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Christopher Hayes

Professor of Organic Chemistry, Faculty of Science

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Biography

Prof. Christopher Hayes began his academic career here in Nottingham with his B.Sc. in July 1992.

He then completed his Ph.D. studies under the supervision of Professor Gerald Pattenden FRS at the 糖心原创 (1992-1995) working on the development of acyl radical chemistry and its application to the total synthesis of phomactin A.

In January 1996, he moved to the University of California at Berkeley (USA) as a NATO Postdoctoral Fellow where he worked in the group of Professor Clayton H. Heathcock on the successful synthesis of the potent anticancer molecules spongistatin 1 and 2.

In September 1997, he returned to Nottingham as a Lecturer in Organic Chemistry, and was subsequently promoted to Reader (2003), Associate Professor (2006) and Professor of Organic Chemistry (2011).

Research Summary

Research is centred in main-stream synthetic organic chemistry, focusing on the organic chemistry of biologically active molecules. His current research interests span a number of areas such as (i)… read more

Recent Publications

Current Research

Research is centred in main-stream synthetic organic chemistry, focusing on the organic chemistry of biologically active molecules. His current research interests span a number of areas such as (i) The total synthesis of biologically active natural products. Targets of current interest are lactacystin (20S proteasome inhibitor), myriocin (immunomodulator) and altemicidin (anti-tumor); (ii) The total synthesis of sequence specific DNA and RNA binding molecules for use as "antigene" and "antisense" therapeutic agents; (iii) The development of new methodology for use in synthesis.

