糖心原创

Contact

• workRoom C214a Biodiscovery Institute 3 (BDI 3)
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 82 30459
• Laura.Sidney@nottingham.ac.uk

Biography

Laura is an independent Senior Research Fellow with an interest in the recycling, reusing and repurposing of surplus ocular human tissue donations to make regenerative therapies. She is particularly focused on regeneration and adult stem cell therapies for the cornea.

Laura graduated from an undergraduate MEng degree in Biomaterial Science and Tissue Engineering from the University of Sheffield (2008), before the joining the inaugural year of the Doctoral Training Centre for Regenerative Medicine, where she completed her PhD in the School of Pharmacy, 糖心原创 (2013). She worked in Academic Ophthalmology as a research fellow from 2013 - 2017, investigating regenerative medicine uses for stem cells derived from the cornea and novel preservation methods for human donor corneas. In 2014, she was awarded the Early Stage Investigator Award by the Tissue and Cell Engineering Society (TCES).

Laura was promoted to Senior Research Fellow and awarded an Anne McLaren Fellowship by the 糖心原创 (2017). In May 2020, Laura was awarded tenure with the School of Medicine as a Senior Research Fellow.

Expertise Summary

• Cornea and eye research (ophthalmology)
• Human and biological tissue processing and preservation by low-temperature vacuum evaporation.
• Adult mesenchymal stem cells and in vitro culture.
• Genomic, phenotypic and functional characterisation of primary human stromal and limbal stem cells of the cornea.
• Cell therapies and biologically-derived materials.
• Processing of surplus human transplant tissue into extracellular matrix (ECM) hydrogels.
• Development of in vitro models of the ocular surface as alternative to toxicity testing and animal testing.

Teaching Summary

MSc Stem Cell Technology and Regenerative Medicine:

• Module Convenor: ONCG4014 Multipotent Stem Cells
• Module Contributor: ONCG4023 Translational Technologies for Stem Cells

Undergraduate and postgraduate tutor for School of Medicine.

Postgraduate Student Advisor in the School of Medicine

Research Summary

Laura's research focuses on the use of surplus ocular human tissue donations to make regenerative therapies. She is particularly focused on eye regeneration and adult stem cell therapies for the cornea.

Broadly, she works in five main areas:

Human donor tissue preservation:

1. Low-temperature vacuum evaporation for biological tissue
2. Dry-preserved human and porcine corneal tissue for transplantation
3. Preservation of amniotic membrane for transplantation

Cell biology of the anterior eye (predominantly cornea):

1. Corneal stromal keratocyte to fibroblast transition
2. Biological and mechanistic understanding of corneal mesenchymal stem cells
3. Limbal stem cell biology and the stem cell niche

Stem cell therapies for the ocular surface:

1. Topical mesenchymal stem cell therapies for the injured eye
2. GMP and optimised mesenchymal stem cell culture and quality control
3. Limbal stem cell therapies and cell sheet technology

Biomaterials derived from surplus human donor tissue:

1. ECM hydrogels for delivery of stem cells to the ocular surface
2. Amniotic membrane derived-biomaterials

In vitro models of the eye:

1. Recellularised corneas as an alternative for animal models
2. Standardised in vitro corneal cell inflammation models

Recent Publications

• MENSAH, ROSEMOND A., JO, SEUNG BIN, KIM, HOON, PARK, SUNG-MIN, PATEL, KAPIL D., CHO, KYONG J., COOK, MICHAEL T., KIRTON, STEWART B., HUTTER, VICTORIA, SIDNEY, LAURA E., ALVES-LIMA, DECIO, LIN, HUNGYEN, LEE, JUNG-HWAN, KIM, HAE-WON and CHAU, DAVID Y. S., 2021. JOURNAL OF BIOMATERIALS APPLICATIONS. 36(5), 912-929
• BEEKEN, LYDIA J., TING, DARREN S. J. and SIDNEY, LAURA E., 2021. STEM CELLS TRANSLATIONAL MEDICINE. 10(1), 39-49
• HOPKINSON, ANDREW, BRITCHFORD, EMILY R. and SIDNEY, LAURA E., 2020. CORNEAL REGENERATION. 2145, 143-157
• RUITER, F. A. A., SIDNEY, L. E., KIICK, K. L., SEGAL, J., I, ALEXANDER, C. and ROSE, F. R. A. J., 2020. BIOMATERIALS SCIENCE. 8(9), 2611-2626

