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Daniel Wilkinson

Principal Research Fellow in Stable Isotope Mass Spectrometry, Faculty of Medicine & Health Sciences

Contact

  • workRoom 4059 Division of Medical Sciences and Graduate Entry Medicine
    Royal Derby Hospital
    Uttoxeter Road
    Derby
    DE22 3DT
    UK
  • work01332 724850

Biography

Since completing my PhD studies at the University of Brighton in 2013, I have been working within the MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research first as a post-doctoral research fellow and more recently as an Assistant Professor. My work over recent years has focused on the development of novel and minimally invasive strategies for monitoring human skeletal muscle metabolism, using stable isotope tracers combined with mass spectrometry, in both health and ageing. In particular, I have been key in the development of an innovative technique for monitoring protein turnover in free living humans through the use of orally administered deuterium oxide or 'heavy water' (a technique that forms a major part of this grant proposal), which can measure, although not limited to, protein turnover over both acute (<2 days) and chronic (several weeks) periods. This method has since been instrumental in securing a number of substantial grants (from BBSRC and the Dunhill Medical Trust) aimed at uncovering some of the mechanisms involved in regulating age-related muscle loss, and the key role of protein turnover in this loss. My current research focus is tasked with the further development of stable isotope tracer techniques to study muscle mass regulation in chronic diseases and ageing, with the specific aim to develop novel non-invasive tracer based tools for monitoring muscle mass, protein synthesis and breakdown, which could in turn be utilized as a potential diagnostic to study aspects of ageing muscle, and the development of sarcopenia (successful in securing funding through MRC-CiC and Abbeyfield). Further to these tracer techniques, I am also currently developing metabolomics and proteomic techniques for application to the MRC-Versus Arthritis Centre's research areas, alongside bioinformatic approaches for data handling. Alongside my research interests I also contribute to both undergraduate (BSc MPT course at the UoN) and postgraduate (GEM course at the UoN and MSc Musculoskeletal Ageing and Health course at the University of Birmingham) teaching.

Expertise Summary

Musculoskeletal Biology

Mass Spectrometry

Stable Isotope Tracers

Teaching Summary

I contribute to teaching on:

- BSc Medical Physiology and Therapeutics

- Graduate Entry Medicine

- MSc Musculoskeletal Ageing and Health (University of Birmingham)