  • NICOLLE, SIMON M., LEWIS, WILLIAM, HAYES, CHRISTOPHER J. and MOODY, CHRISTOPHER J., 2016. Stereoselective Synthesis of Functionalized Pyrrolidines by the Diverted N-H Insertion Reaction of Metallocarbenes with -Aminoketone Derivatives: Angewandte Chemie-International Edition Angewandte Chemie-International Edition. 55(11), 3749-3753
  • BARTON, NAOMI A., MARSH, BENJAMIN J., LEWIS, WILLIAM, NARRAIDOO, NATHALIE, SEYMOUR, GRAHAM B., FRAY, RUPERT and HAYES, CHRISTOPHER J., 2016. Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway?: Chemical Science Chemical Science. 7(5), 3102-3107
  • PALFRAMAN, MATTHEW J., ALHARTHY, RIMA D., POWALOWSKA, PAULINA K. and HAYES, CHRISTOPHER J., 2016. Synthesis of triazole-linked morpholino oligonucleotides via Cu-I catalysed cycloaddition: Organic & Biomolecular Chemistry Organic & Biomolecular Chemistry. 14(11), 3112-3119
  • NICOLLE, SIMON M., LEWIS, WILLIAM, HAYES, CHRISTOPHER J. and MOODY, CHRISTOPHER J., 2015. Stereoselective Synthesis of Highly Substituted Tetrahydrofurans through Diverted Carbene O-H Insertion Reaction: Angewandte Chemie-International Edition Angewandte Chemie-International Edition. 54(29), 8485-8489
  • KETLEY, AMI, CHEN, CATHERINE Z., LI, XIN, ARYA, SUKRAT, ROBINSON, THELMA E., GRANADOS-RIVERON, JAVIER, UDOSEN, INYANG, MORRIS, GLENN E., HOLT, IAN, FURLING, DENIS, CHAOUCH, SORAYA, HAWORTH, BEN, SOUTHALL, NOEL, SHINN, PAUL, ZHENG, WEI, AUSTIN, CHRISTOPHER P., HAYES, CHRISTOPHER J. and BROOK, J. DAVID, 2014. HUMAN MOLECULAR GENETICS. 23(6), 1551-1562
  • BARTRUM, HANNAH E., BLAKEMORE, DAVID C., MOODY, CHRISTOPHER J. and HAYES, CHRISTOPHER J., 2013. TETRAHEDRON. 69(10), 2276-2282
  • MYCOCK, DAVID K., GLOSSOP, PAUL A., LEWIS, WILLIAM and HAYES, CHRISTOPHER J., 2013. TETRAHEDRON LETTERS. 54(1), 55-57
  • PLATZ, JAMIE L., MOORE, REBECCA, BROOK, DAVID and HAYES, CHRISTOPHER, 2013. Reversal of RNA toxicity in myotonic dystrophy type 1 using antisense oligonucleotides ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 245,
  • HAYES, CHRISTOPHER J. and SIMPKINS, NIGEL S., 2013. ORGANIC & BIOMOLECULAR CHEMISTRY. 11(48), 8458-8462
  • FRASER, JAMIE, WILSON, LAURA J., BLUNDELL, REBECCA K. and HAYES, CHRISTOPHER J., 2013. CHEMICAL COMMUNICATIONS. 49(79), 8919-8921
  • BURROUGHS, L, CLARKE, PA, FORINTOS, H, GILKS, JAR, HAYES, CJ, VALE, ME, WADE, W and ZBYTNIEWSKI, M, 2012. Organic & Biomolecular Chemistry. 10(8), 1565-1570
  • PASCERI R, BARTRUM HE, HAYES CJ and MOODY CJ, 2012. Chemical communications (Cambridge, England). 48(99), 12077-9
  • LI, X., ROBINSON, T. E., KETLEY, A., ARYA, S., UDOSEN, I., RIVERON, J. GRANADOS, FURLING, D., HAYES, C. J. and BROOK, J. D., 2012. Observations on oligo-based therapy for Myotonic Dystrophy NEUROMUSCULAR DISORDERS. 22, S27-S27
  • ARYA, S., LI, X., ROBINSON, T. E., UDOSEN, I., CHEN, C., AUSTIN, C., FURLING, D., HAYES, C., BROOK, J. D. and KETLEY, A., 2012. Compound screening in myotonic dystrophy NEUROMUSCULAR DISORDERS. 22, S29-S29
  • KRUSE, S., ZHONG, S., BODI, Z., BUTTON, J., ALCOCER, M.J.C., HAYES, C.J. and FRAY, R., 2011. Scientific Reports. 1, 126
  • BARTRUM, HE, BLAKEMORE, DC, MOODY, CJ and HAYES, CJ, 2011. Chemistry-A European Journal. 17(35), 9586-9589
  • UROOS, M and HAYES, CJ, 2011. Total synthesis of (+)-Cymbodiacetal In: 241st National Meeting and Exposition of the American-Chemical-Society (ACS). -
