糖心原创

School of Mathematical Sciences

Bindi Brook

Professor of Mathematical Medicine and Biology, Faculty of Science

Contact

  • workRoom C26 The Mathematical Sciences Building
    University Park
    Nottingham
    NG7 2RD
    UK
  • work0115 7486065
  • fax0115 9513837

Research Summary

The aim of my research, in biomechanics and the application of mathematics to medicine, is to develop and solve novel mathematical models to provide fundamental insights into biomedical problems that… read more

Recent Publications

  • JAMES E MOORE JR, BINDI S BROOK and ROBERT J B NIBBS, 2018. Current Opinion in Biomedical Engineering.
  • ELIZABETH HOLDEN, JOE COLLIS, BINDI S BROOK and REUBEN D O'DEA, 2018. A multiphase multiscale model for nutrient limited tissue growth The ANZIAM Journal. (In Press.)
  • SAMUEL MAILHOT-LAROUCHE, LOUIS DESCH脢NES, MORGAN GAZZOLA, KATHERINE LORTIE, CYNDI HENRY, BINDI S BROOK, MATHIEU C MORISSETTE and YNUK BOSS脡, 2018. Journal of applied physiology (Bethesda, Md. : 1985).
  • BAKER M, BROOK BS and OWEN MR, 2017. Journal of mathematical biology. (In Press.)

Current Research

The aim of my research, in biomechanics and the application of mathematics to medicine, is to develop and solve novel mathematical models to provide fundamental insights into biomedical problems that complement those obtained by experimental methods. My research involves collaborations with life scientists, clinicians, and theoreticians in highly interdisciplinary projects addressing key clinical problems.

My current work is focussed on mathematical multi-scale models of airway hyper-responsiveness, inflammation and remodelling in asthma. The motivation for my research is to quantify the roles and interactions of the smooth muscle cells, tissues and chemical mediators that are involved in asthma, and specifically in the acute biomechanical contractile response of normal and remodelled airway wall tissue in vivo. To this end my group is developing novel, multi-scale, mathematical models of airway contraction and remodelling, informed by experimental data that explicitly couples the force generated in ASM cells arising from molecular level events, to a biomechanical continuum model of airway tissue. The theoretical models that are being developed each require different mathematical approaches, from discrete-stochastic models at the sub-cellular level through to deterministic-continuum nonlinear (morpho)elastic models at the tissue level.

Past Research

Previously, I was involved in the development of multi-level computational fluid dynamics (CFD) models of inhaled drugs with a Framework 5 European Commission project in order to develop simulation tools for delivery device development and optimisation of inhaled drug deposition and distribution. This was in collaboration with pharmaceutical industry (Aventis Pharma, CFX-Ansys). Prior to this I worked on an EPSRC grant in collaboration with an anaesthetic clinician developing mathematical models to optimise ventilation strategies for mechanically ventilated patients.

My PhD thesis entitled "Haemodynamics of the giraffe jugular vein" under the supervision of Prof T.J. Pedley involved development of mathematical models of flow-structure interactions in collapsible tubes.

