糖心原创

Contact

• workRoom D207B Biodiscovery Institute, Science Road
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 823 1066
• fax0115 823 1059
• ian.sayers@nottingham.ac.uk

Biography

Ian Sayers graduated with a BSc in Biochemistry from Sheffield University, UK in 1993. He stayed at Sheffield and undertook research into the molecular basis of Immunoglobulin E (IgE) receptor interactions with a focus on therapeutic intervention in allergy graduating with a PhD in 1997. Dr Sayers has maintained his research interest in the molecular basis of asthma and allergy spending time with the Asthma Genetics Group in Southampton, UK (1998-2001) and in pre-clinical drug development in New Zealand at Genesis Research and Development Corporation and the Malaghan Institute (2001-2003). In 2004, Dr Sayers joined the 糖心原创 as a Lecturer and has developed a research group focussed to understanding the cellular and molecular mechanisms underlying asthma and COPD. He has subsequently been promoted to Associate Professor (2010), Reader (2013) and Professor (2017).

Expertise Summary

• Spatial transcriptomics and proteomics
• Primary airway cell and tissue models
• CRISPR/Cas9 approaches
• Molecular genetics
• Large scale genetic association/linkage studies
• Recombinant protein expression in bacteria, yeast and mammalian systems
• Site-directed mutagenesis
• Protein purification/analysis
• Gene expression profiling
• Promoter-reporter technology
• Flow cytometry
• RNA-seq

Teaching Summary

I co-ordinate the Respiratory Medicine short course given to medical students in their 3rd year which provides a comprehensive overview of both clinical a research topics of relevance to asthma,… read more

Research Summary

Research Interests

• Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease.
• Stratified medicine in respiratory disease.
• Virus - host interactions in the airways.

Selected Publications

• PORTELLI M and SAYERS I, 2012. Expert review of respiratory medicine. 6(2), 223-36
• STEWART, C.E., TORR, E.E., MOHD JAMILI, N.H., BOSQUILLON, C. and SAYERS, I., 2012. Journal of Allergy. 2012, 943982
• WAN, Y.I., STRACHAN, D.P., EVANS, D.M., HENDERSON, J., MCKEEVER, T., HOLLOWAY, J.W., HALL, I.P. and SAYERS, I., 2011. Journal of Allergy and Clinical Immunology. 127(1), 223-231.e3
• OBEIDAT M, WAIN LV, SHRINE N, KALSHEKER N, SOLER ARTIGAS M, REPAPI E, BURTON PR, JOHNSON T, RAMASAMY A, ZHAO JH, ZHAI G, HUFFMAN JE, VITART V, ALBRECHT E, IGL W, HARTIKAINEN A, POUTA A, CADBY G, HUI J, PALMER LJ, HADLEY D, MCARDLE WL, RUDNICKA AR, BARROSO I, LOOS RJF, WAREHAM NJ, MANGINO M, SORANZO N, SPECTOR TD, GL脛SER S, HOMUTH G, V脰LZKE H, DELOUKAS P, GRANELL R, HENDERSON J, GRKOVIC I, JANKOVIC S, ZGAGA L, POLA艩EK O, RUDAN I, WRIGHT AF, CAMPBELL H, WILD SH, WILSON JF, HEINRICH J, IMBODEN M, PROBST-HENSCH NM, GYLLENSTEN U, JOHANSSON 脜, ZABOLI G, MUSTELIN L, RANTANEN T, SURAKKA I, KAPRIO J, JARVELIN M, HAYWARD C, EVANS DM, KOCH B, MUSK AW, ELLIOTT P, STRACHAN DP, TOBIN MD, SAYERS I, HALL IP and SPIROMETA CONSORTIUM, 2011. Plos one. 6(5), e19382

• View all publications

I co-ordinate the Respiratory Medicine short course given to medical students in their 3rd year which provides a comprehensive overview of both clinical a research topics of relevance to asthma, COPD, lung cancer, IPF and infection. I also teach on the BSC Cancer Studies and several MSc courses.

Past Research

• The role of IgE in asthma and allergy.
• Pre-clinical drug development in asthma.
• The role of the uPA-uPAR axis in airway remodeling.

Future Research

Estimates suggest that 100-150 million people worldwide have asthma. In the UK the prevalence of asthma is particularly high, a recent report showed that in Scotland more than 18% of people experienced asthma symptoms and in England and Wales similar figures were reported, 17% and 15.3% respectively (Global Initiative for Asthma 2004). COPD is a composite term encompassing several diseases including chronic bronchitis and emphysema. COPD is the fourth most common cause of death worldwide (WHO 2004). Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression.

Getting stuck into mucus to find new treatments for severe asthma

The team of researchers led by Professor Ian Sayers have been awarded a 拢3M The group is a collaboration of experts from the Universities of Nottingham, Leicester, Manchester, Leeds, Imperial College London and AstraZeneca.

The lungs produce the jelly-like substance mucus that acts as a gatekeeper controlling access of harmful agents, such as microbes and toxin, into the body by trapping and removing them via the action of airway epithelial cells. However, in asthma, a build-up of mucus with abnormal properties can plug the airways, making symptoms worse, which is known as an exacerbation.

The framework of mucus is provided by large molecules called mucins. In the lung there are two types of mucin (MUC5AC and MUC5B). This group of researchers, along with others, have already shown that MUC5AC is increased in airway mucus in asthma. Importantly, they have identified genetic changes near the genes encoding MUC5AC and MUC5B that alter the levels of these genes and affect the risk of severe asthma.

This programme of work aims to employ state-of-the-art techniques spanning biology and physics to understand the mechanisms that control how mucus is regulated in our airways, how it contributes to severe asthma and how we might target it for therapeutic benefit.

Translating genetic findings to new understanding and therapeutic opportunities

There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. Through a collaborative interdisciplinary endeavour involving a Universities of Nottingham, Leicester and Cambridge we will accelerate discovery of genetic risk factors for lung function impairment, and define the mechanisms and biological pathways underpinning the observed associations. This will use new genomic data from population studies, building on the cross ancestry studies, and integrate with new multi-omic datasets using improved statistical genetic methodologies. To prioritise pathways we will undertake high-throughput functional genomic screens using CRISPR, perform lung digital spatial transcriptomic profiling and utilise informative cell and tissue models. This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease.

