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Centre for Mathematical Medicine and Biology
 

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Gary Mirams

Professor of Mathematical Physiology, Faculty of Science

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Research Summary

My research is in mathematical/computational biology. I work on modelling to address cardiac electrophysiology questions, particularly pharmaceutical drug safety (this involves mathematical modelling… read more

Recent Publications

  • LEI, CHON LOK and MIRAMS, GARY R., 2021. FRONTIERS IN PHYSIOLOGY. 12,
  • KEMP, JACOB M., WHITTAKER, DOMINIC G., VENKATESHAPPA, RAVICHANDRA, PANG, ZHAOKAI, JOHAL, RAJ, SERGEEV, VALENTINE, TIBBITS, GLEN F., MIRAMS, GARY R. and CLAYDON, THOMAS W., 2021. JOURNAL OF GENERAL PHYSIOLOGY. 153(10),
  • CLERX, MICHAEL, MIRAMS, GARY R., ROGERS, ALBERT J., NARAYAN, SANJIV M. and GILES, WAYNE R., 2021. FRONTIERS IN PHYSIOLOGY. 12,
  • WHITTAKER, DOMINIC G., CAPEL, REBECCA A., HENDRIX, MAURICE, CHAN, XIN HUI S., HERRING, NEIL, WHITE, NICHOLAS J., MIRAMS, GARY R. and BURTON, REBECCA-ANN B., 2021. ROYAL SOCIETY OPEN SCIENCE. 8(4),

Current Research

My research is in mathematical/computational biology. I work on modelling to address cardiac electrophysiology questions, particularly pharmaceutical drug safety (this involves mathematical modelling of ion channels, drug interactions with ion channels, cardiac action potential modelling, cardiac tissue modelling and arrhythmia mechanisms). On the mathematical side I am interested in statistical inference for mechanistic models, and in particular experimental design to help calibrate model parameters, select between alternative models, and assess model discrepancy. Please see for more information.

