糖心原创

School of Medicine
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People in Translational Medical Sciences

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Andrew Jackson

Head Host-Tumour Interactions Group, Associate Professor, Deputy Head of the Translational Medical Sciences Unit, Faculty of Medicine & Health Sciences

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Teaching Summary

I am Deputy Director of the Translation Medical Sciences Unity with specialist portfolio for teaching. I convene two Modules that teach advanced immunology and cancer immunology.

I lecture on advanced immunology to honors year BSc Cancer Sciences students and MSc Oncology and students registered on our MSc Cancer Immunology & Biotechnology courses.

Research Summary

The group lead by Dr Andrew Jackson comprises post-doctoral and clinical fellows, PhD students and is supported by the research council, industry, and charitable funding in addition to internal… read more

Selected Publications

  • WANG, Q., FRANKS, H.A., LAX, S.J., EL REFAEE, M., MALECKA, A., SHAH, S., SPENDLOVE, I., GOUGH, M.J., SEEDHOUSE, C., MADHUSUDAN, S., PATEL, P.M. and JACKSON, A.M., 2013. Journal of Immunology. 190(7), 3246-3255
  • SUTAVANI, R.V., BRADLEY, R.G., RAMAGE, J.M., JACKSON, A.M., DURRANT, L.G. and SPENDLOVE, I., 2013. Journal of Immunology. 191(n/a), n/a
  • FRANKS, H.A., WANG, Q., LAX, S.J., COLLINS, M.K., ESCORS, D., PATEL, P.M. and JACKSON, A.M., 2014. International Journal of Cancer. 134(3), 575-586
  • CRITTENDEN M, SAVAGE T, COTTAM B, BHAJAT K, REDMOND W, BAMBINA S, KASIEWICZ M, NEWELL P, JACKSON AM and GOUGH M, 2013. PLoS One. 8(7), e69527

Current Research

The group lead by Dr Andrew Jackson comprises post-doctoral and clinical fellows, PhD students and is supported by the research council, industry, and charitable funding in addition to internal funding from the 糖心原创. Our research focuses on understanding the molecular pathways through which tumours suppress the immune system with a view to first-in-man immunotherapies. My work concerns a range of major tumour types including malignant melanoma, breast cancer, brain tumours in adults and children, and colorectal malignancy.

We have extensive experience in myeloid and T-cell subsets having worked with dendritic cells (DC), macrophage (MO), myeloid derived suppressor cells (MDSC) and cytotoxic, helper and regulatory T-cell subsets. We have a strong pedigree in the exploration of interesting intracellular signaling pathways in immune cells to modify their function or restore immuno-suppression resulting from malignancy. Key pathways of interest include ATM-kinase, p38-MAPK, MEK-ERK and the Unfolded Protein Response pathway (UPR). We have shown that modulation of these pathways impacts on the generation of CD4-responses and this work is now in a pre-clinical phase. The importance of circulating natural DC sets including cDC2, pDC and SlanDC in advanced cancer patients is a major focus.

Recent focus has tested the hypothesis that the myeloid environment is programmed by clue take from the extracellular matrix (ECM). In this regard we have received CRUK funding to establish experimental systems and are presently conducting studies to explore the direct impact of ECM derived from primary patient-derived tumour fibroblasts (FB) on MO and DC. Characterisation of the matrix by 'omics approaches is combined with phenotypic and function descriptions of hypoxic, inflammatory and regulatory myeloid cells and the consequent impact on T-cell responses.

A current major research area concerns the spatial mapping of immune responses in patient tumours. Working with large collections of tumours from breast cancer (UK patients and West African patients), and colorectal cancer patients we have mapped the landscape of macrophage and T-cell subsets. This work is undertaken using Akoya's platform and we are currently developing high-plex staining for the MACSima multiplex imaging system (MRC funded). Advances in analysis and interpretation of the very large data sets obtained from this work are being pioneered by cross-discipline collaborations with diverse teams including academics from Asrtonomy.

Past Research

Adoptive immunotherapy with dendritic cell vaccines

Polyepitope vaccines for advanced malignancy

Next-generation BCG-immunotherapy

BCG-Immunotherapy of bladder cancer

Anti-TNF strategies for rheumatoid arthritis

Future Research

Developing new first-in-man immunotherapies for cancer based on ex vivo DC vaccines, incorporating specific inhibitors of intracellular signalling pathways. Understanding the immune landscape of patients tumours for better stratification and improved treatment.

