糖心原创

Contact

• workBioDiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 823 1135
• David.Bates@nottingham.ac.uk

Biography

I was the founding Director of the 糖心原创 Centre for Cancer Sciences from 2019-2024, and now a supportive member of the centre. My research focuses on teh mechanisms of alternative splicing in cancer, diabetes, and other diseases, as well as physiology. In particular I am interested in the microcirculation and growht and permeability of blood vessels.

I am also Chief Scientific Officer of IsomAb Ltd, a drug discovery company that is developing an isoform specific antibody to the VEGF-A₁₆₅b isoform for cardiovascular disease.

I joined the 糖心原创 as Head of Division of Preclinical Oncology in 2013, and in the same year founded Exonate Ltd, a spin out company based on developing small molecules to regulate mRNA splicing with Prof Steve Harper at University of Bristol, Prof Lucy Donaldson at UoN and Prof Jonathan Morris from UNSW, based on our discovery of new potential drugs for eye disease, cancer and other conditions. Exonate now has successfully completed its phase Ib/IIa clinical trial as an eye drop for treatment of diabetic macular oedema. I am currently Chair of the SAB for Exonate Ltd.

In 2001 I was awarded a BHF Lectureship, and established the Microvascular Research Laboratories in Bristol. In that year I discovered a new class of VEGF molecules. I was appointed Professor of Microvascular Biology and Medicine in the Department of Physiology and Pharmacology in 2007, where I was responsible for a MSci in Physiology with a year in Industry and the second year BSc Physiology course for 120 undergraduate students per year. My laboratory has discovered how new VEGFs contribute to blindness, diabetes, cancer, lung and heart disease and other conditions, resulting in 10 patent applications and >150 peer reviewed papers in both scientific (Nature Medicine, Cancer Cell etc), and medical journals (Cancer Research, Clinical Cancer Research, Nature Reviews Cancer, etc).

I completed my PhD in 1992 at the University of London, on how and why patients treated for breast cancer develop swollen arms (lymphoedema). After a year learning molecular genetics of fruit flies at Glasgow University, I spent three years at the University of California at Davis, where I learned and extended a technique to measure how proteins and fluid move across the walls of individual capillaries, by putting tiny glass needles into the smallest blood vessels of the body. At this point I started investigating a new protein called VEGF - or vascular endothelial growth factor. I continued as a lecturer at the University of Leicester from 1996-1998, using novel chemicals, that were part of the process of developing new drugs now used as anti-cancer agents. I developed methods to investigate how VEGF works to cause blood vessels to grow, and moved to the University of Bristol as a British Heart Foundation (BHF) research fellow in the Department of Physiology in 1999.

Expertise Summary

My focuses on how genes use to form proteins that can have opposite functions in cancer, heart disease, diabetes and other conditions as well as physiology. My interest in cancer research started by investigating how blood vessels control fluid exchange between blood and tissues - the permeability of the vessel wall, the interstital properties and the function of teh lymphatic system, particularly in breast cancer. I moved from tehre to investigate how blood vessels grow, and in particular how a protein called Vascular Endothelial Growth Factor (or VEGF) as well as other proteins made by the body can make new vessels form in health and disease.

This expanded to the role of blood vessel growth and permeability in cancers, heart and vascular disease (including atherosclerosis, coronary ischaemia, and peripheral vascular disease), diabetes, (including retinopathy, which causes blindness, nephropathy, which causes kidney failure, vasculopathy which can cause pain and peripheral ischemia, which can lead to ulcers and amputations). Other diseases that I work on include rheumatoid arthritis, renal disease, lymphatic diseases, and the basic causes of oedema (swelling).

I have always had a keen interest in working with low income countries to address pathologies that impact specifically, or more heavily on these populations. This has taken me to Thailand and PDR Lao to work on cholangiocarcinoma, a cancer of the bile duct, which is common in south east Asia, and to South Africa to work on colorectal cancer, prostate cancer and cervical cancer with African scientists and traditional healers.

These areas have led me into drug discovery research and collaborations worldwide, including with Prof Jonathan Morris in Australia working on compounds that inhibit splicing factor kinases, with Prof Zodwa Dlamini in South Africa on indigenous plant extracts, on antibodies to interstitial proteins with Prof Grith Sorensen in Denmark, and on repurposing anti-cancer agents and seaweed extracts with Profs Wongprasert and Tohtong in Thailand.

My work has been funded by major medical research charities such as the British Heart Foundation, The Wellcome Trust, Cancer Research UK and Diabetes UK, as well as by charities focussed on specific diseases such as teh AMMF (cholangiocarcinoma), Kidney Research UK, the Little Princess Trust (childhood cancers) and the Skin Cancer Research Fund (SCaRF). It has also received substantial support from the UK government through the UKRI route (MRC, BBSRC) as well as from Industry (Roche, Novo Nordisk), and from patent income.