Advanced Interdisciplinary Models of dEstructive lung Disease: AIMED

Destructive lung diseases are the third largest cause of death worldwide, with chronic obstructive pulmonary disease (COPD) alone costing the NHS 拢1.9bn annually. COPD is characterised by destruction of the tissue that make up the air sacs (alveoli) within the lung, leading to airspace enlargement, which reduces the ability of the lung to exchange carbon dioxide and oxygen (i.e. loss of lung function). Lung tissue destruction in COPD is complex, with multiple mechanisms causing lung tissue damage. In contrast, lymphangioleiomyomatosis (LAM), another lung disease associated with tissue destruction that can cause respiratory failure and death, involves a single gene and has a well-understood progression. LAM is rare, primarily affecting younger females; however, the simpler nature of LAM allows a more straightforward starting point for interdisciplinary study of lung tissue destruction and makes it an effective model system for understanding destructive lung disease more widely. We will exploit this to develop and validate mathematical, imaging, and biological approaches for subsequent application to COPD and with broader implications for destructive lung diseases.

This grant brings together significant expertise and includes researchers at Universities of Nottingham, Leicester, Birmingham and the Diamond Light Source.

Getting the right drug to the right patient

As part of the Nottingham NIHR Biomedical Research Centre we have several programmes of work using different -omics platforms to identify patients most likely to gain benefit from biological drugs in severe asthma. Recently we have shown that a nasal gene signature at 3 months can identify patients that went on to have a clinically relevant response to mepolizumab at one year. See paper in . Ongoing studies aim to understand the mechanisms of mepolizumab action in the airways and potentially identify blood-based biomarkers.

Understanding virus - host interactions in the airways

Respiratory viruses such as rhinovirus and respiratory syncytial virus are known to contribute to exacerbation in respiratory diseases such as asthma. Current studies aim to further understand how these viruses interact with the host airway epithelium including developing new models and studying how genetics may be important in these interactions.

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, the cause of COVID-19, causes mild to severe respiratory illness exacerbated by aging and comorbidities. The virus has spread throughout the world leading to the current pandemic. Ongoing studies aim to understand the cellular and molecular mechanisms of how the virus interacts with the airway epithelium and leads to inflammation in the airways.

Functional genomics of the IL33/ST2 axis: a therapeutic target in asthma

The interleukin 33/suppression of tumorigenicity 2 (IL33/ST2) axis has been implicated in multiple human diseases including asthma. ST2 being the receptor for IL33. In particular we and other have shown that genetic polymorphisms spanning the IL33 and IL1RL1 (gene encoding ST2) have been reproducibly associated with . ST2 can exist in multiple forms including a membrane form that signals when IL33 is bound and a soluble form thought to act as a decoy receptor. However, the causative nature of the genetic changes spanning the IL33 and IL1RL1 gene loci are unclear at this time. Interestingly, the IL33/ST2 axis may be particularly important in airway epithelial function in asthma. Ongoing studies aim to further define the genetic association between variants in IL33 and ST2 genes with clinical features in asthma and importantly using tissue and primary cells from asthma patients further define the functional effects of gene polymorphism. See recent publications examining and .

Genetics of Asthma Severity & Phenotypes (GASP) Initiative

As part of an ongoing Asthma UK study Prof Sayers's group have developed a new cohort, the Genetics of Asthma Severity and Phenotypes (GASP) initiative that aims to generate a very large group of asthma patients with extensive clinical information for genetic studies. Recruitment is ongoing involving 20+ centres across the UK. The ultimate aim is to have genome wide association data for all subjects allowing genetic association testing for asthma and clinical features of asthma. We are actively looking for new centres to collaborate.

As part of GASP we have also identified asthma patients with moderate-severe asthma and have now completed the largest moderate-severe asthma case-control analysis to date identifying i. This study was a collaboration between; 糖心原创, University of Leicester, U-BIOPRED and AirPROM.

Targeting the airway epithelium in asthma

The airway epithelium represents a critical interface between the environment and the tissue of the airways. Under normal conditions the epithelium is composed of ciliated columnar, mucus secreting goblet and Clara cells that secrete surfactant. In asthma, epithelial desquamation and dysfunction including impaired barrier function and repair capacity have been reported, see recent . Epithelial damage and abnormal repair shows a correlation with the development of bronchial hyper-responsiveness (BHR) in asthma subjects. Ongoing studies aim to further our understanding of molecular mechanisms underlying these alterations in airway epithelial function using and may provide for asthma.

Collaborators

Prof. Ian Hall, Dr Marios Georgiou, Dr Christopher Coleman, Prof. Luisa Martinez-Pomares, Dr Rachel Clifford, Prof. Bindi Brook, Prof. Simon Johnson, Prof. Reuben O'Dea (Nottingham)

Prof. John Holloway (Southampton), Prof. Gerard Koppelman (Groningen), Prof. Liam Heaney (Belfast), Dr. Bianca Begh茅 (Modena), Prof. Angela Simpson (Manchester), Dr. Adel Mansur (Birmingham), Prof. Neil Thomson (Glasgow), Prof. Christopher Brightling, Prof. Martin Tobin, Dr. Louise Wain, Dr. Nick Shrine, Dr Katherine Fawcett, Dr Anna Guyatt, Dr. Dominick Shaw, dr. Himanchu Kaul (University of Leicester), Dr Emma Rawlins, Dr Joo-Hyeon Lee (Cambridge), Prof. Gowsihan Poologasundarampillia (University of Birmingham), Prof. Ian Adcock (Imperial), Prof. David Thornton (University of Manchester), Prof. Gleb Yakubov (University of Leeds), Dr. Luke Bonser (AstraZeneca).

Research Staff

Robert Hall, Alex Clay, Bridget Evans, Suzannah Entwistle, Rohan Paranjpe, Bitasadat Hosseini, Mobina Khadivar.

