2), 1070-1077
  • ULLENHAG, G.J., SPENDLOVE, I., WATSON, N.F.S., INDAR, A.A., DUBE, M., ROBINS, R.A., MAXWELL-ARMSTRONG, C., SCHOLEFIELD, J.H. and DURRANT, L.G., 2006. Clinical Cancer Research. 12(24), 7389-7396
  • WATSON, N.F.S., SPENDLOVE, I., MADJD, Z., MCGILVRAY, R., GREEN, A.R., ELLIS, I.O., SCHOLEFIELD, J.H. and DURRANT, L.G., 2006. International Journal of Cancer. 118(6), 1445-1452
  • SPENDLOVE, I., RAMAGE, J.M., BRADLEY, R., HARRIS, C. and DURRANT, L.G., 2006. Cancer Immunology & Immunotherapy. 55(8), 987-995
  • WATSON, N. F. S., RAMAGE, J. M., MADJD, Z., SPENDLOVE, I., ELLIS, I. O., SCHOLEFIELD, J. H. and DURRANT, L. G., 2006. International Journal of Cancer. VOL 118(NUMB 1), 6-10
  • WATSON NFS, RAMAGE JM, MADJD Z, SPENDLOVE I, ELLIS IO, SCHOLEFIELD JH and DURRANT LG, 2006. International journal of cancer. Journal international du cancer. 118(1), 6-10
  • PRITCHARD-JONES, K., SPENDLOVE, I., WILTON, C., WHELAN, J., WEEDEN, S., LEWIS, I., HALE, J., DOUGLAS, C., PAGONIS, C., CAMPBELL, B., ALVAREZ, P., HALBERT, G. and DURRANT, L.G., 2005. British Journal of Cancer. 92(8), 1358-1365
  • MADJD, Z., DURRANT, L.G., PINDER, S.E., ELLIS, I.O., RONAN, J., LEWIS, S., RUSHMERE, N.K. and SPENDLOVE, I., 2005. Cancer Immunology, Immunotherapy. 54(2), 149-156
  • MADJD,Z., PARSONS,T., WATSON,N., SPENDLOVE,I., ELLIS,I. and DURRANT,L.G, 2005. Breast Cancer Research. 7(5), R780-R787
  • MADJD, Z., SPENDLOVE, I., PINDER, S. E., ELLIS, I. O. and DURRANT, L. G., 2005. International Journal of Cancer. VOL 117(NUMB 2), 248-255
  • RAMAGE, J.M., METHERINGHAM, R., CONN, A., SPENDLOVE, I., MOSS, R.S., PATTON, D.T., MURRAY, J.C., REES, R.C. and DURRANT, L.G., 2004. International Journal of Cancer. 110(2), 245-250
  • MADJD, Z., DURRANT, L. G., BRADLEY, R., SPENDLOVE, I., ELLIS, I. O. and PINDER, S. E., 2004. Clinical Cancer Research. VOL 10(PART 8), 2797-2803
  • PARSONS, T., SPENDLOVE, I., NIRULA, R., WRITER, M., CARTER, G., CARR, F. and DURRANT, L. G., 2004. Vaccine. VOL 22(NUMBER 25-26), 3487-3494
  • DURRANT,L.G. and SPENDLOVE,I., 2003. Expert Opinion on Emerging Drugs. 8(2), 489-500
  • REES RC, ROBINS RA, PAWELEC G, MULLER L, LI G and SPENDLOVE I, 2003. Cancer immunology, immunotherapy : CII. 52(6), 403-7
  • MORGAN, J., SPENDLOVE, I. and DURRANT, L. G., 2002. Tissue Antigens. VOL 60(PART 3), 213-223
  • LI, L., SPENDLOVE, I., MORGAN, J. and DURRANT, L.G., 2001. British Journal of Cancer. 84(1), 80-86
  • DURRANT, L. G., PARSONS, T., MOSS, R., SPENDLOVE, I., CARTER, G. and CARR, F., 2001. International Journal of Cancer. VOL 92(PART 3), 414-420
  • DURRANT, L G and SPENDLOVE, I, 2001. Immunization against tumor cell surface complement-regulatory proteins. Current Opinion in Investigational Drugs. 2(7), 959-66
  • SPENDLOVE, I., LI, L., POTTER, V., CHRISTIANSEN, D., LOVELAND, B. E. and DURRANT, L. G., 2000. European Journal of Immunology. VOL 30(PART 10), 2944-2953
  • DURRANT, L. G., BUCKLEY, D. J., ROBINS, R. A. and SPENDLOVE, I., 2000. International Journal of Cancer. VOL 85(NUMBER 1), 87-92
  • MCELVEEN, J.E., FURTADO, P.B., SMITH, S.J., CLARK, M.R., SPENDLOVE, I., SEWELL, H.F. and SHAKIB, F., 2000. Molecular Pathology. VOL 53(PART 2), 77-82
  • SPENDLOVE, I, LI, L, CARMICHAEL, J and DURRANT, L G, 1999. Decay accelerating factor (CD55): a target for cancer vaccines? Cancer Research. 59(10), 2282-6
  • DURRANT, L G, BUCKLEY, D J, SPENDLOVE, I and ROBINS, R A, 1997. Hybridoma.. 16(1), 23-6
  • DURRANT, L G and SPENDLOVE, I, 1996. Cancer vaccines. QJM (Quarterly Journal of Medicine). 89(9), 645-51
  • LOWE, J, MCDERMOTT, H, PIKE, I, SPENDLOVE, I, LANDON, M and MAYER, R J, 1992. Journal of Pathology. 166(1), 61-8
  • POLLER, D N, SPENDLOVE, I, BAKER, C, CHURCH, R, ELLIS, I O, PLOWMAN, G D and MAYER, R J, 1992. Journal of Pathology. 168(3), 275-80
  • LOWE, J, ERRINGTON, D R, LENNOX, G, PIKE, I, SPENDLOVE, I, LANDON, M and MAYER, R J, 1992. Neuropathology and Applied Neurobiology. 18(4), 341-50

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