  • FIRFILIONIS, D., HUTCHINGS, F., TAMADONI, R., WALSH, D., TURNBULL, M., ESCOBEDO-COUSIN, E., BAILEY, R. G., GAUSDEN, J., PATEL, A., HACI, D., LIU, Y., LEBEAU, F. E. N., TREVELYAN, A., CONSTANDINOU, T. G., O'NEILL, A., KAISER, M., DEGENAAR, P. and JACKSON, A., 2021. A Closed-Loop Optogenetic Platform: Frontiers in Neuroscience Frontiers in Neuroscience. 15, 10
  • CHASAMPALIOTI, MARIA, GREEN, ANDREW R., ELLIS, IAN O., RAKHA, EMAD A., JACKSON, ANDREW M., SPENDLOVE, IAN and RAMAGE, JUDITH M., 2019. BREAST CANCER RESEARCH AND TREATMENT. 174(1), 93-102
  • MARIA CHASAMPALIOTI, ANDREW R. GREEN, IAN O. ELLIS, EMAD A. RAKHA, ANDREW M. JACKSON, IAN SPENDLOVE and JUDITH M RAMAGE, 2018. Breast Cancer Research and Treatment.
  • JEYARAMAN J, MALECKA A, BILIMORIA P, SHUKLA A, MARAND B, PATEL PM, JACKSON AM and SRI SIVAKUMAR S, 2017. Journal of Materials Chemistry B.
  • STORR SJ, SAFUAN S, AHMAD N, EL-REFAEE M, JACKSON AM and MARTIN SG, 2017. Cancer immunology, immunotherapy : CII. (In Press.)
  • MALECKA A, WANG Q, SHAH S, SUTAVANI R, SPENDLOVE I, RAMAGE J, GREENSMITH J, FRANKS H, GOUGH MJ, SAALBACH A, PATEL PM and JACKSON AM, 2016. Journal of leukocyte biology. 100(2), 381-389
  • CRITTENDEN MR, BAIRD J, FRIEDMAN D, SAVAGE T, UHDE L, ALICE A, COTTAM B, YOUNG K, NEWELL P, NGUYEN C, BAMBINA S, KRAMER G, AKPORIAYE E, MALECKA A, JACKSON A and GOUGH MJ, 2016. Oncotarget.
  • GREENSMITH, JULIE, JACKSON, ANDREW M. and SPENDLOVE, IAN, 2016. PROCEEDINGS OF THE 2016 GENETIC AND EVOLUTIONARY COMPUTATION CONFERENCE (GECCO'16 COMPANION). 7-8
  • LANGOSCH, S., WEHNER, R., MALECKA, A., FRANKS, H.A., SCH脛KEL, K., BACHMANN, M., JACKSON, A.M. and SCHMITZ, M., 2015. Immunobiology.
  • FRANKS, H.A., WANG, Q., LAX, S.J., COLLINS, M.K., ESCORS, D., PATEL, P.M. and JACKSON, A.M., 2014. International Journal of Cancer. 134(3), 575-586
  • CRITTENDEN, M.R., SAVAGE, T., COTTAM, B., BAIRD, J., RODRIGUEZ, P.C., NEWELL, P., YOUNG, K., JACKSON, A.M. and GOUGH, M.J., 2014. Radiation Research. 182(2), 182-190
  • WANG, Q., FRANKS, H.A., LAX, S.J., EL REFAEE, M., MALECKA, A., SHAH, S., SPENDLOVE, I., GOUGH, M.J., SEEDHOUSE, C., MADHUSUDAN, S., PATEL, P.M. and JACKSON, A.M., 2013. Journal of Immunology. 190(7), 3246-3255
  • CRITTENDEN M, SAVAGE T, COTTAM B, BHAJAT K, REDMOND W, BAMBINA S, KASIEWICZ M, NEWELL P, JACKSON AM and GOUGH M, 2013. PLoS One. 8(7), e69527
  • SUTAVANI, R.V., BRADLEY, R.G., RAMAGE, J.M., JACKSON, A.M., DURRANT, L.G. and SPENDLOVE, I., 2013. Journal of Immunology. 191(n/a), n/a
  • WANG, Q., FRANKS, H.A., PORTE, J., EL REFAAE, M., SHAH, S., CROOKS, J., PATEL, P.M. and JACKSON, A.M., 2011. Immunology. 134(1), 60-72
  • FOAN, S., JACKSON, A.M., SPENDLOVE, I. and AICKELIN, U., 2011. Simulating the dynamics of T cell subsets throughout the lifetime Lecture notes in computer science. 6825, 71-76
  • JACKSON, AM, MULCAHY, LA, PORTE, J, FRANKS, HA, EL REFAEE, M, WANG, Q, SHAH, S, ZHU, X and PATEL, PM, 2010. European Cytokine Network. 21(4), 319-328
  • ALEXANDROFF AB, NICHOLSON S, PATEL PM and JACKSON AM, 2010. Immunotherapy. 2(4), 551-60
  • JACKSON, A.M., MULCAHY, L.A., ZHU, X.W., O'DONNELL, D. and PATEL, P.M., 2008. International Journal of Cancer. 123(3), 623-632
  • ZHU, X., MULCAHY, L.A., MOHAMMED, R.A., LEE, A.H., FRANKS, H.A., KILPATRICK, L., YILMAZER, A., PAISH, E.C., ELLIS, I.O., PATEL, P.M. and JACKSON, A.M., 2008. Breast Cancer Research. 10(6), R95