Current Postgraduate Research Students

Yousef Al Zahrani, James Eastall, Matthew Saward, Holly Pedley, Eryk Gadomski, Man Yin Melanie, Angus Spence

Previous Postgraduate Research Students

Emma Szamek (PhD, 2025), Rebecca Cooper (PhD, 2025), Ash Pradhan (PhD, 2024), Guoqing Qian (PhD 2023), Yik Pang (PhD 2022), Karina Bingham (PhD 2022), Maria E. Ketelaar (University of Groningen, PhD 2021), Yousef Al Zahrani (MSc 2019), Binaya KC (PhD 2019), Robert Hall (PhD 2019), Amanda Lewis (MPhil 2018), Jonathan O'loghlin (MRes 2017), Sangita Bhaker (PhD 2017), Alexander Kheirallah (PhD 2017), Kelly Probert (MPhil 2016), Catherine Gowland (PhD 2015), Jon ewis (MRes 2014), Mariel Slater (PhD 2014), Michael Portelli (PhD 2013), Ma'en Obeidat (PhD 2012), Jane Fox (PhD 2011), Yize Wan (PhD 2011), Emily Hodge (PhD 2011), Asif Tulah (PhD 2010), Khalid Al Balushi (PhD 2009), Samantha Peel (PhD 2008).

Funding

The Wellcome Trust, UKRI, Medical Research Council, Biotechnology & Biological Sciences Research Council, Asthma UK, National Institute of Health Research, Boehringer Ingelheim, GlaxoSmithKline plc, British Lung Foundation, Nottingham Hospitals Charity, British Medical Association, Medical Research Council, Hermes Fellowship.