  • LEI, CHON LOK and MIRAMS, GARY R., 2021. FRONTIERS IN PHYSIOLOGY. 12,
  • KEMP, JACOB M., WHITTAKER, DOMINIC G., VENKATESHAPPA, RAVICHANDRA, PANG, ZHAOKAI, JOHAL, RAJ, SERGEEV, VALENTINE, TIBBITS, GLEN F., MIRAMS, GARY R. and CLAYDON, THOMAS W., 2021. JOURNAL OF GENERAL PHYSIOLOGY. 153(10),
  • CLERX, MICHAEL, MIRAMS, GARY R., ROGERS, ALBERT J., NARAYAN, SANJIV M. and GILES, WAYNE R., 2021. FRONTIERS IN PHYSIOLOGY. 12,
  • WHITTAKER, DOMINIC G., CAPEL, REBECCA A., HENDRIX, MAURICE, CHAN, XIN HUI S., HERRING, NEIL, WHITE, NICHOLAS J., MIRAMS, GARY R. and BURTON, REBECCA-ANN B., 2021. ROYAL SOCIETY OPEN SCIENCE. 8(4),
  • LEI, CHON LOK, FABBRI, ALAN, WHITTAKER, DOMINIC G, CLERX, MICHAEL, WINDLEY, MONIQUE J, HILL, ADAM P, MIRAMS, GARY R and DE BOER, TEUN P, 2020. A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer. Wellcome open research. 5, 152
  • CAMPORESI, MARIA, BARTOLUCCI, CHIARA, LEI, CHON LOK, MIRAMS, GARY R., DE BOER, TEUN P. and SEVERI, STEFANO, 2020. 2020 COMPUTING IN CARDIOLOGY.
  • DAVIES, MARK R., MARTINEC, MICHAEL, WALLS, ROBERT, SCHWARZ, ROMAN, MIRAMS, GARY R., WANG, KEN, STEINER, GUIDO, SURINACH, ANDY, FLORES, CARLOS, LAVE, THIERRY, SINGER, THOMAS and POLONCHUK, LIUDMILA, 2020. CELL REPORTS MEDICINE. 1(5),
  • LEI, CHON LOK, CLERX, MICHAEL, WHITTAKER, DOMINIC G., GAVAGHAN, DAVID J., DE BOER, TEUN P. and MIRAMS, GARY R., 2020. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
  • MIRAMS, GARY R., NIEDERER, STEVEN A. and CLAYTON, RICHARD H., 2020. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
  • LEI, CHON LOK, GHOSH, SANMITRA, WHITTAKER, DOMINIC G., ABOELKASSEM, YASSER, BEATTIE, KYLIE A., CANTWELL, CHRIS D., DELHAAS, TAMMO, HOUSTON, CHARLES, NOVAES, GUSTAVO MONTES, PANFILOV, ALEXANDER V., PATHMANATHAN, PRAS, RIABIZ, MARINA, DOS SANTOS, RODRIGO WEBER, WALMSLEY, JOHN, WORDEN, KEITH, MIRAMS, GARY R. and WILKINSON, RICHARD D., 2020. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. 378(2173),
  • RIDDER, BRADLEY J., LEISHMAN, DEREK J., BRIDGLAND-TAYLOR, MATTHEW, SAMIEEGOHAR, MOHAMMADREZA, HAN, XIAOMEI, WU, WENDY W., RANDOLPH, AARON, TRAN, PHU, SHENG, JIANSONG, DANKER, TIMM, LINDQVIST, ANDERS, KONRAD, DANIEL, HEBEISEN, SIMON, POLONCHUK, LIUDMILA, GISSINGER, EVGENIA, RENGANATHAN, MUTHUKRISHNAN, KOCI, BRYAN, WEI, HAIYANG, FAN, JINGSONG, LEVESQUE, PAUL, KWAGH, JAE, IMREDY, JOHN, ZHAI, JIN, ROGERS, MARC, HUMPHRIES, EDWARD, KIRBY, ROBERT, STOELZLE-FEIX, SONJA, BRINKWIRTH, NINA, ROTORDAM, MARIA GIUSTINA, BECKER, NADINE, FRIIS, SOREN, RAPEDIUS, MARKUS, GOETZE, TOM A., STRASSMAIER, TIM, OKEYO, GEORGE, KRAMER, JAMES, KURYSHEV, YURI, WU, CAIYUN, HIMMEL, HERBERT, MIRAMS, GARY R., STRAUSS, DAVID G., BARDENET, REMI and LI, ZHIHUA, 2020. TOXICOLOGY AND APPLIED PHARMACOLOGY. 395,