  • ALHARTHY, RDA and HAYES, CJ, 2011. Procyanidin B3 synthesis: A study of leaving group and Lewis acid activator effects upon interflavan bond formation In: 241st National Meeting and Exposition of the American-Chemical-Society (ACS). -
  • UROOS, M, LEWIS, W, BLAKE, AJ and HAYES, CJ, 2010. Journal Of Organic Chemistry. 75(24), 8465-8470
  • BARTRUM, HE, BLAKEMORE, DC, MOODY, CJ and HAYES, CJ, 2010. Journal Of Organic Chemistry. 75(24), 8674-8676
  • UROOS, M and HAYES, CJ, 2010. Organic Letters. 12(22), 5294-5297
  • BURROUGHS, L, VALE, ME, GILKS, JAR, FORINTOS, H, HAYES, CJ and CLARKE, PA, 2010. Chemical Communications. 46(26), 4776-4778
  • ALHARTHY, RD and HAYES, CJ, 2010. Tetrahedron Letters. 51(8), 1193-1195
  • HAMEED, A, BLAKE, AJ and HAYES, CJ, 2010. Synlett. 535-538
  • SIMPKINS, NS, TAYLOR, JD, WELLER, MD and HAYES, CJ, 2010. Synlett. 639-643
  • BROOK, D., HAYES, C., ROBINSON, T., UDOSEN, I., ARYA, S. and RIVERON, J. GRANADOS, 2010. NEUROMUSCULAR DISORDERS. 20, S10-S10
  • POWLEY, I.R., KONDRASHOV, A., YOUNG, L.A., DOBBYN, H.C., HILL, K., CANNELL, I.G., STONELEY, M., KONG, Y.-W., COTES, J.A., SMITH, G.C.M., WEK, R., HAYES, C., GANT, T.W., SPRIGGS, K.A., BUSHELL, M. and WILLIS, A.E., 2009. Genes & Development. 23(10), 1207-1220
  • ASARI, A and HAYES, CJ, 2009. A 糖心原创 Towards The Total Synthesis Of Tan1251b Sains Malaysiana. 38(6), 869-872
  • SMITH, MR, BLAKE, AJ, HAYES, CJ, STEVENS, MFG and MOODY, CJ, 2009. Journal Of Organic Chemistry. 74(24), 9372-9380
  • HAYES, C.J., SIMPKINS, N.S., KIRK, D.T., MITCHELL, L., BAUDOUX, J., BLAKE, A.J. and WILSON, C., 2009. Journal of the American Chemical Society. 131(23), 8196-8210
  • AIREY, G.D, MOHAMMED, M.H, COLLOP, A.C, PARRY, A. and HAYES, C. J., 2008. Journal of Road Materials and Pavement Design: Special Issue EATA 08. 9, 13-35
  • ESMIEU, W. R., WORDEN, S. M., CATTERICK, D., WILSON, C. and HAYES, C. J., 2008. Org. Lett.. 10, 3045-3048
  • HAYES, C.J., SHERLOCK, A.E., GREEN, M.P., WILSON, C., BLAKE, A.J., SELBY, M.D. and PRODGER, J.C., 2008. Journal of Organic Chemistry. 73(6), 2041-2051
  • COBBOLD, L. C., SPRIGGS, K. A., HAINES, S.J., DOBBYN, H. C., HAYES C., DE MOOR, C. H., LILLEY, K. S., BUSHELL, M. and WILLIS A. E., 2008. Mol. Cell. Biol.. 28, 40-49
  • HAMEED, A., BLAKE, A. J. and HAYES, C. J., 2008. J. Org. Chem.. 73, In Press (In Press.)
  • KOVACS, K., ZHANG, L., LINFORTH, R.S.T., WHITTAKER, B., HAYES, C.J. and FRAY, R.G., 2007. Transgenic Research. 16(1), 121-6
  • CARNALLY, S., BARROW, K., ALEXANDER, M., HAYES, C. J., STOLNIK, S., TENDLER, S. J. B. and ROBERTS, C. J., 2007. Langmuir. 23, 3906 - 3911
  • ASARI, A., ANGELOV, P., AUTY, J. M. and HAYES, C. J., 2007. Tetrahedron Letters. 48, 2631鈥�2634
  • HAYES, C.J., WHITTAKER, B.P., WATSON, S.A. and GRABOWSKA, A.M., 2006. Journal of Organic Chemistry. 71(26), 9701-9712
  • HAYES, C.J., SHERLOCK, A.E. and SELBY, M.D., 2006. Organic and Biomolecular Chemistry. 4(2), 193-195
  • HAYES, C.J., BRADLEY, D.M. and THOMSON, N.M., 2006. Journal of Organic Chemistry. 71(7), 2661-2665
  • HAYES,C.J., BEAVIS,P.W. and HUMPHRIES,L.A., 2006. Chemical Communications. 4501-4502
  • HAYES, C. J., HERBERT, N. M. A., HARRINGTON-FROST, N. M. and PATTENDEN, G., 2005. Organic and Biomolecular Chemistry. VOL 3(NUMB 2), 316-327
  • AUTY, J.M.A., CHURCHER, I. and HAYES, C.J., 2004. Synlett. 8, 1443-1445
  • GARCIA, P. L., BRADLEY, G., HAYES, C. J., KRINTEL, S., SOULTANAS, P. and JANSCAK, P., 2004. Nucleic Acids Research. VOL 32(NUMBER 12), 3771-3778