• SHRINE N, PORTELLI MA, JOHN C, SOLER ARTIGAS M, BENNETT N, HALL R, LEWIS J, HENRY AP, BILLINGTON CK, AHMAD A, PACKER RJ, SHAW D, POGSON ZEK, FOGARTY A, MCKEEVER TM, SINGAPURI A, HEANEY LG, MANSUR AH, CHAUDHURI R, THOMSON NC, HOLLOWAY JW, LOCKETT GA, HOWARTH PH, DJUKANOVIC R, HANKINSON J, NIVEN R, SIMPSON A, CHUNG KF, STERK PJ, BLAKEY JD, ADCOCK IM, HU S, GUO Y, OBEIDAT M, SIN DD, VAN DEN BERGE M, NICKLE DC, BOSS脡 Y, TOBIN MD, HALL IP, BRIGHTLING CE, WAIN LV and SAYERS I, 2018. The Lancet. Respiratory medicine. 7(1), 20-34
• HALL R, HALL IP and SAYERS I, 2018. Respirology (Carlton, Vic.). (In Press.)
• WAIN LV, SHRINE N, ARTIGAS MS, ERZURUMLUOGLU AM, NOYVERT B, BOSSINI-CASTILLO L, OBEIDAT M, HENRY AP, PORTELLI MA, HALL RJ, BILLINGTON CK, RIMINGTON TL, FENECH AG, JOHN C, BLAKE T, JACKSON VE, ALLEN RJ, PRINS BP, , CAMPBELL A, PORTEOUS DJ, JARVELIN MR, WIELSCHER M, JAMES AL, HUI J, WAREHAM NJ, ZHAO JH, WILSON JF, JOSHI PK, STUBBE B, RAWAL R, SCHULZ H, IMBODEN M, PROBST-HENSCH NM, KARRASCH S, GIEGER C, DEARY IJ, HARRIS SE, MARTEN J, RUDAN I, ENROTH S, GYLLENSTEN U, KERR SM, POLASEK O, K脛H脰NEN M, SURAKKA I, VITART V, HAYWARD C, LEHTIM脛KI T, RAITAKARI OT, EVANS DM, HENDERSON AJ, PENNELL CE, WANG CA, SLY PD, WAN ES, BUSCH R, HOBBS BD, LITONJUA AA, SPARROW DW, GULSVIK A, BAKKE PS, CRAPO JD, BEATY TH, HANSEL NN, MATHIAS RA, RUCZINSKI I, BARNES KC, BOSS脡 Y, JOUBERT P, VAN DEN BERGE M, BRANDSMA CA, PAR脡 PD, SIN DD, NICKLE DC, HAO K, GOTTESMAN O, DEWEY FE, BRUSE SE, CAREY DJ, KIRCHNER HL, , JONSSON S, THORLEIFSSON G, JONSDOTTIR I, GISLASON T, STEFANSSON K, SCHURMANN C, NADKARNI G, BOTTINGER EP, LOOS RJ, WALTERS RG, CHEN Z, MILLWOOD IY, VAUCHER J, KURMI OP, LI L, HANSELL AL, BRIGHTLING C, ZEGGINI E, CHO MH, SILVERMAN EK, SAYERS I, TRYNKA G, MORRIS AP, STRACHAN DP, HALL IP and TOBIN MD, 2017. Nature genetics. (In Press.)
• ARTIGAS MS, WAIN LV, SHRINE N, MCKEEVER TM, , SAYERS I, HALL IP and TOBIN MD, 2017. PloS one. 12(1), e0170222
• KHEIRALLAH AK, DE MOOR CH, FAIZ A, SAYERS I and HALL IP, 2017. BMC genomics. 18(1), 248
• RIMINGTON TL, HODGE E, BILLINGTON CK, BHAKER S, K C B, KILTY I, JELINSKY S, HALL IP and SAYERS I, 2017. F1000Research. 6, 460
• ALLEN RJ, PORTE J, BRAYBROOKE R, FLORES C, FINGERLIN TE, OLDHAM JM, GUILLEN-GUIO B, MA SF, OKAMOTO T, JOHN AE, OBEIDAT M, YANG IV, HENRY A, HUBBARD RB, NAVARATNAM V, SAINI G, THOMPSON N, BOOTH HL, HART SP, HILL MR, HIRANI N, MAHER TM, MCANULTY RJ, MILLAR AB, MOLYNEAUX PL, PARFREY H, RASSL DM, WHYTE MKB, FAHY WA, MARSHALL RP, OBALLA E, BOSS脡 Y, NICKLE DC, SIN DD, TIMENS W, SHRINE N, SAYERS I, HALL IP, NOTH I, SCHWARTZ DA, TOBIN MD, WAIN LV and JENKINS RG, 2017. The Lancet. Respiratory medicine. (In Press.)
• IERODIAKONOU, D., PORTELLI, M.A., POSTMA, D.S., KOPPELMAN, G.H., GERRITSEN, J., HACKEN, N.H.T.T., TIMENS, W., BOEZEN, H.M., VONK, J.M. and SAYERS, I., 2016. European Respiratory Journal. 47(5), 1568-1571
• JACKSON VE, NTALLA I, SAYERS I, MORRIS R, WHINCUP P, CASAS JP, AMUZU A, CHOI M, DALE C, KUMARI M, ENGMANN J, KALSHEKER N, CHAPPELL S, GUETTA-BARANES T, MCKEEVER TM, PALMER CN, TAVENDALE R, HOLLOWAY JW, SAYER AA, DENNISON EM, COOPER C, BAFADHEL M, BARKER B, BRIGHTLING C, BOLTON CE, JOHN ME, PARKER SG, MOFFAT MF, WARDLAW AJ, CONNOLLY MJ, PORTEOUS DJ, SMITH BH, PADMANABHAN S, HOCKING L, STIRRUPS KE, DELOUKAS P, STRACHAN DP, HALL IP, TOBIN MD and WAIN LV, 2016. Thorax. 71(6), 501-9
• KHEIRALLAH AK, MILLER S, HALL IP and SAYERS I, 2016. Advances in genetics. 93, 57-145
• IERODIAKONOU D, PORTELLI MA, POSTMA DS, KOPPELMAN GH, GERRITSEN J, TEN HACKEN NH, TIMENS W, BOEZEN HM, VONK JM and SAYERS I, 2016. The European respiratory journal. 47(5), 1568-71
• JOHN M, MCKEEVER T, AL HADDAD M, HALL IP, SAYERS I, COCKCROFT JR and BOLTON CE, 2016. Chronic respiratory disease. 13(3), 247-55
• KETELAAR ME, NAWIJN MC, SHAW DE, KOPPELMAN GH and SAYERS I, 2016. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 46(6), 884-7
• 2016. Physiological reports. 4(18),
• MILLER S, HENRY AP, HODGE E, KHEIRALLAH AK, BILLINGTON CK, RIMINGTON TL, BHAKER SK, OBEIDAT M, MEL脡N E, MERID SK, SWAN C, GOWLAND C, NELSON CP, STEWART CE, BOLTON CE, KILTY I, MALARSTIG A, PARKER SG, MOFFATT MF, WARDLAW AJ, HALL IP and SAYERS I, 2016. PloS one. 11(10), e0164041
• PORTELLI MA, MOSELEY C, STEWART CE, POSTMA DS, HOWARTH P, WARNER JA, HOLLOWAY JW, KOPPELMAN GH, BRIGHTLING C and SAYERS I, 2016. Allergy. (In Press.)
• TORR E, HEATH M, MEE M, SHAW D, SHARP TV and SAYERS I, 2016. Physiological reports. 4(16),
