糖心原创

School of Chemistry
 

Image of Hon Wai Lam

Hon Wai Lam

Professor of Organic Synthesis, Faculty of Science

Contact

  • workRoom A08 The GSK Carbon Neutral Laboratories for Sustainable Chemistry
    Innovation Park
    Triumph Road
    Nottingham
    NG7 2TU
    UK
  • work0115 748 4677

Biography

Hon Wai Lam was born in Harrow, England in 1976, and grew up in northwest London. In 1994, Hon moved to the University of Oxford where he received his M.Chem. degree in chemistry in 1998, conducting undergraduate research with Jeremy Robertson.

He then moved to the 糖心原创 to carry out his Ph.D studies, working under the direction of Gerald Pattenden. There he completed the total synthesis of the proposed structure of amphidinolide A.

In January 2002, Hon moved to Harvard University as a GlaxoSmithKline Postdoctoral Fellow to work with David A. Evans on asymmetric catalysis.

In October 2003, Hon joined the School of Chemistry at the University of Edinburgh as a Lecturer, where he started his independent research around the development of new synthetic methodology, enantioselective catalysis, and natural product synthesis. Hon was promoted to Senior Lecturer in 2009, and to Reader in 2012. Recognition of Hon's work has come in the form of an RSC Harrison-Meldola Memorial Prize (2008), the RSC Hickinbottom Award (2011), and an AstraZeneca Excellence in Chemistry Award 2011.

Hon took up the GSK Chair of Sustainable Chemistry at the School of Chemistry, 糖心原创 on 1st October 2013.

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Research Summary

The principal objective of our research program is the development of new reaction methodology of broad utility to organic synthesis. We are particularly interested in the design of new… read more

Recent Publications

  • RIT, RAJA K. K., LI, HONGYI, ARGENT, STEPHEN P. P., WHEELHOUSE, KATHERINE M. M., WOODWARD, SIMON and LAM, HON WAI, 2023. A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis ADVANCED SYNTHESIS & CATALYSIS.
  • GORBACHEV, DMITRY, SMITH, ELLIOT, ARGENT, STEPHEN P., NEWTON, GRAHAM N. and LAM, HON WAI, 2022. Synthesis of New Morphinan Opioids by TBADT-Catalyzed Photochemical Functionalization at the Carbon Skeleton CHEMISTRY-A EUROPEAN JOURNAL. 28(50),
  • GILLBARD, SIMONE M. and LAM, HON WAI, 2022. Nickel-Catalyzed Arylative Cyclizations of Alkyne- and Allene-Tethered Electrophiles using Arylboron Reagents CHEMISTRY-A EUROPEAN JOURNAL. 28(18),
  • O'BRIEN, LUKE, ARGENT, STEPHEN P., ERMANIS, KRISTAPS and LAM, HON WAI, 2022. Gold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 61(22),

Current Research

The principal objective of our research program is the development of new reaction methodology of broad utility to organic synthesis. We are particularly interested in the design of new metal-catalyzed reactions that result in rapid increases in molecular and/or stereochemical complexity. Projects involve the development of catalytic systems that operate through novel modes of action and which lead to product formation with high levels of diastereo- and enantiocontrol. Current areas of interest include: (i) enantioselective rhodium-catalyzed addition reactions; (ii) the use of C=N-containing azaarenes as activating groups for enantioselective catalysis; (iii) catalytic C-H functionalization reactions, and (iv) application of newly developed methodology to the synthesis of biologically active molecules.