  • JAMES E MOORE JR, BINDI S BROOK and ROBERT J B NIBBS, 2018. Current Opinion in Biomedical Engineering.
  • ELIZABETH HOLDEN, JOE COLLIS, BINDI S BROOK and REUBEN D O'DEA, 2018. A multiphase multiscale model for nutrient limited tissue growth The ANZIAM Journal. (In Press.)
  • SAMUEL MAILHOT-LAROUCHE, LOUIS DESCH脢NES, MORGAN GAZZOLA, KATHERINE LORTIE, CYNDI HENRY, BINDI S BROOK, MATHIEU C MORISSETTE and YNUK BOSS脡, 2018. Journal of applied physiology (Bethesda, Md. : 1985).
  • BAKER M, BROOK BS and OWEN MR, 2017. Journal of mathematical biology. (In Press.)
  • JAFARNEJAD M, ZAWIEJA DC, BROOK BS, NIBBS RJB and MOORE JE, 2017. Journal of immunology (Baltimore, Md. : 1950). (In Press.)
  • RUTH SAUNDERS, HIMANSHU KAUL, RACHID BERAIR, AMISHA SINGAPURI, IGOR L CHERNYAVKSY, LATIFA CHACHI, MICHAEL BIDDLE, AMANDA SUTCLIFFE, MARIE LAURENCIN, GERALD BACHER, MICHELLE BOURNE, IAN D PAVORD, ANDREW J WARDLAW, SALMAN SIDDIQUI, RICHARD KAY, BINDI S BROOK, ROD SMALLWOOD and CHRIS E BRIGHTLING, 2017. European Respiratory Journal. 50, OA283
  • J. E. HIORNS, O.E. JENSEN and B.S. BROOK, 2016. Journal of Applied physiology (Bethesda, Md. : 1985).
  • J.E. HIORNS, C.M. BIDAN, O.E. JENSEN, R. GOSENS, L.E.M. KISTEMAKER, J.J. FREDBERG, J.P. BUTLER, R. KRISHNAN and B.S. BROOK, 2016. Frontiers in Respiratory Physiology.
  • H. CROISIER, X. TAN, J. SNEYD, M.J. SANDERSON and B. S. BROOK, 2015. American Journal of Respiratory Cellular and Molecular Biology. 53, 703-711
  • CHERNYAVSKY, IL, CROISIER, H, CHAPMAN, LAC, KIMPTON, LS, HIORNS, JE, BROOK, BS, JENSEN, OE, BILLINGTON, CK, HALL, IP and JOHNSON, SR, 2014. PLoS ONE. 9(3), e90162
  • BROOK BS, 2014. Journal of applied physiology (Bethesda, Md. : 1985). 116, 980-997
  • J. E. HIORNS, O.E. JENSEN and B. S. BROOK, 2014. Biophysical Journal. 107, 3030-3042
  • NOBLE PB, PASCOE CD, LAN B, ITO S, KISTEMAKER LEM, TATLER AL, PERA T, BROOK BS, GOSENS R and WEST AR, 2014. Pulmonary pharmacology & therapeutics. 29(2), 96-107
  • BROOK, B.S. and JENSEN, O.E., 2013. Mathematical Medicine and Biology. n/a(n/a), n/a
  • H CROISIER, X TAN, J. F. PEREZ-ZOGHBI, M. J. SANDERSON, J. SNEYD and B. S. BROOK, 2013. PLoS One. 8(7), e69598
  • BAKER, M., DENMAN-JOHNSON, S., BROOK, B.S., GAYWOOD, I. and OWEN, M.R., 2012. Mathematical Medicine and Biology. n/a(n/a), n/a
  • BROOK, B.S. and JENSEN, O.E., 2011. A Mechanistic Model For Disruption Of Actin-Myosin Connectivity In An Airway Smooth Muscle Cell American Journal of Respiratory and Critical Care Medicine. 183, A1255
  • BROOK, B.S., KOHL, P and KING, J.R., 2011. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences. (In Press.)
  • CROISIER, H, THUL, R, COOMBES, S, HALL, I.P. and BROOK, B.S., 2011. In: European Conference on Mathematical and Theoretical Biology, Krakow, Poland, 28 June- 2 July, 2011.
  • BROOK, B.S., PEEL, S.E., HALL, I.P., POLITI, A.Z., SNEYD, J., BAI, Y., SANDERSON, M.J. and JENSEN, O.E., 2010. Respiratory Physiology & Neurobiology. 170(1), 44-58
  • LAWFORD, PATRICIA V, NARRACOTT, ANDREW V, MCCORMACK, KEITH, BISBAL, JESUS, MARTIN, CARLOS, BROOK, BINDI S, ZACHARIOU, MARGARITA, KOHL, PETER, FLETCHER, KATHERINE and DIAZ-ZUCCARINI, VANESSA, 2010. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. 368(1921), 2841-51
  • BROOK, B.S., MURPHY, C.M., BREEN, D., MILES, A.W., TILLEY, D.G. and WILSON, A.J., 2009. Computational and Mathematical Methods in Medicine. 10(2), 139-154
  • WILSON, A.J., MURPHY, C.M., BROOK, B.S., BREEN, D., MILES, A.W. and TILLEY, D.G., 2009. Medical Engineering and Physics. 31(9), 1118-1133
  • FENNER, J.W., BROOK, B. S., CLAPWORTHY, G., COVENEY, P.V., FEIPEL, V., GREGERSEN, H., HOSE, D.R., KOHL, P., LAWFORD, P. and MCCORMACK, K.M., 2008. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences. VOL 366(NUMB 1878), 2979-3000
  • BROOK, B S and WATERS, S L, 2008. Journal of Mathematical Biology. 56(6), 893-6
  • BROOK, B.S., MURPHY, C. M., BREEN, D., MILES, A.W, TILLEY, D.G. and WILSON, A.J., 2007. Physiological Measurement. 28, 1451-1464
  • BROOK, B.S. and PEDLEY, T.J., 2002. Journal of Biomechanics. 35(1), 95-107
  • LEY, S., MAYER, D., BROOK, B.S., VAN BEEK, E.J., HEUSSEL, C.P., RINCK, D., HOSE, R., MARKSTALLER, K. and KAUCZOR, H.U., 2002. European Radiology. VOL 12(PART 9), 2218-2228
  • WILSON, A.J., BROOK, B.S., MURPHY, C.M., BREEN, D., MILES, A.W. and TILLEY, D.G., 2002. Multi-modal modelling of the human respiratory system in intensive care IFMBE Proceedings. VOL 3(PART 2), II/1594-1595
  • LEY, S., MAYER, D., BROOK, B., VAN BEEK, E.J.R., HEUSSELL, C.P., HOSE, D.R., RINCK. D. and KAUCZOR, H.U., 2001. Radiological imaging as the basis for a simulation software to advance individualised inhalation therapies In: European Radiology Congress 2001. 30
  • BROOK, B. S., FALLE, S. A. E. G. and PEDLEY, T. J., 1999. Journal of Fluid Mechanics. VOL 396, 223-256
  • PEDLEY, T. J., BROOK, B. S. and SEYMOUR, R. S., 1996. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. VOL 351(ISSUE 1342), 855-866

School of Mathematical Sciences

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University Park
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