  • SCARDINO, A, ALIMANDI M, CORREALE, P, SMITH, SG, BEI, R, FIRAT, H, CUSI MG, FAURE O, GRAF-DUBOIS, S, CENCIONI, G, MARROCCO, J, CHOUAIB, S, LEMMONIER, FA, JACKSON AM and KOSMATOPOLOUS K, 2007. Cancer Research. 67(14), 7028-7036
  • VIEWEG, J and JACKSON, AM, 2005. Expert opinion in Biological Therapy. 26(3), 329-341
  • CHEADLE EJ, O'DONNELL D, SELBY PJ and JACKSON AM, 2005. Infection and immunity. 73(2), 784-94
  • VIEWEG J and JACKSON AM, eds., 2005. Molecular concepts of emerging strategies for prostate cancer treatment. Taylor & Francis Medical Books.
  • JACKSON AM and PORTE J, eds., 2005. Cancer Immunotherapy Oxford University Press.
  • VIEWEG J and JACKSON AM, 2005. Modulation of anti-tumour responses by dendritic cells Springer Seminars in Immunopathology. 26, 239-341
  • YOUNG, SL, MURPHY, M, ZHU, XW, HARNDEN, P, O'DONNELL, MA, JAMES, K, PATEL, PM, SELBY, PJ and JACKSON, AM, 2004. International Journal of Cancer. 112(4), 653-660
  • CLAYTON, RD, DUFFY, SR, WILKINSON, N, GARRY, R and JACKSON, AM, 2004. Human Reproduction. VOL 19(NUMBER 8), 1886-1893
  • YOUNG SL, MURPHY M, ZHU XW, HARNDEN P, O'DONNELL MA, JAMES K, PATEL PM, SELBY PJ and JACKSON AM, 2004. International journal of cancer. Journal international du cancer. 112(4), 653-60
  • CLAYTON RD, DUFFY SR, WILKINSON N, GARRY R and JACKSON AM, 2004. Human reproduction (Oxford, England). 19(8), 1886-93
  • CHEADLE EJ, SELBY PJ and JACKSON AM, 2003. Immunology. 108(1), 79-88
  • RADFORD KJ, JACKSON AM, WANG J, VASSAUX G and LEMOINE NR, 2003. International journal of cancer. Journal international du cancer. 105(6), 811-9
  • CHEADLE EJ and JACKSON AM, 2002. Immunology. 107(1), 10-9
  • RADFORD KJ, HIGGINS DE, PASQUINI S, CHEADLE EJ, CARTA L, JACKSON AM, LEMOINE NR and VASSAUX G, 2002. Gene therapy. 9(21), 1455-63
  • SMITH SG, PATEL PM, PORTE J, SELBY PJ and JACKSON AM, 2001. Human dendritic cells genetically engineered to express a melanoma polyepitope DNA vaccine induce multiple cytotoxic T-cell responses. Clinical cancer research : an official journal of the American Association for Cancer Research. 7(12), 4253-61
  • TOMITA T, JACKSON AM, HIDA N, HAYAT M, DIXON MF, SHIMOYAMA T, AXON AT, ROBINSON PA and CRABTREE JE, 2001. The Journal of infectious diseases. 183(4), 620-7
  • SMITH SG, PATEL PM, SELBY PJ and JACKSON AM, 2001. Immunology letters. 76(2), 79-88
  • PRESCOTT S, JACKSON AM, HAWKYARD SJ, ALEXANDROFF AB and JAMES K, 2000. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 31 Suppl 3, S91-3
  • ALEXANDROFF AB, JACKSON AM, PATERSON T, HALEY JL, ROSS JA, LONGO DL, MURPHY WJ, JAMES K and TAUB DD, 2000. Molecular immunology. 37(9), 515-26
  • ALEXANDROFF AB, JACKSON AM, O'DONNELL MA and JAMES K, 1999. Lancet. 353(9165), 1689-94
  • HALEY JL, YOUNG DG, ALEXANDROFF A, JAMES K and JACKSON AM, 1999. Enhancing the immunotherapeutic potential of mycobacteria by transfection with tumour necrosis factor-alpha. Immunology. 96(1), 114-21
  • JACKSON AM, IVSHINA AV, SENKO O, KUZNETSOVA A, SUNDAN A, O'DONNELL MA, CLINTON S, ALEXANDROFF AB, SELBY PJ, JAMES K and KUZNETSOV VA, 1998. The Journal of urology. 159(3), 1054-63
  • BRENNAN FM, CHANTRY D, JACKSON AM, MAINI RN and FELDMANN M, eds., 1998. Cytokine production in culture by cells isolated from the synovial membrane Academic Press.