Recent Publications

  • ABDULLA H, PHILLIPS B, WILKINSON D, GATES A, LIMB M, JANDOVA T, BASS J, LEWIS J, WILLIAMS J, SMITH K, IDRIS I and ATHERTON PJ, 2022. J Clin Endocrinol Metab. dgac613
  • GHARAHDAGHI N, RUDRAPPA S, BROOK MS, FARRASH W, IDRIS I, ABDUL AZIZ MH, KADI F, PAPAIONNOU K, PHILLIPS BE, SIAN T, HERROD PJ, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2022. J Cachexia Sarcopenia Muscle. 13(2), 1134-1150
  • INNS, THOMAS B., BASS, JOSEPH J., HARDY, EDWARD J. O., WILKINSON, DANIEL J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Motor unit dysregulation following 15 days of unilateral lower limb immobilisation JOURNAL OF PHYSIOLOGY-LONDON. 600(21), 4753-4769
  • BROOK MS, STOKES T, GORISSEN SHM, BASS J, MCGLORY C, CEGIELSKI J, WILKINSON DJ, PHILLIPS BE, SMITH K, PHILLIPS SM and ATHERTON PJ, 2022. J Cachexia, Sarcopenia Muscle. 13(4), 2005-2016
  • ABDULLA H, PHILLIPS B, WILKINSON D, GATES A, LIMB M, JANDOVA T, BASS J, LEWIS J, WILLIAMS J, SMITH K, IDRIS I and ATHERTON PJ, 2022. J Clin Endocrinol Metab. dgac613
  • GHARAHDAGHI N, RUDRAPPA S, BROOK MS, FARRASH W, IDRIS I, ABDUL AZIZ MH, KADI F, PAPAIONNOU K, PHILLIPS BE, SIAN T, HERROD PJ, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2022. J Cachexia Sarcopenia Muscle. 13(2), 1134-1150
  • INNS, THOMAS B., BASS, JOSEPH J., HARDY, EDWARD J. O., WILKINSON, DANIEL J., STASHUK, DANIEL W., ATHERTON, PHILIP J., PHILLIPS, BETHAN E. and PIASECKI, MATHEW, 2022. Motor unit dysregulation following 15 days of unilateral lower limb immobilisation JOURNAL OF PHYSIOLOGY-LONDON. 600(21), 4753-4769
  • BROOK MS, STOKES T, GORISSEN SHM, BASS J, MCGLORY C, CEGIELSKI J, WILKINSON DJ, PHILLIPS BE, SMITH K, PHILLIPS SM and ATHERTON PJ, 2022. J Cachexia, Sarcopenia Muscle. 13(4), 2005-2016
  • CLARK BC, GROOMS DR, ETHERIDGE T, WILKINSON DJ, ZHU S, ARNOLD WD and SZEWCZYK NJ, 2022. Frontiers in Physiol. 13, 971103
  • GUO Y, JONES EJ, INNS TB, ELY IA, STASHUK DW, WILKINSON DJ, SMITH K, PIASECKI J, PHILLIPS BE, ATHERTON PJ and PIASECKI M, 2022. Acta Physiol (Oxf). 235(2), e13803
  • WILKINSON DJ, BROOK MS and SMITH K, 2022. Clin Nutr Open Sci. 45, 112
  • COCKING DI, DAMION RA, FRANKS H, JACONELLI M, WILKINSON D, BROOK M, AUER DP and BOWTELL R, 2022. Magn Reson Med. (In Press.)
  • MAGUIRE RF, WILKINSON DJ, ENGLAND TJ and O'SULLIVAN SE, 2021. Med Cannabis Cannabinoids. 4, 86-96
  • WILLIS CRG, AMES RM, DEANE CS, PHILLIPS BE, BOEREBOOM CL, ABDULLA H, BUKHARI SSI, LUND JN, WILLIAMS JP, WILKINSON DJ, SMITH K, KADI F, SZEWCZYK NJ, ATHERTON PJ and ETHERIDGE T, 2020. Aging (Albany NY). 12, 1
  • JOANISSE S, ASHCROFT S, WILKINSON DJ, POLLOCK RD, O'BRIEN KA, PHILLIPS BE, SMITH K, LAZARUS NR, HARRIDGE S, ATHERTON PJ and PHILP A, 2020. J Gerontol A Biol Sci Med Sci. glaa005
  • FARRASH W, BROOK M, CROSSLAND H, PHILLIPS BE, CEGIELSKI J, WILKINSON DJ, CONSTANTIN-TEODOSIU D, GREENHAFF PL, SMITH K, CLEASBY M and ATHERTON PJ, 2020. Am J Physiol Endocrinol Metab: 318(6):E943-E955. 318(6), 贰943-拢955
