糖心原创

Contact

• workRoom E/E 1724 Child Health, E Floor East Block, QMC,
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30252
• andrew.prayle@nottingham.ac.uk

Biography

Andrew graduated from Nottingham in 2003 with a BMBS and entered clinical practice. He commenced the paediatric postgraduate training scheme in 2005. In 2009, he commenced a PhD in child health, and was awarded a NIHR Doctoral Research Fellowship in 2010, where he studied biomarkers of toxicity in children and adults with cystic fibrosis. Post PhD, after a further period of clinical practice he returned to research and holds a NIHR Academic Clinical Lecturer post in Child Health. He subsequently completed specialist training, and held a locum consultant post in Paediatric Respiratory, Critical Care and Transport Medicine, before his current post at the 糖心原创 as a Clinical Associate Professor in Paediatric Respiratory Medicine.

Expertise Summary

Andrew's expertise is in MRI in young children - his studies include whole day MRI protocols for children aged 6 and over with cystic fibrosis, and using an upright MRI scanner for lung imaging in children as young as 3 years. He also undertakes studies of novel lung function tests in young children and infants. All of these studies are designed to address the need for better tests of lung health in young children, infants and babies.

Andrew is interested in improving the health of children with rare diseases, in particular Ataxia-Telangiectasia and Cystic Fibrosis. He sits on the Research Advisory Committee for ActionforA-T

Andrew has an interest in understanding how clinical trials influence research practice, and how the medical literature influences medical practice. Andrew is interested in applying machine learning to clinical problems.

Teaching Summary

Andrew teaches in the Masters of Public Health (/pgstudy/course/taught/public-health-mph), on the Data Organisation and Management in Epidemiology module. This taught… read more

Research Summary

Andrew is currently working on identifying pulmonary endpoints for clinical trials, with the goal of improving the pulmonary health of children. During childhood the lungs develop and grow, and the… read more

Recent Publications

• PRAYLE AP, COX T, SMITH SJ, RYCROFT-MALONE J, THOMAS KS, HUGHES DA and SMYTH AR, 2017. Thorax. (In Press.)
• SAFAVI, S., PRAYLE, A.P., HALL, I.P. and PARMAR, J., 2017. Cochrane Database of Systematic Reviews. 2017(9),
• STEWART E, PRAYLE AP, TOOKE A, PASALODOS S, SURI M, BUSH A and BHATT JM, 2016. Archives of disease in childhood. 101(12), 1137-1141
• HURLEY MN, , PRAYLE AP and FLUME P, 2015. Paediatric respiratory reviews. 16(4), 246-8

• View all publications

Andrew teaches in the Masters of Public Health (/pgstudy/course/taught/public-health-mph), on the Data Organisation and Management in Epidemiology module. This taught course in R teaches the fundamentals of working with epidemiological and clinical data and preparing it for analysis.

Current Research

Andrew is currently working on identifying pulmonary endpoints for clinical trials, with the goal of improving the pulmonary health of children. During childhood the lungs develop and grow, and the single biggest predictor of your lifespan as an adult is your lung function. Therefore, it is important to optimize the health of the lungs in childhood. In recent years, it has become clear that our current tools for assessing lung health, particularly in young children, are either too invasive for clinical research, or to insensitive to subtle changes in lung function. Andrew is therefore running a number of projects to investigate the application of pulmonary MRI and other novel methods of lung ehalth testing in children as endpoints in clinical trials.

