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School of Mathematical Sciences

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Roman Syunyaev

Senior Research Fellow,

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Research Summary

My main research focus is cardiac electrophysiology in general and computational cardiology in particular. Despite recent progress, potential practical applications of computational models are still… read more

Selected Publications

  • PIKUNOV, ANDREY V, SYUNYAEV, ROMAN A, ALI, RHEEDA, PRAKOSA, ADITYO, GAMS, ANNA, BOYLE, PATRICK M, STECKMEISTER, VANESSA, KUTSCHKA, INGO, RYTKIN, ERIC, VOIGT, NIELS and OTHERS, 2025. Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins Circulation: Arrhythmia and Electrophysiology. 18(9), e013898
  • ABRASHEVA, VERONIKA O, KOVALENKO, SANDAARA G, SLOTVITSKY, MIHAIL, ROMANOVA, SERAFIMA 袗, AITOVA, ALERIA A, FROLOVA, SHEIDA, TSVELAYA, VALERIA and SYUNYAEV, ROMAN A, 2024. Human sodium current voltage-dependence at physiological temperature measured by coupling a patch-clamp experiment to a mathematical model The Journal of Physiology. 602(4), 633-661
  • DEVIATIIAROV, RUSLAN M, GAMS, ANNA, KULAKOVSKIY, IVAN V, BUYAN, ANDREY, MESHCHERYAKOV, GEORGY, SYUNYAEV, ROMAN, SINGH, RAMESH, SHAH, PALAK, TATARINOVA, TATIANA V, GUSEV, OLEG and OTHERS, 2023. An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure Nature Cardiovascular Research. 2(1), 58-75
  • RYBASHLYKOV, DMITRY, BRENNAN, JACLYN, LIN, ZEXU, EFIMOV, IGOR R and SYUNYAEV, ROMAN, 2022. Open-source low-cost cardiac optical mapping system Plos one. 17(3), e0259174

Current Research

My main research focus is cardiac electrophysiology in general and computational cardiology in particular. Despite recent progress, potential practical applications of computational models are still limited by imprecise description of ionic channels kinetics, incomplete understanding of cellular and tissue electrophysiology, and complex drug interactions. Thus, any attempt to develop clinical applications requires careful consideration of the models we use, verifying these against experimental data and quantifying uncertainty in our predictions. My past research is thus bridging experimental and computational studies: cell-, tissue-, and pathology-specific models informed by genetic and functional data, heterogeneity and synchronization within cardiac tissue, arrhythmogenesis and normal rhythm propagation, as well as developing novel tools for processing experimental data, such as optical mapping and patch-clamp recordings.