Teaching Summary

Since moving to Nottingham I have led the development of a new undergraduate course in Cancer Sciences, the first of its kind in the UK, and potentially worldwide. The course now recruits up to 70… read more

Research Summary

I have programs focussing on controlling blood vessel growth in age related macular degeneration, diabetes, cancer of the bile duct, melanoma, basic mechanisms of blood vessel function (including… read more

Recent Publications

• GRANT ZL, WHITEHEAD L, WONG VHY, HE Z, YAN RY, MILES AR, BENEST AV, BATES DO, PRAHST C, BENTLEY K, BUI BV, SYMONS RC and COULTAS L, 2020. The Journal of clinical investigation. (In Press.)
• MAKHAFOLA, T. J., MBELE, M., YACQUB-USMAN, K., HENDREN, A., HAIGH, D. B., BLACKLEY, Z., MEYER, M., MONGAN, N. P., BATES, D. O. and DLAMINI, Z., 2020. Front Oncol. 10, 547392
• BOONSRI, B., YACQUB-USMAN, K., THINTHARUA, P., MYINT, K. Z., SAE-LAO, T., COLLIER, P., SURIYONPLENGSAENG, C., LARBCHAROENSUB, N., BALASUBRAMANIAN, B., VENKATRAMAN, S., EGBUNIWE, I. U., GOMEZ, D., MUKHERJEE, A., KUMKATE, S., JANVILISRI, T., ZAITOUN, A. M., KUAKPAETOON, T., TOHTONG, R., GRABOWSKA, A. M., BATES, D. O. and WONGPRASERT, K., 2020. Cancer Res Treat.
• HULL, R., MBELE, M., MAKHAFOLA, T., HICKS, C., WANG, S. M., REIS, R. M., MEHROTRA, R., MKHIZE-KWITSHANA, Z., HUSSAIN, S., KIBIKI, G., BATES, D. O. and DLAMINI, Z., 2020. Oncol Lett. 20(4), 42

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I am a qualified backcountry ski guide (脺bungsleiter) for the Austrial Alpine Club and have led hut to hut tours, mainly through the Tuxer and Stubai Alps in Austria. Over the last ten years I have embarked on an attempt to ski the length of teh Alpine Arc from Trieste in the East to Nice in the West. This is documented at .

Since moving to Nottingham I have led the development of a new undergraduate course in Cancer Sciences, the first of its kind in the UK, and potentially worldwide. The course now recruits up to 70 students a year. I led the course design, planning and resourcing, secured the pump priming from the University (拢1.9M) to recruit 7 full time and 4 part time academic staff, leading a team of 5 academics to put this in place. I played a significant role in the curriculum development, and taught on all three years of the course. In 2023 I was awarded teh Lord Dearing Award for Teaching Excellence

Prior to this I had an extensive undergraduate teaching background, in Bristol, at the University of Leicester, UC Davis, and at St George's Hospital Medical School. I have redesigned modules (cardiovascular, molecular physiology and cell signalling), and implemented new modules (microcirculation), as well as taken responsibility for the running of the 2^nd year course in Physiology in Bristol (120 students per year). The feedback I have had from the students that I have taught, have consistently described the lectures as entertaining, enthusiastic, and clear. I was particularly proud to note feedback on my second year teaching "Best lecturer of the year", particularly as I gave the last three lectures of the year immediately before the exams!

Current Research

I have programs focussing on controlling blood vessel growth in age related macular degeneration, diabetes, cancer of the bile duct, melanoma, basic mechanisms of blood vessel function (including control of vascular permeability and the contribution of the endothelial surface coat - the glycocalyx), and pre-eclampsia