  • LI, ZHIHUA, MIRAMS, GARY R., YOSHINAGA, TAKASHI, RIDDER, BRADLEY J., HAN, XIAOMEI, CHEN, JANELL E., STOCKBRIDGE, NORMAN L., WISIALOWSKI, TODD A., DAMIANO, BRUCE, SEVERI, STEFANO, MORISSETTE, PIERRE, KOWEY, PETER R., HOLBROOK, MARK, SMITH, GODFREY, RASMUSSON, RANDALL L., LIU, MICHAEL, SONG, ZHEN, QU, ZHILIN, LEISHMAN, DEREK J., STEIDL-NICHOLS, JILL, RODRIGUEZ, BLANCA, BUENO-OROVIO, ALFONSO, ZHOU, XIN, PASSINI, ELISA, EDWARDS, ANDREW G., MOROTTI, STEFANO, NI, HAIBO, GRANDI, ELEONORA, CLANCY, COLLEEN E., VANDENBERG, JAMIE, HILL, ADAM, NAKAMURA, MIKIKO, SINGER, THOMAS, POLONCHUK, LIUDMILA, GREITER-WILKE, ANDREA, WANG, KEN, NAVE, STEPHANE, FULLERTON, AARON, SOBIE, ERIC A., PACI, MICHELANGELO, TSHINANU, FLORA MUSUAMBA and STRAUSS, DAVID G., 2020. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy CLINICAL PHARMACOLOGY & THERAPEUTICS. 107(1), 102-111
  • LIN, YU-PING, BAKOWSKI, DANIEL, MIRAMS, GARY R. and PAREKH, ANANT B., 2019. NATURE COMMUNICATIONS. 10,
  • BEENTJES, C. H. L., TAYLOR-KING, J. P., BAYANI, A., DAVIS, C. N., DUNSTER, J. L., JABBARI, S., MIRAMS, G. R., JENKINSON, C., KILBY, M. D., HEWISON, M. and TAMBLYN, J. A., 2019. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 190, 152-160
  • LI, ZHIHUA, MIRAMS, GARY R. and STRAUSS, DAVID G., 2019. Response to "CiPA's Complexity Bias" CLINICAL PHARMACOLOGY & THERAPEUTICS. 105(6), 1325-1325
  • BOWLER, LOUISE A., GAVAGHAN, DAVID J., MIRAMS, GARY R. and WHITELEY, JONATHAN P., 2019. BULLETIN OF MATHEMATICAL BIOLOGY. 81(1), 7-38
  • LI, ZHIHUA, RIDDER, BRADLEY J., HAN, XIAOMEI, WU, WENDY W., SHENG, JIANSONG, TRAN, PHU N., WU, MIN, RANDOLPH, AARON, JOHNSTONE, ROSS H., MIRAMS, GARY R., KURYSHEV, YURI, KRAMER, JAMES, WU, CAIYUN, CRUMB, WILLIAM J., JR. and STRAUSS, DAVID G., 2019. Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative CLINICAL PHARMACOLOGY & THERAPEUTICS. 105(2), 466-475
  • CLERX, MICHAEL, BEATTIE, KYLIE A., GAVAGHAN, DAVID J. and MIRAMS, GARY R., 2019. BIOPHYSICAL JOURNAL. 117(12), 2420-2437
  • LEI, CHON LOK, CLERX, MICHAEL, BEATTIE, KYLIE A., MELGARI, DARIO, HANCOX, JULES C., GAVAGHAN, DAVID J., POLONCHUK, LIUDMILA, WANG, KEN and MIRAMS, GARY R., 2019. BIOPHYSICAL JOURNAL. 117(12), 2455-2470
  • LEI, CHON LOK, CLERX, MICHAEL, GAVAGHAN, DAVID J., POLONCHUK, LIUDMILA, MIRAMS, GARY R. and WANG, KEN, 2019. BIOPHYSICAL JOURNAL. 117(12), 2438-2454
  • SAMANTA, KRISHNA, MIRAMS, GARY R. and PAREKH, ANANT B., 2018. NATURE COMMUNICATIONS. 9,
  • BEATTIE, K, HILL, AP, CUI, Y, VANDENBERG, JI, GAVAGHAN, DJ, DE BOER, TP and MIRAMS, GR, 2018. The Journal of Physiology. 596(10), 1813-1828