  • DAVIES RW, BASS JJ, CARSON BP, NORTON C, KOZIOR M, WILKINSON DJ, BROOK MS, ATHERTON PJ, SMITH K and JAKEMAN PM, 2020. Nutrients. 12(3), 845
  • BROOK MS, WILKINSON DJ and ATHERTON PJ, 2020. Curr Opin Clin Nutr Metab Care. 23(3), 174-180
  • ABDULLA H, PHILLIPS BE, WILKINSON DJ, LIMB M, JANDOVA T, BASS JJ, RANKIN D, CEGIELSKI J, SAYA M, CROSSLAND H, WILLIAMS JP, SMITH K, IDRIS I and ATHERTON PJ, 2020. Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle Ageing Cell. e13202
  • CROSSLAND, HANNAH, PIASECKI, JESSICA, MCCORMICK, DANIEL, PHILLIPS, BETHAN E., WILKINSON, DANIEL J., SMITH, KENNETH, MCPHEE, JAMIE S., PIASECKI, MATHEW and ATHERTON, PHILIP J., 2020. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 319(2), R184-R194
  • BASS JJ, NAKHUDA A, DEANE CS, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY DE and ATHERTON PJ, 2020. Molecular Metabolism. 42, 101059
  • ABDULLA H, PHILLIPS BE, WILKINSON DJ, LIMB M, JANDOVA T, BASS JJ, RANKIN D, CEGIELSKI J, SAYDA M, CROSSLAND H, WILLIAMS JP, SMITH K, IDRIS I and ATHERTON PJ, 2020. Aging Cell. 19(9), e13202
  • WILKINSON DJ, RODRIGUEZ-BLANCO G, DUNN WB, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, SMITH K, GALLAGHER IJ and ATHERTON PJ, 2020. Aging (Albany NY). 12(13), 12517-12533
  • SAYDA MH, PHILLIPS BE, WILLIAMS JP, GREENHAFF PL, WILKINSON DJ, SMITH K and ATHERTON PJ, 2020. Nutrients. 12(10), 3029
  • CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Am J Physiol Cell Physiol. 319(6), C1151-C1157
  • CROSSLAND H, SMITH K, IDRIS I, PHILLIPS BE, ATHERTON PJ and WILKINSON DJ, 2020. Exp Physiol. 106(3), 585-592
  • RAMZAN I, TAYLOR M, PHILLIPS BE, WILKINSON DJ, SMITH K, HESSION K, IDRIS I and ATHERTON PJ, 2020. Nutrients. 12(1), 95
  • BASS JJ, KAZI AA, DEANE CS, NAKHUDA A, ASHCROFT SP, BROOK MS, WILKINSON DJ, PHILLIPS BE, PHILP A, TARUM J, KADI F, ANDERSEN D, GARCIA AM, SMITH K, GALLAGHER IJ, SZEWCZYK NJ, CLEASBY ME and ATHERTON PJ, 2020. J Physiol. 599(3), 063-070
  • DEANE CS, AMES RM, PHILLIPS BE, WEEDON MN, WILLIS CRG, BOEREBOOM C, ABDULLA H, BUKHARI SSI, LUND JN, WILLIAMS JP, WILKINSON DJ, SMITH K, GALLAGHER IJ, KADI F, SZEWCZYK NJ, ATHERTON PJ and ETHERIDGE T, 2019. Aging. 11(7), 2111-2126
  • DAVIES RW, BASS JJ, CARSON BP, NORTON C, KOZIOR M, AMIGO-BENAVENT M, WILKINSON DJ, BROOK MS, ATHERTON PJ, SMITH K and JAKEMAN PM, 2019. Nutrients. 11(7),
  • GHARAHDAGHI N, RUDRAPPA S, BROOK MS, IDRIS I, CROSSLAND H, HAMROCK C, ABDUL AZIZ MH, KADI F, TARUM J, GREENHAFF PL, CONSTANTIN-TEODOSIU D, CEGIELSKI J, PHILLIPS BE, WILKINSON DJ, SZEWCZYK NJ, SMITH K and ATHERTON PJ, 2019. J Cachexia Sarcopenia Muscle. 10(6), 1276-1294
  • CROSSLAND H, SMITH K, ATHERTON PJ and WILKINSON DJ, 2018. J Cell Physiol.
  • WILKINSON DJ, PIASECKI M and ATHERTON PJ, 2018. Ageing Res Rev. 47, 123-132
  • BASS JJ, WILKINSON DJ, RANKIN D, PHILLIPS BE, SZEWCZYK NJ and SMITH K, 2017. Scand J Med Sci Sports. 27(1), 4-25