• PRAYLE AP, COX T, SMITH SJ, RYCROFT-MALONE J, THOMAS KS, HUGHES DA and SMYTH AR, 2017. Thorax. (In Press.)
• SAFAVI, S., PRAYLE, A.P., HALL, I.P. and PARMAR, J., 2017. Cochrane Database of Systematic Reviews. 2017(9),
• STEWART E, PRAYLE AP, TOOKE A, PASALODOS S, SURI M, BUSH A and BHATT JM, 2016. Archives of disease in childhood. 101(12), 1137-1141
• HURLEY MN, , PRAYLE AP and FLUME P, 2015. Paediatric respiratory reviews. 16(4), 246-8
• HURLEY MN, PRAYLE AP and FLUME P, 2015. The Cochrane database of systematic reviews. CD009730
• HURLEY MN, MCKEEVER TM, PRAYLE AP, FOGARTY AW and SMYTH AR, 2014. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 13(4), 410-5
• JOHN M, HUSSAIN S, PRAYLE A, SIMMS R, COCKCROFT JR and BOLTON CE, 2013. Respiratory research. 14, 31
• PRAYLE, A., JAIN, K., WATSON, A. and SMYTH, A. R., 2013. ARE MORNING DOSES OF INTRAVENOUS TOBRAMYCIN LESS NEPHROTOXIC THAN EVENING? EVIDENCE FROM URINARY BIOMARKERS IN THE CRITIC STUDY PEDIATRIC PULMONOLOGY. 48, 299-299
• JOHN, MICHELLE, HUSSAIN, SAMIA, PRAYLE, ANDREW, SIMMS, REBECCA, COCKCROFT, JOHN R. and BOLTON, CHARLOTTE E., 2013. RESPIRATORY RESEARCH. 14,
• JAIN, K., PRAYLE, A., MCCULLOCH, T. A., POPE, M., SYMONDS, M. and SMYTH, A. R., 2013. GENE EXPRESSION OF CFTR AND RENAL ENDOCYTIC RECEPTORS IS NOT ALTERED IN THE KIDNEYS OF YOUNG PIGLETS WITH CYSTIC FIBROSIS PEDIATRIC PULMONOLOGY. 48, 271-271
• PRAYLE, ANDREW P. and SMYTH, ALAN R., 2013. EXPERT OPINION ON PHARMACOTHERAPY. 14(3), 323-329
• MODI, NEENA, CLARK, HOWARD, WOLFE, INGRID, COSTELLO, ANTHONY and BUDGE, HELEN, 2013. LANCET. 381(9860), 73-87
• PRAYLE, A., 2013.
• PRAYLE, A. and MIGHTEN, J., 2013.
• PRAYLE AP and SMYTH AR, 2013. Expert opinion on pharmacotherapy. 14(3), 323-9
• HURLEY, M N, PRAYLE, A P and SMYTH, A R, 2012. Journal of Cystic Fibrosis. 11(1), 14-17
• PRAYLE, A.P., HURLEY, M.N. and SMYTH, A.R., 2012. BMJ. 344(7838), d7373
• HURLEY MN and PRAYLE AP, 2012. Paediatric respiratory reviews. 13(3), 160-1
• HURLEY, MATTHEW N. and PRAYLE, ANDREW P., 2012. PAEDIATRIC RESPIRATORY REVIEWS. 13(3), 160-161
• MODI N, CLARK H, WOLFE I, COSTELLO A, BUDGE H, , GOODIER R, HYDE MJ, LUMSDEN D, PRAYLE A and ROLAND D, 2012. Lancet (London, England). 381(9860), 73-87
• PRAYLE, ANDREW, ATKINSON, MARIA and SMYTH, ALAN, 2011. Paediatric respiratory reviews. 12(1), 60-9
• MCCULLOCH T, PRAYLE A, LUNN A and WATSON AR, 2011. Pediatric Nephrology (Berlin, Germany). 26(7), 1163-6
• MCCULLOCH, TOM, PRAYLE, ANDREW, LUNN, ANDY and WATSON, ALAN R., 2011. PEDIATRIC NEPHROLOGY. 26(7), 1163-1166
• LO, D. K. H., HURLEY, M. H., PRAYLE, A. and SMYTH, A. R., 2011. THORAX. 66, A163-A163
• PRAYLE, ANDREW, WATSON, ALAN, FORTNUM, HEATHER and SMYTH, ALAN, 2010. Thorax. 65(7), 654-8
• PRAYLE, A.P., HURLEY, M.N. and SMYTH, A.R., 2010. Cochrane Database of Systematic Reviews. 2010(11), 1-18
• PRAYLE A and SMYTH AR, 2010. Current Opinion In Pulmonary Medicine. 16(6), 604-10
• PRAYLE, ANDREW, WATSON, ALAN, FORTNUM, HEATHER and SMYTH, ALAN, 2010. THORAX. 65(7), 654-658
• PRAYLE, AP, POINTON, K, MANHIRE, AR, BALDWIN, DR and RICHARDSON, CM, 2004. Are patients adequately assessed prior to percutaneous lung biopsy? THORAX. 59(1), 64-64