• GRANT ZL, WHITEHEAD L, WONG VHY, HE Z, YAN RY, MILES AR, BENEST AV, BATES DO, PRAHST C, BENTLEY K, BUI BV, SYMONS RC and COULTAS L, 2020. The Journal of clinical investigation. (In Press.)
• MAKHAFOLA, T. J., MBELE, M., YACQUB-USMAN, K., HENDREN, A., HAIGH, D. B., BLACKLEY, Z., MEYER, M., MONGAN, N. P., BATES, D. O. and DLAMINI, Z., 2020. Front Oncol. 10, 547392
• BOONSRI, B., YACQUB-USMAN, K., THINTHARUA, P., MYINT, K. Z., SAE-LAO, T., COLLIER, P., SURIYONPLENGSAENG, C., LARBCHAROENSUB, N., BALASUBRAMANIAN, B., VENKATRAMAN, S., EGBUNIWE, I. U., GOMEZ, D., MUKHERJEE, A., KUMKATE, S., JANVILISRI, T., ZAITOUN, A. M., KUAKPAETOON, T., TOHTONG, R., GRABOWSKA, A. M., BATES, D. O. and WONGPRASERT, K., 2020. Cancer Res Treat.
• HULL, R., MBELE, M., MAKHAFOLA, T., HICKS, C., WANG, S. M., REIS, R. M., MEHROTRA, R., MKHIZE-KWITSHANA, Z., HUSSAIN, S., KIBIKI, G., BATES, D. O. and DLAMINI, Z., 2020. Oncol Lett. 20(4), 42
• HULL, R., MBELE, M., MAKHAFOLA, T., HICKS, C., WANG, S. M., REIS, R. M., MEHROTRA, R., MKHIZE-KWITSHANA, Z., KIBIKI, G., BATES, D. O. and DLAMINI, Z., 2020. Oncol Lett. 20(3), 2058-2074
• KETELAAR, M. E., PORTELLI, M. A., DIJK, F. N., SHRINE, N., FAIZ, A., VERMEULEN, C. J., XU, C. J., HANKINSON, J., BHAKER, S., HENRY, A. P., BILLINGTON, C. K., SHAW, D. E., JOHNSON, S. R., BENEST, A. V., PANG, V., BATES, D. O., POGSON, Z. E. K., FOGARTY, A., MCKEEVER, T. M., SINGAPURI, A., HEANEY, L. G., MANSUR, A. H., CHAUDHURI, R., THOMSON, N. C., HOLLOWAY, J. W., LOCKETT, G. A., HOWARTH, P. H., NIVEN, R., SIMPSON, A., TOBIN, M. D., HALL, I. P., WAIN, L. V., BLAKEY, J. D., BRIGHTLING, C. E., OBEIDAT, M., SIN, D. D., NICKLE, D. C., BOSSE, Y., VONK, J. M., VAN DEN BERGE, M., KOPPELMAN, G. H., SAYERS, I. and NAWIJN, M. C., 2020. J Allergy Clin Immunol.
• ALLEN, C. L., MALHI, N. K., WHATMORE, J. L., BATES, D. O. and ARKILL, K. P., 2020. Microcirculation. 27(6), e12623
• WILSON, D. H., JARMAN, E. J., MELLIN, R. P., WILSON, M. L., WADDELL, S. H., TSOKKOU, P., YOUNGER, N. T., RAVEN, A., BHALLA, S. R., NOLL, A. T. R., OLDE DAMINK, S. W., SCHAAP, F. G., CHEN, P., BATES, D. O., BANALES, J. M., DEAN, C. H., HENDERSON, D. J., SANSOM, O. J., KENDALL, T. J. and BOULTER, L., 2020. Nat Commun. 11(1), 445
• OWEN-WOODS, C., JOULIA, R., BARKAWAY, A., ROLAS, L., MA, B., NOTTEBAUM, A. F., ARKILL, K. P., STEIN, M., GIRBL, T., GOLDING, M., BATES, D. O., VESTWEBER, D., VOISIN, M. B. and NOURSHARGH, S., 2020. Journal of Clinical Investigation. 130(5), 2301-2318
• STEVENS, M., STAR, E., LEE, M., INNES, E., LI, L., BOWLER, E., HARPER, S., BATES, D. O. and OLTEAN, S., 2019. RNA Biol. 16(12), 1672-1681
• MACHADO, M. J. C., BOARDMAN, R., RIU, F., EMANUELI, C., BENEST, A. V. and BATES, D. O., 2019. Microcirculation. 26(6), e12549
• LI, N., BABAEI-JADIDI, R., LORENZI, F., SPENCER-DENE, B., CLARKE, P., DOMINGO, E., TULCHINSKY, E., VRIES, R. G. J., KERR, D., PAN, Y., HE, Y., BATES, D. O., TOMLINSON, I., CLEVERS, H. and NATERI, A. S., 2019. Oncogenesis. 8(3), 13
• BOARDMAN, R., PANG, V., MALHI, N., LYNCH, A. P., LEACH, L., BENEST, A. V., BATES, D. O. and MACHADO, M. J. C., 2019. Am J Physiol Heart Circ Physiol. 316(5), H1065-H1075
• ONIONS, K. L., GAMEZ, M., BUCKNER, N. R., BAKER, S. L., BETTERIDGE, K. B., DESIDERI, S., DALLYN, B. P., RAMNATH, R. D., NEAL, C. R., FARMER, L. K., MATHIESON, P. W., GNUDI, L., ALITALO, K., BATES, D. O., SALMON, A. H. J., WELSH, G. I., SATCHELL, S. C. and FOSTER, R. R., 2019. Diabetes. 68(1), 172-187
