ÌÇÐÄÔ­´´

Contact

• workNuclear Medicine
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 9709172
• Helen.Betts@nottingham.ac.uk

Research Summary

My research focuses on the development of novel radiotracers for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging.

PET and SPECT are whole body imaging techniques that use trace quantities of radioisotope-tagged bioactive molecules to probe biological function. I'm interested to develop new radiochemical methods for attaching the radiolabels, as well as designing new radiolabelled compounds for clinically relevant targets, and investigating these radiotracers in clinical trials.

Recent projects include development of new radiotracers for imaging bacterial infection, hypoxia imaging in cancer patients using ¹⁸F-HX4 (OXYPET Trial), development of new fluorine-18 labelled molecules for protein synthesis imaging, and various early stage radiochemistry projects using fluorine-18, zirconium-89 and technetium-99m. My background is in radiochemistry and synthetic chemistry, and more recently CTIMP imaging trials.

Recent Publications

• H.M. BETTS, J.C. LUCKETT and P.J. HILL, 2024. Molecular Imaging and Biology.
• N. K. RAMAKRISHNAN, H. M. BETTS, S. MILICEVIC SEPHTON, X. ZHOU, D. J. WILLIAMSON, S. SAWIAK and F. AIGBIRHIO, 2022. Nuclear Medicine and Biology. 114-115, 71-77
• H.M. BETTS, R.A. O'CONNOR, J.A. CHRISTIAN, V. VINAYAKAMOORTHY, K. FOWERAKER, A.C. PASCOE and A.C. PERKINS, 2019. Nuclear Medicine Communications. 40(1), 73-78
• A. O'CONNOR and H.M. BETTS, 2017. . In: S. CHUA, ed., Clinicians’ Guides to Radionuclide Hybrid Imaging PET/CT in Radiotherapy Planning. Springer. 45-50

• View all publications

• H.M. BETTS, J.C. LUCKETT and P.J. HILL, 2024. Molecular Imaging and Biology.
• N. K. RAMAKRISHNAN, H. M. BETTS, S. MILICEVIC SEPHTON, X. ZHOU, D. J. WILLIAMSON, S. SAWIAK and F. AIGBIRHIO, 2022. Nuclear Medicine and Biology. 114-115, 71-77
• H.M. BETTS, R.A. O'CONNOR, J.A. CHRISTIAN, V. VINAYAKAMOORTHY, K. FOWERAKER, A.C. PASCOE and A.C. PERKINS, 2019. Nuclear Medicine Communications. 40(1), 73-78
• A. O'CONNOR and H.M. BETTS, 2017. . In: S. CHUA, ed., Clinicians’ Guides to Radionuclide Hybrid Imaging PET/CT in Radiotherapy Planning. Springer. 45-50
• H.M. BETTS, S. MILICEVIC SEPHTON, C. TONG, R.O. AWAIS, P.J. HILL, A.C. PERKINS and F.I. AIGBIRHIO, 2016. Journal of Medicinal Chemistry. 59(20), 9422-9430
• D.R. TURTON, H.M. BETTS, D. DUTTON and A.C. PERKINS, 2015. Nuclear Medicine and Biology. 42(5), 494-498
• H.M. BETTS, S.I. PASCU, A. BUCHARD, P.D. BONNITCHA and J.R. DILWORTH, 2014. RSC Advances. 4, 12964-12970.
• H.M. BETTS and E.G. ROBINS, 2014. Journal of Labelled Compounds and Radiopharmaceuticals. 57(4), 215-218
• P.D. BONNITCHA, S.R. BAYLY, M.B.M. THEOBALD, H.M. BETTS, J.S. LEWIS and J.R. DILWORTH, 2010. Journal of Inorganic Biochemistry. 104(2), 126-135
• H.M. BETTS, P.J. BARNARD, S.R. BAYLY, J.R. DILWORTH, A.D. GEE and J.P. HOLLAND, 2008. Angewandte Chemie. 47(44), 8416-8419
• S.R. BAYLY, R.C. KING, D.J. HONESS, P.J. BARNARD, H.M. BETTS, J.P. HOLLAND, R. HUETING, P.D. BONNITCHA, J.R. DILWORTH, F.I. AIGBIRHIO and M. CHRISTLIEB, 2008. Journal of Nuclear Medicine. 49(11), 1862-1868
• S.I. PASCU, P.A. WAGHORN, T.D. CONRY, B. LIN, H.M. BETTS, J.R. DILWORTH, R.B. SIM, G.C. CHURCHILL, F.I. AIGBIRHIO and J.E. WARREN, 2008. Dalton Transactions. 16, 2107-2110
• P.J. BARNARD, S.R. BAYLY, H.M. BETTS, P.D. BONNITCHA, M. CHRISTLIEB, J.R. DILWORTH, J.P. HOLLAND and S.I. PASCU, 2008. Towards New Copper Based Radiopharmaceuticals Quarterly Journal of Nuclear Medicine and Molecular Imaging. 52(2), 174-184
• J.P. HOLLAND, P.J. BARNARD, S.R. BAYLY, H.M. BETTS, G.C. CHURCHILL, J.R. DILWORTH, R. EDGE, J.C. GREEN and R. HUETING, 2008. European Journal of Inorganic Chemistry. 12, 1985-1993
• S.I. PASCU, P.A. WAGHORN, T.D. CONRY, H.M. BETTS, J.R. DILWORTH, G.C. CHURCHILL, T. POKROVSKA, M. CHRISTLIEB, F.I. AIGBIRHIO and J.E. WARREN, 2007. Dalton Transactions. 43, 4988-4997
• J.P. HOLLAND, F.I. AIGBIRHIO, H.M. BETTS, P.D. BONNITCHA, P. BURKE, M. CHRISTLIEB, G.C. CHURCHILL, A. R. COWLEY, J.R. DILWORTH, P.S. DONNELLY, J.C. GREEN, J.M. PEACH, S.R. VASUDEVAN and J.E. WARREN, 2007. Inorganic Chemistry. 46(2), 465-485