• MILLER S, MEL脡N E, MERID SK, HALL IP and SAYERS I, 2016. Respiratory research. 17(1), 95
• WAIN, L. V., SHRINE, N., MILLER, S., JACKSON, V. E., NTALLA, I., SOLER ARTIGAS, M., BILLINGTON, C. K., KHEIRALLAH, A. K., ALLEN, R., COOK, J. P., PROBERT, K., OBEIDAT, M., BOSSE, Y., HAO, K., POSTMA, D. S., PARE, P. D., RAMASAMY, A., U. K. BRAIN EXPRESSION CONSORTIUM, MAGI, R., MIHAILOV, E., REINMAA, E., MELEN, E., O'CONNELL, J., FRANGOU, E., DELANEAU, O., OX, G. S. K. CONSORTIUM, FREEMAN, C., PETKOVA, D., MCCARTHY, M., SAYERS, I., DELOUKAS, P., HUBBARD, R., PAVORD, I., HANSELL, A. L., THOMSON, N. C., ZEGGINI, E., MORRIS, A. P., MARCHINI, J., STRACHAN, D. P., TOBIN, M. D. and HALL, I. P., 2015. Lancet Respir Med. 3(10), 769-81
• SOLER ARTIGAS M, WAIN LV, MILLER S, KHEIRALLAH AK, HUFFMAN JE, NTALLA I, SHRINE N, OBEIDAT M, TROCHET H, MCARDLE WL, ALVES AC, HUI J, ZHAO JH, JOSHI PK, TEUMER A, ALBRECHT E, IMBODEN M, RAWAL R, LOPEZ LM, MARTEN J, ENROTH S, SURAKKA I, POLASEK O, LYYTIK脛INEN LP, GRANELL R, HYSI PG, FLEXEDER C, MAHAJAN A, BEILBY J, BOSS脡 Y, BRANDSMA CA, CAMPBELL H, GIEGER C, GL脛SER S, GONZ脕LEZ JR, GRALLERT H, HAMMOND CJ, HARRIS SE, HARTIKAINEN AL, HELI脰VAARA M, HENDERSON J, HOCKING L, HORIKOSHI M, HUTRI-K脛H脰NEN N, INGELSSON E, JOHANSSON 脜, KEMP JP, KOLCIC I, KUMAR A, LIND L, MEL脡N E, MUSK AW, NAVARRO P, NICKLE DC, PADMANABHAN S, RAITAKARI OT, RIED JS, RIPATTI S, SCHULZ H, SCOTT RA, SIN DD, STARR JM, , VI脩UELA A, V脰LZKE H, WILD SH, WRIGHT AF, ZEMUNIK T, JARVIS DL, SPECTOR TD, EVANS DM, LEHTIM脛KI T, VITART V, K脛H脰NEN M, GYLLENSTEN U, RUDAN I, DEARY IJ, KARRASCH S, PROBST-HENSCH NM, HEINRICH J, STUBBE B, WILSON JF, WAREHAM NJ, JAMES AL, MORRIS AP, JARVELIN MR, HAYWARD C, SAYERS I, STRACHAN DP, HALL IP and TOBIN MD, 2015. Nature communications. 6, 8658
• SAYERS I, PORTELLI MA and SIEDLINSKI M, 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(12), 4759
• WAIN LV, SHRINE N, MILLER S, JACKSON VE, NTALLA I, SOLER ARTIGAS M, BILLINGTON CK, KHEIRALLAH AK, ALLEN R, COOK JP, PROBERT K, OBEIDAT M, BOSS脡 Y, HAO K, POSTMA DS, PAR脡 PD, RAMASAMY A, , M脛GI R, MIHAILOV E, REINMAA E, MEL脡N E, O'CONNELL J, FRANGOU E, DELANEAU O, , FREEMAN C, PETKOVA D, MCCARTHY M, SAYERS I, DELOUKAS P, HUBBARD R, PAVORD I, HANSELL AL, THOMSON NC, ZEGGINI E, MORRIS AP, MARCHINI J, STRACHAN DP, TOBIN MD and HALL IP, 2015. The Lancet. Respiratory medicine. 3(10), 769-81
• WAIN LV, ODENTHAL-HESSE L, ABUJABER R, SAYERS I, BEARDSMORE C, GAILLARD EA, CHAPPELL S, DOGARU CM, MCKEEVER T, GUETTA-BARANES T, KALSHEKER N, KUEHNI CE, HALL IP, TOBIN MD and HOLLOX EJ, 2014. PloS one. 9(1), e84192
• SLATER M, RIVETT DW, WILLIAMS L, MARTIN M, HARRISON T, SAYERS I, BRUCE KD and SHAW D, 2014. Thorax. 69, 673-674
• LOTH DW, ARTIGAS MS, GHARIB SA, WAIN LV, FRANCESCHINI N, KOCH B, POTTINGER TD, SMITH AV, DUAN Q, OLDMEADOW C, LEE MK, STRACHAN DP, JAMES AL, HUFFMAN JE, VITART V, RAMASAMY A, WAREHAM NJ, KAPRIO J, WANG X, TROCHET H, K脛H脰NEN M, FLEXEDER C, ALBRECHT E, LOPEZ LM, DE JONG K, THYAGARAJAN B, ALVES AC, ENROTH S, OMENAAS E, JOSHI PK, FALL T, VI脩UELA A, LAUNER LJ, LOEHR LR, FORNAGE M, LI G, WILK JB, TANG W, MANICHAIKUL A, LAHOUSSE L, HARRIS TB, NORTH KE, RUDNICKA AR, HUI J, GU X, LUMLEY T, WRIGHT AF, HASTIE ND, CAMPBELL S, KUMAR R, PIN I, SCOTT RA, PIETIL脛INEN KH, SURAKKA I, LIU Y, HOLLIDAY EG, SCHULZ H, HEINRICH J, DAVIES G, VONK JM, WOJCZYNSKI M, POUTA A, JOHANSSON A, WILD SH, INGELSSON E, RIVADENEIRA F, V脰LZKE H, HYSI PG, EIRIKSDOTTIR G, MORRISON AC, ROTTER JI, GAO W, POSTMA DS, WHITE WB, RICH SS, HOFMAN A, ASPELUND T, COUPER D, SMITH LJ, PSATY BM, LOHMAN K, BURCHARD EG, UITTERLINDEN AG, GARCIA M, JOUBERT BR, MCARDLE WL, MUSK AB, HANSEL N, HECKBERT SR, ZGAGA L, VAN MEURS JBJ, NAVARRO P, RUDAN I, OH Y, REDLINE S, JARVIS DL, ZHAO JH, RANTANEN T, O'CONNOR GT, RIPATTI S, SCOTT RJ, KARRASCH S, GRALLERT H, GADDIS NC, STARR JM, WIJMENGA C, MINSTER RL, LEDERER DJ, PEKKANEN J, GYLLENSTEN U, CAMPBELL H, MORRIS AP, GL脛SER S, HAMMOND CJ, BURKART KM, BEILBY J, KRITCHEVSKY SB, GUDNASON V, HANCOCK DB, WILLIAMS OD, POLASEK O, ZEMUNIK T, KOLCIC I, PETRINI MF, WJST M, KIM WJ, PORTEOUS DJ, SCOTLAND G, SMITH BH, VILJANEN A, HELI脰VAARA M, ATTIA JR, SAYERS I, HAMPEL R, GIEGER C, DEARY IJ, BOEZEN HM, NEWMAN A, JARVELIN M, WILSON JF, LIND L, STRICKER BH, TEUMER A, SPECTOR TD, MEL脡N E, PETERS MJ, LANGE LA, BARR RG, BRACKE KR, VERHAMME FM, SUNG J, HIEMSTRA PS, CASSANO PA, SOOD A, HAYWARD C, DUPUIS J, HALL IP, BRUSSELLE GG, TOBIN MD and LONDON SJ, 2014. Nature genetics. (In Press.)