• BATES, D. O., BEAZLEY-LONG, N., BENEST, A. V., YE, X., VED, N., HULSE, R. P., BARRATT, S., MACHADO, M. J., DONALDSON, L. F., HARPER, S. J., PEIRIS-PAGES, M., TORTONESE, D. J., OLTEAN, S. and FOSTER, R. R., 2018. Compr Physiol. 8(3), 955-979
• BESTALL, S. M., HULSE, R. P., BLACKLEY, Z., SWIFT, M., VED, N., PATON, K., BEAZLEY-LONG, N., BATES, D. O. and DONALDSON, L. F., 2018. J Cell Sci.
• NEAL, C. R., ARKILL, K., BELL, J. S., BETTERIDGE, K. B., BATES, D. O., WINLOVE, C. P., SALMON, A. H. and HARPER, S. J., 2018. Am J Physiol Renal Physiol.
• VED, N., DA VITORIA LOBO, M. E., BESTALL, S. M., L. VIDUEIRA C, BEAZLEY-LONG, N., BALLMER-HOFER, K., HIRASHIMA, M., BATES, D. O., DONALDSON, L. F. and HULSE, R. P., 2018. J Physiol.
• NOWAK-SLIWINSKA, P., ALITALO, K., ALLEN, E., ANISIMOV, A., APLIN, A. C., AUERBACH, R., AUGUSTIN, H. G., BATES, D. O., VAN BEIJNUM, J. R., BENDER, R. H. F., BERGERS, G., BIKFALVI, A., BISCHOFF, J., BOCK, B. C., BROOKS, P. C., BUSSOLINO, F., CAKIR, B., CARMELIET, P., CASTRANOVA, D., CIMPEAN, A. M., CLEAVER, O., COUKOS, G., DAVIS, G. E., DE PALMA, M., DIMBERG, A., DINGS, R. P. M., DJONOV, V., DUDLEY, A. C., DUFTON, N. P., FENDT, S. M., FERRARA, N., FRUTTIGER, M., FUKUMURA, D., GHESQUIERE, B., GONG, Y., GRIFFIN, R. J., HARRIS, A. L., HUGHES, C. C. W., HULTGREN, N. W., IRUELA-ARISPE, M. L., IRVING, M., JAIN, R. K., KALLURI, R., KALUCKA, J., KERBEL, R. S., KITAJEWSKI, J., KLAASSEN, I., KLEINMANN, H. K., KOOLWIJK, P., KUCZYNSKI, E., KWAK, B. R., MARIEN, K., MELERO-MARTIN, J. M., MUNN, L. L., NICOSIA, R. F., NOEL, A., NURRO, J., OLSSON, A. K., PETROVA, T. V., PIETRAS, K., PILI, R., POLLARD, J. W., POST, M. J., QUAX, P. H. A., RABINOVICH, G. A., RAICA, M., RANDI, A. M., RIBATTI, D., RUEGG, C., SCHLINGEMANN, R. O., SCHULTE-MERKER, S., SMITH, L. E. H., SONG, J. W., STACKER, S. A., STALIN, J., STRATMAN, A. N., VAN DE VELDE, M., VAN HINSBERGH, V. W. M., VERMEULEN, P. B., WALTENBERGER, J., WEINSTEIN, B. M., XIN, H., YETKIN-ARIK, B., YLA-HERTTUALA, S., YODER, M. C. and GRIFFIOEN, A. W., 2018. Angiogenesis.
• STEVENS, M., NEAL, C. R., SALMON, A. H. J., BATES, D. O., HARPER, S. J. and OLTEAN, S., 2018. Nephron. 139(1), 51-62
• TZELEPIS, K., DE BRAEKELEER, E., ASPRIS, D., BARBIERI, I., VIJAYABASKAR, M. S., LIU, W. H., GOZDECKA, M., METZAKOPIAN, E., TOOP, H. D., DUDEK, M., ROBSON, S. C., HERMIDA-PRADO, F., YANG, Y. H., BABAEI-JADIDI, R., GARYFALLOS, D. A., PONSTINGL, H., DIAS, J. M. L., GALLIPOLI, P., SEILER, M., BUONAMICI, S., VICK, B., BANNISTER, A. J., RAD, R., PRINJHA, R. K., MARIONI, J. C., HUNTLY, B., BATSON, J., MORRIS, J. C., PINA, C., BRADLEY, A., JEREMIAS, I., BATES, D. O., YUSA, K., KOUZARIDES, T. and VASSILIOU, G. S., 2018. Nat Commun. 9(1), 5378
• DESCAMPS, B., SAIF, J., BENEST, A. V., BIGLINO, G., BATES, D. O., CHAMORRO-JORGANES, A. and EMANUELI, C., 2018. Arteriosclerosis Thrombosis and Vascular Biology. 38(9), 2117-2125
• VED N, HULSE RP, BESTALL SM, DONALDSON LF, BAINBRIDGE JW and BATES DO, 2017. Clinical science (London, England : 1979). (In Press.)
• BARRATT SL, BLYTHE T, JARRETT C, OURRADI K, SHELLEY-FRASER G, DAY MJ, QIU Y, HARPER S, MAHER TM, OLTEAN S, HAMES TJ, SCOTTON CJ, WELSH GI, BATES DO and MILLAR AB, 2017. American journal of respiratory and critical care medicine. (In Press.)
• PRUSZKO M, MILANO E, FORCATO M, DONZELLI S, GANCI F, DI AGOSTINO S, DE PANFILIS S, FAZI F, BATES DO, BICCIATO S, ZYLICZ M, ZYLICZ A, BLANDINO G and FONTEMAGGI G, 2017. EMBO reports. (In Press.)