  • YOUNG DG, JACKSON AM and JAMES K, 1997. Biochemical Society transactions. 25(2), 365S
  • JACKSON AM, LIEN E, ALEXANDROFF AB, PRESCOTT S, ESPEVIK T, JAMES K, SELBY PJ and SUNDAN A, 1997. British journal of urology. 80(5), 766-71
  • JACKSON AM, ALEXANDROV AB, PRESCOTT S and JAMES K, 1995. Cancer immunology, immunotherapy : CII. 40(2), 119-24
  • JACKSON AM, ALEXANDROFF AB, KELLY RW, SKIBINSKA A, ESUVARANATHAN K, PRESCOTT S, CHISHOLM GD and JAMES K, 1995. Clinical and experimental immunology. 99(3), 369-75
  • ESUVARANATHAN K, ALEXANDROFF AB, MCINTYRE M, JACKSON AM, PRESCOTT S, CHISHOLM GD and JAMES K, 1995. The Journal of urology. 154(2 Pt 1), 572-5
  • ALEXANDROFF AB, JACKSON AM, CHISHOLM GD and JAMES K, 1995. European journal of cancer (Oxford, England : 1990). 31A(12), 2059-66
  • JACKSON AM, ALEXANDROFF AB, LAPPIN MB, ESUVARANATHAN K, JAMES K and CHISHOLM GD, 1994. Control of leucocyte function-associated antigen-1-dependent cellular conjugation by divalent cations. Immunology. 81(1), 120-6
  • JACKSON AM, ALEXANDROFF AB, MCINTYRE M, ESUVARANATHAN K, JAMES K and CHISHOLM GD, 1994. Journal of clinical pathology. 47(4), 309-12
  • ALEXANDROFF AB, JACKSON AM, ESUVARANATHAN K, PRESCOTT S and JAMES K, 1994. Immunology letters. 40(2), 117-24
  • JACKSON AM, PRESCOTT S, HAWKYARD SJ, JAMES K and CHISHOLM G, 1993. Cancer immunology, immunotherapy : CII. 36(1), 25-30
  • HAWKYARD SJ, JACKSON AM, PRESCOTT S, JAMES K and CHISHOLM GD, 1993. The effect of recombinant cytokines on bladder cancer cells in vitro. The Journal of urology. 150(2 Pt 1), 514-8
  • JACKSON AM, ALEXANDROV AB, GRIBBEN SC, ESUVARNATHAN K and JAMES K, 1993. International journal of cancer. Journal international du cancer. 55(6), 921-5
  • HAWKYARD SJ, JACKSON AM, HAWKINS RA, JAMES K, SMYTH JF and CHISHOLM GD, 1992. Urological research. 20(3), 229-32
  • JACKSON AM, HAWKYARD SJ, PRESCOTT S, RITCHIE AW, JAMES K and CHISHOLM GD, 1992. An investigation of factors influencing the in vitro induction of LAK activity against a variety of human bladder cancer cell lines. The Journal of urology. 147(1), 207-11
  • HAWKYARD SJ, JACKSON AM, JAMES K, PRESCOTT S, SMYTH JF and CHISHOLM GD, 1992. The inhibitory effects of interferon gamma on the growth of bladder cancer cells. The Journal of urology. 147(5), 1399-403
  • JACKSON AM, ALEXANDROV AB, PRESCOTT S, JAMES K and CHISHOLM GD, 1992. Role of adhesion molecules in lymphokine-activated killer cell killing of bladder cancer cells: further evidence for a third ligand for leucocyte function-associated antigen-1. Immunology. 76(2), 286-91
  • JACKSON AM, ALEXANDROV AB, PRESCOTT S, JAMES K and CHISHOLM GD, 1992. Expression of adhesion molecules by bladder cancer cells: modulation by interferon-gamma and tumour necrosis factor-alpha. The Journal of urology. 148(5), 1583-6
  • BRENNAN FM, JACKSON AM, CHANTRY D, MAINI RN and FELDMANN M, 1989. Inhibitory effect of TNF伪 antibodies on synovial cell interleukin-1 production in Rheumatoid Arthritis Lancet. 244-247
  • BRENNAN FM, CHANTRY D, JACKSON AM, MAINI RN and FELDMANN M, 1989. Journal of autoimmunity. 2 Suppl, 177-86
  • BRENNAN FM, LONDEI M, JACKSON AM, HERCEND T, BRENNER MB, MAINI RN and FELDMANN M, 1988. Journal of autoimmunity. 1(4), 319-26

School of Medicine

糖心原创
Medical School
Nottingham, NG7 2UH

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