• WAIN LV, SAYERS I, SOLER ARTIGAS M, PORTELLI MA, ZEGGINI E, OBEIDAT M, SIN DD, BOSS脡 Y, NICKLE D, BRANDSMA C, MALARSTIG A, VANGJELI C, JELINSKY SA, JOHN S, KILTY I, MCKEEVER T, SHRINE NRG, COOK JP, PATEL S, SPECTOR TD, HOLLOX EJ, HALL IP and TOBIN MD, 2014. PLoS genetics. 10(5), e1004314
• PORTELLI MA, HODGE E and SAYERS I, 2014. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. (In Press.)
• KONING H, VAN OOSTERHOUT AJM, BROUWER U, DEN BOEF LE, GRAS R, REINDERS-LUINGE M, BRANDSMA C, VAN DER TOORN M, HYLKEMA MN, WILLEMSE BWM, SAYERS I, KOPPELMAN GH and NAWIJN MC, 2014. PloS one. 9(7), e98197
• SINGH SR, BILLINGTON CK, SAYERS I and HALL IP, 2014. Respiratory research. 15, 57
• PORTELLI MA, STEWART CE, HALL IP, BRIGHTLING CE and SAYERS I, 2014. American journal of respiratory cell and molecular biology. (In Press.)
• SAYERS I, 2013. Clinical science (London, England : 1979). 124(8), 517-9
• STEWART CE and SAYERS I, 2013. Lung.
• EMILY HODGE, WILLIAM Y.C. CHANG, KATHERINE A. SELBY, IAN P. HALL and IAN SAYERS, 2013. Ann Allergy Asthma Immunol. 111(1), 38-44.e1
• BARLOW, J.L., PEEL, S., FOX, J., PANOVA, V., HARDMAN, C.S., CAMELO, A., BUCKS, C., WU, X., KANE, C.M., NEILL, D.R., FLYNN, R.J., SAYERS, I., HALL, I.P. and MCKENZIE, A.N.J., 2013. Journal of Allergy and Clinical Immunology. 132(4), 933-941
• HODGE E, CHANG WYC, SELBY KA, HALL IP and SAYERS I, 2013. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 111(1), 38-44
• HODGE E, NELSON CP, MILLER S, BILLINGTON CK, STEWART CE, SWAN C, MALARSTIG A, HENRY AP, GOWLAND C, MEL脡N E, HALL IP and SAYERS I, 2013. Respiratory research. 14, 77
• OBEIDAT M, MILLER S, PROBERT K, BILLINGTON CK, HENRY AP, HODGE E, NELSON CP, STEWART CE, SWAN C, WAIN LV, ARTIGAS MS, MEL脡N E, USHEY K, HAO K, LAMONTAGNE M, BOSS脡 Y, POSTMA DS, TOBIN MD, SAYERS I and HALL IP, 2013. PloS one. 8(9), e74630
• TULAH AS, HOLLOWAY JW and SAYERS I, 2013. BMC medical genetics. 14(1), 100 (In Press.)
• PORTELLI MA, SIEDLINSKI M, STEWART CE, POSTMA DS, NIEUWENHUIS MA, VONK JM, NURNBERG P, ALTMULLER J, MOFFATT MF, WARDLAW AJ, PARKER SG, CONNOLLY MJ, KOPPELMAN GH and SAYERS I, 2013. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. (In Press.)
• STEWART, C.E., NIJMEH, H.S., BRIGHTLING, C.E. and SAYERS, I., 2012. Thorax. 67(6), 477-487
• STEWART, C.E., TORR, E.E., MOHD JAMILI, N.H., BOSQUILLON, C. and SAYERS, I., 2012. Journal of Allergy. 2012, 943982
• PORTELLI M and SAYERS I, 2012. Expert review of respiratory medicine. 6(2), 223-36
• WAN YI, SHRINE NRG, SOLER ARTIGAS M, WAIN LV, BLAKEY JD, MOFFATT MF, BUSH A, CHUNG KF, COOKSON WOCM, STRACHAN DP, HEANEY L, AL-MOMANI BAH, MANSUR AH, MANNEY S, THOMSON NC, CHAUDHURI R, BRIGHTLING CE, BAFADHEL M, SINGAPURI A, NIVEN R, SIMPSON A, HOLLOWAY JW, HOWARTH PH, HUI J, MUSK AW, JAMES AL, AUSTRALIAN ASTHMA GENETICS CONSORTIUM, BROWN MA, BALTIC S, FERREIRA MAR, THOMPSON PJ, TOBIN MD, SAYERS I and HALL IP, 2012. Thorax. 67(9), 762-8
• TULAH AS, BEGH脡 B, BARTON SJ, HOLLOWAY JW and SAYERS I, 2012. BMC medical genetics. 13(1), 110 (In Press.)
• WAN, Y.I., STRACHAN, D.P., EVANS, D.M., HENDERSON, J., MCKEEVER, T., HOLLOWAY, J.W., HALL, I.P. and SAYERS, I., 2011. Journal of Allergy and Clinical Immunology. 127(1), 223-231.e3
• KONING H, SAYERS I, STEWART CE, DE JONG D, TEN HACKEN NHT, POSTMA DS, VAN OOSTERHOUT AJM, NAWIJN MC and KOPPELMAN GH, 2011. The Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology. (In Press.)
• SOLER ARTIGAS, M., WAIN, L.V., REPAPI, E., OBEIDAT, M., SAYERS, I., BURTON, P.R., JOHNSON, T., ZHAO, J.H., ALBRECHT, E., DOMINICZAK, A.F., KERR, S.M., SMITH, B.H., CADBY, G., HUI, J., PALMER, L.J., HINGORANI, A.D., WANNAMETHEE, S.G., WHINCUP, P.H., EBRAHIM, S., SMITH, G.D., BARROSO, I., LOOS, R.J.F., WAREHAM, N.J., COOPER, C., DENNISON, E., SHAHEEN, S.O., LIU, J.Z., MARCHINI, J., MEDICAL RESEARCH COUNCIL NATIONAL SURVEY OF HEALTH AND DEVELOPMENT (NSHD) RESPIRATORY STUDY TEAM, DAHGAM, S., NALUAI, A.T., OLIN, A., KARRASCH, S., HEINRICH, J., SCHULZ, H., MCKEEVER, T.M., PAVORD, I.D., HELI脰VAARA, M., RIPATTI, S., SURAKKA, I., BLAKEY, J.D., K膧H脰NEN, M., BRITTON, J.R., NYBERG, F., HOLLOWAY, J.W., LAWLOR, D.A., MORRIS, R.W., JAMES, A.L., JACKSON, C.M., HALL, I.P., TOBIN, M.D. and SPIROMETA CONSORTIUM, 2011. American Journal of Respiratory and Critical Care Medicine. 184(7), 786-795