• View all publications

• MENSAH, ROSEMOND A., JO, SEUNG BIN, KIM, HOON, PARK, SUNG-MIN, PATEL, KAPIL D., CHO, KYONG J., COOK, MICHAEL T., KIRTON, STEWART B., HUTTER, VICTORIA, SIDNEY, LAURA E., ALVES-LIMA, DECIO, LIN, HUNGYEN, LEE, JUNG-HWAN, KIM, HAE-WON and CHAU, DAVID Y. S., 2021. JOURNAL OF BIOMATERIALS APPLICATIONS. 36(5), 912-929
• BEEKEN, LYDIA J., TING, DARREN S. J. and SIDNEY, LAURA E., 2021. STEM CELLS TRANSLATIONAL MEDICINE. 10(1), 39-49
• HOPKINSON, ANDREW, BRITCHFORD, EMILY R. and SIDNEY, LAURA E., 2020. CORNEAL REGENERATION. 2145, 143-157
• RUITER, F. A. A., SIDNEY, L. E., KIICK, K. L., SEGAL, J., I, ALEXANDER, C. and ROSE, F. R. A. J., 2020. BIOMATERIALS SCIENCE. 8(9), 2611-2626
• MARSIT, NAGI M., SIDNEY, LAURA E., BRITCHFORD, EMILY R., MCINTOSH, OWEN D., ALLEN, CLAIRE L., ASHRAF, WAHEED, BAYSTON, ROGER and HOPKINSON, ANDREW, 2019. SCIENTIFIC REPORTS. 9,
• MORALES, MARIANA LIZETH OROZCO, MARSIT, NAGI M., MCINTOSH, OWEN D., HOPKINSON, ANDREW and SIDNEY, LAURA E., 2019. WORLD JOURNAL OF STEM CELLS. 11(2), 84-99
• ROSE, JAMES B., SIDNEY, LAURA E., PATIENT, JAMES, WHITE, LISA J., DUA, HARMINDER S., EL HAJ, ALICIA J., HOPKINSON, ANDREW and ROSE, FELICITY R. A. J., 2019. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 107(4), 828-838
• SIDNEY, LAURA E. and HOPKINSON, ANDREW, 2018. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 12(1), E203-E215
• PRINA E, MISTRY P, SIDNEY LE, YANG J, WILDMAN RD, BERTOLIN M, BREDA C, FERRARI B, BARBARO V, HOPKINSON A, DUA HS, FERRARI S and ROSE FRAJ, 2017. Stem cell reviews. 13(3), 430-441
• PRINA, ELISABETTA, MISTRY, PRITESH, SIDNEY, LAURA E., YANG, JING, WILDMAN, RICKY D., BERTOLIN, MARINA, BREDA, CLAUDIA, FERRARI, BARBARA, BARBARO, VANESSA, HOPKINSON, ANDREW, DUA, HARMINDER S., FERRARI, STEFANO and ROSE, FELICITY R. A. J., 2017. STEM CELL REVIEWS AND REPORTS. 13(3), 430-441
• MARSIT, NAGI M., SIDNEY, LAURA E., BRANCH, MATTHEW J., WILSON, SAMANTHA L. and HOPKINSON, ANDREW, 2017. PLASMA PROCESSES AND POLYMERS. 14(7),
• NAGYMIHALY, RICHARD, VEREB, ZOLTAN, ALBERT, REKA, SIDNEY, LAURA, DUA, HARMINDER, HOPKINSON, ANDREW and PETROVSKI, GORAN, 2017. CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 45(5), 509-519
• SIDNEY LE and HOPKINSON A, 2016. Journal of tissue engineering and regenerative medicine. (In Press.)
• WILSON, SAMANTHA L., SIDNEY, LAURA E., DUNPHY, SIOBHAN E., DUA, HARMINDER S. and HOPKINSON, ANDREW, 2016. CURRENT EYE RESEARCH. 41(6), 769-782
• STEWART, ELIZABETH A., WEI, RUOXIN, BRANCH, MATTHEW J., SIDNEY, LAURA E. and AMOAKU, WINFRIED M., 2015. EXPERIMENTAL EYE RESEARCH. 138, 114-123
• SIDNEY, LAURA E., BRANCH, MATTHEW J., DUA, HARMINDER S. and HOPKINSON, ANDREW, 2015. CYTOTHERAPY. 17(12), 1706-1722
• ALTAAN, SAIEF L., GUPTA, ANKUR, SIDNEY, LAURA E., ELALFY, MOHAMED S., AGARWAL, AMAR and DUA, HARMINDER S., 2015. BRITISH JOURNAL OF OPHTHALMOLOGY. 99(5), 710-713