  • HAYES, C. J. AND SPRING, D. R., 2004. Highlights from the 39th ESF,EUCHEM Conference on Stereochemistry, Burgenstock, Switzerland, April 2004 Chem. Commun.. 2365-2367
  • DODDRIDGE, Z. A., BERTRAM, R. D., HAYES, C. J. and SOULTANAS, P., 2003. Biochemistry. VOL 42(PART 11), 3239-3246
  • FOOTE, K. M., HAYES, C. J., JOHN, M. P. and PATTENDEN, G., 2003. Organic and Biomolecular Chemistry. VOL 1(NUMB 22), 3917-3948
  • HEATHCOCK, C. H., MCLAUGHLIN, M., MEDINA, J., HUBBS, J. L., WALLACE, G. A., SCOTT, R., CLAFFEY, M. M., HAYES, C. J. and OTT, G. R., 2003. Journal of the American Chemical Society. VOL 125(PART 42), 12844-12849
  • BERTRAM, R. D., HAYES, C. J. and SOULTANAS, P., 2002. Biochemistry. VOL 41(PART 24), 7725-7731
  • MAPITSE, R. and HAYES, C. J., 2002. Tetrahedron Letters. VOL 43(NUMBER 19), 3541 - 3542
  • GREEN, M. P., PRODGER, J. C. and HAYES, C. J., 2002. Tetrahedron Letters. VOL 43(NUMBER 37), 6609 - 6611
  • WORDEN, S. M., MAPITSE, R. and HAYES, C. J., 2002. Tetrahedron Letters. VOL 43(PART 34), 6011-6014
  • BRADLEY, D. M., MAPITSE, R., THOMSON, N. M. and HAYES, C. J., 2002. Journal of Organic Chemistry. VOL 67(PART 22), 7613-7617
  • GREEN, M. P., PRODGER, J. C. and HAYES, C. J., 2002. Tetrahedron Letters. VOL 43(NUMBER 14), 2649 - 2652
  • ABBAS, S., BERTRAM, R.D. and HAYES, C.J., 2001. Organic Letters. 3(21), 3365-3367
  • LERA, M. and HAYES, C.J., 2001. Organic Letters. 3(17), 2765-2768
  • GREEN, M. P., PRODGER, J. C., SHERLOCK, A. E. and HAYES, C. J., 2001. Organic Letters. VOL 3(NUMB 21), 3377-3380
  • ABBAS, S., HAYES, C. J. and WORDEN, S., 2000. Tetrahedron Letters. VOL 41(PART 17), 3215-3220
  • ABBAS, S. and HAYES, C. J., 2000. Tetrahedron Letters. VOL 41(PART 22), 4513-1417
  • LERA, M. and HAYES, C. J., 2000. Organic Letters. VOL 2(NUMB 24), 3873-3876
  • CLAFFEY, M. M., HAYES, C. J. and HEATHCOCK, C. H., 1999. Journal of Organic Chemistry. VOL 64(NUMBER 22), 8267-8274
  • BEDFORD, S. B., BELL, K. E., BENNETT, F., HAYES, C. J., KNIGHT, D. W. and SHAW, D., 1999. J. Chem. Soc., Perkin Trans. 1. 2143
  • ABBAS, S. and HAYES, C. J., 1999. A Novel Palladium-Catalysed Coupling Strategy for the Rapid Synthesis of Nucleic Acid Analogues Bearing Modified Backbones Synlett. NUMBER 7, 1124-1126
  • GABAITSEKGOSI, R. and HAYES, C.J., 1999. Tetrahedron Letters. VOL 40(NUMBER 43), 7713-7716
  • HAYES, C. J. and HEATHCOCK, C. H., 1997. Journal of Organic Chemistry. VOL 62(NUMBER 9), 2678-2679
  • HAYES, C. J. and PATTENDEN, G., 1996. Tetrahedron Letters. VOL 37(NUMBER 2), 271-274
  • FOOTE, K. M., HAYES, C. J. and PATTENDEN, G., 1996. Tetrahedron Letters. VOL 37(NUMBER 2), 275-278
  • HAYES, C. J and PATTENDEN, G., 1996. Tetrahedron Letters. 37, 271-274
  • HAYES, C. J and PATTENDEN, G., 1996. Tetrahedron Letters. 37, 271-274
  • HAYES, C. J and PATTENDEN, G., 1996. Tetrahedron Letters. 37, 271-274
  • JONES, R. C. F., BATES, A. D., CRANE, J. and HAYES, C. J., 1994. Reactions of Hetero(bis)nucleophiles with 3-Acyltetramic Acids J. Chem. Res. (S). 444
  • BEDFORD, S. B., BELL, K. E., FENTON, G., HAYES, C. J., KNIGHT, D. W. and SHAW, D., 1992. Iodoetherification of Homoallylic Alcohols-A Stereoselective Approach to Tetrahydrofurans Tetrahedron Letters. 6511
  • JONES, R. C. F., BATES, A. D., CRANE, J. and HAYES, C. J., Reactions of Hetero(bis)nucleophiles with 3-Acyltetramic Acids J. Chem. Res. (S). 1997, 444

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