• ARTIGAS, M.S., LOTH, D.W., WAIN, L.V., GHARIB, S.A., OBEIDAT, M., TANG, W., ZHAI, G., ZHAO, J.H., SMITH, A.V., HUFFMAN, J.E., ALBRECHT, E., JACKSON, C.M., EVANS, D.M., CADBY, G., FORNAGE, M., MANICHAIKUL, A., LOPEZ, L.M., JOHNSON, T., ALDRICH, M.C., ASPELUND, T., BARROSO, I., CAMPBELL, H., CASSANO, P.A., COUPER, D.J., EIRIKSDOTTIR, G., FRANCESCHINI, N., GARCIA, M., GIEGER, C., GISLASON, G.K., GRKOVIC, I., HAMMOND, C.J., HANCOCK, D.B., HARRIS, T.B., RAMASAMY, A., HECKBERT, S.R., HELI脰VAARA, M., HOMUTH, G., HYSI, P.G., JAMES, A.L., JANKOVIC, S., JOUBERT, B.R., KARRASCH, S., KLOPP, N., KOCH, B., KRITCHEVSKY, S.B., LAUNER, L.J., LIU, Y., LOEHR, L.R., LOHMAN, K., LOOS, R.J.F., LUMLEY, T., AL BALUSHI, K.A., ANG, W.Q., BARR, R.G., BEILBY, J., BLAKEY, J.D., BOBAN, M., BORASKA, V., BRISMAN, J., BRITTON, J.R., BRUSSELLE, G.G., COOPER, C., CURJURIC, I., DAHGAM, S., DEARY, I.J., EBRAHIM, S., EIJGELSHEIM, M., FRANCKS, C., GAYSINA, D., GRANELL, R., GU, X., HANKINSON, J.L., HARDY, R., HARRIS, S.E., HENDERSON, J., HENRY, A., HINGORANI, A.D., HOFMAN, A., HOLT, P.G., HUI, J., HUNTER, M.L., IMBODEN, M., JAMESON, K.A., KERR, S.M., KOLCIC, I., KRONENBERG, F., LIU, J.Z., MARCHINI, J., MCKEEVER, T., MORRIS, A.D., OLIN, A., PORTEOUS, D.J., POSTMA, D.S., RICH, S.S., RING, S.M., RIVADENEIRA, F., ROCHAT, T., SAYER, A.A., SAYERS, I., SLY, P.D., SMITH, G.D., SOOD, A., STARR, J.M., UITTERLINDEN, A.G., VONK, J.M., WANNAMETHEE, S.G., WHINCUP, P.H., WIJMENGA, C., WILLIAMS, O.D., WONG, A., MANGINO, M., MARCIANTE, K.D., MCARDLE, W.L., MEIBOHM, B., MORRISON, A.C., NORTH, K.E., OMENAAS, E., PALMER, L.J., PIETIL脛INEN, K.H., PIN, I., POLA艩EK, O., POUTA, A., PSATY, B.M., HARTIKAINEN, A., RANTANEN, T., RIPATTI, S., ROTTER, J.I., RUDAN, I., RUDNICKA, A.R., SCHULZ, H., SHIN, S.Y., SPECTOR, T.D., SURAKKA, I., VITART, V., V脰LZKE, H., WAREHAM, N.J., WARRINGTON, N.M., WICHMANN, H., WILD, S.H., WILK, J.B., WJST, M., WRIGHT, A.F., ZGAGA, L., ZEMUNIK, T., PENNELL, C.E., NYBERG, F., KUH, D., HOLLOWAY, J.W., BOEZEN, H.M., LAWLOR, D.A., MORRIS, R.W., PROBST-HENSCH, N., INTERNATIONAL LUNG CANCER CONSORTIUM, GIANT CONSORTIUM, KAPRIO, J., WILSON, J.F., HAYWARD, C., K脛H脰NEN, M., HEINRICH, J., MUSK, A.W., JARVIS, D.L., GL脛SER, S., J脛RVELIN, M., STRICKER, B.H.C., ELLIOTT, P., O'CONNOR, G.T., STRACHAN, D.P., LONDON, S.J., HALL, I.P., GUDNASON, V. and TOBIN, M.D., 2011. Nature Genetics. 43(11), 1082-1090
• TULAH AS, PARKER SG, MOFFATT MF, WARDLAW AJ, CONNOLLY MJ and SAYERS I, 2011. Bmc Medical Genetics. 12(1), 173 (In Press.)
• KOPPELMAN GH and SAYERS I, 2011. The Journal Of Allergy And Clinical Immunology. 128(3), 479-84
• OBEIDAT M, WAIN LV, SHRINE N, KALSHEKER N, SOLER ARTIGAS M, REPAPI E, BURTON PR, JOHNSON T, RAMASAMY A, ZHAO JH, ZHAI G, HUFFMAN JE, VITART V, ALBRECHT E, IGL W, HARTIKAINEN A, POUTA A, CADBY G, HUI J, PALMER LJ, HADLEY D, MCARDLE WL, RUDNICKA AR, BARROSO I, LOOS RJF, WAREHAM NJ, MANGINO M, SORANZO N, SPECTOR TD, GL脛SER S, HOMUTH G, V脰LZKE H, DELOUKAS P, GRANELL R, HENDERSON J, GRKOVIC I, JANKOVIC S, ZGAGA L, POLA艩EK O, RUDAN I, WRIGHT AF, CAMPBELL H, WILD SH, WILSON JF, HEINRICH J, IMBODEN M, PROBST-HENSCH NM, GYLLENSTEN U, JOHANSSON 脜, ZABOLI G, MUSTELIN L, RANTANEN T, SURAKKA I, KAPRIO J, JARVELIN M, HAYWARD C, EVANS DM, KOCH B, MUSK AW, ELLIOTT P, STRACHAN DP, TOBIN MD, SAYERS I, HALL IP and SPIROMETA CONSORTIUM, 2011. Plos one. 6(5), e19382
• SINGH, SHAILENDRA R, BILLINGTON, CHARLOTTE K, SAYERS, IAN and HALL, IAN P, 2010. American journal of physiology. Lung cellular and molecular physiology.
• REPAPI, E., SAYERS, I., WAIN, L.V., BURTON, P.R., JOHNSON, T., OBEIDAT, M., ZHAO, J.H., RAMASAMY, A., ZHAI, G., VITART, V., HUFFMAN, J.E., IGL, W., ALBRECHT, E., DELOUKAS, P. and HENDERSON, J., 2010. Nature Genetics. 42(1), 36-44
• SINGH, SHAILENDRA R., BILLINGTON, CHARLOTTE K., SAYERS, IAN and HALL, IAN P., 2010. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 299(2), L169-L183
• SAYERS,, HAWLEY,, STEWART,, BILLINGTON,, HENRY,, LEIGHTON-DAVIES,, CHARLTON, and HALL,, 2009. Pharmacogenetic characterization of indacaterol, a novel beta(2)-adrenoceptor agonist. British journal of pharmacology.
• BLAKEY, J D, SAYERS, I, RING, S M, STRACHAN, D P and HALL, I P, 2009. Thorax. 64(5), 381-7
• STEWART, CERI E and SAYERS, IAN, 2009. BMC molecular biology. 10, 75
• STEWART,, HALL,, PARKER,, MOFFATT,, WARDLAW,, CONNOLLY,, RUSE, and SAYERS,, 2009. PLAUR polymorphisms and lung function in UK smokers. BMC Medical Genetics. 10(1), 112
• BARTON, S.J., KOPPELMAN, G.H., VONK, J.M., BROWNING, C.A., NOLTE, I.M., STEWART, C.E., BAINBRIDGE, S., MUTCH, S., ROSE-ZERILLI, M.J., POSTMA, D.S., MANIATIS, N., HENRY, A.P., HALL, I.P., HOLGATE, S.T., TIGHE, P., HOLLOWAY, J.W. and SAYERS, I., 2009. Journal of Allergy and Clinical Immunology. 123(6), 1391-1400.e17