• MORTARA L, BENEST AV, BATES DO and NOONAN DM, 2017. Current opinion in pharmacology. 35, 66-74 (In Press.)
• STEVENS M, NEAL CR, SALMON AHJ, BATES DO, HARPER SJ and OLTEAN S, 2017. The Journal of physiology. (In Press.)
• SAE-LAO T, TOHTONG R, BATES DO and WONGPRASERT K, 2017. The American journal of Chinese medicine. 45(3), 615-633
• CASTLE-MILLER J, BATES DO and TORTONESE DJ, 2017. Proceedings of the National Academy of Sciences of the United States of America. 114(12), E2514-E2523
• BATSON J, TOOP HD, REDONDO C, BABAEI-JADIDI R, CHAIKUAD A, WEARMOUTH SF, GIBBONS B, ALLEN C, TALLANT C, ZHANG J, DU C, HANCOX JC, HAWTREY T, DA ROCHA J, GRIFFITH R, KNAPP S, BATES DO and MORRIS JC, 2017. ACS chemical biology. 12(3), 825-832
• BENEST AV and BATES DO, 2016. Methods in molecular biology (Clifton, N.J.). 1430, 345-54
• DLAMINI Z, MBITA Z and BATES DO, 2016. Methods in molecular biology (Clifton, N.J.). 1379, E1
• YE X, ABOU-RAYYAH Y, BISCHOFF J, RITCHIE A, SEBIRE NJ, WATTS P, CHURCHILL AJ and BATES DO, 2016. The Journal of pathology. 239(2), 139-51
• GAMMONS MV and BATES DO, 2016. Methods in molecular biology (Clifton, N.J.). 1430, 317-32
• HULSE RP, DRAKE RA, BATES DO and DONALDSON LF, 2016. Neurobiology of disease. 96, 186-200
• BATES DO, MORRIS JC, OLTEAN S and DONALDSON LF, 2016. Pharmacological reviews. 69(1), 63-79
• STONE OA, CARTER JG, LIN PC, PALEOLOG E, MACHADO MJ and BATES DO, 2016. The Journal of physiology. 595(5), 1575-1591
• LOBO DP, WEMYSS AM, SMITH DJ, STRAUBE A, BETTERIDGE KB, SALMON AH, FOSTER RR, ELHEGNI HE, SATCHELL SC, LITTLE HA, PACHECO-G脫MEZ R, SIMMONS MJ, HICKS MR, BATES DO, RODGER A, DAFFORN TR and ARKILL KP, 2016. Nano research. 8(10), 3307-3315
• DE BROT S, NTEKIM A, CARDENAS R, JAMES V, ALLEGRUCCI C, HEERY D, BATES DO, ODUM N, PERSSON JL and MONGAN NP, 2015. Endocrine-related cancer. 22(3), R107-23
• HULSE RP, BEAZLEY-LONG N, VED N, BESTALL SM, RIAZ H, SINGHAL P, BALLMER HOFER K, HARPER SJ, BATES DO and DONALDSON LF, 2015. Clinical science (London, England : 1979). 129(8), 741-56
• OLTEAN S, QIU Y, FERGUSON JK, STEVENS M, NEAL C, RUSSELL A, KAURA A, ARKILL KP, HARRIS K, SYMONDS C, LACEY K, WIJEYARATNE L, GAMMONS M, WYLIE E, HULSE RP, ALSOP C, COPE G, DAMODARAN G, BETTERIDGE KB, RAMNATH R, SATCHELL SC, FOSTER RR, BALLMER-HOFER K, DONALDSON LF, BARRATT J, BAELDE HJ, HARPER SJ, BATES DO and SALMON AHJ, 2015. Journal of the American Society of Nephrology : JASN. 26(8), 1889-1904
• BEAZLEY-LONG N, GASTON K, HARPER SJ, ORLANDO A and BATES DO, 2015. Novel mechanisms of resistance to vemurafenib in melanoma - V600E B-Raf reversion and switching VEGF-A splice isoform expression. American journal of cancer research. 5(1), 433-41
• DLAMINI Z, MBITA Z and BATES DO, 2015. Methods in molecular biology (Clifton, N.J.). 1379, 201-11
• VIEIRA GC, CHOCKALINGAM S, MELEGH Z, GREENHOUGH A, MALIK S, SZEMES M, PARK JH, KAIDI A, ZHOU L, CATCHPOOLE D, MORGAN R, BATES DO, GABB PD and MALIK K, 2015. Oncotarget. 6(37), 40053-67
• BUNNI J, SHELLEY-FRASER G, STEVENSON K, OLTEAN S, SALMON A, HARPER SJ, CARTER JG and BATES DO, 2015. Circulating levels of anti-angiogenic VEGF-A isoform (VEGF-Axxxb) in colorectal cancer patients predicts tumour VEGF-A ratios. American journal of cancer research. 5(6), 2083-9