  • DALY, AIDAN C, CLERX, MICHAEL, BEATTIE, KYLIE A, COOPER, JONATHAN, GAVAGHAN, DAVID J and MIRAMS, GARY R, 2018. Reproducible model development in the cardiac electrophysiology Web Lab. Progress in biophysics and molecular biology.
  • LI, ZHIHUA, RIDDER, BRADLEY J, HAN, XIAOMEI, WU, WENDY W, SHENG, JIANSONG, TRAN, PHU N, WU, MIN, RANDOLPH, AARON, JOHNSTONE, ROSS H, MIRAMS, GARY R, KURYSHEV, YURI, KRAMER, JAMES, WU, CAIYUN, CRUMB, WILLIAM J JR and STRAUSS, DAVID G, 2018. Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative. Clinical pharmacology and therapeutics.
  • ASTON D, CAPEL RA, FORD KL, CHRISTIAN HC, MIRAMS GR, ROG-ZIELINSKA EA, KOHL P, GALIONE A, BURTON RA and TERRAR DA, 2017. Scientific reports. 7, 40620
  • JOHNSTONE RH, BARDENET R, GAVAGHAN DJ and MIRAMS GR, 2017. Wellcome open research. 1, 6
  • LIGNEAU, XAVIER, SHAH, RASHMI R., BERREBI-BERTRAND, ISABELLE, MIRAMS, GARY R., ROBERT, PHILIPPE, LANDAIS, LAURENT, MAISON-BLANCHE, PIERRE, FAIVRE, JEAN-FRANCOIS, LECOMTE, JEANNE-MARIE and SCHWARTZ, JEAN-CHARLES, 2017. BRITISH JOURNAL OF PHARMACOLOGY. 174(23), 4449-4463
  • LEI, CHON LOK, WANG, KEN, CLERX, MICHAEL, JOHNSTONE, ROSS H., HORTIGON-VINAGRE, MARIA P., ZAMORA, VICTOR, ALLAN, ANDREW, SMITH, GODFREY L., GAVAGHAN, DAVID J., MIRAMS, GARY R. and POLONCHUK, LIUDMILA, 2017. FRONTIERS IN PHYSIOLOGY. 8,
  • CHANG, KELLY C., DUTTA, SARA, MIRAMS, GARY R., BEATTIE, KYLIE A., SHENG, JIANSONG, TRAN, PHU N., WU, MIN, WU, WENDY W., COLATSKY, THOMAS, STRAUSS, DAVID G. and LI, ZHIHUA, 2017. FRONTIERS IN PHYSIOLOGY. 8,
  • MCMILLAN, BETH, GAVAGHAN, DAVID J. and MIRAMS, GARY R., 2017. TOXICOLOGY RESEARCH. 6(6), 912-921
  • HARTUNG, THOMAS, FITZGERALD, REX E., JENNINGS, PAUL, MIRAMS, GARY R., PEITSCH, MANUEL C., ROSTAMI-HODJEGAN, AMIN, SHAH, IMRAN, WILKS, MARTIN F. and STURLA, SHANA J., 2017. CHEMICAL RESEARCH IN TOXICOLOGY. 30(4), 870-882
  • MAHONEY VM, MEZZANO V, MIRAMS GR, MAASS K, LI Z, CERRONE M, VASQUEZ C, BAPAT A, DELMAR M and MORLEY GE, 2016. Scientific reports. 6, 26744
  • AP HILL, MD PERRY, N ABI-GERGES, J-P COUDEREC, B FERMINI, JC HANCOX, BC KNOLLMANN, GR MIRAMS, J SKINNER, W ZAREBA and JI VANDENBERG, 2016. The Journal of physiology. 594(23), 6893-6908
  • GR MIRAMS, P PATHMANATHAN, RA GRAY, P CHALLENOR and RH CLAYTON, 2016. The Journal of physiology. 594(23), 6833-6847
  • DAVIES MR, WANG K, MIRAMS GR, CARUSO A, NOBLE D, WALZ A, LAV脡 T, SCHULER F, SINGER T and POLONCHUK L, 2016. Drug discovery today. 21(6), 924-38
  • COOPER J, SCHARM M and MIRAMS GR, 2016. Biophysical journal. 110(2), 292-300
  • JOHNSTONE RH, CHANG ET, BARDENET R, DE BOER TP, GAVAGHAN DJ, PATHMANATHAN P, CLAYTON RH and MIRAMS GR, 2016. Journal of Molecular and Cellular Cardiology. 96, 49-62
  • KAR P, MIRAMS GR, CHRISTIAN HC and PAREKH AB, 2016. Molecular cell. 64(4), 746-759