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  • RIT, RAJA K. K., LI, HONGYI, ARGENT, STEPHEN P. P., WHEELHOUSE, KATHERINE M. M., WOODWARD, SIMON and LAM, HON WAI, 2023. A Scalable Synthesis of Chiral Himbert Diene Ligands for Asymmetric Catalysis ADVANCED SYNTHESIS & CATALYSIS.
  • GORBACHEV, DMITRY, SMITH, ELLIOT, ARGENT, STEPHEN P., NEWTON, GRAHAM N. and LAM, HON WAI, 2022. Synthesis of New Morphinan Opioids by TBADT-Catalyzed Photochemical Functionalization at the Carbon Skeleton CHEMISTRY-A EUROPEAN JOURNAL. 28(50),
  • GILLBARD, SIMONE M. and LAM, HON WAI, 2022. Nickel-Catalyzed Arylative Cyclizations of Alkyne- and Allene-Tethered Electrophiles using Arylboron Reagents CHEMISTRY-A EUROPEAN JOURNAL. 28(18),
  • O'BRIEN, LUKE, ARGENT, STEPHEN P., ERMANIS, KRISTAPS and LAM, HON WAI, 2022. Gold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 61(22),
  • GREEN, HARLEY, ARGENT, STEPHEN P. and LAM, HON WAI, 2021. CHEMISTRY-A EUROPEAN JOURNAL. 27(19), 5897-5900
  • GILLBARD, SIMONE M., GREEN, HARLEY, ARGENT, STEPHEN P. and LAM, HON WAI, 2021. CHEMICAL COMMUNICATIONS. 57(36), 4436-4439
  • DI SANZA, RICCARDO, THI LE NHON NGUYEN, IQBAL, NAEEM, ARGENT, STEPHEN P., LEWIS, WILLIAM and LAM, HON WAI, 2020. CHEMICAL SCIENCE. 11(9), 2401-2406
  • GROVES, ALISTAIR, SUN, JINWEI, PARKE, HAL R. I., CALLINGHAM, MICHAEL, ARGENT, STEPHEN P., TAYLOR, LAURENCE J. and LAM, HON WAI, 2020. CHEMICAL SCIENCE. 11(10), 2759-2764
  • O'BRIEN, LUKE, KARAD, SOMNATH NARAYAN, LEWIS, WILLIAM and LAM, HON WAI, 2019. Rhodium-catalyzed arylative cyclization of alkynyl malonates by 1,4-rhodium(i) migration CHEMICAL COMMUNICATIONS. 55(76), 11366-11369
  • RUSCOE, REBECCA E., CALLINGHAM, MICHAEL, BAKER, JOSHUA A., KORKIS, STAMATIS E. and LAM, HON WAI, 2019. CHEMICAL COMMUNICATIONS. 55(6), 838-841
  • DOOLEY, JOHNATHON D. and LAM, HON WAI, 2018. CHEMISTRY-A EUROPEAN JOURNAL. 24(16), 4050-4054
  • LUO, YUNFEI, WALES, STEVEN M., KORKIS, STAMATIS E., ROY, IAIN D., LEWIS, WILLIAM and LAM, HON WAI, 2018. CHEMISTRY-A EUROPEAN JOURNAL. 24(33), 8315-8319
  • THI LE NHON NGUYEN, INCERTI-PRADILLOS, CELIA A., LEWIS, WILLIAM and HON WAI LAM, 2018. CHEMICAL COMMUNICATIONS. 54(44), 5622-5625
  • KARAD, SOMNATH NARAYAN, PANCHAL, HEENA, CLARKE, CHRISTOPHER, LEWIS, WILLIAM and LAM, HON WAI, 2018. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57(29), 9122-9125
  • GILLBARD, SIMONE M., CHUNG, CHIEH-HSU, KARAD, SOMNATH NARAYAN, PANCHAL, HEENA, LEWIS, WILLIAM and LAM, HON WAI, 2018. CHEMICAL COMMUNICATIONS. 54(83), 11769-11772
  • PANCHAL, HEENA, CLARKE, CHRISTOPHER, BELL, CHARLES, KARAD, SOMNATH NARAYAN, LEWIS, WILLIAM and LAM, HON WAI, 2018. CHEMICAL COMMUNICATIONS. 54(87), 12389-12392
  • PARTRIDGE, BENJAMIN M., CALLINGHAM, MICHAEL, LEWIS, WILLIAM and LAM, HON WAI, 2017. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 56(25), 7227-7232
  • YAP, CONNOR, LENAGH-SNOW, GABRIEL M. J., KARAD, SOMNATH NARAYAN, LEWIS, WILLIAM, DIORAZIO, LOUIS J. and LAM, HON WAI, 2017. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 56(28), 8216-8220
  • ZHU, SHAOQUN, PATHIGOOLLA, ATCHUTARAO, LOWE, GRACE, WALSH, DARREN A., COOPER, MICK, LEWIS, WILLIAM and LAM, HON WAI, 2017. CHEMISTRY-A EUROPEAN JOURNAL. 23(69), 17598-17604
  • MARTINEZ, JOSE I., SMITH, JOSHUA J., HEPBURN, HAMISH B. and LAM, HON WAI, 2016. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 55(3), 1108-1112