• SIDNEY, LAURA E., MCINTOSH, OWEN D. and HOPKINSON, ANDREW, 2015. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 56(12), 7225-7235
• SIDNEY, L.E., HEATHMAN, T.R.J., BRITCHFORD, E.R., ABED, A., RAHMAN, C.V. and BUTTERY, L.D.K., 2015. Tissue Engineering - Part A. 21(1-2), 362-373
• ALTAAN, S.L., GUPTA, A., SIDNEY, L.E., ELALFY, M.S., AGARWAL, A. and DUA, H.S., 2015. British Journal of Ophthalmology. 99(5), 710-713
• WILSON SL, SIDNEY LE, DUNPHY SE, DUA HS and HOPKINSON A, 2015. Current eye research. 41(6), 769-82
• SIDNEY LE, MCINTOSH OD and HOPKINSON A, 2015. Investigative ophthalmology & visual science. 56(12), 7225-35
• SIDNEY LE, BRANCH MJ, DUA HS and HOPKINSON A, 2015. Cytotherapy. 17(12), 1706-22
• STEWART EA, WEI R, BRANCH MJ, SIDNEY LE and AMOAKU WM, 2015. Experimental eye research. 138, 114-23
• SIDNEY, LAURA E., HEATHMAN, THOMAS R. J., BRITCHFORD, EMILY R., ABED, ARIF, RAHMAN, CHERYL V. and BUTTERY, LEE D. K., 2015. TISSUE ENGINEERING PART A. 21(1-2), 362-373
• SIDNEY LE, KIRKHAM GR and BUTTERY LD, 2014. Stem cells and development. 23(6), 605-17
• SIDNEY, LAURA E., BRANCH, MATTHEW J., DUNPHY, SIOBHAN E., DUA, HARMINDER S. and HOPKINSON, ANDREW, 2014. STEM CELLS. 32(6), 1380-1389
• SIDNEY, LAURA E., KIRKHAM, GLEN R. and BUTTERY, LEE D., 2014. STEM CELLS AND DEVELOPMENT. 23(6), 605-617
• WILSON SL, SIDNEY LE, DUNPHY SE, ROSE JB and HOPKINSON A, 2013. Journal of functional biomaterials. 4(3), 114-61
• SAWKINS, M. J., BOWEN, W., DHADDA, P., MARKIDES, H., SIDNEY, L. E., TAYLOR, A. J., ROSE, F. R. A. J., BADYLAK, S. F., SHAKESHEHH, K. M. and WHITE, L. J., 2013. ACTA BIOMATERIALIA. 9(8), 7865-7873
• HASHMANI, K., BRANCH, M.J., SIDNEY, L.E., DHILLON, P.S., VERMA, M., MCINTOSH, O.D., HOPKINSON, A. and DUA, H.S., 2013. Stem Cell Research & Therapy. 75
• SAWKINS, M.J., BOWEN, W., DHADDA, P., MARKIDES, H., SIDNEY, L.E., TAYLOR, A.J., ROSE, F.R.A.J., BADYLAK, S.F., SHAKESHEFF, K.M. and WHITE, L.J., 2013. Acta Biomaterialia. 9(8), 7865-7873
• WILSON, SAMANTHA L., SIDNEY, LAURA E., DUNPHY, SIOBHAN E., ROSE, JAMES B. and HOPKINSON, ANDREW, 2013. Keeping an Eye on Decellularized Corneas: A Review of Methods, Characterization and Applications Journal of Functional Biomaterials. 4(3), 114-161
• HASHMANI, KHURRAM, BRANCH, MATTHEW JAMES, SIDNEY, LAURA ELIZABETH, DHILLON, PERMESH SINGH, VERMA, MEGHA, MCINTOSH, OWEN DOUGLAS, HOPKINSON, ANDREW and DUA, HARMINDER SINGH, 2013. STEM CELL RESEARCH & THERAPY. 4,
• SIDNEY, L.E. and BUTTERY, L.D.K., 2011. European Cells and Materials. 22(SUPPL.3), 26
• SIDNEY, L. E., WALSH, D. and BUTTERY, L. D. K., 2010. Tissue Engineering in Hostile Environments: The Effect of Proinflammatory Cytokines on Embryonic Stem Cells and Primary Bone Cells JOURNAL OF PHARMACY AND PHARMACOLOGY. 62(10), 1494-1495