  • BROOK MS, WILKINSON DJ, ATHERTON PJ and SMITH K, 2017. Current opinion in clinical nutrition and metabolic care. (In Press.)
  • DEANE CS, WILKINSON DJ, PHILLIPS BE, SMITH K, ETHERIDGE T and ATHERTON PJ, 2017. American journal of physiology. Endocrinology and metabolism. 312(4), E282-E299
  • BROOK, MATTHEW S., WILKINSON, DANIEL J., ATHERTON, PHILIP J. and SMITH, KEN, 2017. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE. 20(5), 375-381
  • BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JL, PHILLIPS BE, SWECZYK NJ, KAINULAINEN H, LENSU S, KOCH LG, BRITTON SL, GREENHAFF PL, SMITH K and ATHERTON PJ, 2017. American journal of physiology. Endocrinology and metabolism. ajpendo.00157.2017 (In Press.)
  • BROOK MS, WILKINSON DJ and ATHERTON PJ, 2017. Current opinion in clinical nutrition and metabolic care. 20(6), 433-439
  • BROOK, M.S., WILKINSON, D.J., PHILLIPS, B.E., PEREZ-SCHINDLER, J., PHILP, A., SMITH, K. and ATHERTON, P.J., 2016. Acta Physiologica. 216(1), 15-41
  • WILKINSON DJ, 2016. Mass spectrometry reviews. (In Press.)
  • RUDRAPPA SS, WILKINSON D, GREENHAFF PL, SMITH K and IDRIS I, 2016. Frontiers in Physiology: Striated Muscle Physiology. 25(7), 361
  • BROOK MS, WILKINSON DJ, MITCHELL MK, LUND JN, PHILLIPS BE, SZEWCYZK NJ, GREENHAFF PL, SMITH K and ATHERTON PJ, 2016. JOURNAL OF PHYSIOLOGY-LONDON. 594(24), 7399鈥�7417
  • WILKINSON DJ, BROOK MS, SMITH K and ATHERTON PJ, 2016. The Journal of physiology. (In Press.)
  • MITCHELL WK, PHILLIPS BE, WILKINSON DJ, WILLIAMS JP, RANKIN D, LUND JN, SMITH K and ATHERTON PJ, 2016. Clinical nutrition (Edinburgh, Scotland). (In Press.)
  • RUDRAPPA SS, WILKINSON DJ, GREENHAFF PL, SMITH K, IDRIS I and ATHERTON PJ, 2016. Frontiers in physiology. 7, 361
  • BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JN, PHILLIPS BE, SZEWCZYK NJ, GREENHAFF PL and SMITH K, 2016. J Physiol. 594(24), 7399-741
  • MITCHELL WK, WILKINSON DJ, PHILLIPS BE, LUND JN and SMITH K, 2016. Adv Nutr. 7(4), 828S-38S
  • BELTRAN VALLS MR, WILKINSON DJ, NARICI MV, SMITH K, PHILLIPS BE, CAPOROSSI D and ATHERTON PJ, 2015. The journals of gerontology. Series A, Biological sciences and medical sciences. 70(2), 174-81
  • MITCHELL WK, PHILLIPS BE, WILLIAMS JP, RANKIN D, LUND JN, WILKINSON DJ, SMITH K and ATHERTON PJ, 2015. American journal of physiology. Endocrinology and metabolism. ajpendo.00112.2015 (In Press.)
  • BROOK MS, WILKINSON DJ, MITCHELL WK, LUND JN, SZEWCZYK NJ, GREENHAFF PL, SMITH K and ATHERTON PJ, 2015. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(11), 4485-96
  • WILKINSON DJ, CEGIELSKI J, PHILLIPS BE, BOEREBOOM C, LUND JN, ATHERTON PJ and SMITH K, 2015. Physiological reports. 3(7),
  • WILKINSON, DANIEL J., ATHERTON, PHILIP J., PHILLIPS, BETHAN E., GREENHAFF, PAUL L. and SMITH, KENNETH, 2015. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 308(9), E847-E847
  • ATHERTON, P.J., PHILLIPS, B.E. and WILKINSON, D.J., 2015. Progress in Molecular Biology and Translational Science.