• BEGH脡, B, HALL, I P, PARKER, S G, MOFFATT, M F, WARDLAW, A, CONNOLLY, M J, FABBRI, L M, RUSE, C and SAYERS, I, 2009. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy.
• DUROUDIER, N P, TULAH, A S and SAYERS, I, 2009. Allergy. 64(6), 823-39
• HOLLOWAY, J W, BARTON, S J and SAYERS, I, 2009. Allergy.
• DENHAM, SAMUEL, KOPPELMAN, GERARD H, BLAKEY, JOHN, WJST, MATTHIAS, FERREIRA, MANUEL A, HALL, IAN P and SAYERS, IAN, 2008. Respiratory Research. 9, 38
• ASLAM, A, LEWIS, R J, WHEATLEY, A, PLEASS, R J and SAYERS, I, 2008. Allergy. 63(7), 942-3
• HOLLOWAY, J.W., BARTON, S.J., HOLGATE, S.T., ROSE-ZERILLI, M.J. and SAYERS, I., 2008. Allergy. 63(8), 1046-1053
• DUROUDIER, NATHALIE P, SAYERS, IAN, CASTAGNA, CHARLOTTE CARABOTT, FENECH, ANTHONY G, HALAPI, EVA, SWAN, CAROLINE and HALL, IAN P, 2007. Cell biochemistry and biophysics. 47(1), 119-30
• HALL, I P and SAYERS, I, 2007. European Respiratory Journal. 29(6), 1239-45
• SMITH, NATALIE, BROWNING, CLAUDIA A, DUROUDIER, NATHALIE, STEWART, CERI, PEEL, SAMANTHA, SWAN, CAROLINE, HALL, IAN P and SAYERS, IAN, 2007. Respiratory Research. 8, 68
• JAME, A J, LACKIE, P M, CAZALY, A M, SAYERS, I, PENROSE, J F, HOLGATE, S T and SAMPSON, A P, 2007. Clinical and Experimental Allergy. 37(6), 880-92
• KONSTANTINIDIS, A K, BARTON, S J, SAYERS, I, YANG, I A, LORDAN, J L, RORKE, S, CLOUGH, J B, HOLGATE, S T and HOLLOWAY, J W, 2007. European Respiratory Journal. 30(1), 40-7
• HALL, I.P., BLAKEY, J.D., AL BALUSHI, K.A., WHEATLEY, A., SAYERS, I., PEMBREY, M.E., RING, S.M., MCARDLE, W.L. and STRACHAN, D.P., 2006. Lancet. 368(9537), 771-779
• SWAN, C., RICHARDS, S.A., DUROUDIER, N.P., SAYERS, I. and HALL, I.P., 2006. American Journal of Respiratory Cell and Molecular Biology. 35(1), 118-126
• SAYERS, I., SWAN, C. and HALL, I. P., 2006. European Journal of Pharmacology. 531(1-3), 9-12
• HAO, L, SAYERS, I, CAKEBREAD, J A, BARTON, S J, BEGH脡, B, HOLGATE, S T, SAMPSON, A P and HOLLOWAY, J W, 2006. Clinical and Experimental Allergy. 36(6), 735-41
• SAYERS, I. and HALL, I.P., 2005. Current Allergy & Asthma Reports. 5(2), 101-108
• SAYERS, I., HOUSDEN, J.E.M., SPIVEY, A.C. and HELM, B.A., 2004. Journal of Biological Chemistry. 279(34), 35320-35325
• SAYERS, I., SEVERN, W., SCANGA, C.B., HUDSON, J., LE GROS, G. and HARPER, J.L., 2004. Journal of Allergy and Clinical Immunology. 114(2), 302-309
• SAYERS, I., BARTON, S., RORKE, S., BEGH脡, B., HAYWARD, B., VAN EERDEWEGH, P., KEITH, T., CLOUGH, J.B., YE, S., HOLLOWAY, J.W., SAMPSON, A.P. and HOLGATE, S.T., 2003. Thorax. 58(5), 417-424
• SAYERS, I., BARTON, S., RORKE, S., SAWYER, J., PENG, Q., BEGH脡, B., YE, S., KEITH, T., CLOUGH, J.B., HOLLOWAY, J.W., SAMPSON, A.P. and HOLGATE, S.T., 2003. Clinical and Experimental Allergy. 33(8), 1103-1110
• BEGH脙漏, B, BARTON, S, RORKE, S, PENG, Q, SAYERS, I, GAUNT, T, KEITH, T P, CLOUGH, J B, HOLGATE, S T and HOLLOWAY, J W, 2003. Clinical and Experimental Allergy. 33(8), 1111-7
• SAYERS, I, SAMPSON, A P, YE, S and HOLGATE, S T, 2003. European Journal of Human Genetics. 11(8), 619-22
• SAYERS, I., LE GROS, G. and HARPER, J. L., 2003. CURRENT MEDICINAL CHEMISTRY ANTIINFLAMMATORY AND ANTIALLERGY AGENTS. VOL 2(PART 2), 143-156
• SAMPSON, A P, SIDDIQUI, S, BUCHANAN, D, HOWARTH, P H, HOLGATE, S T, HOLLOWAY, J W and SAYERS, I, 2000. Thorax. 55 Suppl 2, S28-31
• SAYERS I and HELM BA, 1999. The structural basis of human IgE-Fc receptor interactions. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 29(5), 585-94
• HELM BA, SAYERS I, SWAN J, SMYTH LJ, CAIN SA, SUTER M, MACHADO DC, SPIVEY AC and PADLAN EA, 1998. Protein and cell engineering of components of the human immunoglobulin E receptor/effector system: applications for therapy and diagnosis. Technology and health care : official journal of the European Society for Engineering and Medicine. 6(2-3), 195-207
• SAYERS I, CAIN SA, SWAN JR, PICKETT MA, WATT PJ, HOLGATE ST, PADLAN EA, SCHUCK P and HELM BA, 1998. Biochemistry. 37(46), 16152-64
• HELM BA, SAYERS I, PADLAN EA, MCKENDRICK JE and SPIVEY AC, 1998. Structure/function studies on IgE as a basis for the development of rational IgE antagonists. Allergy. 53(45 Suppl), 77-82
• HELM BA, SAYERS I, HIGGINBOTTOM A, MACHADO DC, LING Y, AHMAD K, PADLAN EA and WILSON AP, 1996. Identification of the high affinity receptor binding region in human immunoglobulin E. The Journal of biological chemistry. 271(13), 7494-500