• WU WK, GEORGIADIS A, COPLAND DA, LIYANAGE S, LUHMANN UF, ROBBIE SJ, LIU J, WU J, BAINBRIDGE JW, BATES DO, ALI RR, NICHOLSON LB and DICK AD, 2015. The American journal of pathology. 185(8), 2324-35
• HULSE RP, BEAZLEY-LONG N, HUA J, KENNEDY H, PRAGER J, BEVAN H, QIU Y, FERNANDES ES, GAMMONS MV, BALLMER-HOFER K, GITTENBERGER DE GROOT AC, CHURCHILL AJ, HARPER SJ, BRAIN SD, BATES DO and DONALDSON LF, 2014. Neurobiology of disease.
• ARKILL, KENTON P., QVORTRUP, KLAUS, STARBORG, TOBIAS, MANTELL, JUDITH M., KNUPP, CARLO, MICHEL, C. CHARLES, HARPER, STEVE J., SALMON, ANDY HJ, SQUIRE, JOHN M., BATES, DAVE O. and NEAL, CHRIS R., 2014. BMC NEPHROLOGY. 15,
• MAVROU A, BRAKSPEAR K, HAMDOLLAH-ZADEH M, DAMODARAN G, BABAEI-JADIDI R, OXLEY J, GILLATT DA, LADOMERY MR, HARPER SJ, BATES DO and OLTEAN S, 2014. Oncogene. 34(33), 4311-9
• CARTER JG, GAMMONS MV, DAMODARAN G, CHURCHILL AJ, HARPER SJ and BATES DO, 2014. Angiogenesis. 18(1), 23-30
• KIKUCHI R, NAKAMURA K, MACLAUCHLAN S, NGO DT, SHIMIZU I, FUSTER JJ, KATANASAKA Y, YOSHIDA S, QIU Y, YAMAGUCHI TP, MATSUSHITA T, MUROHARA T, GOKCE N, BATES DO, HAMBURG NM and WALSH K, 2014. Nature medicine. 20(12), 1464-71
• HAMDOLLAH ZADEH MA, AMIN EM, HOAREAU-AVEILLA C, DOMINGO E, SYMONDS KE, YE X, HEESOM KJ, SALMON A, D'SILVA O, BETTERIDGE KB, WILLIAMS AC, KERR DJ, SALMON AH, OLTEAN S, MIDGLEY RS, LADOMERY MR, HARPER SJ, VAREY AH and BATES DO, 2014. Molecular oncology. 9(1), 167-78
• BILLS VL, HAMDOLLAH-ZADEH M, SOOTHILL PW, HARPER SJ and BATES DO, 2014. BMC pregnancy and childbirth. 14, 278
• NGO DT, FARB MG, KIKUCHI R, KARKI S, TIWARI S, BIGORNIA SJ, BATES DO, LAVALLEY MP, HAMBURG NM, VITA JA, HESS DT, WALSH K and GOKCE N, 2014. Circulation. 130(13), 1072-80
• THICHANPIANG P, HARPER SJ, WONGPRASERT K and BATES DO, 2014. TNF-伪-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation. Molecular vision. 20, 781-9
• GAMMONS MV, LUCAS R, DEAN R, COUPLAND SE, OLTEAN S and BATES DO, 2014. British journal of cancer. 111(3), 477-85
• ARKILL KP, QVORTRUP K, STARBORG T, MANTELL JM, KNUPP C, MICHEL CC, HARPER SJ, SALMON AH, SQUIRE JM, BATES DO and NEAL CR, 2014. BMC nephrology. 15, 24
• DELCOMBEL R, JANSSEN L, VASSY R, GAMMONS M, HADDAD O, RICHARD B, LETOURNEUR D, BATES D, HENDRICKS C, WALTENBERGER J, STARZEC A, SOUNNI NE, NO脣L A, DEROANNE C, LAMBERT C and COLIGE A, 2013. Angiogenesis. 16(2), 353-71
• BEAZLEY-LONG, N., HUA, J., JEHLE, T., HULSE, R.P., DERSCH, R., LEHRLING, C., BEVAN, H., QIU, Y., LAGR脠ZE, W.A., WYNICK, D., CHURCHILL, A.J., KEHOE, P., HARPER, S.J., BATES, D.O. and DONALDSON, L.F., 2013. The American Journal of Pathology. 183(3), 918-929
• OLTEAN S and BATES DO, 2013. Oncogene. 33(46), 5311-8
• BATES DO, MAVROU A, QIU Y, CARTER JG, HAMDOLLAH-ZADEH M, BARRATT S, GAMMONS MV, MILLAR AB, SALMON AH, OLTEAN S and HARPER SJ, 2013. PloS one. 8(7), e68399
• GAMMONS MV, FEDOROV O, IVISON D, DU C, CLARK T, HOPKINS C, HAGIWARA M, DICK AD, COX R, HARPER SJ, HANCOX JC, KNAPP S and BATES DO, 2013. Investigative ophthalmology & visual science. 54(9), 6052-62
• GAMMONS MV, DICK AD, HARPER SJ and BATES DO, 2013. Investigative ophthalmology & visual science. 54(8), 5797-806
• ARKILL, K. P., NEAL, C. R., MANTELL, J. M., MICHEL, C. C., QVORTRUP, K., ROSTGAARD, J., BATES, D. O., KNUPP, C. and SQUIRE, J. M., 2012. Microcirculation. 19(4), 343-51
• BATES, D.O., CATALANO, P.J., SYMONDS, K.E., VAREY, A.H.R., RAMANI, P., O'DWYER, P.J., GIANTONIO, B.J., MEROPOL, N.J., BENSON, A.B. and HARPER, S.J., 2012. Clinical Cancer Research. 18(22), 6384-6391