  • PHILLIPS, B.E., ATHERTON, P.J., VARADHAN, K., LIMB, M.C., WILKINSON, D.J., SJ脴BERG, K.A., SMITH, K. and WILLIAMS, J.P., 2015. Journal of Physiology. 593(12), 2721-2734
  • FRANCHI MV, WILKINSON DJ, QUINLAN JI, MITCHELL WK, LUND JN, WILLIAMS JP, REEVES ND, SMITH K, ATHERTON PJ and NARICI MV, 2015. Physiological reports. 3(11),
  • ATHERTON PJ, PHILLIPS BE and WILKINSON DJ, 2015. Progress in molecular biology and translational science. 135, 75-98
  • BROOK MS, WILKINSON DJ, SMITH K and ATHERTON PJ, 2015. European journal of sport science. 16(6), 633-44
  • BROOK MS, WILKINSON DJ, PHILLIPS BE, PEREZ-SCHINDLER J, PHILP A, SMITH K and ATHERTON PJ, 2015. Acta physiologica (Oxford, England). 216(1), 15-41
  • WILKINSON DJ, ATHERTON PJ, PHILLIPS BE, GREENHAFF PL and SMITH K, 2015. American journal of physiology. Endocrinology and metabolism. 308(9), E847
  • PHILLIPS BE, ATHERTON PJ, VARADHAN K, LIMB MC, WILKINSON DJ, SJ脴BERG KA, SMITH K and WILLIAMS JP, 2015. The Journal of physiology. 593(12), 2721-34
  • BUKHARI SS, PHILLIPS BE, WILKINSON DJ, LIMB MC, RANKIN D, MITCHELL WK, KOBAYASHI H, GREENHAFF PL, SMITH K and ATHERTON PJ, 2015. American journal of physiology. Endocrinology and metabolism. 308(12), E1056-65
  • WILKINSON DJ, FRANCHI MV, BROOK MS, NARICI MV, WILLIAMS JP, MITCHELL WK, SZEWCZYK NJ, GREENHAFF PL, ATHERTON PJ and SMITH K, 2014. American journal of physiology. Endocrinology and metabolism. 306(5), E571-9
  • ABDULLA H, PHILLIPS B, SMITH K, WILKINSON D, ATHERTON P and IDRIS I, 2014. Physiological Mechanisms of Action of Incretin and Insulin in Regulating Skeletal Muscle Metabolism. Current diabetes reviews. (In Press.)
  • PHILLIPS BE, ATHERTON PJ, VARADHAN K, WILKINSON DJ, LIMB M, SELBY AL, RENNIE MJ, SMITH K and WILLIAMS JP, 2014. American journal of physiology. Endocrinology and metabolism. 306(2), E168-76
  • WILKINSON, DJ, HOSSAIN, T, HILL, DS, PHILLIPS, BE, CROSSLAND, H, WILLIAMS, J, LOUGHNA, P, CHURCHWARD-VENNE, TA, BREEN, L, PHILLIPS, SM, ETHERIDGE, T, RATHMACHER, JA, SMITH, K, SZEWCZYK, NJ and ATHERTON, PJ, 2013. JOURNAL OF PHYSIOLOGY-LONDON. 591(11), 2911-2923
  • CROSSLAND H, KAZI AA, LANG CH, TIMMONS JA, PIERRE P, WILKINSON DJ, SMITH K, SZEWCZYK NJ and ATHERTON PJ, 2013. American journal of physiology. Endocrinology and metabolism. 305(2), E183-93
  • ETHERIDGE, T., ATHERTON, P.J., WILKINSON, D., SELBY, A., RANKIN, D., WEBBORN, N., SMITH, K. and WATT, P.W., 2011. American Journal of Physiology. Endocrinology and Metabolism. 301(4), E697-E702
  • WILKINSON DJ, SMEETON NJ, CASTLE PC and WATT PW, 2011. Metabolic brain disease. 26(3), 203-12
  • ATHERTON, P.J., ETHERIDGE, T., WATT, P.W., WILKINSON, D., SELBY, A., RANKIN, D., SMITH, K. and RENNIE, M.J., 2010. American Journal of Clinical Nutrition. 92(5), 1080-1088
  • WILKINSON DJ, SMEETON NJ and WATT PW, 2010. Progress in neurobiology. 91(3), 200-19

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