  • SAMANTA K, KAR P, MIRAMS GR and PAREKH AB, 2015. Cell reports. 12(2), 203-16
  • CAPEL RA, HERRING N, KALLA M, YAVARI A, MIRAMS GR, DOUGLAS G, BUB G, CHANNON K, PATERSON DJ, TERRAR DA and BURTON RA, 2015. Heart rhythm : the official journal of the Heart Rhythm Society. 12(10), 2186-94
  • WILLIAMS G and MIRAMS GR, 2015. Journal of pharmacological and toxicological methods. 75, 10-6
  • COOPER J, SPITERI RJ and MIRAMS GR, 2015. Frontiers in physiology. 5, 511
  • WANG K, LEE P, MIRAMS GR, SARATHCHANDRA P, BORG TK, GAVAGHAN DJ, KOHL P and BOLLENSDORFF C, 2015. American journal of physiology. Heart and circulatory physiology. 308(9), H1112-25
  • WALMSLEY J, MIRAMS GR, PITT-FRANCIS J, RODRIGUEZ B and BURRAGE K, 2014. Journal of theoretical biology. 365, 325-36
  • MIRAMS GR, DAVIES MR, BROUGH SJ, BRIDGLAND-TAYLOR MH, CUI Y, GAVAGHAN DJ and ABI-GERGES N, 2014. Journal of pharmacological and toxicological methods. 70(3), 246-54
  • OSBORNE JM, BERNABEU MO, BRUNA M, CALDERHEAD B, COOPER J, DALCHAU N, DUNN SJ, FLETCHER AG, FREEMAN R, GROEN D, KNAPP B, MCINERNY GJ, MIRAMS GR, PITT-FRANCIS J, SENGUPTA B, WRIGHT DW, YATES CA, GAVAGHAN DJ, EMMOTT S and DEANE C, 2014. PLoS computational biology. 10(3), e1003506
  • ELKINS RC, DAVIES MR, BROUGH SJ, GAVAGHAN DJ, CUI Y, ABI-GERGES N and MIRAMS GR, 2013. Journal of pharmacological and toxicological methods. 68(1), 112-22
  • BEATTIE KA, LUSCOMBE C, WILLIAMS G, MUNOZ-MURIEDAS J, GAVAGHAN DJ, CUI Y and MIRAMS GR, 2013. Journal of pharmacological and toxicological methods. 68(1), 88-96
  • MIRAMS GR, ARTHURS CJ, BERNABEU MO, BORDAS R, COOPER J, CORRIAS A, DAVIT Y, DUNN SJ, FLETCHER AG, HARVEY DG, MARSH ME, OSBORNE JM, PATHMANATHAN P, PITT-FRANCIS J, SOUTHERN J, ZEMZEMI N and GAVAGHAN DJ, 2013. PLoS computational biology. 9(3), e1002970
  • WALMSLEY J, RODRIGUEZ JF, MIRAMS GR, BURRAGE K, EFIMOV IR and RODRIGUEZ B, 2013. PloS one. 8(2), e56359
  • BRIDGE, LJ, MIRAMS, GR, KIEFFER, ML, KING, JR and KEPINSKI, S, 2012. Mathematical Biosciences. 235(1), 32-44
  • ZEMZEMI N, BERNABEU MO, SAIZ J, COOPER J, PATHMANATHAN P, MIRAMS GR, PITT-FRANCIS J and RODRIGUEZ B, 2012. British journal of pharmacology. 168(3), 718-33
  • MIRAMS GR, FLETCHER AG, MAINI PK and BYRNE HM, 2012. Journal of theoretical biology. 312, 143-56
  • JONSSON MK, VOS MA, MIRAMS GR, DUKER G, SARTIPY P, DE BOER TP and VAN VEEN TA, 2012. Journal of molecular and cellular cardiology. 52(5), 998-1008
  • MIRAMS GR, DAVIES MR, CUI Y, KOHL P and NOBLE D, 2012. British journal of pharmacology. 167(5), 932-45
  • MIRAMS GR and NOBLE D, 2012. Annals of the New York Academy of Sciences. 1245, 44-7