• OLTEAN, S., NEAL, C. R., MAVROU, A., PATEL, P., AHAD, T., ALSOP, C., LEE, T., SISON, K., QIU, Y., HARPER, S. J., BATES, D. O. and SALMON, A. H., 2012. Am J Physiol Renal Physiol. 303(7), F1026-36
• QIU, Y., SEAGER, M., OSMAN, A., CASTLE-MILLER, J., BEVAN, H., TORTONESE, D. J., MURPHY, D., HARPER, S. J., FRASER, H. M., DONALDSON, L. F. and BATES, D. O., 2012. Reproduction. 143(4), 501-11
• SALMON, A.H.J., FERGUSON, J.K., BURFORD, J.L., GEVORGYAN, H., NAKANO, D., HARPER, S.J., BATES, D.O. and PETI-PETERDI, J., 2012. Journal of the American Society of Nephrology. 23(8), 1339-1350
• OLTEAN S, GAMMONS M, HULSE R, HAMDOLLAH-ZADEH M, MAVROU A, DONALDSON L, SALMON AH, HARPER SJ, LADOMERY MR and BATES DO, 2012. Biochemical Society transactions. 40(4), 831-5
• BATES DO, CATALANO PJ, SYMONDS KE, VAREY AH, RAMANI P, O'DWYER PJ, GIANTONIO BJ, MEROPOL NJ, BENSON AB and HARPER SJ, 2012. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(22), 6384-91
• OLTEAN S, NEAL CR, MAVROU A, PATEL P, AHAD T, ALSOP C, LEE T, SISON K, QIU Y, HARPER SJ, BATES DO and SALMON AH, 2012. American journal of physiology. Renal physiology. 303(7), F1026-36
• SALMON AH, FERGUSON JK, BURFORD JL, GEVORGYAN H, NAKANO D, HARPER SJ, BATES DO and PETI-PETERDI J, 2012. Journal of the American Society of Nephrology : JASN. 23(8), 1339-50
• ARKILL KP, NEAL CR, MANTELL JM, MICHEL CC, QVORTRUP K, ROSTGAARD J, BATES DO, KNUPP C and SQUIRE JM, 2012. Microcirculation (New York, N.Y. : 1994). 19(4), 343-51
• WOOLARD, J., VOUSDEN, W., MOSS, S.J., KRISHNAKUMAR, A., GAMMONS, M.V.R., NOWAK, D.G., DIXON, N., MICKLEFIELD, J., SPANNHOFF, A., BEDFORD, M.T., GREGORY, M.A., MARTIN, C.J., LEADLAY, P.F., ZHANG, M.Q., HARPER, S.J., BATES, D.O. and WILKINSON, B., 2011. Chemical Science. 2(2), 273-278
• AMIN, E.M., OLTEAN, S., HUA, J., GAMMONS, M.V., HAMDOLLAH-ZADEH, M., WELSH, G.I., CHEUNG, M.K., NI, L., KASE, S., RENNEL, E.S., SYMONDS, K.E., NOWAK, D.G., ROYER-POKORA, B., SALEEM, M.A., HAGIWARA, M., SCHUMACHER, V.A., HARPER, S.J., HINTON, D.R., BATES, D.O. and LADOMERY, M.R., 2011. Cancer Cell. 20(6), 768-780
• BATES, D. O., 2011. Biochem Soc Trans. 39(6), 1576-82
• BILLS, V. L., SALMON, A. H., HARPER, S. J., OVERTON, T. G., NEAL, C. R., JEFFERY, B., SOOTHILL, P. W. and BATES, D. O., 2011. BJOG. 118(10), 1253-61
• CARTER, J. G., CHERRY, J., WILLIAMS, K., TURNER, S., BATES, D. O. and CHURCHILL, A. J., 2011. Curr Eye Res. 36(4), 328-35
• EMMETT, M. S., LANATI, S., DUNN, D. B., STONE, O. A. and BATES, D. O., 2011. Microcirculation. 18(3), 172-82
• RENNEL, E. S., REGULA, J. T., HARPER, S. J., THOMAS, M., KLEIN, C. and BATES, D. O., 2011. Microcirculation. 18(7), 598-607
• NOWAK, D.G., AMIN, E.M., RENNEL, E.S., HOAREAU-AVEILLA, C., GAMMONS, M., DAMODORAN, G., HAGIWARA, M., HARPER, S.J., WOOLARD, J., LADOMERY, M.R. and BATES, D.O., 2010. Journal of Biological Chemistry. 285(8), 5532-5540
• BATES, D. O., 2010. Cardiovasc Res. 87(2), 262-71
• BATES, D. O., 2010. Pathophysiology. 17(4), 289-94
• CRISTOFARO, B., STONE, O. A., CAPORALI, A., DAWBARN, D., IERONIMAKIS, N., REYES, M., MADEDDU, P., BATES, D. O. and EMANUELI, C., 2010. Arterioscler Thromb Vasc Biol. 30(6), 1143-50
• EMMETT, M. S., SYMONDS, K. E., RIGBY, H., COOK, M. G., PRICE, R., METCALFE, C., ORLANDO, A. and BATES, D. O., 2010. BMC Cancer. 10, 208