  • SMITH, JOSHUA J., BEST, DANIEL and LAM, HON WAI, 2016. CHEMICAL COMMUNICATIONS. 52(19), 3770-3772
  • KORKIS, STAMATIS E., BURNS, DAVID J. and LAM, HON WAI, 2016. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138(37), 12252-12257
  • CLARKE, CHRISTOPHER, INCERTI-PRADILLOS, CELIA A. and LAM, HON WAI, 2016. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 138(26), 8068-8071
  • KHAN, IMTIAZ, CHIDIPUDI, SURESH REDDY and LAM, HON WAI, 2015. CHEMICAL COMMUNICATIONS. 51(13), 2613-2616
  • BURNS, ALAN R., MADEC, AMAEL G. E., LOW, DARRYL W., ROY, IAIN D. and LAM, HON WAI, 2015. CHEMICAL SCIENCE. 6(6), 3550-3555
  • CHOI, BONNIE, SAXENAA, AAKARSH, SMITH, JOSHUA J., CHURCHILL, GWYDION H. and LAM, HON WAI, 2015. SYNLETT. 26(3), 350-354
  • BEST, DANIEL, BURNS, DAVID J. and LAM, HON WAI, 2015. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(25), 7410-7413
  • BURNS, DAVID J., BEST, DANIEL, WIECZYSTY, MARTIN D. and LAM, HON WAI, 2015. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(34), 9958-9962
  • CHIDIPUDI, SURESH REDDY, BURNS, DAVID J., KHAN, IMTIAZ and LAM, HON WAI, 2015. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 54(47), 13975-13979
  • BEST, DANIEL and LAM, HON WAI, 2014. JOURNAL OF ORGANIC CHEMISTRY. 79(3), 831-845
  • ROY, IAIN D., BURNS, ALAN R., PATTISON, GRAHAM, MICHEL, BORIS, PARKER, ALEXANDRA J. and LAM, HON WAI, 2014. CHEMICAL COMMUNICATIONS. 50(22), 2865-2868
  • LUO, YUNFEI, ROY, IAIN D, MADEC, AMAEL G E and LAM, HON WAI, 2014. Angewandte Chemie International Edition. 53(16), 4186-90
  • PARTRIDGE, BENJAMIN M., GONZALEZ, JORGE SOLANA and LAM, HON WAI, 2014. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 53(25), 6523-6527
  • KUJAWA, SZYMON, BEST, DANIEL, BURNS, DAVID J. and LAM, HON WAI, 2014. CHEMISTRY-A EUROPEAN JOURNAL. 20(28), 8599-8602
  • BURNS, DAVID J. and LAM, HON WAI, 2014. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 53(37), 9931-9935
  • HEPBURN, HAMISH B. and LAM, HON WAI, 2014. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 53(43), 11605-11610
  • SIMPSON, ALAIN J. and LAM, HON WAI, 2013. ORGANIC LETTERS. 15(11), 2586-2589
  • DOOLEY, JOHNATHON D., CHIDIPUDI, SURESH REDDY and LAM, HON WAI, 2013. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 135(29), 10829-10836
  • CHIDIPUDI, SURESH REDDY, WIECZYSTY, MARTIN D., KHAN, IMTIAZ and LAM, HON WAI, 2013. ORGANIC LETTERS. 15(3), 570-573
  • HEPBURN, HAMISH B., CHOTSAENG, NAWASIT, LUO, YUNFEI and LAM, HON WAI, 2013. SYNTHESIS-STUTTGART. 45(19), 2649-2661
  • SAXENA, A., CHOI, B. and LAM, H.W., 2012. Journal of the American Chemical Society. 134(20), 8428-8431
  • CHIDIPUDI, S.R., KHAN, I. and LAM, H.W., 2012. Angewandte Chemie International Edition. 51(48), 12115-12119
  • LUO, Y., HEPBURN, H.B., CHOTSAENG, N. and LAM, H.W., 2012. Angewandte Chemie International Edition. 51(33), 8309-8313
  • LUO, YUNFEI, CARNELL, ANDREW J. and LAM, HON WAI, 2012. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 51(27), 6762-6766
  • SMITH, DONNA L., GOUNDRY, WILLIAM R. F. and LAM, HON WAI, 2012. CHEMICAL COMMUNICATIONS. 48(10), 1505-1507
  • FALLAN, CHARLENE and HON WAI LAM, 2012. CHEMISTRY-A EUROPEAN JOURNAL. 18(36), 11214-11218
  • LOW, DARRYL W., PATTISON, GRAHAM, WIECZYSTY, MARTIN D., CHURCHILL, GWYDION H. and LAM, HON WAI, 2012. ORGANIC LETTERS. 14(10), 2548-2551