  • PIKUNOV, ANDREY V, SYUNYAEV, ROMAN A, ALI, RHEEDA, PRAKOSA, ADITYO, GAMS, ANNA, BOYLE, PATRICK M, STECKMEISTER, VANESSA, KUTSCHKA, INGO, RYTKIN, ERIC, VOIGT, NIELS and OTHERS, 2025. Role of Structural Versus Cellular Remodeling in Atrial Arrhythmogenesis: Insights From Personalized Digital Twins Circulation: Arrhythmia and Electrophysiology. 18(9), e013898
  • ABRASHEVA, VERONIKA O, KOVALENKO, SANDAARA G, SLOTVITSKY, MIHAIL, ROMANOVA, SERAFIMA 袗, AITOVA, ALERIA A, FROLOVA, SHEIDA, TSVELAYA, VALERIA and SYUNYAEV, ROMAN A, 2024. Human sodium current voltage-dependence at physiological temperature measured by coupling a patch-clamp experiment to a mathematical model The Journal of Physiology. 602(4), 633-661
  • DEVIATIIAROV, RUSLAN M, GAMS, ANNA, KULAKOVSKIY, IVAN V, BUYAN, ANDREY, MESHCHERYAKOV, GEORGY, SYUNYAEV, ROMAN, SINGH, RAMESH, SHAH, PALAK, TATARINOVA, TATIANA V, GUSEV, OLEG and OTHERS, 2023. An atlas of transcribed human cardiac promoters and enhancers reveals an important role of regulatory elements in heart failure Nature Cardiovascular Research. 2(1), 58-75
  • RYBASHLYKOV, DMITRY, BRENNAN, JACLYN, LIN, ZEXU, EFIMOV, IGOR R and SYUNYAEV, ROMAN, 2022. Open-source low-cost cardiac optical mapping system Plos one. 17(3), e0259174
  • SMIRNOV, DMITRII, PIKUNOV, ANDREY, SYUNYAEV, ROMAN, DEVIATIIAROV, RUSLAN, GUSEV, OLEG, ARAS, KEDAR, GAMS, ANNA, KOPPEL, AARON and EFIMOV, IGOR R, 2020. Genetic algorithm-based personalized models of human cardiac action potential PloS one. 15(5), e0231695
  • GAMILOV, TIMUR, KOPYLOV, PHILIPP, SEROVA, MARIA, SYUNYAEV, ROMAN, PIKUNOV, ANDREY, BELOVA, SOFYA, LIANG, FUYOU, ALASTRUEY, JORDI and SIMAKOV, SERGEY, 2020. Computational analysis of coronary blood flow: The role of asynchronous pacing and arrhythmias Mathematics. 8(8), 1205
  • SMIRNOV, DMITRII, PIKUNOV, ANDREY, SYUNYAEV, ROMAN, DEVIATIIAROV, RUSLAN, GUSEV, OLEG, ARAS, KEDAR, GAMS, ANNA, KOPPEL, AARON and EFIMOV, IGOR R, 2020. Genetic algorithm-based personalized models of human cardiac action potential PloS one. 15(5), e0231695
  • CATHEY, BRIANNA, OBAID, SOFIAN, ZOLOTAREV, ALEXANDER M, PRYAMONOSOV, ROMAN A, SYUNYAEV, ROMAN A, GEORGE, SHARON A and EFIMOV, IGOR R, 2019. Open-source multiparametric optocardiography Scientific reports. 9(1), 721
  • KARPAEV, ALEXEY A, SYUNYAEV, ROMAN A and ALIEV, RUBIN R, 2018. Effects of fibroblast-myocyte coupling on the sinoatrial node activity: A computational study International journal for numerical methods in biomedical engineering. 34(5), e2966
  • GLOSCHAT, CHRISTOPHER, ARAS, KEDAR, GUPTA, SHUBHAM, FAYE, N ROKHAYA, ZHANG, HANYU, SYUNYAEV, ROMAN A, PRYAMONOSOV, ROMAN A, ROGERS, JACK, KAY, MATTHEW W and EFIMOV, IGOR R, 2018. RHYTHM: an open source imaging toolkit for cardiac panoramic optical mapping Scientific reports. 8(1), 2921
  • SYUNYAEV, ROMAN A and ALIEV, RUBIN R, 2017. Computer simulations of reentrant activity in the rabbit sinoatrial node International journal for numerical methods in biomedical engineering. 33(2), e02792
  • KHOKHLOVA, AD, SYUNYAEV, RA, RYVKIN, AM, SHMARKO, DV, GONOTKOV, MA, LEBEDEVA, EA, GOLOVKO, VA, MOSKVIN, AS, SOLOVYOVA, OE and ALIEV, RR, 2016. The effects of intracellular calcium dynamics on the electrical activity of the cells of the sinoatrial node Biophysics. 61, 893-900
  • TOLSTOKOROV, A. S., SYUNYAEV, R.A. and ALIEV, R. R., 2015. Simulation of the Fibroblast Effect on Electrical Activity of Sinoatrial Node Cells Biophysics. 60(2), 322-329
  • SYUNYAEV, RA and ALIEV, RR, 2012. Action potential propagation and phase dynamics in the sinoatrial node Russian Journal of Numerical Analysis and Mathematical Modelling. 27(5), 493-506
  • SYUNYAEV, RA and ALIEV, RR, 2012. Computer simulation of microreentry in the sinoatrial node Biophysics. 57, 676-680
  • SYUNYAEV, RA and ALIEV, RR, 2012. Action potential propagation and phase dynamics in the sinoatrial node Russian Journal of Numerical Analysis and Mathematical Modelling. 27(5), 493-506
  • SYUNYAEV, RA and ALIEV, RR, 2011. Computer simulation of 3D electrical activity in the sinoatrial node Russ. J. Numer. Anal. Math. Modelling. 26(6), 575-587
  • SYUNYAEV, RA and ALIEV, RR, 2010. Computer simulations of pacemaker shift in the sinoatrial node Biophysics. 55(6), 1025-1029
  • SYUNYAEV, RA and ALIEV, RR, 2009. Modeling of the influence of gap-junction coupling on synchronization of central and peripheral sinoatrial node cells Biophysics. 54(1), 58-60

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