• FOSTER, R. R., WELSH, G. I., SATCHELL, S. C., MARLOW, R. D., WHERLOCK, M. D., PONS, D., MATHIESON, P. W., BATES, D. O. and SALEEM, M. A., 2010. Cell Calcium. 48(1), 44-53
• HARPER, S. J. and BATES, D. O., 2010. J Am Soc Nephrol. 21(12), 2009-11
• HUA, J., SPEE, C., KASE, S., RENNEL, E. S., MAGNUSSEN, A. L., QIU, Y., VAREY, A., DHAYADE, S., CHURCHILL, A. J., HARPER, S. J., BATES, D. O. and HINTON, D. R., 2010. Invest Ophthalmol Vis Sci. 51(8), 4282-8
• LANATI, S., DUNN, D.B., ROUSSIGNE, M., EMMETT, M.S., CARRIERE, V., JULLIEN, D., BUDGE, J., FRYER, J., ERARD, M., CAILLER, F., GIRARD, J.P. and BATES, D.O., 2010. Cancer Research. 70(20), 8138-8148
• MAGNUSSEN, A. L., RENNEL, E. S., HUA, J., BEVAN, H. S., BEAZLEY LONG, N., LEHRLING, C., GAMMONS, M., FLOEGE, J., HARPER, S. J., AGOSTINI, H. T., BATES, D. O. and CHURCHILL, A. J., 2010. Invest Ophthalmol Vis Sci. 51(8), 4273-81
• PEIRIS-PAGES, M., HARPER, S. J., BATES, D. O. and RAMANI, P., 2010. J Pathol. 222(2), 138-47
• QIU, Y., FERGUSON, J., OLTEAN, S., NEAL, C. R., KAURA, A., BEVAN, H., WOOD, E., SAGE, L. M., LANATI, S., NOWAK, D. G., SALMON, A. H., BATES, D. and HARPER, S. J., 2010. J Am Soc Nephrol. 21(9), 1498-509
• VARET, J., DOUGLAS, S. K., GILMARTIN, L., MEDFORD, A. R., BATES, D. O., HARPER, S. J. and MILLAR, A. B., 2010. Am J Physiol Lung Cell Mol Physiol. 298(6), L768-74
• WU, W. K., LLEWELLYN, O. P., BATES, D. O., NICHOLSON, L. B. and DICK, A. D., 2010. Immunobiology. 215(9-10), 796-803
• BENEST, A. V. and BATES, D. O., 2009. Measurement of angiogenic phenotype by use of two-dimensional mesenteric angiogenesis assay: Methods Mol Biol Methods Mol Biol. 467, 251-70
• BILLS, V. L., VARET, J., MILLAR, A., HARPER, S. J., SOOTHILL, P. W. and BATES, D. O., 2009. Clin Sci (Lond). 116(3), 265-72
• FOSTER, R. R., ZADEH, M. A., WELSH, G. I., SATCHELL, S. C., YE, Y., MATHIESON, P. W., BATES, D. O. and SALEEM, M. A., 2009. Cell Calcium. 45(4), 384-90
• QIU, Y., HOAREAU-AVEILLA, C., OLTEAN, S., HARPER, S. J. and BATES, D. O., 2009. Biochem Soc Trans. 37(Pt 6), 1207-13
• RENNEL, E. S., HARPER, S. J. and BATES, D. O., 2009. Future Oncol. 5(5), 703-12
• RENNEL, E. S., VAREY, A. H., CHURCHILL, A. J., WHEATLEY, E. R., STEWART, L., MATHER, S., BATES, D. O. and HARPER, S. J., 2009. Br J Cancer. 101(7), 1183-93
• SALMON, A. H., NEAL, C. R., SAGE, L. M., GLASS, C. A., HARPER, S. J. and BATES, D. O., 2009. Cardiovasc Res. 83(1), 24-33
• STONE, O. A., RICHER, C., EMANUELI, C., VAN WEEL, V., QUAX, P. H., KATARE, R., KRAENKEL, N., CAMPAGNOLO, P., BARCELOS, L. S., SIRAGUSA, M., SALA-NEWBY, G. B., BALDESSARI, D., MIONE, M., VINCENT, M. P., BENEST, A. V., AL HAJ ZEN, A., GONZALEZ, J., BATES, D. O., ALHENC-GELAS, F. and MADEDDU, P., 2009. Arterioscler Thromb Vasc Biol. 29(5), 657-64
• WOOLARD, J., BEVAN, H. S., HARPER, S. J. and BATES, D. O., 2009. Microcirculation. 16(7), 572-92
• NOWAK, D.G., WOOLARD, J., AMIN, E.M., KONOPATSKAYA, O., SALEEM, M.A., CHURCHILL, A.J., LADOMERY, M.R., HARPER, S.J. and BATES, D.O., 2008. Journal of Cell Science. 121(20), 3487-3495
• RENNEL, E.S., WAINE, E., GUAN, H., SCH脺LER, Y., LEENDERS, W., WOOLARD, J., SUGIONO, M., GILLATT, D., KLEINERMAN, E.S., BATES, D.O. and HARPER, S.J., 2008. British Journal of Cancer. 98(7), 1250-1257
• VAREY, A. H. R., RENNEL, E. S., QIU, Y., BEVAN, H. S., PERRIN, R. M., RAFFY, S., DIXON, A. R., PARASKEVA, C., ZACCHEO, O., HASSAN, A. B., HARPER, S. J. and BATES, D. O., 2008. BRITISH JOURNAL OF CANCER. 98(8), 1366-1379