  • BURNS, ALAN R., GONZALEZ, JORGE SOLANA and LAM, HON WAI, 2012. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 51(43), 10827-10831
  • SMITH, DONNA L., CHIDIPUDI, SURESH REDDY, GOUNDRY, WILLIAM R. and LAM, HON WAI, 2012. ORGANIC LETTERS. 14(18), 4934-4937
  • BEST, DANIEL, KUJAWA, SZYMON and LAM, HON WAI, 2012. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 134(44), 18193-18196
  • LAM, HON WAI, 2011. SYNTHESIS-STUTTGART. 2011-2043
  • FALLAN, CHARLENE, QUIGLEY, PAUL F. and LAM, HON WAI, 2011. JOURNAL OF ORGANIC CHEMISTRY. 76(10), 4112-4118
  • SAXENA, AAKARSH and LAM, HON WAI, 2011. CHEMICAL SCIENCE. 2(12), 2326-2331
  • CHERCHEJA, SERGHEI, SIMPSON, JULIET K. and LAM, HON WAI, 2011. TETRAHEDRON. 67(21), 3839-3845
  • PATTISON, G., PIRAUX, G. and LAM, H.W., 2010. Journal of the American Chemical Society. 132(41), 14373-14375
  • GOURDET, BENOIT, RUDKIN, MAIRI E. and LAM, HON WAI, 2010. ORGANIC LETTERS. 12(11), 2554-2557
  • GOURDET, BENOIT, SMITH, DONNA L. and LAM, HON WAI, 2010. TETRAHEDRON. 66(32), 6026-6031
  • GOURDET, BENOIT and LAM, HON WAI, 2010. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 49(46), 8733-8737
  • BROGAN, SAMANTHA, CARTER, NEIL B. and LAM, HON WAI, 2010. SYNLETT. 615-617
  • GOURDET, BENOIT and LAM, HON WAI, 2009. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131(11), 3802-+
  • RUPNICKI, LESZEK, SAXENA, AAKARSH and LAM, HON WAI, 2009. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 131(30), 10386-+
  • OSWALD, CLAIRE L., PETERSON, JUSTINE A. and LAM, HON WAI, 2009. ORGANIC LETTERS. 11(20), 4504-4507
  • GOURDET, BENOIT, RUDKIN, MAIRI E., WATTS, CIORSDAIDH A. and LAM, HON WAI, 2009. JOURNAL OF ORGANIC CHEMISTRY. 74(20), 7849-7858
  • WANG, YI and LAM, HON WAI, 2009. JOURNAL OF ORGANIC CHEMISTRY. 74(3), 1353-1355
  • MARGALEF, ISABEL VILLANUEVA, RUPNICKI, LESZEK and LAM, HON WAI, 2008. TETRAHEDRON. 64(34), 7896-7901
  • PRIETO, OSCAR and LAM, HON WAI, 2008. ORGANIC & BIOMOLECULAR CHEMISTRY. 6(1), 55-57
  • FORDYCE, EUAN A. F., WANG, YI, LUEBBERS, THOMAS and LAM, HON WAI, 2008. CHEMICAL COMMUNICATIONS. 1124-1126
  • LUMBY, RALPH J. R., JOENSUU, PEKKA M. and LAM, HON WAI, 2008. TETRAHEDRON. 64(33), 7729-7740
  • WANG, YI, FORDYCE, EUAN A. F., CHEN, FUNG YAN and LAM, HON WAI, 2008. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 47(38), 7350-7353
  • FORDYCE, EUAN A. F., LUEBBERS, THOMAS and LAM, HON WAI, 2008. ORGANIC LETTERS. 10(18), 3993-3996
  • JOENSUU, PEKKA M., MURRAY, GORDON J., FORDYCE, EUAN. A. F., LUEBBERS, THOMAS and LAM, HON WAI, 2008. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 130(23), 7328-7338
  • RUDKIN, MAIRI E., JOENSUU, PEKKA M., MACLACHLAN, WILLIAM S. and LAM, HON WAI, 2008. ORGANIC LETTERS. 10(14), 2939-2942
  • SCANSETTI, MYRIAM, HU, XIANGPING, MCDERMOTT, BENJAMIN P. and LAM, HON WAI, 2007. ORGANIC LETTERS. 9(11), 2159-2162
  • LUMBY, RALPH J. R., JOENSUU, PEKKA M. and LAM, HON WAI, 2007. ORGANIC LETTERS. 9(21), 4367-4370
  • LAM, HON WAI, JOENSUU, PEKKA M., MURRAY, GORDON J., FORDYCE, EUAN A. F., PRIETO, OSCAR and LUEBBERS, THOMAS, 2006. ORGANIC LETTERS. 8(17), 3729-3732
  • LAM, HW, MURRAY, GJ and FIRTH, JD, 2005. ORGANIC LETTERS. 7(25), 5743-5746
  • LAM, HW and JOENSUU, PM, 2005. ORGANIC LETTERS. 7(19), 4225-4228

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