  • QUINN TA, GRANITE S, ALLESSIE MA, ANTZELEVITCH C, BOLLENSDORFF C, BUB G, BURTON RA, CERBAI E, CHEN PS, DELMAR M, DIFRANCESCO D, EARM YE, EFIMOV IR, EGGER M, ENTCHEVA E, FINK M, FISCHMEISTER R, FRANZ MR, GARNY A, GILES WR, HANNES T, HARDING SE, HUNTER PJ, IRIBE G, JALIFE J, JOHNSON CR, KASS RS, KODAMA I, KOREN G, LORD P, MARKHASIN VS, MATSUOKA S, MCCULLOCH AD, MIRAMS GR, MORLEY GE, NATTEL S, NOBLE D, OLESEN SP, PANFILOV AV, TRAYANOVA NA, RAVENS U, RICHARD S, ROSENBAUM DS, RUDY Y, SACHS F, SACHSE FB, SAINT DA, SCHOTTEN U, SOLOVYOVA O, TAGGART P, TUNG L, VARR脫 A, VOLDERS PG, WANG K, WEISS JN, WETTWER E, WHITE E, WILDERS R, WINSLOW RL and KOHL P, 2011. Progress in biophysics and molecular biology. 107(1), 4-10
  • BRIDGE LJ, MIRAMS GR, KIEFFER ML, KING JR and KEPINSKI S, 2011. Mathematical biosciences. 235(1), 32-44
  • COOPER J, MIRAMS GR and NIEDERER SA, 2011. Progress in biophysics and molecular biology. 107(1), 11-20
  • FLETCHER K, SHAH RR, THOMAS A, TOBIN F, RODRIGUEZ B, MIRAMS GR, SAIZ J and NOBLE D, 2011. Drug safety. 34(5), 439-43
  • MIRAMS GR, CUI Y, SHER A, FINK M, COOPER J, HEATH BM, MCMAHON NC, GAVAGHAN DJ and NOBLE D, 2011. Cardiovascular research. 91(1), 53-61
  • MIRAMS, G.R and BYRNE, H.M. AND KING, J.R., 2010. J. Math. Biol.. 60, 131-160
  • OSBORNE, J.M., WALTER, A., KERSHAW, S., MIRAMS, G.R., FLETCHER, A.G., PATHMANATHAN, P., GAVAGHAN, D., JENSEN, O.E., MAINI, P.K. and BYRNE, H.M., 2010. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences. 368, 5013-5028
  • WALMSLEY J, MIRAMS G, BAHOSHY M, BOLLENSDORFF C, RODRIGUEZ B and BURRAGE K, 2010. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2010, 1457-60
  • MURRAY PJ, KANG JW, MIRAMS GR, SHIN SY, BYRNE HM, MAINI PK and CHO KH, 2010. Biophysical journal. 99(3), 716-25
  • OSBORNE JM, WALTER A, KERSHAW SK, MIRAMS GR, FLETCHER AG, PATHMANATHAN P, GAVAGHAN D, JENSEN OE, MAINI PK and BYRNE HM, 2010. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences. 368(1930), 5013-28
  • VAN LEEUWEN, I.M.M, MIRAMS, G.R, WALTER, A, FLETCHER, A, MURRAY, P, OSBORNE, J, COOPER, J, PITT-FRANCIS, J, MOMTAHAN, L, PATHMANATHAN, P, WHITELEY, J.P, JENSEN, O.E, EASTBURN, S.J and VARMA,, 2009. Cell Proliferation. 42, 617-636
  • VAN LEEUWEN IM, MIRAMS GR, WALTER A, FLETCHER A, MURRAY P, OSBORNE J, VARMA S, YOUNG SJ, COOPER J, DOYLE B, PITT-FRANCIS J, MOMTAHAN L, PATHMANATHAN P, WHITELEY JP, CHAPMAN SJ, GAVAGHAN DJ, JENSEN OE, KING JR, MAINI PK, WATERS SL and BYRNE HM, 2009. Cell proliferation. 42(5), 617-36
  • PATHMANATHAN P, COOPER J, FLETCHER A, MIRAMS G, MURRAY P, OSBORNE J, PITT-FRANCIS J, WALTER A and CHAPMAN SJ, 2009. Physical biology. 6(3), 036001

Centre for Mathematical Medicine and Biology

School of Mathematical Sciences
糖心原创
Nottingham, NG7 2RD

telephone: +44 (0) 115 748 6065
fax: +44 (0) 115 951 3837
email: bindi.brook@nottingham.ac.uk